{"id":"https://openalex.org/W4399326568","doi":"https://doi.org/10.2147/rrcc.s449513","title":"Clinical Application of PINK1 and ACSL4 Protein Levels in the Acute Myocardial Infarction Patients and Prognosis Evaluation After PCI","display_name":"Clinical Application of PINK1 and ACSL4 Protein Levels in the Acute Myocardial Infarction Patients and Prognosis Evaluation After PCI","publication_year":2024,"publication_date":"2024-06-01","ids":{"openalex":"https://openalex.org/W4399326568","doi":"https://doi.org/10.2147/rrcc.s449513"},"language":"en","primary_location":{"id":"doi:10.2147/rrcc.s449513","doi":"https://doi.org/10.2147/rrcc.s449513","is_oa":true,"landing_page_url":"https://doi.org/10.2147/rrcc.s449513","pdf_url":"https://www.dovepress.com/getfile.php?fileID=99654","source":{"id":"https://openalex.org/S2765035434","display_name":"Research Reports in Clinical Cardiology","issn_l":"1179-8475","issn":["1179-8475"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Reports in Clinical Cardiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=99654","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Wei Ao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Ao","raw_affiliation_strings":["Department of Cardiology, Yueyang People's Hospital, Hunan Normal University, Yueyang City, Hunan Province, 414000, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Yueyang People's Hospital, Hunan Normal University, Yueyang City, Hunan Province, 414000, People's Republic of China","institution_ids":["https://openalex.org/I173759888"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ping Duan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144683","display_name":"Seventh People's Hospital of Shanghai","ror":"https://ror.org/045vwy185","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Duan","raw_affiliation_strings":["Department of Cardiology, Shanghai Seventh People\u2019s Hospital, Shanghai City, 200000, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Shanghai Seventh People\u2019s Hospital, Shanghai City, 200000, People\u2019s Republic of China","institution_ids":["https://openalex.org/I4210144683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087037018","display_name":"Ping Luo","orcid":"https://orcid.org/0000-0003-4728-2415","observed_orcids":["https://orcid.org/0000-0003-4728-2415"]},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Luo","raw_affiliation_strings":["Department of Cardiology, Yueyang People's Hospital, Hunan Normal University, Yueyang City, Hunan Province, 414000, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Yueyang People's Hospital, Hunan Normal University, Yueyang City, Hunan Province, 414000, People's Republic of China","institution_ids":["https://openalex.org/I173759888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045647974","display_name":"Dikai Xiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dikai Xiang","raw_affiliation_strings":["Department of Cardiology, Yueyang People's Hospital, Hunan Normal University, Yueyang City, Hunan Province, 414000, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Yueyang People's Hospital, Hunan Normal University, Yueyang City, Hunan Province, 414000, People's Republic of China","institution_ids":["https://openalex.org/I173759888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079396359","display_name":"Qin Wang","orcid":"https://orcid.org/0000-0002-1079-5914","observed_orcids":["https://orcid.org/0000-0002-1079-5914"]},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qin Wang","raw_affiliation_strings":["Department of Cardiology, Yueyang People's Hospital, Hunan Normal University, Yueyang City, Hunan Province, 414000, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Yueyang People's Hospital, Hunan Normal University, Yueyang City, Hunan Province, 414000, People's Republic of China","institution_ids":["https://openalex.org/I173759888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007658350","display_name":"Yanjiao Ren","orcid":"https://orcid.org/0000-0003-4393-2505","observed_orcids":["https://orcid.org/0000-0003-4393-2505"]},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanjiao Ren","raw_affiliation_strings":["Department of Cardiology, Yueyang People's Hospital, Hunan Normal University, Yueyang City, Hunan Province, 414000, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Yueyang People's Hospital, Hunan Normal University, Yueyang City, Hunan Province, 414000, People's Republic of China","institution_ids":["https://openalex.org/I173759888"]}]},{"author_position":"last","author":{"id":null,"display_name":"Qiwei He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiwei He","raw_affiliation_strings":["Department of Cardiology, Yueyang People's Hospital, Hunan Normal University, Yueyang City, Hunan Province, 414000, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Yueyang People's Hospital, Hunan Normal University, Yueyang City, Hunan Province, 414000, People's Republic of China","institution_ids":["https://openalex.org/I173759888"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1806,"currency":"USD","value_usd":1806},"apc_paid":{"value":1806,"currency":"USD","value_usd":1806},"fwci":0.2779,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.57781199,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"Volume 15","issue":null,"first_page":"45","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.948199987411499,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myocardial-infarction","display_name":"acute myocardial infarction","score":0.9129999876022339},{"id":"https://openalex.org/keywords/pink1","display_name":"PINK1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/acsl4","display_name":"ACSL4","score":0.9980000257492065},{"id":"https://openalex.org/keywords/percutaneous-coronary-intervention","display_name":"percutaneous coronary intervention","score":0.9660000205039978},{"id":"https://openalex.org/keywords/major-adverse-cardiovascular-events","display_name":"major adverse cardiovascular events","score":0.9390000104904175},{"id":"https://openalex.org/keywords/prognosis-prediction","display_name":"outcome prediction","score":0.6980000138282776},{"id":"https://openalex.org/keywords/syntax-score","display_name":"SYNTAX score","score":0.9240000247955322},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7310000061988831},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9501487016677856},{"id":"https://openalex.org/C45393284","wikidata":"https://www.wikidata.org/wiki/Q191012","display_name":"Conventional PCI","level":3,"score":0.7856884002685547},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.7282018065452576},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6972877383232117},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6878781914710999}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.2147/rrcc.s449513","doi":"https://doi.org/10.2147/rrcc.s449513","is_oa":true,"landing_page_url":"https://doi.org/10.2147/rrcc.s449513","pdf_url":"https://www.dovepress.com/getfile.php?fileID=99654","source":{"id":"https://openalex.org/S2765035434","display_name":"Research Reports in Clinical Cardiology","issn_l":"1179-8475","issn":["1179-8475"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Reports in Clinical Cardiology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:7880fdb84c644153916ced992dbe8761","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7880fdb84c644153916ced992dbe8761","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Reports in Clinical Cardiology, Vol Volume 15, Pp 45-53 (2024)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/93205","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/clinical-application-of-pink1-and-acsl4-protein-levels-in-the-acute-my-peer-reviewed-fulltext-article-RRCC","pdf_url":"https://www.dovepress.com/article/download/93205","source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/rrcc.s449513","doi":"https://doi.org/10.2147/rrcc.s449513","is_oa":true,"landing_page_url":"https://doi.org/10.2147/rrcc.s449513","pdf_url":"https://www.dovepress.com/getfile.php?fileID=99654","source":{"id":"https://openalex.org/S2765035434","display_name":"Research Reports in Clinical Cardiology","issn_l":"1179-8475","issn":["1179-8475"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Reports in Clinical Cardiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4399326568.pdf","grobid_xml":"https://content.openalex.org/works/W4399326568.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W2549188196","https://openalex.org/W2557944616","https://openalex.org/W2562825495","https://openalex.org/W2756212640","https://openalex.org/W2784299734","https://openalex.org/W2889802726","https://openalex.org/W2892058170","https://openalex.org/W2901716735","https://openalex.org/W2937747675","https://openalex.org/W2964076726","https://openalex.org/W2982613776","https://openalex.org/W2996791939","https://openalex.org/W3003960907","https://openalex.org/W3046725027","https://openalex.org/W3046809128","https://openalex.org/W3126488481","https://openalex.org/W3138703087","https://openalex.org/W4200441722","https://openalex.org/W4210920365","https://openalex.org/W4213455992","https://openalex.org/W4230914943","https://openalex.org/W4289521157"],"related_works":["https://openalex.org/W2374589537","https://openalex.org/W3134414980","https://openalex.org/W2753659515","https://openalex.org/W4390787878","https://openalex.org/W4384662970","https://openalex.org/W4410352222","https://openalex.org/W4399706821","https://openalex.org/W2041864708","https://openalex.org/W7134889207","https://openalex.org/W4391815423"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"explore":[2],"the":[3,29,56,77,95,101,107,127,135,139,144,152,159,164,223,234,254,267],"clinical":[4,110],"application":[5],"of":[6,112,218,226,237,247,256,269],"PTEN-induced":[7,278],"kinase":[8,279],"1":[9],"(PINK1)":[10],"and":[11,28,68,105,109,114,194,220,239,249,258],"acyl-CoA":[12],"synthetase":[13,282],"long":[14,283],"chain":[15,284],"family":[16,285],"4":[17],"(ACSL4)":[18],"protein":[19,124,141,161],"levels":[20,108,246],"in":[21,117,126,134,143,151,202],"patients":[22,40,92,204,228,271],"with":[23,173,186],"acute":[24,275],"myocardial":[25,276],"infarction":[26],"(AMI)":[27],"prognosis":[30,201,225,268,290],"evaluation":[31],"after":[32,86,205,229,272],"percutaneous":[33,287],"coronary":[34,288],"intervention":[35],"(PCI).":[36],"Methods:":[37],"152":[38,89],"AMI":[39,203,227,270],"who":[41],"underwent":[42],"PCI":[43,230],"at":[44],"our":[45],"hospital":[46],"from":[47],"October":[48],"2021":[49],"to":[50,233,253],"February":[51],"2023":[52],"were":[53,60,98,196],"selected":[54,99],"as":[55,100],"study":[57,119,128],"group.":[58,103],"They":[59],"divided":[61],"into":[62],"a":[63,69,210],"MACE":[64,71,145,154],"group":[65,72,129,146,155],"(31":[66],"cases)":[67,74],"non":[70,153],"(121":[73],"based":[75],"on":[76],"major":[78],"adverse":[79],"cardiovascular":[80],"events":[81],"(MACE)":[82],"within":[83],"28":[84],"days":[85],"PCI.":[87,273],"Additionally,":[88],"angina":[90],"pectoris":[91],"admitted":[93],"during":[94],"same":[96],"period":[97],"control":[102,136],"Measure":[104],"analyze":[106],"significance":[111],"PINK1":[113,123,140,168,208,219,238,248],"ACSL4":[115,160,181,195,221,240,250],"proteins":[116],"all":[118],"subjects.":[120],"Results:":[121],"The":[122,215,244],"level":[125,142,162],"was":[130,147,163,170,183,209,231],"lower":[131,148],"than":[132,149],"that":[133,150],"group,":[137],"while":[138,158,180,207],"(P<":[156,166,213,241],"0.05),":[157,179],"opposite":[165],"0.05);":[167,191,214],"expression":[169,182,245],"negatively":[171],"correlated":[172,185],"SYNTAX":[174,187],"score":[175,188],"(r=\u2212":[176],"0.602,":[177],"P<":[178,190],"positively":[184],"(r=0.683,":[189],"Age,":[192],"LVEF,":[193],"risk":[197],"factors":[198],"for":[199,222,266],"poor":[200],"PCI,":[206],"protective":[211],"factor":[212],"combined":[216,260],"prediction":[217],"postoperative":[224],"superior":[232],"individual":[235],"detection":[236,261],"0.05).":[242],"Conclusion:":[243],"are":[251],"related":[252],"occurrence":[255],"AMI,":[257],"their":[259],"has":[262],"high":[263],"predictive":[264],"power":[265],"Keywords:":[274],"infarction,":[277],"1,":[280],"Acyl-CoA":[281],"4,":[286],"intervention,":[289]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-06-05T00:00:00"}