{"id":"https://openalex.org/W4399560201","doi":"https://doi.org/10.1016/s0168-8278(24)01792-6","title":"SAT-231 GL0034 (Utreglutide), a long acting, glucagon-like peptide-1 receptor agonist, improves body weight loss, lipid and liver injury markers in individuals with obesity: A phase 1 multiple ascending dose study","display_name":"SAT-231 GL0034 (Utreglutide), a long acting, glucagon-like peptide-1 receptor agonist, improves body weight loss, lipid and liver injury markers in individuals with obesity: A phase 1 multiple ascending dose study","publication_year":2024,"publication_date":"2024-06-01","ids":{"openalex":"https://openalex.org/W4399560201","doi":"https://doi.org/10.1016/s0168-8278(24)01792-6"},"language":"en","primary_location":{"id":"doi:10.1016/s0168-8278(24)01792-6","doi":"https://doi.org/10.1016/s0168-8278(24)01792-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-8278(24)01792-6","pdf_url":null,"source":{"id":"https://openalex.org/S83651209","display_name":"Journal of Hepatology","issn_l":"0168-8278","issn":["0168-8278","1600-0641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hepatology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006342728","display_name":"Rajamannar Thennati","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rajamannar Thennati","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041316789","display_name":"VINOD S. BURADE","orcid":"https://orcid.org/0009-0008-3710-3667","observed_orcids":["https://orcid.org/0009-0008-3710-3667"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vinod Burade","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000945570","display_name":"Muthukumaran Natarajan","orcid":"https://orcid.org/0000-0002-8674-6991","observed_orcids":["https://orcid.org/0000-0002-8674-6991"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Muthukumaran Natarajan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072236826","display_name":"Pradeep Kumar Shahi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pradeep Shahi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113296366","display_name":"Ravishankara Nagaraja","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ravishankara Nagaraja","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101215121","display_name":"SUDEEP K. AGRAWAL","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sudeep Agrawal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086009768","display_name":"Bernard J. Jandrain","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernard Jandrain","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084662929","display_name":"Thierry Duvauchelle","orcid":"https://orcid.org/0000-0002-4762-588X","observed_orcids":["https://orcid.org/0000-0002-4762-588X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thierry Duvauchelle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059098934","display_name":"Richard E. Pratley","orcid":"https://orcid.org/0000-0002-2912-1389","observed_orcids":["https://orcid.org/0000-0002-2912-1389"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard E. Pratley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079729308","display_name":"Bernard Thorens","orcid":"https://orcid.org/0000-0002-3738-0129","observed_orcids":["https://orcid.org/0000-0002-3738-0129"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernard Thorens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004120950","display_name":"Tina Vilsb\u00f8ll","orcid":"https://orcid.org/0000-0002-0456-6787","observed_orcids":["https://orcid.org/0000-0002-0456-6787"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tina Vilsb\u00f8ll","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5052059601","display_name":"Rohit Seth Loomba","orcid":"https://orcid.org/0000-0002-4845-9991","observed_orcids":["https://orcid.org/0000-0002-4845-9991"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rohit Loomba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4950,"currency":"USD","value_usd":4950},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"80","issue":null,"first_page":"S615","last_page":"S616"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.08240000158548355,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.9599999785423279},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9819999933242798},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.7910000085830688},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.7400000095367432},{"id":"https://openalex.org/keywords/liver-injury-biomarkers","display_name":"liver injury biomarkers","score":0.9129999876022339},{"id":"https://openalex.org/keywords/multiple-ascending-dose","display_name":"multiple ascending dose","score":0.621999979019165},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.621999979019165},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5884023308753967},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5852006673812866},{"id":"https://openalex.org/C185280430","wikidata":"https://www.wikidata.org/wiki/Q14909910","display_name":"Glucagon-like peptide 1 receptor","level":4,"score":0.569587767124176},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.5091599822044373},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4971363842487335},{"id":"https://openalex.org/C2776398474","wikidata":"https://www.wikidata.org/wiki/Q424611","display_name":"Glucagon-like peptide-1","level":4,"score":0.47355785965919495},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44890445470809937},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4424322843551636},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.4351254999637604},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.43040359020233154},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2892685532569885},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.2368454933166504}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0168-8278(24)01792-6","doi":"https://doi.org/10.1016/s0168-8278(24)01792-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-8278(24)01792-6","pdf_url":null,"source":{"id":"https://openalex.org/S83651209","display_name":"Journal of Hepatology","issn_l":"0168-8278","issn":["0168-8278","1600-0641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hepatology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4410172723","https://openalex.org/W4384941356","https://openalex.org/W4399461718","https://openalex.org/W4400822445","https://openalex.org/W4411300143","https://openalex.org/W4410169552","https://openalex.org/W4381377921","https://openalex.org/W4399459303","https://openalex.org/W3161808125","https://openalex.org/W7163665814"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-06-13T00:00:00"}