{"id":"https://openalex.org/W4399487231","doi":"https://doi.org/10.1371/journal.pone.0305252","title":"Identification of novel biomarkers to distinguish clear cell and non-clear cell renal cell carcinoma using bioinformatics and machine learning","display_name":"Identification of novel biomarkers to distinguish clear cell and non-clear cell renal cell carcinoma using bioinformatics and machine learning","publication_year":2024,"publication_date":"2024-06-10","ids":{"openalex":"https://openalex.org/W4399487231","doi":"https://doi.org/10.1371/journal.pone.0305252","pmid":"https://pubmed.ncbi.nlm.nih.gov/38857246","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11164351"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0305252","doi":"https://doi.org/10.1371/journal.pone.0305252","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0305252","pdf_url":null,"source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pone.0305252","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5099073789","display_name":"Chanita Panwoon","orcid":"https://orcid.org/0009-0002-4494-0646","observed_orcids":["https://orcid.org/0009-0002-4494-0646"]},"institutions":[{"id":"https://openalex.org/I179193067","display_name":"Khon Kaen University","ror":"https://ror.org/03cq4gr50","country_code":"TH","type":"education","lineage":["https://openalex.org/I179193067"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Chanita Panwoon","raw_affiliation_strings":["Faculty of Medicine, Department of Pathology, Khon Kaen University, Khon Kaen, Thailand"],"raw_orcid":"https://orcid.org/0009-0002-4494-0646","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Pathology, Khon Kaen University, Khon Kaen, Thailand","institution_ids":["https://openalex.org/I179193067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027417160","display_name":"Wunchana Seubwai","orcid":"https://orcid.org/0000-0002-9265-5113","observed_orcids":["https://orcid.org/0000-0002-9265-5113"]},"institutions":[{"id":"https://openalex.org/I179193067","display_name":"Khon Kaen University","ror":"https://ror.org/03cq4gr50","country_code":"TH","type":"education","lineage":["https://openalex.org/I179193067"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Wunchana Seubwai","raw_affiliation_strings":["Faculty of Medicine, Center for Translational Medicine, Khon Kaen University, Khon Kaen, Thailand","Faculty of Medicine, Department of Forensic Medicine, Khon Kaen University, Khon Kaen, Thailand"],"raw_orcid":"https://orcid.org/0000-0002-9265-5113","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Center for Translational Medicine, Khon Kaen University, Khon Kaen, Thailand","institution_ids":["https://openalex.org/I179193067"]},{"raw_affiliation_string":"Faculty of Medicine, Department of Forensic Medicine, Khon Kaen University, Khon Kaen, Thailand","institution_ids":["https://openalex.org/I179193067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062246651","display_name":"Malinee Thanee","orcid":"https://orcid.org/0009-0007-6163-3740","observed_orcids":["https://orcid.org/0009-0007-6163-3740"]},"institutions":[{"id":"https://openalex.org/I179193067","display_name":"Khon Kaen University","ror":"https://ror.org/03cq4gr50","country_code":"TH","type":"education","lineage":["https://openalex.org/I179193067"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Malinee Thanee","raw_affiliation_strings":["Faculty of Medicine, Department of Pathology, Khon Kaen University, Khon Kaen, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Pathology, Khon Kaen University, Khon Kaen, Thailand","institution_ids":["https://openalex.org/I179193067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042545433","display_name":"Sakkarn Sangkhamanon","orcid":"https://orcid.org/0000-0002-5203-8700","observed_orcids":["https://orcid.org/0000-0002-5203-8700"]},"institutions":[{"id":"https://openalex.org/I179193067","display_name":"Khon Kaen University","ror":"https://ror.org/03cq4gr50","country_code":"TH","type":"education","lineage":["https://openalex.org/I179193067"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Sakkarn Sangkhamanon","raw_affiliation_strings":["Faculty of Medicine, Department of Pathology, Khon Kaen University, Khon Kaen, Thailand"],"raw_orcid":"https://orcid.org/0000-0002-5203-8700","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Pathology, Khon Kaen University, Khon Kaen, Thailand","institution_ids":["https://openalex.org/I179193067"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042545433"],"corresponding_institution_ids":["https://openalex.org/I179193067"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":1.4546,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.83776615,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"19","issue":"6","first_page":"e0305252","last_page":"e0305252"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"clear cell renal cell carcinoma","score":0.9079999923706055},{"id":"https://openalex.org/keywords/non-clear-cell-renal-cell-carcinoma","display_name":"non-clear cell renal cell carcinoma","score":0.9829999804496765},{"id":"https://openalex.org/keywords/renal-cell-carcinoma-subtypes","display_name":"renal cell carcinoma subtypes","score":0.7720000147819519},{"id":"https://openalex.org/keywords/papillary-renal-cell-carcinoma","display_name":"papillary renal cell carcinoma","score":0.9639999866485596},{"id":"https://openalex.org/keywords/chromophobe-renal-cell-carcinoma","display_name":"chromophobe renal cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.7620000243186951},{"id":"https://openalex.org/keywords/ndufa4l2","display_name":"NDUFA4L2","score":0.8640000224113464},{"id":"https://openalex.org/keywords/dat","display_name":"DAT","score":0.8629999756813049},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.7039999961853027},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.5270000100135803},{"id":"https://openalex.org/keywords/pd-1-signaling","display_name":"PD-1 signaling","score":0.7519999742507935},{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.7409999966621399},{"id":"https://openalex.org/keywords/lymphovascular-invasion","display_name":"lymphovascular invasion","score":0.8500000238418579},{"id":"https://openalex.org/keywords/decision-tree-classifier","display_name":"decision tree classification","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C2781278892","wikidata":"https://www.wikidata.org/wiki/Q18556340","display_name":"Clear cell renal cell carcinoma","level":3,"score":0.868483304977417},{"id":"https://openalex.org/C78795084","wikidata":"https://www.wikidata.org/wiki/Q5113900","display_name":"Chromophobe cell","level":4,"score":0.6475242376327515},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.46823376417160034},{"id":"https://openalex.org/C2778560582","wikidata":"https://www.wikidata.org/wiki/Q18347894","display_name":"Clear cell","level":3,"score":0.461868554353714},{"id":"https://openalex.org/C2776531350","wikidata":"https://www.wikidata.org/wiki/Q16877679","display_name":"Papillary renal cell carcinomas","level":3,"score":0.43034490942955017},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.41074568033218384},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4011861979961395},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3525674343109131},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.293285071849823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2817021310329437},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.23543870449066162},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.17347219586372375}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0305252","doi":"https://doi.org/10.1371/journal.pone.0305252","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0305252","pdf_url":null,"source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11164351","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11164351","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11164351/pdf/pone.0305252.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:38857246","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38857246","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:851d8359f0534d91805dbb25f378f5c7","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/851d8359f0534d91805dbb25f378f5c7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 19, Iss 6, p e0305252 (2024)","raw_type":"article"},{"id":"doi:10.60692/j7yg1-j4137","doi":"https://doi.org/10.60692/j7yg1-j4137","is_oa":true,"landing_page_url":"https://doi.org/10.60692/j7yg1-j4137","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/xjrtk-98d38","doi":"https://doi.org/10.60692/xjrtk-98d38","is_oa":true,"landing_page_url":"https://doi.org/10.60692/xjrtk-98d38","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0305252","doi":"https://doi.org/10.1371/journal.pone.0305252","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0305252","pdf_url":null,"source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322335","display_name":"Khon Kaen University","ror":"https://ror.org/03cq4gr50"},{"id":"https://openalex.org/F4320337178","display_name":"Cholangiocarcinoma Research Institute, Khon Kaen University","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4399487231.pdf","grobid_xml":"https://content.openalex.org/works/W4399487231.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1842974971","https://openalex.org/W2050140657","https://openalex.org/W2067786443","https://openalex.org/W2111547563","https://openalex.org/W2126991164","https://openalex.org/W2146257635","https://openalex.org/W2148143831","https://openalex.org/W2161859073","https://openalex.org/W2177870565","https://openalex.org/W2252413525","https://openalex.org/W2287830002","https://openalex.org/W2288987079","https://openalex.org/W2399988802","https://openalex.org/W2521222592","https://openalex.org/W2613084028","https://openalex.org/W2769869685","https://openalex.org/W2778455075","https://openalex.org/W2787491135","https://openalex.org/W2900909683","https://openalex.org/W2904346214","https://openalex.org/W2911746302","https://openalex.org/W2917524635","https://openalex.org/W2942869373","https://openalex.org/W2974687396","https://openalex.org/W3014505556","https://openalex.org/W3033336697","https://openalex.org/W3117178118","https://openalex.org/W3127220194","https://openalex.org/W3142487487","https://openalex.org/W3156130046","https://openalex.org/W3175548382","https://openalex.org/W3210525534","https://openalex.org/W4206826888","https://openalex.org/W4220831425","https://openalex.org/W4230096730","https://openalex.org/W4322504391","https://openalex.org/W4322770604","https://openalex.org/W4366316326","https://openalex.org/W4383536149"],"related_works":["https://openalex.org/W4406374419","https://openalex.org/W2601710247","https://openalex.org/W4417522938","https://openalex.org/W3131051786","https://openalex.org/W1490420264","https://openalex.org/W7053090693","https://openalex.org/W3030665845","https://openalex.org/W2167059316","https://openalex.org/W1976892551","https://openalex.org/W4309646501"],"abstract_inverted_index":{"Renal":[0],"cell":[1,15,20],"carcinoma":[2],"(RCC),":[3],"accounting":[4],"for":[5,23,87,117,133,159,175],"90%":[6],"of":[7,61,140,236,244],"all":[8],"kidney":[9],"cancer,":[10],"is":[11],"categorized":[12],"into":[13],"clear":[14],"RCC":[16,21,68,72,150,161],"(ccRCC)":[17],"and":[18,54,63,70,84,89,99,170,180,193,203,209,231,246,260,272,280,285],"non-clear":[19],"(non-ccRCC)":[22],"treatment":[24],"based":[25,217,241],"on":[26,146,218,242],"the":[27,32,197,224,254],"current":[28],"NCCN":[29],"Guidelines.":[30],"Thus,":[31],"classification":[33,239],"will":[34],"be":[35],"associated":[36,266],"with":[37,226,257,267],"therapeutic":[38],"implications.":[39],"This":[40],"study":[41],"aims":[42],"to":[43,47,125,292],"identify":[44,126],"novel":[45,290],"biomarkers":[46,291],"differentiate":[48],"ccRCC":[49,62,88,113,186,295],"from":[50,76,149,296],"non-ccRCC":[51,64,90],"using":[52,93,105,152,164],"bioinformatics":[53,279],"machine":[55,118,156,281],"learning.":[56],"The":[57,107,138],"gene":[58,131,142],"expression":[59,79,139,264],"profiles":[60],"subtypes":[65],"(including":[66],"papillary":[67],"(pRCC)":[69],"chromophobe":[71],"(chRCC)),":[73],"were":[74,82,91,103,114,162,167,211,287],"obtained":[75],"TCGA.":[77],"Differential":[78],"genes":[80,111,172],"(DEGs)":[81],"identified,":[83],"specific":[85,174],"DEGs":[86,176,184],"explored":[92],"a":[94,127,135],"Venn":[95],"diagram.":[96],"Gene":[97],"Ontology":[98],"pathway":[100],"enrichment":[101],"analysis":[102],"performed":[104],"DAVID.":[106],"top":[108],"ten":[109],"expressed":[110],"in":[112,177,185,188,196,213,275],"then":[115],"selected":[116],"learning":[119,157,282],"analysis.":[120],"Feature":[121,215],"selection":[122,216],"was":[123,144,265],"operated":[124],"minimum":[128],"highly":[129],"effective":[130],"set":[132,143],"constructing":[134],"predictive":[136],"model.":[137],"best-performing":[141],"validated":[145],"tissue":[147],"samples":[148],"patients":[151],"immunohistochemistry":[153],"techniques.":[154],"Subsequently,":[155],"models":[158,240,252],"diagnosing":[160],"developed":[163],"H-scores.":[165],"There":[166],"910,":[168],"415,":[169],"835":[171],"significantly":[173],"ccRCC,":[178],"pRCC,":[179],"chRCC,":[181],"respectively.":[182],"Specific":[183],"enriched":[187,212],"PD-1":[189],"signaling,":[190],"immune":[191,198],"system,":[192,199],"cytokine":[194],"signaling":[195,205],"whereas":[200],"TCA":[201],"cycle":[202],"respiratory,":[204],"by":[206],"insulin":[207],"receptor,":[208],"metabolism":[210],"chRCC.":[214],"Decision":[219,250],"Tree":[220,251],"Classifier":[221],"revealed":[222,248],"that":[223,249],"model":[225],"two":[227],"genes,":[228],"including":[229],"NDUFA4L2":[230,263,284],"DAT,":[232],"had":[233],"an":[234],"accuracy":[235,259],"98.89%.":[237],"Supervised":[238],"H-score":[243],"NDUFA4L2,":[245],"DAT":[247,286],"showed":[253],"best":[255],"performance":[256],"82%":[258],"0.9":[261],"AUC.":[262],"lymphovascular":[268],"invasion,":[269],"pathologic":[270],"stage":[271,274],"pT":[273],"ccRCC.":[276],"Using":[277],"integrated":[278],"analysis,":[283],"identified":[288],"as":[289],"differential":[293],"diagnosis":[294],"non-ccRCC.":[297]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-06-11T00:00:00"}