{"id":"https://openalex.org/W4399389840","doi":"https://doi.org/10.1128/jcm.00416-24","title":"Mitigation of errors on an FDA-approved platform for cytomegalovirus viral load assay","display_name":"Mitigation of errors on an FDA-approved platform for cytomegalovirus viral load assay","publication_year":2024,"publication_date":"2024-06-06","ids":{"openalex":"https://openalex.org/W4399389840","doi":"https://doi.org/10.1128/jcm.00416-24","pmid":"https://pubmed.ncbi.nlm.nih.gov/38842311","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11250505"},"language":"en","primary_location":{"id":"doi:10.1128/jcm.00416-24","doi":"https://doi.org/10.1128/jcm.00416-24","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jcm.00416-24","pdf_url":null,"source":{"id":"https://openalex.org/S53087977","display_name":"Journal of Clinical Microbiology","issn_l":"0095-1137","issn":["0095-1137","1070-633X","1098-660X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11250505/pdf/jcm.00416-24.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062722741","display_name":"Jung-Ho Youn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jung-Ho Youn","raw_affiliation_strings":["Department of Laboratory Medicine, NIH, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084435431","display_name":"Lorenzo Walker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lorenzo Walker","raw_affiliation_strings":["Department of Laboratory Medicine, NIH, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022597277","display_name":"Seth D. Carlson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seth Carlson","raw_affiliation_strings":["Department of Clinical Research Informatics, NIH, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research Informatics, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113241677","display_name":"Craig Soutar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig Soutar","raw_affiliation_strings":["Department of Laboratory Medicine, NIH, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018348776","display_name":"Karen M. Frank","orcid":"https://orcid.org/0000-0002-9970-4133","observed_orcids":["https://orcid.org/0000-0002-9970-4133"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Frank","raw_affiliation_strings":["Department of Laboratory Medicine, NIH, Bethesda, Maryland, USA"],"raw_orcid":"https://orcid.org/0000-0002-9970-4133","affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016895895","display_name":"Adrian M. Zelazny","orcid":"https://orcid.org/0000-0003-2847-7428","observed_orcids":["https://orcid.org/0000-0003-2847-7428"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrian Zelazny","raw_affiliation_strings":["Department of Laboratory Medicine, NIH, Bethesda, Maryland, USA"],"raw_orcid":"https://orcid.org/0000-0003-2847-7428","affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017656260","display_name":"Sanchita Basu Das","orcid":"https://orcid.org/0000-0002-2246-7942","observed_orcids":["https://orcid.org/0000-0002-2246-7942"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanchita Das","raw_affiliation_strings":["Department of Laboratory Medicine, NIH, Bethesda, Maryland, USA"],"raw_orcid":"https://orcid.org/0000-0002-2246-7942","affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, NIH, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1299303238"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1096135,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"62","issue":"7","first_page":"e0041624","last_page":"e0041624"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13690","display_name":"Quality and Safety in Healthcare","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medical-device-recall","display_name":"medical device recall","score":0.6940000057220459},{"id":"https://openalex.org/keywords/immunoglobulin-levels","display_name":"immunoglobulin levels","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.6839460134506226},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.644981861114502},{"id":"https://openalex.org/C2777732132","wikidata":"https://www.wikidata.org/wiki/Q6946","display_name":"Cytomegalovirus","level":5,"score":0.5816224217414856},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5206843614578247},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.5110806226730347},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.5009975433349609},{"id":"https://openalex.org/C2992293740","wikidata":"https://www.wikidata.org/wiki/Q4781752","display_name":"Drug approval","level":3,"score":0.4815507233142853},{"id":"https://openalex.org/C2910866203","wikidata":"https://www.wikidata.org/wiki/Q6946","display_name":"Cytomegalovirus infections","level":4,"score":0.4730643033981323},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.4609032869338989},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3086845576763153},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.25141555070877075},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.1958446204662323},{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.18955975770950317},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.1487923562526703},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.139463871717453},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.13238894939422607},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.12506559491157532},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003586","descriptor_name":"Cytomegalovirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003951","descriptor_name":"Diagnostic Errors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014486","descriptor_name":"United States Food and Drug Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1128/jcm.00416-24","doi":"https://doi.org/10.1128/jcm.00416-24","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jcm.00416-24","pdf_url":null,"source":{"id":"https://openalex.org/S53087977","display_name":"Journal of Clinical Microbiology","issn_l":"0095-1137","issn":["0095-1137","1070-633X","1098-660X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11250505","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11250505","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11250505/pdf/jcm.00416-24.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Microbiol","raw_type":"Text"},{"id":"pmid:38842311","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38842311","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical microbiology","raw_type":"Letter"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11250505","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11250505","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11250505/pdf/jcm.00416-24.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Microbiol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4399389840.pdf","grobid_xml":"https://content.openalex.org/works/W4399389840.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W1966869845","https://openalex.org/W2613909574","https://openalex.org/W4285793354","https://openalex.org/W4300464102","https://openalex.org/W4318620396","https://openalex.org/W4390743119"],"related_works":["https://openalex.org/W4397004623","https://openalex.org/W4404412764","https://openalex.org/W4366754878","https://openalex.org/W4386569837","https://openalex.org/W2329822494","https://openalex.org/W4390483138","https://openalex.org/W2802640715","https://openalex.org/W2146450426","https://openalex.org/W2307163696","https://openalex.org/W2039795099"],"abstract_inverted_index":{"KEYWORDS":[0],"automated":[1],"platforms,":[2],"CMV":[3,27,64,236,328,337,361],"viral":[4,245,329],"load":[5,246,330],"monitoring,":[6],"device":[7,20],"recall":[8,21,110],"O":[9],"n":[10],"14":[11],"September":[12],"2023,":[13],"Hologic":[14,169,379],"Inc.":[15],"issued":[16],"an":[17,142,165,172,290,409],"urgent":[18],"medical":[19],"notifica":[22],"tion":[23],"for":[24,31,235,323,326,360,363,417],"the":[25,35,39,41,45,57,67,83,96,105,109,122,154,187,194,200,203,206,215,219,226,239,243,261,293,304,316,343,376,386,393,400,438,472,478],"Aptima":[26,240],"Quant":[28],"Assay":[29],"(Aptima)":[30],"ML2":[32,112,294,346,401,453,479],"errors":[33,155,195,276,295,347,450],"on":[34,260,303,375,437],"Panther":[36],"Instrument.Approved":[37],"by":[38,168,225],"FDA,":[40],"performance":[42],"characteristics":[43],"of":[44,77,81,95,104,162,176,186,272,312,335,345,355,369,392,430,442,459,471],"assay":[46,58,65,74,190,247,259],"had":[47,414,421,454,481],"been":[48,157],"compared":[49],"in":[50,59,75,149,179,184,320,348,468,499],"a":[51,79,116,127,160,180,254,310,333,364,422,428,433,496],"large":[52],"study":[53],"previously":[54],"(1).We":[55],"verified":[56],"our":[60,192,349],"laboratory":[61],"using":[62,72],"COBAS":[63],"as":[66,223,253],"comparator":[68],"and":[69,138,164,198,208,232,242,296,308,318,388,461],"started":[70],"clinically":[71],"this":[73,150,340,373],"February":[76],"2023.Within":[78],"month":[80],"adopting":[82],"assay,":[84],"we":[85,384],"encountered":[86],"\"ML2":[87],"error":[88,113,120,201,207,220,317,424,480],"flags\"":[89],"that":[90,153,171,211,217,248,396,413,448],"are":[91,212],"due":[92,269],"to":[93,108,115,141,270,278],"clogging":[94,185],"magnetic":[97],"wash":[98,134],"station":[99],"aspirators":[100],"after":[101,133,214],"initial":[102],"aspiration":[103],"sample":[106,181,204,216],"according":[107],"notification.An":[111],"refers":[114],"liquid":[117,131],"level":[118,132,494,506],"sensing":[119],"where":[121],"Magnetic":[123],"Wash":[124],"Station":[125],"reports":[126],"higher":[128],"than":[129,452],"acceptable":[130],"fluid":[135],"is":[136],"dispensed":[137],"it":[139],"leads":[140],"invalid":[143,228,321],"specimen":[144],"result.The":[145],"vendor":[146],"also":[147,250,403],"indicated":[148,170],"notification":[151],"document":[152],"have":[156],"reported":[158],"with":[159,238,399,475],"frequency":[161,344],"0.54%":[163],"investigation":[166,291,377],"conducted":[167],"abnormally":[173],"high":[174,381,455,497,512],"concentration":[175],"globulin":[177,382],"proteins":[178],"may":[182],"result":[183],"analyzer":[188],"during":[189,339,372],"processing.In":[191],"experience,":[193],"occurred":[196],"randomly":[197,404,445],"once":[199],"occurred,":[202],"causing":[205,477],"all":[209],"samples":[210,264,299,325,357,395,407,441,447,476],"queued":[213],"caused":[218],"were":[221,230,287,397],"flagged":[222],"\"invalid\"":[224],"instrument.These":[227],"results":[229,234,322,416],"random,":[231],"affected":[233],"associated":[237,398],"assay;":[241],"EBV":[244],"was":[249,351],"being":[251,358],"performed":[252,289,332],"Fusion":[255],"Open":[256],"Access":[257],"Taqman":[258],"same":[262],"instrument.Since":[263],"could":[265],"not":[266],"be":[267],"re-tested":[268],"lack":[271],"residual":[273],"volume,":[274],"these":[275,443],"led":[277],"fresh":[279],"blood":[280],"draws":[281],"from":[282,300,378,408],"those":[283],"patients":[284,302,412,474],"whose":[285],"specimens":[286],"affected.We":[288],"into":[292],"identified":[297],"nine":[298,305,473],"seven":[301],"different":[306],"occasions":[307],"over":[309],"period":[311],"63":[313],"days":[314],"triggered":[315,449],"resulted":[319],"95":[324],"quantitative":[327],"assay.We":[331],"total":[334,389,513],"1,039":[336],"assays":[338],"time;":[341],"thus,":[342],"experience":[350],"0.87%.In":[352],"addition,":[353],"invalidation":[354],"additional":[356,410],"tested":[359],"accounted":[362],"much":[365],"greater":[366],"failure":[367,429],"rate":[368],"about":[370],"10%":[371],"time.Based":[374],"indicating":[380],"levels,":[383],"checked":[385],"immunoglobulin":[387,456,484],"protein":[390,514],"levels":[391,458,523],"plasma":[394],"errors.We":[402],"selected":[405,446],"27":[406,444],"26":[411],"documented":[415],"CMV/EBV":[418],"quantitation":[419],"or":[420,432,486,495,511],"non-ML2":[423],"flag":[425],"(these":[426],"included":[427],"control":[431],"volume":[434],"pipetting":[435],"error)":[436],"instrument.Only":[439],"two":[440],"other":[451],"(IgG)":[457],"2,098":[460],"1,910":[462],"mg/dL":[463],"(normal":[464],"range:":[465,491,509,520],"556-1,631":[466],"mg/dL);":[467],"contrast,":[469],"six":[470],"either":[482],"elevated":[483],"IgG":[485],"IgM":[487],"(n":[488,503,515],"=":[489,504,516],"5;":[490],"1,772-6,453":[492],"mg/dL)":[493],"\u03b3-globulin":[498],"serum":[500],"electrophoresis":[501],"test":[502],"1;":[505,517],"2.9;":[507],"normal":[508,519],"0.8-1.8g/dL)":[510],"10.2;":[518],"6.4-8.3":[521],"g/dL)":[522]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-06-07T00:00:00"}