{"id":"https://openalex.org/W4399478014","doi":"https://doi.org/10.5173/ceju.2023.273","title":"Efficacy of botulinum toxin in the management of refractory de novo overactive bladder symptoms in women after midurethral sling placement retrospective, single center study","display_name":"Efficacy of botulinum toxin in the management of refractory de novo overactive bladder symptoms in women after midurethral sling placement retrospective, single center study","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4399478014","doi":"https://doi.org/10.5173/ceju.2023.273","pmid":"https://pubmed.ncbi.nlm.nih.gov/39345325","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11428366"},"language":"en","primary_location":{"id":"doi:10.5173/ceju.2023.273","doi":"https://doi.org/10.5173/ceju.2023.273","is_oa":false,"landing_page_url":"https://doi.org/10.5173/ceju.2023.273","pdf_url":null,"source":{"id":"https://openalex.org/S4210228274","display_name":"Editor-in-Chief s Voice List of Authors is an Important Element in a Scientific Publication","issn_l":"2080-4806","issn":["2080-4806","2080-4873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","ki-jl-1","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Central European Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-2916751/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039799349","display_name":"Sameh Hijazi","orcid":"https://orcid.org/0000-0002-3044-2075","observed_orcids":["https://orcid.org/0000-0002-3044-2075"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sameh Hijazi","raw_affiliation_strings":["Klinikum Ibbenb\u00fcren","Department of Urology, Hospital Ibbenbueren, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3044-2075","affiliations":[{"raw_affiliation_string":"Klinikum Ibbenb\u00fcren","institution_ids":[]},{"raw_affiliation_string":"Department of Urology, Hospital Ibbenbueren, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038341013","display_name":"Leonidas Karapanos","orcid":"https://orcid.org/0000-0001-7608-7673","observed_orcids":["https://orcid.org/0000-0001-7608-7673"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Leonidas Karapanos","raw_affiliation_strings":["Klinikum Ibbenb\u00fcren","Department of Urology, Uro-Oncology, Robot-Assisted and Reconstructive Surgery, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinikum Ibbenb\u00fcren","institution_ids":[]},{"raw_affiliation_string":"Department of Urology, Uro-Oncology, Robot-Assisted and Reconstructive Surgery, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026533117","display_name":"Luisa Halbe","orcid":"https://orcid.org/0000-0002-6713-1334","observed_orcids":["https://orcid.org/0000-0002-6713-1334"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Luisa Halbe","raw_affiliation_strings":["Klinikum Ibbenb\u00fcren","Department of Urology, Uro-Oncology, Robot-Assisted and Reconstructive Surgery, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinikum Ibbenb\u00fcren","institution_ids":[]},{"raw_affiliation_string":"Department of Urology, Uro-Oncology, Robot-Assisted and Reconstructive Surgery, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048118430","display_name":"Axel Heidenreich","orcid":"https://orcid.org/0000-0002-2511-3664","observed_orcids":["https://orcid.org/0000-0002-2511-3664"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Axel Heidenreich","raw_affiliation_strings":["Klinikum Ibbenb\u00fcren","Department of Urology, Uro-Oncology, Robot-Assisted and Reconstructive Surgery, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinikum Ibbenb\u00fcren","institution_ids":[]},{"raw_affiliation_string":"Department of Urology, Uro-Oncology, Robot-Assisted and Reconstructive Surgery, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059159823","display_name":"Viktoria Hasselhof","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Viktoria Hasselhof","raw_affiliation_strings":["Klinikum Ibbenb\u00fcren","Department of Urology, Hospital Ibbenbueren, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinikum Ibbenb\u00fcren","institution_ids":[]},{"raw_affiliation_string":"Department of Urology, Hospital Ibbenbueren, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160679597","display_name":"Amer Alkhalfa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amer Alkhalfa","raw_affiliation_strings":["Klinikum Ibbenb\u00fcren","Department of Urology and Pediatric Urology, St.-Clemens-Hospital Geldern, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinikum Ibbenb\u00fcren","institution_ids":[]},{"raw_affiliation_string":"Department of Urology and Pediatric Urology, St.-Clemens-Hospital Geldern, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032062270","display_name":"Bara Barakat","orcid":"https://orcid.org/0000-0002-3078-5406","observed_orcids":["https://orcid.org/0000-0002-3078-5406"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bara Barakat","raw_affiliation_strings":["Klinikum Ibbenb\u00fcren","Department of Urology, Hospital Ibbenbueren, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinikum Ibbenb\u00fcren","institution_ids":[]},{"raw_affiliation_string":"Department of Urology, Hospital Ibbenbueren, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7406,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.67185675,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"77","issue":"2","first_page":"213","last_page":"217"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10418","display_name":"Pelvic floor disorders treatments","score":0.06920000165700912,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/onabotulinumtoxina","display_name":"onabotulinumtoxinA","score":0.9139999747276306},{"id":"https://openalex.org/keywords/overactive-bladder","display_name":"overactive bladder","score":0.9480000138282776},{"id":"https://openalex.org/keywords/midurethral-sling","display_name":"midurethral sling","score":0.9449999928474426},{"id":"https://openalex.org/keywords/refractory-overactive-bladder","display_name":"refractory overactive bladder","score":0.7279999852180481},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.7760000228881836},{"id":"https://openalex.org/keywords/nocturia","display_name":"nocturia","score":0.7289999723434448},{"id":"https://openalex.org/keywords/urinary-urgency","display_name":"urinary urgency","score":0.6639999747276306},{"id":"https://openalex.org/keywords/urinary-incontinence","display_name":"urinary incontinence","score":0.7250000238418579},{"id":"https://openalex.org/keywords/urodynamics","display_name":"urodynamics","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C2778941218","wikidata":"https://www.wikidata.org/wiki/Q331231","display_name":"Overactive bladder","level":3,"score":0.8768208026885986},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.847528338432312},{"id":"https://openalex.org/C178103971","wikidata":"https://www.wikidata.org/wiki/Q199771","display_name":"Sling (weapon)","level":2,"score":0.7730437517166138},{"id":"https://openalex.org/C2780073493","wikidata":"https://www.wikidata.org/wiki/Q7523837","display_name":"Single Center","level":2,"score":0.6385180950164795},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.5790194272994995},{"id":"https://openalex.org/C2777478456","wikidata":"https://www.wikidata.org/wiki/Q208413","display_name":"Botulinum toxin","level":2,"score":0.5638536214828491},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.45648524165153503},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.45556923747062683},{"id":"https://openalex.org/C3017551082","wikidata":"https://www.wikidata.org/wiki/Q1863718","display_name":"Sacral nerve stimulation","level":2,"score":0.4509989619255066},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4086032807826996},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.5173/ceju.2023.273","doi":"https://doi.org/10.5173/ceju.2023.273","is_oa":false,"landing_page_url":"https://doi.org/10.5173/ceju.2023.273","pdf_url":null,"source":{"id":"https://openalex.org/S4210228274","display_name":"Editor-in-Chief s Voice List of Authors is an Important Element in a Scientific Publication","issn_l":"2080-4806","issn":["2080-4806","2080-4873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","ki-jl-1","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Central European Journal of Urology","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-2916751/v1","doi":"https://doi.org/10.21203/rs.3.rs-2916751/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-2916751/v1","pdf_url":"https://www.researchsquare.com/article/rs-2916751/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11428366","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11428366","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11428366/pdf/CEJU-77-273.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cent European J Urol","raw_type":"Text"},{"id":"pmid:39345325","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39345325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Central European journal of urology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-2916751/v1","doi":"https://doi.org/10.21203/rs.3.rs-2916751/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-2916751/v1","pdf_url":"https://www.researchsquare.com/article/rs-2916751/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4399478014.pdf","grobid_xml":"https://content.openalex.org/works/W4399478014.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1527342068","https://openalex.org/W1866380676","https://openalex.org/W1943017709","https://openalex.org/W1967312126","https://openalex.org/W1978697642","https://openalex.org/W1982663743","https://openalex.org/W1993273510","https://openalex.org/W2010906872","https://openalex.org/W2020664647","https://openalex.org/W2022977725","https://openalex.org/W2043465531","https://openalex.org/W2043938107","https://openalex.org/W2055878940","https://openalex.org/W2096998881","https://openalex.org/W2149114901","https://openalex.org/W2179229362","https://openalex.org/W2215319445","https://openalex.org/W2279769450","https://openalex.org/W2322667171","https://openalex.org/W2365677293","https://openalex.org/W2527695426","https://openalex.org/W2532165988","https://openalex.org/W2538463650","https://openalex.org/W2590428970","https://openalex.org/W2719687191","https://openalex.org/W2743294685","https://openalex.org/W2744375987","https://openalex.org/W2984977877","https://openalex.org/W3135862631","https://openalex.org/W3139353937","https://openalex.org/W4247777061","https://openalex.org/W4250630073"],"related_works":["https://openalex.org/W4377821262","https://openalex.org/W1866380676","https://openalex.org/W2063307429","https://openalex.org/W2605824210","https://openalex.org/W4392373340","https://openalex.org/W4280633329","https://openalex.org/W7165820655","https://openalex.org/W2799549867","https://openalex.org/W7099269909","https://openalex.org/W23468579"],"abstract_inverted_index":{"Introduction:":[0],"This":[1],"study":[2,34],"aimed":[3],"o":[4],"evaluate":[5],"the":[6,83,101,228,241],"efficacy":[7],"of":[8,85,93,100,106,144,153,170,186,201,207,212,230,240,253],"onabotulinumtoxin":[9],"A":[10,31],"(onaBTX-A)":[11],"intradetrusor":[12],"injections":[13,200,218],"in":[14,117,140,150,176,205],"women":[15,40,52,171],"with":[16,54,147,246],"refractory":[17,56,231],"de":[18,57,232],"novo":[19,58,233],"overactive":[20],"bladder":[21],"(OAB)":[22],"following":[23,60,181],"midurethral":[24],"sling":[25],"(MUS)":[26],"placement.":[27,237],"Material":[28],"and":[29,48,66,68,72,89,97,109,120,125,133,142,159,179,224],"methods:":[30],"retrospective":[32],"single-center":[33],"was":[35,189],"conducted.":[36],"We":[37],"screened":[38],"372":[39],"who":[41],"underwent":[42],"MUS":[43,61,236],"surgery":[44],"between":[45],"August":[46],"2009":[47],"January":[49],"2022.":[50],"54/372":[51],"diagnosed":[53],"pharmacologically":[55],"OAB":[59,87,95,234],"were":[62,75,82,115,137,203],"evaluated":[63],"using":[64],"cystoscopy":[65],"urodynamics,":[67],"after":[69,103,192,209,235],"tape":[70],"erosion":[71],"obstructive":[73],"voiding":[74,131],"excluded,":[76],"they":[77],"received":[78],"onaBTX-A":[79,202,217,247],"therapy.":[80],"Outcomes":[81],"reduction":[84,175],"self-reported":[86],"symptoms":[88],"leakage":[90],"episodes,":[91],"improvement":[92],"validated":[94],"scores":[96],"adverse":[98],"events":[99],"procedure":[102],"a":[104,148,210,250],"follow-up":[105,226],"3,":[107,123],"6,":[108],"12":[110,126],"months.":[111,214],"Results:":[112],"Successful":[113],"results":[114],"reported":[116,172],"81%,":[118],"68%,":[119],"43%":[121],"at":[122,222],"6":[124],"months":[127],"respectively.":[128],"Postoperatively,":[129],"median":[130,134,184,211],"frequency":[132],"nocturia":[135,160],"episodes":[136,161,180],"significantly":[138,190],"improved":[139],"70%":[141],"77%":[143],"women,":[145],"respectively,":[146],"decrease":[149],"daily":[151],"number":[152,185],"voids":[154],"(-4.1,":[155],"p":[156,163,196],"=":[157,164,197],"0.0001)":[158],"(-2.2,":[162],"0.005).":[165],"At":[166],"3":[167],"months,":[168],"80%":[169],"an":[173],">25%":[174],"urgency":[177],"severity":[178],"injection.":[182],"The":[183],"pads":[187],"used":[188],"reduced":[191],"injection":[193],"(-2":[194],"pads;":[195],"0.03).":[198],"Repeat":[199],"performed":[204],"61%":[206],"patients":[208,242],"11":[213],"Conclusions:":[215],"Intravesical":[216],"are":[219],"clinically":[220],"effective":[221],"3-":[223],"6-month":[225],"for":[227,244],"treatment":[229],"Over":[238],"60%":[239],"opted":[243],"retreatment":[245],"due":[248],"to":[249],"high":[251],"level":[252],"satisfaction.":[254]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-06-11T00:00:00"}