{"id":"https://openalex.org/W4399520051","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.6554","title":"Biomarkers in a phase 1b study of investigational microbiome therapeutic SER-155 in adults undergoing allogeneic hematopoietic cell transplantation (allo-HCT).","display_name":"Biomarkers in a phase 1b study of investigational microbiome therapeutic SER-155 in adults undergoing allogeneic hematopoietic cell transplantation (allo-HCT).","publication_year":2024,"publication_date":"2024-06-01","ids":{"openalex":"https://openalex.org/W4399520051","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.6554"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2024.42.16_suppl.6554","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.6554","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2024.42.16_suppl.6554","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066163702","display_name":"Doris M. Ponce","orcid":"https://orcid.org/0000-0002-9422-5766","observed_orcids":["https://orcid.org/0000-0002-9422-5766"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Doris M. Ponce","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068463990","display_name":"Swarna Pandian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164905","display_name":"Seres Therapeutics (United States)","ror":"https://ror.org/05fn8qw23","country_code":"US","type":"company","lineage":["https://openalex.org/I4210164905"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Swarna Pandian","raw_affiliation_strings":["Seres Therapeutics, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seres Therapeutics, Cambridge, MA","institution_ids":["https://openalex.org/I4210164905"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003503263","display_name":"Marcel R.M. van den Brink","orcid":"https://orcid.org/0000-0003-0696-4401","observed_orcids":["https://orcid.org/0000-0003-0696-4401"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcel R. M. van den Brink","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113949583","display_name":"Satyajit Kosuri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satyajit Kosuri","raw_affiliation_strings":["University of Chicago, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058557833","display_name":"Nandita Khera","orcid":"https://orcid.org/0000-0002-0577-3155","observed_orcids":["https://orcid.org/0000-0002-0577-3155"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nandita Khera","raw_affiliation_strings":["Division of Hematology/Oncology, Mayo Clinic, Phoenix, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Mayo Clinic, Phoenix, AZ","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210127938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041335047","display_name":"Zachariah Michael DeFilipp","orcid":"https://orcid.org/0000-0002-7994-8974","observed_orcids":["https://orcid.org/0000-0002-7994-8974"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachariah Michael DeFilipp","raw_affiliation_strings":["Massachusetts General Hospital, Division of Hematology and Oncology/Department of Medicine, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Division of Hematology and Oncology/Department of Medicine, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002731684","display_name":"Bindu Tejura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164905","display_name":"Seres Therapeutics (United States)","ror":"https://ror.org/05fn8qw23","country_code":"US","type":"company","lineage":["https://openalex.org/I4210164905"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bindu Tejura","raw_affiliation_strings":["Seres Therapeutics, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seres Therapeutics, Cambridge, MA","institution_ids":["https://openalex.org/I4210164905"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023536891","display_name":"David I. Lichter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164905","display_name":"Seres Therapeutics (United States)","ror":"https://ror.org/05fn8qw23","country_code":"US","type":"company","lineage":["https://openalex.org/I4210164905"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David I Lichter","raw_affiliation_strings":["Seres Therapeutics, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seres Therapeutics, Cambridge, MA","institution_ids":["https://openalex.org/I4210164905"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085617814","display_name":"Meghan E. Chafee","orcid":"https://orcid.org/0000-0003-4603-0128","observed_orcids":["https://orcid.org/0000-0003-4603-0128"]},"institutions":[{"id":"https://openalex.org/I4210164905","display_name":"Seres Therapeutics (United States)","ror":"https://ror.org/05fn8qw23","country_code":"US","type":"company","lineage":["https://openalex.org/I4210164905"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meghan Chafee","raw_affiliation_strings":["Seres Therapeutics, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seres Therapeutics, Cambridge, MA","institution_ids":["https://openalex.org/I4210164905"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055123505","display_name":"Kankana Bardhan","orcid":"https://orcid.org/0000-0002-6995-1205","observed_orcids":["https://orcid.org/0000-0002-6995-1205"]},"institutions":[{"id":"https://openalex.org/I4210164905","display_name":"Seres Therapeutics (United States)","ror":"https://ror.org/05fn8qw23","country_code":"US","type":"company","lineage":["https://openalex.org/I4210164905"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kankana Bardhan","raw_affiliation_strings":["Seres Therapeutics, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seres Therapeutics, Cambridge, MA","institution_ids":["https://openalex.org/I4210164905"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011528491","display_name":"Nathan D. Hicks","orcid":"https://orcid.org/0000-0002-6631-8383","observed_orcids":["https://orcid.org/0000-0002-6631-8383"]},"institutions":[{"id":"https://openalex.org/I4210164905","display_name":"Seres Therapeutics (United States)","ror":"https://ror.org/05fn8qw23","country_code":"US","type":"company","lineage":["https://openalex.org/I4210164905"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan D Hicks","raw_affiliation_strings":["Seres Therapeutics, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seres Therapeutics, Cambridge, MA","institution_ids":["https://openalex.org/I4210164905"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088092528","display_name":"Emily Walsh","orcid":"https://orcid.org/0009-0006-8666-225X","observed_orcids":["https://orcid.org/0009-0006-8666-225X"]},"institutions":[{"id":"https://openalex.org/I4210164905","display_name":"Seres Therapeutics (United States)","ror":"https://ror.org/05fn8qw23","country_code":"US","type":"company","lineage":["https://openalex.org/I4210164905"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Walsh","raw_affiliation_strings":["Seres Therapeutics, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seres Therapeutics, Cambridge, MA","institution_ids":["https://openalex.org/I4210164905"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038829006","display_name":"Mary\u2010Jane Lombardo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164905","display_name":"Seres Therapeutics (United States)","ror":"https://ror.org/05fn8qw23","country_code":"US","type":"company","lineage":["https://openalex.org/I4210164905"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary-Jane Lombardo","raw_affiliation_strings":["Seres Therapeutics, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seres Therapeutics, Cambridge, MA","institution_ids":["https://openalex.org/I4210164905"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008573434","display_name":"Christopher B. Ford","orcid":"https://orcid.org/0000-0002-4079-8673","observed_orcids":["https://orcid.org/0000-0002-4079-8673"]},"institutions":[{"id":"https://openalex.org/I4210164905","display_name":"Seres Therapeutics (United States)","ror":"https://ror.org/05fn8qw23","country_code":"US","type":"company","lineage":["https://openalex.org/I4210164905"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher B. Ford","raw_affiliation_strings":["Seres Therapeutics, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seres Therapeutics, Cambridge, MA","institution_ids":["https://openalex.org/I4210164905"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009499028","display_name":"Lisa L. Von Moltke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164905","display_name":"Seres Therapeutics (United States)","ror":"https://ror.org/05fn8qw23","country_code":"US","type":"company","lineage":["https://openalex.org/I4210164905"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa von Moltke","raw_affiliation_strings":["Seres Therapeutics, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seres Therapeutics, Cambridge, MA","institution_ids":["https://openalex.org/I4210164905"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016390534","display_name":"Matthew R. Henn","orcid":"https://orcid.org/0000-0001-8734-5797","observed_orcids":["https://orcid.org/0000-0001-8734-5797"]},"institutions":[{"id":"https://openalex.org/I4210164905","display_name":"Seres Therapeutics (United States)","ror":"https://ror.org/05fn8qw23","country_code":"US","type":"company","lineage":["https://openalex.org/I4210164905"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew R. Henn","raw_affiliation_strings":["Seres Therapeutics, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seres Therapeutics, Cambridge, MA","institution_ids":["https://openalex.org/I4210164905"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035685537","display_name":"Jonathan U. Peled","orcid":"https://orcid.org/0000-0002-4029-7625","observed_orcids":["https://orcid.org/0000-0002-4029-7625"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan U. Peled","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":null,"display_name":"Seres Therapeutics SER-155 Team","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seres Therapeutics SER-155 Team","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"16_suppl","first_page":"6554","last_page":"6554"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.03290000185370445,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/acute-graft-versus-host-disease","display_name":"acute graft-versus-host disease","score":0.9769999980926514},{"id":"https://openalex.org/keywords/circulating-biomarkers","display_name":"circulating biomarkers","score":0.765999972820282},{"id":"https://openalex.org/keywords/st2","display_name":"ST2","score":0.7490000128746033},{"id":"https://openalex.org/keywords/reg3a","display_name":"REG3A","score":0.8970000147819519},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7620000243186951},{"id":"https://openalex.org/keywords/intestinal-barrier-integrity","display_name":"intestinal barrier integrity","score":0.628000020980835},{"id":"https://openalex.org/keywords/vancomycin","display_name":"vancomycin","score":0.6169999837875366},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8755061030387878},{"id":"https://openalex.org/C2993713153","wikidata":"https://www.wikidata.org/wiki/Q211709","display_name":"Hematopoietic cell","level":4,"score":0.7124574780464172},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6191962957382202},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.5920701622962952},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.573328971862793},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4384008049964905},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.43617263436317444},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40354183316230774},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34572261571884155},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.31462401151657104},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2137688398361206},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2024.42.16_suppl.6554","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.6554","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2024.42.16_suppl.6554","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319085","display_name":"Seres Therapeutics","ror":"https://ror.org/05fn8qw23"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391601041","https://openalex.org/W4389243964","https://openalex.org/W4310104784","https://openalex.org/W4389234139","https://openalex.org/W4281864377","https://openalex.org/W2984053251","https://openalex.org/W4200488420","https://openalex.org/W4407975249","https://openalex.org/W7122621466","https://openalex.org/W4410809199"],"abstract_inverted_index":{"6554":[0],"Background:":[1],"Acute":[2],"graft-":[3],"versus-host":[4],"disease":[5],"(aGvHD)":[6],"is":[7,61,83],"a":[8,87,308],"life-threatening":[9],"complication":[10],"following":[11],"allo-HCT.":[12,95,197],"Microbiome":[13],"dysfunction":[14],"and":[15,53,78,82,102,125,139,167,173,194,238,252,300,328,351],"associated":[16],"GI":[17,72,75,80,222,247],"barrier":[18,76],"disruption":[19],"may":[20],"contribute":[21],"to":[22,69,234,268,307],"aGvHD":[23,126,276,290],"via":[24],"activation":[25],"of":[26,40,45,119,136,144,147,186,203,240,273,295,354],"inflammatory":[27,54,301],"immune":[28],"responses.":[29],"Circulating":[30],"biomarkers":[31,168,297,333],"in":[32,86,92,171,210,218],"the":[33,71,107,201,204,224,253,349],"peri-transplant":[34],"period":[35],"are":[36],"correlated":[37],"with":[38,150,221,348],"risk":[39],"severe":[41,287,330],"aGvHD,":[42],"including":[43],"suppression":[44],"tumorigenicity":[46],"2":[47,134],"(ST2),":[48],"regenerating":[49],"islet-derived":[50],"3-alpha":[51],"(Reg3a)":[52],"cytokines":[55,302],"(IL6,":[56],"IFN\u03d2\u03b3":[57],"&":[58],"TNF\u03b1).":[59],"SER-155":[60,137,206,255,269,318],"an":[62],"investigational":[63],"cultivated":[64],"oral":[65,151,157],"microbiome":[66,148],"therapeutic":[67],"designed":[68],"restructure":[70],"microbiome,":[73],"improve":[74],"integrity":[77],"reduce":[79],"inflammation":[81],"being":[84],"assessed":[85,170],"2-part":[88],"Phase":[89],"1b":[90],"study":[91,187],"adults":[93,178],"undergoing":[94],"We":[96],"present":[97],"preliminary":[98,345],"safety,":[99],"GvHD,":[100],"PK,":[101],"exploratory":[103],"biomarker":[104],"data":[105],"from":[106],"completed":[108],"open-label":[109,316],"Cohort":[110],"1":[111,184],"through":[112,281,322],"Day":[113,262,282,323,339],"100":[114,283,324],"post-HCT.":[115],"Methods:":[116],"Adult":[117],"recipients":[118],"allo-HCT":[120],"were":[121,128,169,208,216,231,258,266,303,334],"eligible.":[122],"HCT":[123,251,338],"conditioning":[124,149],"prophylaxis":[127],"per":[129],"investigator":[130],"discretion.":[131],"Patients":[132],"received":[133,181],"courses":[135],"(pre-HCT":[138],"post-neutrophil":[140],"engraftment,":[141],"each":[142,199],"comprised":[143],"4":[145],"days":[146,156],"vancomycin":[152],"followed":[153],"by":[154],"10":[155],"SER-155.":[158,235,355],"The":[159,271],"primary":[160],"endpoint":[161],"was":[162,284,291,319],"safety.":[163],"Strain":[164],"engraftment":[165],"(PK)":[166],"stool":[172],"plasma":[174,296],"samples.":[175],"Results:":[176],"Fifteen":[177],"enrolled;":[179],"13":[180],"at":[182,337],"least":[183],"course":[185],"drug":[188],"(median":[189],"age":[190],"67;":[191],"54%":[192],"male),":[193],"11":[195],"underwent":[196],"Following":[198],"course,":[200],"majority":[202],"16":[205],"strains":[207],"detected":[209],"stool.":[211],"Treatment-emergent":[212],"adverse":[213],"events":[214],"(AEs)":[215],"reported":[217],"all":[219],"patients":[220],"AEs":[223,229,239],"most":[225],"common.":[226],"No":[227,264],"serious":[228],"(SAEs)":[230],"deemed":[232],"related":[233],"Most":[236],"SAEs":[237,327],"special":[241],"interest":[242],"(ie,":[243],"BSIs,":[244],"invasive":[245],"or":[246,341],"infections)":[248],"occurred":[249],"between":[250],"2nd":[254],"course.":[256],"There":[257],"no":[259,286,329],"deaths":[260],"before":[261],"100.":[263],"BSIs":[265],"attributable":[267],"strains.":[270],"rate":[272],"grade":[274,288],"2-4":[275],"based":[277],"on":[278],"MAGIC":[279],"criteria":[280],"45.5%;":[285],"3-4":[289],"observed.":[292],"Median":[293],"levels":[294],"REG3\u03b1,":[298],"ST2":[299],"not":[304,335],"elevated":[305,336],"relative":[306],"reference":[309],"range":[310],"(Table).":[311],"Conclusions:":[312],"In":[313],"this":[314],"small":[315],"cohort,":[317],"generally":[320],"well-tolerated":[321],"without":[325],"drug-related":[326],"aGvHD.":[331],"Plasma":[332],"0":[340],"neutrophil":[342],"recovery.":[343],"These":[344],"observations":[346],"align":[347],"design":[350],"preclinical":[352],"evaluation":[353],"Clinical":[356],"trial":[357],"information:":[358],"NCT04995653":[359],".":[360],"[Table:":[361],"see":[362],"text]":[363]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2024-06-12T00:00:00"}