{"id":"https://openalex.org/W4399445554","doi":"https://doi.org/10.1002/bmc.5920","title":"Gas chromatography mass spectrometer determination of dimethylamine impurity in N,N\u2010dimethylformamide solvent by derivatization of N,N\u2010dimethylbenzamide with benzoyl chloride agent","display_name":"Gas chromatography mass spectrometer determination of dimethylamine impurity in N,N\u2010dimethylformamide solvent by derivatization of N,N\u2010dimethylbenzamide with benzoyl chloride agent","publication_year":2024,"publication_date":"2024-06-06","ids":{"openalex":"https://openalex.org/W4399445554","doi":"https://doi.org/10.1002/bmc.5920","pmid":"https://pubmed.ncbi.nlm.nih.gov/38844433"},"language":"en","primary_location":{"id":"doi:10.1002/bmc.5920","doi":"https://doi.org/10.1002/bmc.5920","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bmc.5920","pdf_url":null,"source":{"id":"https://openalex.org/S123979729","display_name":"Biomedical Chromatography","issn_l":"0269-3879","issn":["0269-3879","1099-0801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Chromatography","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104432858","display_name":"Kousrali Sayyad","orcid":"https://orcid.org/0000-0002-7057-2608","observed_orcids":["https://orcid.org/0000-0002-7057-2608"]},"institutions":[{"id":"https://openalex.org/I875944469","display_name":"Koneru Lakshmaiah Education Foundation","ror":"https://ror.org/02k949197","country_code":"IN","type":"education","lineage":["https://openalex.org/I875944469"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sayyad Kousrali","raw_affiliation_strings":["Department of Engineering Chemistry Koneru Lakshmaiah Education Foundation  Hyderabad India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering Chemistry Koneru Lakshmaiah Education Foundation  Hyderabad India","institution_ids":["https://openalex.org/I875944469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072439550","display_name":"Leela Prasad Kowtharapu","orcid":"https://orcid.org/0000-0003-1199-2458","observed_orcids":["https://orcid.org/0000-0003-1199-2458"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leela Prasad Kowtharapu","raw_affiliation_strings":["Analytical Development Department Shenzhen DEC Pharmaceutical Co., Ltd  Shenzhen China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical Development Department Shenzhen DEC Pharmaceutical Co., Ltd  Shenzhen China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012125502","display_name":"Tanmoy Mondal","orcid":"https://orcid.org/0000-0002-3060-795X","observed_orcids":["https://orcid.org/0000-0002-3060-795X"]},"institutions":[{"id":"https://openalex.org/I875944469","display_name":"Koneru Lakshmaiah Education Foundation","ror":"https://ror.org/02k949197","country_code":"IN","type":"education","lineage":["https://openalex.org/I875944469"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Tanmoy Mondal","raw_affiliation_strings":["Department of Engineering Chemistry Koneru Lakshmaiah Education Foundation  Hyderabad India"],"raw_orcid":"https://orcid.org/0000-0002-3060-795X","affiliations":[{"raw_affiliation_string":"Department of Engineering Chemistry Koneru Lakshmaiah Education Foundation  Hyderabad India","institution_ids":["https://openalex.org/I875944469"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012125502"],"corresponding_institution_ids":["https://openalex.org/I875944469"],"apc_list":{"value":3680,"currency":"USD","value_usd":3680},"apc_paid":null,"fwci":1.9209,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.84689258,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"38","issue":"8","first_page":"e5920","last_page":"e5920"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.7226999998092651,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.7226999998092651,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.2750999927520752,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10180","display_name":"Analytical chemistry methods development","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dimethylformamide","display_name":"dimethylformamide","score":0.9710000157356262},{"id":"https://openalex.org/keywords/benzoyl-chloride-derivatization","display_name":"benzoyl chloride derivatization","score":0.972000002861023},{"id":"https://openalex.org/keywords/n-n-dimethylbenzamide","display_name":"N,N-dimethylbenzamide","score":1.0},{"id":"https://openalex.org/keywords/impurity-determination","display_name":"impurity determination","score":0.722000002861023},{"id":"https://openalex.org/keywords/amine-derivatization","display_name":"amine derivatization","score":0.6309999823570251},{"id":"https://openalex.org/keywords/analytical-method-validation","display_name":"analytical method validation","score":0.48399999737739563},{"id":"https://openalex.org/keywords/ich-q2-guidelines","display_name":"ICH Q2 guidelines","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C2780825948","wikidata":"https://www.wikidata.org/wiki/Q408022","display_name":"Dimethylamine","level":2,"score":0.9225356578826904},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9219993352890015},{"id":"https://openalex.org/C2777712214","wikidata":"https://www.wikidata.org/wiki/Q409298","display_name":"Dimethylformamide","level":3,"score":0.6086281538009644},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6014138460159302},{"id":"https://openalex.org/C40875361","wikidata":"https://www.wikidata.org/wiki/Q2356542","display_name":"Reagent","level":2,"score":0.5708423852920532},{"id":"https://openalex.org/C2778695967","wikidata":"https://www.wikidata.org/wiki/Q44791900","display_name":"Chloride","level":2,"score":0.5475724935531616},{"id":"https://openalex.org/C2776923573","wikidata":"https://www.wikidata.org/wiki/Q2294884","display_name":"Derivatization","level":3,"score":0.5465854406356812},{"id":"https://openalex.org/C2780471494","wikidata":"https://www.wikidata.org/wiki/Q146505","display_name":"Solvent","level":2,"score":0.5420857071876526},{"id":"https://openalex.org/C123460561","wikidata":"https://www.wikidata.org/wiki/Q677065","display_name":"Gas chromatography","level":2,"score":0.5079596638679504},{"id":"https://openalex.org/C131779359","wikidata":"https://www.wikidata.org/wiki/Q471875","display_name":"Amine gas treating","level":2,"score":0.4835943579673767},{"id":"https://openalex.org/C2781464203","wikidata":"https://www.wikidata.org/wiki/Q412825","display_name":"Benzoyl chloride","level":2,"score":0.43010690808296204},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.42453593015670776},{"id":"https://openalex.org/C2779607525","wikidata":"https://www.wikidata.org/wiki/Q14982","display_name":"Methanol","level":2,"score":0.4187333583831787},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.38545894622802734},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.13176584243774414}],"mesh":[{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001565","descriptor_name":"Benzoates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004123","descriptor_name":"Dimethylamines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004123","descriptor_name":"Dimethylamines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004126","descriptor_name":"Dimethylformamide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004340","descriptor_name":"Drug Contamination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057230","descriptor_name":"Limit of Detection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/bmc.5920","doi":"https://doi.org/10.1002/bmc.5920","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bmc.5920","pdf_url":null,"source":{"id":"https://openalex.org/S123979729","display_name":"Biomedical Chromatography","issn_l":"0269-3879","issn":["0269-3879","1099-0801"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Chromatography","raw_type":"journal-article"},{"id":"pmid:38844433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38844433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical chromatography : BMC","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320325735","display_name":"K L University","ror":"https://ror.org/02k949197"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1994056899","https://openalex.org/W2018284275","https://openalex.org/W2035610824","https://openalex.org/W2036245115","https://openalex.org/W2042822616","https://openalex.org/W2057351108","https://openalex.org/W2115504368","https://openalex.org/W2164265091","https://openalex.org/W2289049348","https://openalex.org/W2343377814","https://openalex.org/W2510419799","https://openalex.org/W2582830176","https://openalex.org/W2795148843","https://openalex.org/W2807305953","https://openalex.org/W2904003507","https://openalex.org/W2912570183","https://openalex.org/W2914031514","https://openalex.org/W2980038898","https://openalex.org/W2980446800","https://openalex.org/W2981070004","https://openalex.org/W2984130930","https://openalex.org/W3010075113","https://openalex.org/W3014709580","https://openalex.org/W3162261530","https://openalex.org/W4233740433","https://openalex.org/W4251710237","https://openalex.org/W4285094501","https://openalex.org/W4310668123","https://openalex.org/W4321497331","https://openalex.org/W4324195240","https://openalex.org/W4382459385","https://openalex.org/W4388015810","https://openalex.org/W4392774164"],"related_works":["https://openalex.org/W2370226008","https://openalex.org/W1988138977","https://openalex.org/W2318505182","https://openalex.org/W2376682164","https://openalex.org/W1992324955","https://openalex.org/W2588132403","https://openalex.org/W2104321317","https://openalex.org/W3145673893","https://openalex.org/W7162650539","https://openalex.org/W3215265904"],"abstract_inverted_index":{"This":[0,49],"study":[1],"describes":[2],"the":[3,65,70,75,81,123,140,144,155],"development":[4],"of":[5,93,117,132,168],"a":[6,21,27],"reliable":[7],"and":[8,26,78,103,111,176],"linear":[9],"analytical":[10],"method":[11,50,141],"for":[12,120,147,158],"precisely":[13],"determining":[14],"dimethylamine":[15],"impurity":[16],"in":[17,122,162],"N,N-dimethylformamide":[18],"solvent":[19],"utilizing":[20],"benzoyl":[22,42],"chloride":[23,33,43],"derivatization":[24],"reagent":[25],"gas":[28],"chromatography":[29],"mass":[30],"spectrometer.":[31],"Benzoyl":[32],"was":[34,87,95,127,134,149,160,170],"used":[35],"to":[36,97,136,151,172],"derivatize":[37],"dimethylamine.":[38],"At":[39],"normal":[40],"temperature,":[41],"combined":[44],"with":[45],"dimethylamine,":[46],"producing":[47],"N,N-dimethylbenzamide.":[48],"separated":[51],"N,N-dimethylbenzamide":[52,94,121,133,148,159,169],"using":[53,107],"Rtx-5":[54],"amine":[55],"(30":[56],"m":[57],"\u00d7":[58,61],"0.32":[59],"mm":[60],"1.50":[62],"\u03bcm)":[63],"as":[64,69,74,80],"stationary":[66],"phase,":[67],"helium":[68],"carrier":[71],"gas,":[72,77],"argon":[73],"collision":[76],"methanol":[79],"diluent.":[82],"The":[83,90,114,129,165],"column":[84],"flow":[85],"rate":[86],"2":[88],"mL/min.":[89],"retention":[91],"time":[92],"determined":[96,171],"be":[98,137,152,173],"8.5":[99],"min.":[100],"Precision,":[101],"linearity,":[102],"accuracy":[104],"were":[105],"tested":[106],"ICH":[108],"Q2":[109],"(R2)":[110],"USP<1225>":[112],"guidelines.":[113],"percentage":[115,166],"coefficient":[116,131],"variation":[118],"(CV)":[119],"system":[124],"suitability":[125],"parameter":[126],"1.1%.":[128],"correlation":[130],"found":[135,150],">0.99.":[138],"In":[139],"precision":[142],"parameter,":[143],"%":[145,156],"CV":[146,157],"1.9%,":[153],"whereas":[154],"1.2%":[161],"intermediate":[163],"precision.":[164],"recovery":[167],"between":[174],"80%":[175],"98%.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-06-08T00:00:00"}