{"id":"https://openalex.org/W4399346635","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.1102","title":"Sequential combination of sacituzumab govitecan and talazoparib in metastatic triple negative breast cancer (mTNBC): Results from a phase II study.","display_name":"Sequential combination of sacituzumab govitecan and talazoparib in metastatic triple negative breast cancer (mTNBC): Results from a phase II study.","publication_year":2024,"publication_date":"2024-06-01","ids":{"openalex":"https://openalex.org/W4399346635","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.1102"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2024.42.16_suppl.1102","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.1102","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2024.42.16_suppl.1102","pdf_url":"https://ascopubs.org/doi/pdf/10.1200/JCO.2024.42.16_suppl.1102","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ascopubs.org/doi/pdf/10.1200/JCO.2024.42.16_suppl.1102","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006042046","display_name":"Rachel O. Abelman","orcid":"https://orcid.org/0000-0002-3946-7420","observed_orcids":["https://orcid.org/0000-0002-3946-7420"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Occhiogrosso Abelman","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018738915","display_name":"Laura M. Spring","orcid":"https://orcid.org/0000-0001-8904-3514","observed_orcids":["https://orcid.org/0000-0001-8904-3514"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Spring","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028403057","display_name":"Andrzej Niemierko","orcid":"https://orcid.org/0000-0002-8895-5500","observed_orcids":["https://orcid.org/0000-0002-8895-5500"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrzej Niemierko","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Elizabeth Abraham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Abraham","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009875169","display_name":"Mary McNeice","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary McNeice","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070723223","display_name":"Jennifer Goff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Goff","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101372275","display_name":"Amanda Valenti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Valenti","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025351031","display_name":"Seth Andrew Wander","orcid":"https://orcid.org/0000-0002-4127-4708","observed_orcids":["https://orcid.org/0000-0002-4127-4708"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seth Andrew Wander","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057580348","display_name":"Steven Jay Isakoff","orcid":"https://orcid.org/0000-0002-6677-1014","observed_orcids":["https://orcid.org/0000-0002-6677-1014"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven J. Isakoff","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017550097","display_name":"Beverly Moy","orcid":"https://orcid.org/0000-0003-3472-1140","observed_orcids":["https://orcid.org/0000-0003-3472-1140"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beverly Moy","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087308492","display_name":"Dejan Juric","orcid":"https://orcid.org/0000-0003-2983-7704","observed_orcids":["https://orcid.org/0000-0003-2983-7704"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dejan Juric","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039802529","display_name":"Neelima Vidula","orcid":"https://orcid.org/0000-0002-5963-7052","observed_orcids":["https://orcid.org/0000-0002-5963-7052"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neelima Vidula","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089866079","display_name":"Adrienne Gropper Waks","orcid":"https://orcid.org/0000-0001-5649-7229","observed_orcids":["https://orcid.org/0000-0001-5649-7229"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrienne Gropper Waks","raw_affiliation_strings":["Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088801158","display_name":"Heather Anne Parsons","orcid":"https://orcid.org/0000-0001-8178-6612","observed_orcids":["https://orcid.org/0000-0001-8178-6612"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather Anne Parsons","raw_affiliation_strings":["Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052735318","display_name":"Leif William Ellisen","orcid":"https://orcid.org/0000-0003-0444-7910","observed_orcids":["https://orcid.org/0000-0003-0444-7910"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leif W. Ellisen","raw_affiliation_strings":["Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069056507","display_name":"Sara M. Tolaney","orcid":"https://orcid.org/0000-0002-5940-8671","observed_orcids":["https://orcid.org/0000-0002-5940-8671"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara M. Tolaney","raw_affiliation_strings":["Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034972183","display_name":"Aditya Bardia","orcid":"https://orcid.org/0000-0003-4885-1157","observed_orcids":["https://orcid.org/0000-0003-4885-1157"]},"institutions":[{"id":"https://openalex.org/I2799798094","display_name":"UCLA Health","ror":"https://ror.org/01d88se56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aditya Bardia","raw_affiliation_strings":["UCLA Health Jonsson Comprehensive Cancer Center, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCLA Health Jonsson Comprehensive Cancer Center, Los Angeles, CA","institution_ids":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"16_suppl","first_page":"1102","last_page":"1102"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.044199999421834946,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sacituzumab-govitecan","display_name":"sacituzumab govitecan","score":0.9980000257492065},{"id":"https://openalex.org/keywords/talazoparib","display_name":"talazoparib","score":1.0},{"id":"https://openalex.org/keywords/metastatic-triple-negative-breast-cancer","display_name":"metastatic triple-negative breast cancer","score":0.9789999723434448},{"id":"https://openalex.org/keywords/sequential-therapy","display_name":"sequential therapy","score":0.8119999766349792},{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.9179999828338623},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.9120000004768372},{"id":"https://openalex.org/keywords/parp-inhibition","display_name":"PARP inhibition","score":0.5220000147819519},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.4819999933242798},{"id":"https://openalex.org/keywords/objective-response-rate","display_name":"objective response rate","score":0.7570000290870667},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9819999933242798},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9729999899864197},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.8360000252723694},{"id":"https://openalex.org/keywords/g-csf-prophylaxis","display_name":"G-CSF prophylaxis","score":0.8450000286102295},{"id":"https://openalex.org/keywords/clinical-benefit-rate","display_name":"clinical benefit rate","score":0.597000002861023},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9027737975120544},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.6476972699165344},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6012579202651978},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.5744323134422302},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5666857957839966},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5143483877182007},{"id":"https://openalex.org/C2992734768","wikidata":"https://www.wikidata.org/wiki/Q48964","display_name":"Triple negative","level":4,"score":0.44931429624557495},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39816945791244507}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2024.42.16_suppl.1102","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.1102","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2024.42.16_suppl.1102","pdf_url":"https://ascopubs.org/doi/pdf/10.1200/JCO.2024.42.16_suppl.1102","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1200/jco.2024.42.16_suppl.1102","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.1102","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2024.42.16_suppl.1102","pdf_url":"https://ascopubs.org/doi/pdf/10.1200/JCO.2024.42.16_suppl.1102","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4399346635.pdf","grobid_xml":"https://content.openalex.org/works/W4399346635.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3088359096","https://openalex.org/W4282967965","https://openalex.org/W4313826298","https://openalex.org/W4281785944","https://openalex.org/W4296010679","https://openalex.org/W4362692147","https://openalex.org/W4403020118","https://openalex.org/W3168784009","https://openalex.org/W7124139116","https://openalex.org/W3169907277"],"abstract_inverted_index":{"1102":[0],"Background:":[1],"The":[2,138,163,185,242,284],"antibody-drug":[3],"conjugate":[4],"(ADC)":[5],"sacituzumab":[6],"govitecan":[7],"(SG)":[8],"has":[9],"demonstrated":[10,64,368],"improvement":[11],"in":[12,27,271,276,309,323,361],"overall":[13,160],"survival":[14,157,161,345],"for":[15,203,336],"patients":[16,106,182,211],"with":[17,46,67,73,107,126,329,363],"metastatic":[18,204],"triple":[19],"negative":[20],"breast":[21],"cancer":[22],"(mTNBC).":[23],"Despite":[24],"great":[25],"interest":[26],"enhancing":[28],"efficacy":[29],"of":[30,76,198,217,274,313,325,371],"ADCs":[31],"using":[32],"combination":[33,362,384],"therapy,":[34],"there":[35],"are":[36],"no":[37],"approved":[38],"regimens.":[39],"Preclinical":[40],"data":[41,218,346],"suggest":[42],"that":[43],"SG":[44,77,118,360,388],"synergizes":[45],"Poly":[47],"ADP-ribose":[48],"polymerase":[49],"inhibitors":[50],"(PARPi)":[51],"to":[52,178,192,208,228,239,250,263,379,387],"induce":[53],"DNA":[54],"damage":[55],"and":[56,78,124,152,159,230,252,299,305,311,344,367],"cell":[57],"death.":[58],"Though":[59],"the":[60,79,91,142,253,351,382],"phase":[61,92,102,357],"1b":[62],"study":[63],"intolerable":[65],"myelosuppression":[66],"simultaneous":[68],"dosing,":[69],"tolerability":[70],"was":[71,117,136,141,171,188,222,233,245,258,334,365],"improved":[72],"sequential":[74],"administration":[75],"PARPi":[80],"talazoparib":[81,127,364],"(Bardia":[82],"AACR":[83],"2022).":[84],"Here":[85],"we":[86],"report":[87],"clinical":[88,375],"outcomes":[89],"from":[90],"II":[93,103,358],"dose":[94,116,319],"expansion":[95],"cohort":[96],"(NCT04039230).":[97],"Methods:":[98],"In":[99,354],"a":[100,196,330],"single-arm":[101,356],"study,":[104,359],"adult":[105],"measurable":[108],"mTNBC":[109],"(per":[110],"ASCO/CAP":[111],"guidelines)":[112],"were":[113,183,269,281,290,307,321],"eligible.":[114],"Starting":[115],"at":[119,168,215,255,350],"10mg/kg":[120],"on":[121,129,213],"days":[122,130,338],"1":[123],"8":[125],"1mg":[128],"15-21.":[131],"Growth":[132],"factor":[133],"(G-CSF)":[134],"prophylaxis":[135],"required.":[137],"primary":[139],"endpoint":[140],"confirmed":[143,243],"Objective":[144],"Response":[145],"Rate":[146,166],"(ORR)":[147],"calculated":[148],"per":[149],"RECIST":[150],"v1.1":[151],"secondary":[153],"endpoints":[154],"included":[155],"progression-free":[156],"(PFS)":[158],"(OS).":[162],"Clinical":[164,390],"Benefit":[165],"(CBR)":[167],"6":[169,256],"months":[170,224,235,257],"also":[172],"measured.":[173],"Results:":[174],"From":[175],"June":[176],"2021":[177],"March":[179],"2023,":[180],"26":[181],"enrolled.":[184],"median":[186,197,231],"age":[187],"54":[189],"(range,":[190,206],"35":[191],"81).":[193],"Patients":[194],"received":[195],"2":[199],"prior":[200],"therapy":[201],"lines":[202],"disease":[205,340],"0":[207],"7).":[209],"6/26":[210],"remain":[212],"treatment":[214,282,287],"time":[216],"cutoff.":[219],"Median":[220],"PFS":[221],"6.2":[223],"(95%":[225,236,247,260],"CI,":[226,237,248,261],"3.7":[227],"12.8),":[229],"OS":[232],"18.0":[234],"10.7":[238],"not":[240],"evaluable).":[241],"ORR":[244],"30.1%":[246],"14":[249],"52)":[251],"CBR":[254],"53.8%":[259],"33":[262],"73).":[264],"Serious":[265],"adverse":[266],"events":[267],"(AEs)":[268],"seen":[270,308],"10":[272],"(38.5%)":[273],"patients;":[275],"7":[277],"(26.9%)":[278],"serious":[279],"AEs":[280,289],"related.":[283],"most":[285],"common":[286],"related":[288],"anemia":[291,306],"(92.3%),":[292],"neutropenia":[293,304],"(88.5%),":[294],"nausea":[295],"(84.6%)":[296],"fatigue":[297],"(80.7%),":[298],"thrombocytopenia":[300],"(65.3%).":[301],"Grade":[302],"\u22653":[303],"80.7%":[310],"34.6%":[312],"cases,":[314],"respectively.":[315],"One":[316,327],"or":[317],"more":[318],"reductions":[320],"required":[322],"58.0%":[324],"patients.":[326],"patient":[328],"germline":[331],"BRCA":[332],"mutation":[333],"treated":[335],"625":[337],"before":[339],"progression.":[341],"Updated":[342],"biomarker":[343],"will":[347],"be":[348],"presented":[349],"meeting.":[352],"Conclusions:":[353],"this":[355],"feasible":[366],"preliminary":[369],"evidence":[370],"efficacy.":[372],"A":[373],"randomized":[374],"trial":[376,391],"is":[377,385],"needed":[378],"determine":[380],"if":[381],"SG-PARPi":[383],"superior":[386],"monotherapy.":[389],"information:":[392],"NCT04039230":[393],".":[394]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2024-06-05T00:00:00"}
