{"id":"https://openalex.org/W4399481111","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.7045","title":"Real world incidence, prevention, and management of tumor lysis syndrome in patients with chronic lymphocytic leukemia treated with venetoclax in the inpatient and outpatient settings.","display_name":"Real world incidence, prevention, and management of tumor lysis syndrome in patients with chronic lymphocytic leukemia treated with venetoclax in the inpatient and outpatient settings.","publication_year":2024,"publication_date":"2024-06-01","ids":{"openalex":"https://openalex.org/W4399481111","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.7045"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2024.42.16_suppl.7045","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.7045","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2024.42.16_suppl.7045","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088473676","display_name":"Yannis K. Valtis","orcid":"https://orcid.org/0000-0001-8927-8006","observed_orcids":["https://orcid.org/0000-0001-8927-8006"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yannis Valtis","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079606054","display_name":"David Nemirovsky","orcid":"https://orcid.org/0009-0007-6971-1408","observed_orcids":["https://orcid.org/0009-0007-6971-1408"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Nemirovsky","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081153667","display_name":"Andriy Derkach","orcid":"https://orcid.org/0000-0003-2178-8493","observed_orcids":["https://orcid.org/0000-0003-2178-8493","https://orcid.org/0000-0002-0395-362X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andriy Derkach","raw_affiliation_strings":["Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042723532","display_name":"Lindsey Elizabeth Roeker","orcid":"https://orcid.org/0000-0002-3806-059X","observed_orcids":["https://orcid.org/0000-0002-3806-059X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsey Elizabeth Roeker","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086323244","display_name":"Saumya Sharan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saumya Sharan","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037806906","display_name":"Charlene C. Kabel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charlene Kabel","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068659097","display_name":"Ricardo Ort\u00edz","orcid":"https://orcid.org/0000-0002-8072-947X","observed_orcids":["https://orcid.org/0000-0002-8072-947X"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ricardo Ortiz","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, St. Luke's Roosevelt, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, St. Luke's Roosevelt, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040703931","display_name":"Mark Blaine Geyer","orcid":"https://orcid.org/0000-0001-5248-9117","observed_orcids":["https://orcid.org/0000-0001-5248-9117"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Blaine Geyer","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"16_suppl","first_page":"7045","last_page":"7045"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12845","display_name":"Methemoglobinemia and Tumor Lysis Syndrome","score":0.5175999999046326,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12845","display_name":"Methemoglobinemia and Tumor Lysis Syndrome","score":0.5175999999046326,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.46140000224113464,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-lysis-syndrome","display_name":"tumor lysis syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/venetoclax","display_name":"venetoclax","score":0.9909999966621399},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/small-lymphocytic-lymphoma","display_name":"small lymphocytic lymphoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/bcl2-inhibitors","display_name":"BCL-2 inhibitor","score":0.9039999842643738},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.6710000038146973},{"id":"https://openalex.org/keywords/allopurinol","display_name":"allopurinol","score":0.8920000195503235},{"id":"https://openalex.org/keywords/rasburicase","display_name":"rasburicase","score":0.8240000009536743},{"id":"https://openalex.org/keywords/phosphate-binders","display_name":"phosphate binders","score":0.8209999799728394},{"id":"https://openalex.org/keywords/hyperuricemia","display_name":"hyperuricemia","score":0.8410000205039978},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.5170000195503235},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9448144435882568},{"id":"https://openalex.org/C2779788671","wikidata":"https://www.wikidata.org/wiki/Q998803","display_name":"Tumor lysis syndrome","level":3,"score":0.9202694892883301},{"id":"https://openalex.org/C2779675984","wikidata":"https://www.wikidata.org/wiki/Q23671272","display_name":"Venetoclax","level":4,"score":0.9062075614929199},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.7366089820861816},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5783902406692505},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47453773021698},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.45629218220710754},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.44229748845100403},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.390430212020874},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.22063633799552917},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2024.42.16_suppl.7045","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.7045","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2024.42.16_suppl.7045","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4401450947","https://openalex.org/W3094829169","https://openalex.org/W2906536837","https://openalex.org/W2994656866","https://openalex.org/W7204729794","https://openalex.org/W3211353714","https://openalex.org/W3026437760","https://openalex.org/W4392293083","https://openalex.org/W2940351544","https://openalex.org/W4404470667"],"abstract_inverted_index":{"7045":[0],"Background:":[1],"Venetoclax":[2],"(ven)":[3],"is":[4],"a":[5,300],"BCL2":[6],"inhibitor":[7],"used":[8],"for":[9,160,272,278,286],"the":[10,98,108,111,121,239,371],"treatment":[11],"(tx)":[12],"of":[13,47,85,110,155,158,199,224,268,358,367],"chronic":[14],"lymphocytic":[15,73],"leukemia":[16],"(CLL)":[17],"which":[18],"can":[19],"cause":[20],"clinical":[21,251,329],"or":[22,71,118,309],"laboratory":[23],"(lab)":[24],"tumor":[25],"lysis":[26],"syndrome":[27],"(TLS).":[28],"A":[29],"dose":[30],"ramp-up":[31],"schedule":[32],"and":[33,41,76,120,148,178,213,234,248,284,335],"prophylaxis":[34],"strategies":[35],"are":[36],"incorporated":[37],"into":[38],"NCCN":[39],"guidelines":[40],"prescribing":[42,130],"information.":[43,131],"Prior":[44],"reports":[45],"have":[46,299,362],"TLS":[48,94,103,167,247,256,261,269,294,302,325,330,347,369],"focused":[49],"mostly":[50],"on":[51,107,116],"patients":[52],"(pts)":[53],"with":[54,69,79,141,189,280],"relapsed/refractory":[55],"CLL":[56,70],"receiving":[57],"ven":[58,81,129,136,195,221],"as":[59,126],"monotherapy.":[60,196],"Methods:":[61],"We":[62,133],"included":[63,134],"pts":[64,140,162,192,200,225,243,259],">18y":[65],"who":[66,292,344,351],"were":[67,150,201,216,254,295,339],"diagnosed":[68],"small":[72],"lymphoma":[74],"(SLL)":[75],"received":[77,194,226],"tx":[78,159],"commercial":[80],"in":[82,262,370],"any":[83,281],"line":[84,157],"therapy":[86],"at":[87,169,208,304],"our":[88],"institution":[89,320],"from":[90],"1/1/2016":[91],"to":[92,298,349,364],"12/31/2020.":[93],"was":[95,105,145,153,270,326,331],"defined":[96,127],"using":[97],"modified":[99],"Cairo":[100],"Bishop":[101],"Criteria.":[102],"risk":[104,168,303],"based":[106],"size":[109],"largest":[112],"lymph":[113],"node":[114],"(LN)":[115],"imaging":[117],"examination":[119],"absolute":[122],"lymphocyte":[123],"count":[124],"(ALC)":[125],"by":[128],"Results:":[132],"616":[135],"escalations":[137],"among":[138,172,180,342],"136":[139],"CLL.":[142],"Median":[143],"age":[144],"70":[146],"years":[147],"86%":[149,223],"white.":[151],"Ven":[152],"part":[154],"first":[156],"48":[161],"(35%).":[163],"11%":[164],"had":[165,207],"high":[166],"baseline;":[170],"37%":[171],"those":[173,181,187,273,279,287,343,350],"escalated":[174,182,202,217,274,288],"exclusively":[175,183,203,218,275,289],"inpatient":[176],"(IP)":[177],"2%":[179],"outpatient":[184,372],"(OP).":[185],"Among":[186,238],"treated":[188],"ven,":[190],"47":[191],"(35%)":[193],"74":[197],"(54%)":[198],"OP,":[204],"35":[205],"(26%)":[206],"least":[209],"one":[210,265],"prophylactic":[211,236,282],"hospitalization":[212,283],"27":[214],"(20%)":[215],"IP.":[219],"During":[220],"initiation,":[222],"allopurinol,":[227],"71%":[228],"intravenous":[229],"hydration,":[230,360],"18%":[231],"phosphate":[232],"binders,":[233],"10%":[235],"rasburicase.":[237],"entire":[240],"cohort,":[241],"8":[242],"(5.9%)":[244],"developed":[245,250,260,293,345],"lab":[246,324,346],"zero":[249],"TLS.":[252],"There":[253],"11":[255],"events;":[257],"2":[258],"more":[263,296,340],"than":[264],"escalation.":[266],"Incidence":[267],"15%":[271],"IP,":[276],"5.7%":[277],"2.7%":[285],"OP.":[290],"Those":[291],"likely":[297],"higher":[301],"baseline,":[305],"preceding":[306],"isolated":[307],"hyperuricemia,":[308],"CrCl":[310],"measurement":[311],"<":[312],"60":[313],"mL/min":[314],"(Table).":[315],"Conclusions:":[316],"In":[317],"this":[318],"single":[319],"retrospective":[321],"cohort":[322],"study,":[323],"observed,":[327],"though":[328],"not.":[332,353],"Baseline":[333],"hyperuricemia":[334],"impaired":[336],"renal":[337],"function":[338],"common":[341],"compared":[348],"did":[352],"Prophylactic":[354],"measures,":[355],"including":[356],"use":[357],"IV":[359],"may":[361],"contributed":[363],"low":[365],"rates":[366],"observed":[368],"setting.":[373],"[Table:":[374],"see":[375],"text]":[376]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-06-11T00:00:00"}