{"id":"https://openalex.org/W4399599286","doi":"https://doi.org/10.2463/mrms.rev.2024-0053","title":"Beyond Macrostructure: Is There a Role for Radiomics Analysis in Neuroimaging ?","display_name":"Beyond Macrostructure: Is There a Role for Radiomics Analysis in Neuroimaging ?","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4399599286","doi":"https://doi.org/10.2463/mrms.rev.2024-0053","pmid":"https://pubmed.ncbi.nlm.nih.gov/38880615","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11234947"},"language":"en","primary_location":{"id":"doi:10.2463/mrms.rev.2024-0053","doi":"https://doi.org/10.2463/mrms.rev.2024-0053","is_oa":true,"landing_page_url":"https://doi.org/10.2463/mrms.rev.2024-0053","pdf_url":"https://www.jstage.jst.go.jp/article/mrms/23/3/23_rev.2024-0053/_pdf","source":{"id":"https://openalex.org/S90653425","display_name":"Magnetic Resonance in Medical Sciences","issn_l":"1347-3182","issn":["1347-3182","1880-2206"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313210","host_organization_name":"Japan Society of Magnetic Resonance in Medicine","host_organization_lineage":["https://openalex.org/P4310313210"],"host_organization_lineage_names":["Japan Society of Magnetic Resonance in Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance in Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jstage.jst.go.jp/article/mrms/23/3/23_rev.2024-0053/_pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047157013","display_name":"Sandhitsu R. Das","orcid":"https://orcid.org/0000-0003-0530-2887","observed_orcids":["https://orcid.org/0000-0003-0530-2887"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sandhitsu R. Das","raw_affiliation_strings":["Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA","Penn Image Computing and Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA","Penn Memory Center, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Penn Image Computing and Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Penn Memory Center, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037877469","display_name":"Ademola Enitan Ilesanmi","orcid":"https://orcid.org/0000-0002-1193-9932","observed_orcids":["https://orcid.org/0000-0002-1193-9932"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ademola Ilesanmi","raw_affiliation_strings":["Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA","Penn Image Computing and Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-1193-9932","affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Penn Image Computing and Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041387594","display_name":"David A. Wolk","orcid":"https://orcid.org/0000-0002-3554-3481","observed_orcids":["https://orcid.org/0000-0002-3554-3481","https://orcid.org/0000-0001-9447-5805"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Wolk","raw_affiliation_strings":["Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA","Penn Memory Center, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Penn Memory Center, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005451810","display_name":"James C. Gee","orcid":"https://orcid.org/0000-0002-2258-0187","observed_orcids":["https://orcid.org/0000-0002-2258-0187"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James C. Gee","raw_affiliation_strings":["Penn Image Computing and Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA"],"raw_orcid":"https://orcid.org/0000-0002-2258-0187","affiliations":[{"raw_affiliation_string":"Penn Image Computing and Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5047157013"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":1.0859,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.72634979,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"23","issue":"3","first_page":"367","last_page":"376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.043800000101327896,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiomics","display_name":"radiomics","score":0.9940000176429749},{"id":"https://openalex.org/keywords/neuroimaging-biomarkers","display_name":"neuroimaging biomarkers","score":0.8740000128746033},{"id":"https://openalex.org/keywords/texture-analysis","display_name":"texture analysis","score":0.6800000071525574},{"id":"https://openalex.org/keywords/quantitative-mri","display_name":"quantitative MRI","score":0.8069999814033508},{"id":"https://openalex.org/keywords/high-field-mri","display_name":"high-field MRI","score":0.9819999933242798},{"id":"https://openalex.org/keywords/neural-network","display_name":"artificial neural networks","score":0.6660000085830688},{"id":"https://openalex.org/keywords/multimodal-data-integration","display_name":"multimodal data integration","score":0.8169999718666077},{"id":"https://openalex.org/keywords/digital-histopathology","display_name":"digital histopathology","score":0.9789999723434448},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8429999947547913},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9789999723434448},{"id":"https://openalex.org/keywords/brain-structure","display_name":"brain structure","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.8425779938697815},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6437497735023499},{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.6379220485687256},{"id":"https://openalex.org/C2778559731","wikidata":"https://www.wikidata.org/wiki/Q23808793","display_name":"Radiomics","level":2,"score":0.6107867956161499},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4998941421508789},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.48432815074920654},{"id":"https://openalex.org/C165696696","wikidata":"https://www.wikidata.org/wiki/Q11287","display_name":"Exploit","level":2,"score":0.41451412439346313},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.41244903206825256},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37873730063438416},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3499240279197693},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.33556491136550903},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.32567304372787476},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.10679975152015686},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000097188","descriptor_name":"Radiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.2463/mrms.rev.2024-0053","doi":"https://doi.org/10.2463/mrms.rev.2024-0053","is_oa":true,"landing_page_url":"https://doi.org/10.2463/mrms.rev.2024-0053","pdf_url":"https://www.jstage.jst.go.jp/article/mrms/23/3/23_rev.2024-0053/_pdf","source":{"id":"https://openalex.org/S90653425","display_name":"Magnetic Resonance in Medical Sciences","issn_l":"1347-3182","issn":["1347-3182","1880-2206"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313210","host_organization_name":"Japan Society of Magnetic Resonance in Medicine","host_organization_lineage":["https://openalex.org/P4310313210"],"host_organization_lineage_names":["Japan Society of Magnetic Resonance in Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance in Medical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11234947","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11234947","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11234947/pdf/mrms-23-367.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magn Reson Med Sci","raw_type":"Text"},{"id":"pmid:38880615","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38880615","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2463/mrms.rev.2024-0053","doi":"https://doi.org/10.2463/mrms.rev.2024-0053","is_oa":true,"landing_page_url":"https://doi.org/10.2463/mrms.rev.2024-0053","pdf_url":"https://www.jstage.jst.go.jp/article/mrms/23/3/23_rev.2024-0053/_pdf","source":{"id":"https://openalex.org/S90653425","display_name":"Magnetic Resonance in Medical Sciences","issn_l":"1347-3182","issn":["1347-3182","1880-2206"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313210","host_organization_name":"Japan Society of Magnetic Resonance in Medicine","host_organization_lineage":["https://openalex.org/P4310313210"],"host_organization_lineage_names":["Japan Society of Magnetic Resonance in Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance in Medical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000912895","display_name":"Penn Alzheimer's Disease Research Center (ADRC)","funder_award_id":"P30AG072979","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4399599286.pdf","grobid_xml":"https://content.openalex.org/works/W4399599286.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W1970706614","https://openalex.org/W1974853994","https://openalex.org/W1990140735","https://openalex.org/W2044465660","https://openalex.org/W2125043543","https://openalex.org/W2135046866","https://openalex.org/W2138930389","https://openalex.org/W2174661749","https://openalex.org/W2783775739","https://openalex.org/W2798054687","https://openalex.org/W2889691470","https://openalex.org/W2895687530","https://openalex.org/W2906994123","https://openalex.org/W2909341957","https://openalex.org/W2928953430","https://openalex.org/W2950086191","https://openalex.org/W2958089299","https://openalex.org/W2989596723","https://openalex.org/W3009266521","https://openalex.org/W3014247165","https://openalex.org/W3074741277","https://openalex.org/W3112964755","https://openalex.org/W3113191400","https://openalex.org/W3126197619","https://openalex.org/W3127106548","https://openalex.org/W3131532480","https://openalex.org/W3137659085","https://openalex.org/W3157001030","https://openalex.org/W3161987231","https://openalex.org/W3164390524","https://openalex.org/W3164989023","https://openalex.org/W3171849353","https://openalex.org/W3174086521","https://openalex.org/W3178386347","https://openalex.org/W3186246625","https://openalex.org/W3196105426","https://openalex.org/W3199368218","https://openalex.org/W3204030525","https://openalex.org/W3208091253","https://openalex.org/W3208620984","https://openalex.org/W3215958759","https://openalex.org/W4200191097","https://openalex.org/W4200385797","https://openalex.org/W4206771551","https://openalex.org/W4206929543","https://openalex.org/W4207034881","https://openalex.org/W4210572355","https://openalex.org/W4223430324","https://openalex.org/W4224223045","https://openalex.org/W4224249244","https://openalex.org/W4237186189","https://openalex.org/W4283725517","https://openalex.org/W4285083522","https://openalex.org/W4289842561","https://openalex.org/W4290614101","https://openalex.org/W4291415397","https://openalex.org/W4294912031","https://openalex.org/W4303859604","https://openalex.org/W4306247176","https://openalex.org/W4313299867","https://openalex.org/W4316664925","https://openalex.org/W4321371946","https://openalex.org/W4323652596","https://openalex.org/W4324344458","https://openalex.org/W4361190068","https://openalex.org/W4376225182","https://openalex.org/W4379796979","https://openalex.org/W4379880742","https://openalex.org/W4382133330","https://openalex.org/W4383217072","https://openalex.org/W4383370984","https://openalex.org/W4383903795","https://openalex.org/W4384523451","https://openalex.org/W4384563863","https://openalex.org/W4385186694","https://openalex.org/W4386021181","https://openalex.org/W4386075969","https://openalex.org/W4386797621","https://openalex.org/W4387692359","https://openalex.org/W4388383507","https://openalex.org/W4388662783","https://openalex.org/W4389179256","https://openalex.org/W4389619138","https://openalex.org/W4390110710","https://openalex.org/W4390813134","https://openalex.org/W4390966613","https://openalex.org/W4391110090","https://openalex.org/W4391432169","https://openalex.org/W4391509766","https://openalex.org/W4392844919","https://openalex.org/W4394754148","https://openalex.org/W4395025889","https://openalex.org/W4396834842","https://openalex.org/W4415929054"],"related_works":["https://openalex.org/W2969397457","https://openalex.org/W3164291812","https://openalex.org/W6989944710","https://openalex.org/W4409122401","https://openalex.org/W7125357423","https://openalex.org/W7061488525","https://openalex.org/W2072511378","https://openalex.org/W2964880159","https://openalex.org/W6949992669","https://openalex.org/W2884156795"],"abstract_inverted_index":{"The":[0],"most":[1,216],"commonly":[2],"used":[3],"neuroimaging":[4],"biomarkers":[5],"of":[6,39,99,109,136,150,166,173,180,191,217,225,235,246,256,262,265],"brain":[7,48],"structure,":[8],"particularly":[9,90],"in":[10,30,50,120,148,202],"neurodegenerative":[11],"diseases,":[12],"have":[13,42],"traditionally":[14],"been":[15],"summary":[16,255],"measurements":[17],"from":[18,21],"ROIs":[19],"derived":[20],"structural":[22],"MRI,":[23,89],"such":[24,79],"as":[25,80,253],"volume":[26],"and":[27,37,83,162,175,193,212,229],"thickness.":[28],"Advances":[29],"MR":[31],"acquisition":[32],"techniques,":[33],"including":[34],"high-field":[35],"imaging,":[36],"emergence":[38],"learning-based":[40],"methods":[41],"opened":[43],"up":[44],"opportunities":[45,133],"to":[46,55,70,116,186,223,231,241],"interrogate":[47],"structure":[49],"finer":[51],"detail,":[52],"allowing":[53],"investigators":[54],"move":[56],"beyond":[57],"macrostructural":[58],"measurements.":[59],"On":[60,104],"the":[61,68,105,114,151,188,218,247,260,273],"one":[62],"hand,":[63,107],"superior":[64],"signal":[65],"contrast":[66],"has":[67,113],"potential":[69,115],"make":[71],"appearance-based":[72],"metrics":[73],"that":[74,122,143],"directly":[75],"analyze":[76],"intensity":[77],"patterns,":[78],"texture":[81],"analysis":[82],"radiomics":[84],"features,":[85],"more":[86],"reliable.":[87],"Quantitative":[88],"at":[91,139,170],"high-field,":[92],"can":[93,123],"also":[94],"provide":[95],"a":[96,206,254,263],"richer":[97],"set":[98,179],"measures":[100],"with":[101,127,159,205,268],"greater":[102],"interpretability.":[103],"other":[106,226,232],"use":[108],"neural":[110],"networks-based":[111],"techniques":[112],"exploit":[117],"subtle":[118],"patterns":[119],"images":[121],"now":[124],"be":[125,242],"mined":[126],"advanced":[128],"imaging.":[129],"Finally,":[130],"there":[131],"are":[132,169],"for":[134],"integration":[135],"multimodal":[137],"data":[138],"different":[140],"spatial":[141],"scales":[142],"is":[144,220,238],"enabled":[145],"by":[146,155],"developments":[147,201],"many":[149],"above":[152],"techniques-for":[153],"example,":[154],"combining":[156],"digital":[157],"histopathology":[158],"high-resolution":[160],"ex-vivo":[161],"in-vivo":[163],"MRI.":[164],"Some":[165],"these":[167],"approaches":[168],"early":[171],"stages":[172],"development":[174],"present":[176],"their":[177],"own":[178],"challenges.":[181],"Nonetheless,":[182],"they":[183],"hold":[184],"promise":[185],"drive":[187],"next":[189],"generation":[190],"validation":[192],"biomarker":[194],"studies.":[195],"This":[196],"article":[197],"will":[198],"survey":[199],"recent":[200,257],"this":[203],"area,":[204],"particular":[207],"focus":[208],"on":[209],"Alzheimer's":[210],"disease":[211],"related":[213],"disorders.":[214],"However,":[215],"discussion":[219,261],"equally":[221],"relevant":[222],"imaging":[224],"neurological":[227],"disorders,":[228],"even":[230],"organ":[233],"systems":[234],"interest.":[236],"It":[237],"not":[239],"meant":[240],"an":[243,269],"exhaustive":[244],"review":[245],"available":[248],"literature,":[249],"but":[250],"rather":[251],"presented":[252],"trends":[258],"through":[259],"collection":[264],"representative":[266],"studies":[267],"eye":[270],"towards":[271],"what":[272],"future":[274],"may":[275],"hold.":[276]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2024-06-14T00:00:00"}
