{"id":"https://openalex.org/W4399519932","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.6533","title":"In-depth analysis of responders in the phase 3 PhALLCON trial of ponatinib vs imatinib in newly diagnosed Ph+ ALL.","display_name":"In-depth analysis of responders in the phase 3 PhALLCON trial of ponatinib vs imatinib in newly diagnosed Ph+ ALL.","publication_year":2024,"publication_date":"2024-06-01","ids":{"openalex":"https://openalex.org/W4399519932","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.6533"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2024.42.16_suppl.6533","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.6533","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2024.42.16_suppl.6533","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049385583","display_name":"Elias Joseph Jabbour","orcid":"https://orcid.org/0000-0003-4465-6119","observed_orcids":["https://orcid.org/0000-0003-4465-6119"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elias Jabbour","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090435894","display_name":"Hagop M. Kantarjian","orcid":"https://orcid.org/0000-0002-1908-3307","observed_orcids":["https://orcid.org/0000-0002-1908-3307"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hagop M. Kantarjian","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040369089","display_name":"Ibrahim Taha Aldoss","orcid":"https://orcid.org/0000-0001-9564-4498","observed_orcids":["https://orcid.org/0000-0001-9564-4498"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ibrahim Aldoss","raw_affiliation_strings":["City of Hope National Medical Center, Duarte, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City of Hope National Medical Center, Duarte, CA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003682435","display_name":"Pau Montesinos","orcid":"https://orcid.org/0000-0002-3275-5593","observed_orcids":["https://orcid.org/0000-0002-3275-5593"]},"institutions":[{"id":"https://openalex.org/I3019010403","display_name":"Hospital Universitari i Polit\u00e8cnic La Fe","ror":"https://ror.org/01ar2v535","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I3019010403","https://openalex.org/I4210166036"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pau Montesinos","raw_affiliation_strings":["Hospital Universitari i Polit\u00e8cnic La Fe, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitari i Polit\u00e8cnic La Fe, Valencia, Spain","institution_ids":["https://openalex.org/I3019010403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034614925","display_name":"Jessica Taft Leonard","orcid":"https://orcid.org/0000-0001-5576-0048","observed_orcids":["https://orcid.org/0000-0001-5576-0048"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Taft Leonard","raw_affiliation_strings":["Oregon Health & Science University, Portland, OR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health & Science University, Portland, OR","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000360404","display_name":"David G\u00f3mez\u2010Almaguer","orcid":"https://orcid.org/0000-0002-0460-6427","observed_orcids":["https://orcid.org/0000-0002-0460-6427"]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]},{"id":"https://openalex.org/I4210132044","display_name":"Hospital Universitario Dr Jos\u00e9 Eleuterio Gonzalez","ror":"https://ror.org/030ms0x66","country_code":"MX","type":"healthcare","lineage":["https://openalex.org/I4210132044"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"David Gomez-Almaguer","raw_affiliation_strings":["Hospital Universitario Dr. Jos\u00e9 Eleuterio Gonz\u00e1lez, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario Dr. Jos\u00e9 Eleuterio Gonz\u00e1lez, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Monterrey, Mexico","institution_ids":["https://openalex.org/I169046204","https://openalex.org/I4210132044"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049910941","display_name":"Maria R. Baer","orcid":"https://orcid.org/0000-0002-9499-1348","observed_orcids":["https://orcid.org/0000-0002-9499-1348"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria R. Baer","raw_affiliation_strings":["University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I4390039317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036874214","display_name":"Carlo B Gambacorti-Passerini","orcid":"https://orcid.org/0000-0001-6058-515X","observed_orcids":["https://orcid.org/0000-0001-6058-515X"]},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlo Gambacorti-Passerini","raw_affiliation_strings":["University of Milano-Bicocca, Monza, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Milano-Bicocca, Monza, Italy","institution_ids":["https://openalex.org/I66752286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006561610","display_name":"James K. McCloskey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324520350","display_name":"Hackensack University Medical Center","ror":"https://ror.org/008zj0x80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324520350"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James K. McCloskey","raw_affiliation_strings":["Hackensack University Medical Center, Hackensack, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hackensack University Medical Center, Hackensack, NJ","institution_ids":["https://openalex.org/I1324520350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069675532","display_name":"Yosuke Minami","orcid":"https://orcid.org/0000-0003-0863-0739","observed_orcids":["https://orcid.org/0000-0003-0863-0739"]},"institutions":[{"id":"https://openalex.org/I4210145079","display_name":"National Cancer Center Hospital East","ror":"https://ror.org/03rm3gk43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145079"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yosuke Minami","raw_affiliation_strings":["National Cancer Center Hospital East, Kashiwa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Center Hospital East, Kashiwa, Japan","institution_ids":["https://openalex.org/I4210145079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044624520","display_name":"Cristina Papayannidis","orcid":"https://orcid.org/0000-0001-8705-8333","observed_orcids":["https://orcid.org/0000-0001-8705-8333"]},"institutions":[{"id":"https://openalex.org/I4210117483","display_name":"Istituto di Ematologia di Bologna","ror":"https://ror.org/01mze9517","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210117483"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cristina Papayannidis","raw_affiliation_strings":["IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia \u201cL. e A. Ser\u00e0gnoli\u201d, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia \u201cL. e A. Ser\u00e0gnoli\u201d, Bologna, Italy","institution_ids":["https://openalex.org/I4210117483"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052564121","display_name":"Philippe H. Rousselot","orcid":"https://orcid.org/0000-0003-3238-4494","observed_orcids":["https://orcid.org/0000-0003-3238-4494"]},"institutions":[{"id":"https://openalex.org/I4210159263","display_name":"Centre Hospitalier de Versailles","ror":"https://ror.org/053evvt91","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210159263"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Philippe Rousselot","raw_affiliation_strings":["Centre Hospitalier de Versailles, UMR1184, Universit\u00e9 de Versailles Paris Saclay, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Hospitalier de Versailles, UMR1184, Universit\u00e9 de Versailles Paris Saclay, Paris, France","institution_ids":["https://openalex.org/I4210159263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038004259","display_name":"Pankit J. Vachhani","orcid":"https://orcid.org/0000-0001-9779-6217","observed_orcids":["https://orcid.org/0000-0001-9779-6217"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pankit Vachhani","raw_affiliation_strings":["University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038660651","display_name":"Eunice S. Wang","orcid":"https://orcid.org/0000-0002-8644-0968","observed_orcids":["https://orcid.org/0000-0002-8644-0968"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eunice S. Wang","raw_affiliation_strings":["Roswell Park Comprehensive Cancer Center, Buffalo, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roswell Park Comprehensive Cancer Center, Buffalo, NY","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101080453","display_name":"Lin Yang","orcid":"https://orcid.org/0000-0003-1106-7457","observed_orcids":["https://orcid.org/0000-0003-1106-7457"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lin Yang","raw_affiliation_strings":["Takeda Development Center Americas, Inc., Lexington, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda Development Center Americas, Inc., Lexington, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108627038","display_name":"Meliessa G. Hennessy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meliessa Hennessy","raw_affiliation_strings":["Takeda Development Center Americas, Inc., Lexington, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda Development Center Americas, Inc., Lexington, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049967785","display_name":"Alexander Vorog","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Vorog","raw_affiliation_strings":["Takeda Development Center Americas, Inc., Lexington, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda Development Center Americas, Inc., Lexington, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057465699","display_name":"Niti Patel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Niti Patel","raw_affiliation_strings":["Takeda Development Center Americas, Inc., Lexington, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda Development Center Americas, Inc., Lexington, MA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084354003","display_name":"Josep\u2010Mar\u00eda Ribera","orcid":"https://orcid.org/0000-0003-1042-6024","observed_orcids":["https://orcid.org/0000-0003-1042-6024"]},"institutions":[{"id":"https://openalex.org/I4210089592","display_name":"Josep Carreras Leukaemia Research Institute","ror":"https://ror.org/00btzwk36","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089592","https://openalex.org/I4210144824","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose-Maria Ribera-Santasusana","raw_affiliation_strings":["ICO \u2013 Hospital Germans Trias i Pujol, Josep Carreras Leukaemia Research Institute, Badalona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICO \u2013 Hospital Germans Trias i Pujol, Josep Carreras Leukaemia Research Institute, Badalona, Spain","institution_ids":["https://openalex.org/I4210089592"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":16,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"16_suppl","first_page":"6533","last_page":"6533"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.02889999933540821,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/philadelphia-chromosome-positive-acute-lymphoblastic-leukemia","display_name":"Philadelphia chromosome-positive acute lymphoblastic leukemia","score":0.902999997138977},{"id":"https://openalex.org/keywords/ponatinib","display_name":"ponatinib","score":0.8650000095367432},{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.9990000128746033},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.6100000143051147},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.7990000247955322},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9169999957084656},{"id":"https://openalex.org/keywords/age-subgroup-analysis","display_name":"age subgroup analysis","score":0.4020000100135803},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.7929999828338623},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C2780381907","wikidata":"https://www.wikidata.org/wiki/Q198728","display_name":"Ponatinib","level":5,"score":0.909132719039917},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8950506448745728},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.8168861865997314},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5438509583473206},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5375155806541443},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32404404878616333},{"id":"https://openalex.org/C2779536868","wikidata":"https://www.wikidata.org/wiki/Q419940","display_name":"Dasatinib","level":4,"score":0.31215232610702515},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.1371077001094818}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2024.42.16_suppl.6533","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.6533","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2024.42.16_suppl.6533","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4401876090","https://openalex.org/W4389220908","https://openalex.org/W2960250745","https://openalex.org/W4405041723","https://openalex.org/W4385667002","https://openalex.org/W4386270943","https://openalex.org/W3108997239","https://openalex.org/W4362589882","https://openalex.org/W4321216779","https://openalex.org/W4283362794"],"abstract_inverted_index":{"6533":[0],"Background:":[1],"Ponatinib,":[2],"a":[3,20,37,340],"third-generation":[4],"BCR::ABL":[5],"TKI,":[6],"has":[7],"potent":[8],"activity":[9],"against":[10],"all":[11],"clinically":[12],"relevant":[13],"BCR::ABL1":[14,74,336],"variants,":[15],"including":[16],"T315I.":[17],"PhALLCON":[18],"(NCT03589326),":[19],"phase":[21],"3":[22,116],"trial":[23,347],"comparing":[24],"frontline":[25,317],"TKIs":[26],"in":[27,215,278,311],"adults":[28],"with":[29,36,53,79,199,226,245,264,287,313,322],"Ph+":[30,82,320],"ALL,":[31,321],"met":[32],"its":[33],"primary":[34],"endpoint":[35],"higher":[38,323],"rate":[39],"of":[40,50,64,112,175,195,229,290,319,325],"minimum":[41],"residual":[42],"disease\u2013negative":[43],"(MRD-neg)":[44],"complete":[45],"remission":[46],"(CR)":[47],"at":[48,66,100,155,223,255,327],"end":[49],"induction":[51],"(EOI)":[52],"ponatinib":[54,88,127,217,230,246,265,280],"vs":[55,213,218,247,266,281],"imatinib":[56,105,129,219,248,267,282,310],"(34.4%/16.7%;":[57],"P=0.002).":[58],"Here,":[59],"we":[60],"report":[61],"response":[62],"rates":[63,289,324],"MRD-neg":[65,98,149,222,254,326],"any":[67,156,224,256,328],"time":[68,157,257],"and":[69,73,158,181,233,294,299,335,339],"PFS":[70,159,238,332],"by":[71,125,166,177,202],"age":[72,178,232,334],"variant":[75,184,234,337],"subgroups.":[76],"Methods:":[77],"Adults":[78],"newly":[80],"diagnosed":[81],"ALL":[83],"were":[84,221,258],"randomized":[85,196],"2:1":[86],"to":[87,93,163,173,261,302,309,344],"(30":[89],"mg":[90,95,107],"QD":[91,96],"reduced":[92],"15":[94],"upon":[97],"CR":[99,165],"or":[101,104,128,133,171],"after":[102],"EOI)":[103],"(600":[106],"QD)":[108],"plus":[109],"20":[110],"cycles":[111],"reduced-intensity":[113,314],"chemotherapy":[114,315],"(induction:":[115],"cycles;":[117,120],"consolidation:":[118],"6":[119],"maintenance:":[121],"11":[122],"cycles),":[123],"followed":[124],"single-agent":[126],"until":[130],"disease":[131],"progression":[132],"unacceptable":[134],"toxicity.":[135],"Hematopoietic":[136],"stem":[137],"cell":[138],"transplant":[139],"(HSCT)":[140],"was":[141,239,275,307],"per":[142],"investigator\u2019s":[143],"discretion.":[144],"Post":[145],"hoc":[146],"analyses":[147],"compared":[148],"(":[150],"BCR::":[151,182],"ABL1IS":[152],"\u22640.01%;":[153],"MR4)":[154],"(any-cause":[160],"death,":[161],"failure":[162,172],"achieve":[164],"EOI,":[167],"relapse":[168],"from":[169],"CR,":[170],"achieve/loss":[174],"MRD-neg)":[176],"(</\u226565":[179],"y)":[180],"ABL1":[183],"(p190/p210).":[185],"Data":[186],"cutoff:":[187],"Aug":[188],"12,":[189],"2022.":[190],"Results:":[191],"In":[192],"the":[193,216,279],"population":[194],"patients":[197],"(pts)":[198],"p190/p210":[200],"confirmed":[201],"central":[203],"lab":[204],"(n=232;":[205],"154/78":[206],"ponatinib/imatinib;":[207],"median":[208],"follow-up":[209],"20.1":[210],"mo),":[211],"68%":[212],"50%":[214],"arms":[220,283],"time,":[225,329],"similar":[227],"benefit":[228],"across":[231,249,333],"subgroups":[235,250],"(Table).":[236,251],"Median":[237],"more":[240],"than":[241],"twice":[242],"as":[243],"long":[244],"Pts":[252],"achieving":[253],"less":[259],"likely":[260],"have":[262],"HSCT":[263],"(32%/56%).":[268],"Among":[269],"107/42":[270],"pts":[271],"without":[272],"HSCT,":[273],"exposure":[274],">2-fold":[276],"longer":[277,331],"(median":[284],"12.8/5.1":[285],"mo)":[286],"comparable":[288,343],"arterial":[291],"occlusive":[292],"(3%/2%)":[293],"venous":[295],"thromboembolic":[296],"events":[297],"(11%/12%),":[298],"discontinuations":[300],"due":[301],"TEAEs":[303],"(13%/14%).":[304],"Conclusions:":[305],"Ponatinib":[306],"superior":[308],"combination":[312],"for":[316],"treatment":[318],"substantially":[330],"subgroups,":[338],"safety":[341],"profile":[342],"imatinib.":[345],"Clinical":[346],"information:":[348],"NCT03589326":[349],".":[350],"[Table:":[351],"see":[352],"text]":[353]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2024-06-12T00:00:00"}
