{"id":"https://openalex.org/W4399324178","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.e13150","title":"The long noncoding RNA MANCR to promote and stabilize triple negative breast cancer.","display_name":"The long noncoding RNA MANCR to promote and stabilize triple negative breast cancer.","publication_year":2024,"publication_date":"2024-06-01","ids":{"openalex":"https://openalex.org/W4399324178","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.e13150"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2024.42.16_suppl.e13150","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.e13150","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e13150","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2024.42.16_suppl.e13150","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2024.42.16_suppl.e13150","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070006588","display_name":"Janine  S. A. Warren","orcid":"https://orcid.org/0000-0002-2408-6000","observed_orcids":["https://orcid.org/0000-0002-2408-6000"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janine Warren","raw_affiliation_strings":["University of Vermont Larner College of Medicine, Burlington, VT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Vermont Larner College of Medicine, Burlington, VT","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051268951","display_name":"Bodhisattwa Banerjee","orcid":"https://orcid.org/0000-0001-9358-6976","observed_orcids":["https://orcid.org/0000-0001-9358-6976"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bodhisattwa Banerjee","raw_affiliation_strings":["University of Vermont Larner College of Medicine, Burlington, VT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Vermont Larner College of Medicine, Burlington, VT","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081119848","display_name":"Janet Lee Stein","orcid":"https://orcid.org/0000-0002-2474-6822","observed_orcids":["https://orcid.org/0000-0002-2474-6822"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet Stein","raw_affiliation_strings":["University of Vermont Larner College of Medicine, Burlington, VT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Vermont Larner College of Medicine, Burlington, VT","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110166645","display_name":"Gary Stein","orcid":"https://orcid.org/0000-0001-8762-5422","observed_orcids":["https://orcid.org/0000-0001-8762-5422"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Stein","raw_affiliation_strings":["University of Vermont Larner College of Medicine, Burlington, VT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Vermont Larner College of Medicine, Burlington, VT","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031362021","display_name":"Jane B. Lian","orcid":"https://orcid.org/0000-0001-8683-9138","observed_orcids":["https://orcid.org/0000-0001-8683-9138"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane Lian","raw_affiliation_strings":["University of Vermont Larner College of Medicine, Burlington, VT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Vermont Larner College of Medicine, Burlington, VT","institution_ids":["https://openalex.org/I111236770"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111236770"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"16_suppl","first_page":"e13150","last_page":"e13150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.9900000095367432},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.7120000123977661},{"id":"https://openalex.org/keywords/fragile-sites","display_name":"fragile sites","score":0.902999997138977},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.6620000004768372},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5839999914169312},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cell-proliferation-and-invasion","display_name":"cell proliferation and invasion","score":0.5979999899864197},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6830000281333923},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.875},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.6240000128746033},{"id":"https://openalex.org/keywords/chip-seq","display_name":"ChIP-seq","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7687627077102661},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.6250761151313782},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.597233772277832},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.4694257378578186},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4580785632133484},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.441560834646225},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3691784739494324},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.364687442779541},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34113845229148865},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33392053842544556},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26511332392692566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1668524146080017}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2024.42.16_suppl.e13150","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.e13150","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e13150","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2024.42.16_suppl.e13150","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1200/jco.2024.42.16_suppl.e13150","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.e13150","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e13150","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2024.42.16_suppl.e13150","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4399324178.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4411289834","https://openalex.org/W7221492548","https://openalex.org/W2740189552","https://openalex.org/W2786391361","https://openalex.org/W3171797674","https://openalex.org/W3111704751","https://openalex.org/W4386363364","https://openalex.org/W4362593004","https://openalex.org/W7160844104","https://openalex.org/W7223179966"],"abstract_inverted_index":{"e13150":[0],"Background:":[1],"Cancer":[2,23],"remains":[3],"a":[4,30,46,65,111,186],"leading":[5],"cause":[6],"of":[7,68,80,87,110,171,185,214,269,296,369],"death":[8],"worldwide,":[9],"despite":[10],"many":[11,368],"advances":[12],"in":[13,73,102,116,126,145,148,158,217,245,282,318,350,376],"cancer":[14,41],"treatment":[15,37,264],"over":[16,259],"the":[17,27,74,78,81,85,93,166,180,212,255,267,283,319,370,385,395],"past":[18],"decade.":[19],"Triple":[20],"Negative":[21],"Breast":[22],"(TNBC)":[24],"is":[25,108,123],"among":[26,64],"highest":[28],"with":[29,57,118,182,247,315,340,381],"poor":[31],"prognosis.":[32],"Early":[33],"diagnosis":[34],"and":[35,83,106,129,177,229,239,254,274,301,363,379,398],"modern":[36],"regimens":[38],"for":[39,55,338],"breast":[40],"(BC)":[42],"have":[43],"led":[44],"to":[45,76,137,154,210,272,276,313,325,360],"high":[47],"disease-free":[48],"survival":[49,52,113],"rate.":[50],"Still,":[51],"decreases":[53,230],"significantly":[54],"patients":[56,117,339],"metastatic":[58],"disease.":[59],"Long":[60],"non-coding":[61],"RNAs":[62],"are":[63,132,299,303],"recent":[66],"class":[67],"epigenetic":[69],"regulators":[70],"that":[71,223,292,332,354,392],"function":[72],"nucleus":[75],"support":[77],"stability":[79,324,401],"cells":[82,131,151,162,271],"maintain":[84],"fidelity":[86],"chromatin":[88,204],"interactions.":[89],"Our":[90,143],"laboratory":[91],"discovered":[92],"long":[94],"noncoding":[95],"RNA":[96,207],"MANCR":[97,122,136,190,215,224,244,262,294,308,322,334,359,393,404],"(LINC00704)":[98],"as":[99],"being":[100],"upregulated":[101],"human":[103],"BC":[104],"tumors":[105,249,343,357],"this":[107],"indicative":[109],"worse":[112],"rate":[114],"than":[115],"low":[119],"MANCR-expressing":[120],"tumors.":[121],"aberrantly":[124],"expressed":[125],"TNBC":[127,150,161,218,270,342,356,396],"cells,":[128,285],"these":[130,326,388],"highly":[133],"dependent":[134],"on":[135],"retain":[138],"their":[139],"tumorigenic":[140],"characteristics.":[141],"Methods:":[142],"functional":[144],"vitro":[146],"studies":[147,352],"MDA-MB-231":[149,284],"used":[152],"GapmerRs":[153],"knockdown":[155,225],"MANCR.":[156],"For":[157],"vivo":[159,351],"studies,":[160],"were":[163,311,374],"injected":[164],"into":[165],"4th":[167],"mammary":[168],"fat":[169],"pad":[170],"mice,":[172],"allowed":[173],"initial":[174],"tumor":[175,252,257],"formation,":[176,236],"then":[178],"treated":[179],"animals":[181,246],"2":[183],"nmol/g":[184],"negative":[187],"control":[188],"or":[189],"targeting":[191,243,333,403],"GapmeR.":[192],"We":[193,221],"also":[194,265],"identified":[195,287,373],"genome":[196,346,400],"interaction":[197],"sites":[198,291,317,383],"at":[199],"single":[200],"nucleotide":[201],"resolution":[202],"by":[203,206,344,402],"isolation":[205],"purification":[208],"(ChIRP)-seq":[209],"determine":[211],"mechanism":[213],"activity":[216],"cells.":[219],"Results:":[220],"found":[222,312,375],"promotes":[226],"DNA":[227],"damage":[228],"cell":[231],"proliferation,":[232],"migration,":[233],"anchorage-independent":[234],"colony":[235],"transwell":[237],"invasion,":[238],"overall":[240],"survival.":[241],"Additionally,":[242],"existing":[248],"drastically":[250],"inhibited":[251,266],"growth":[253],"end-point":[256],"mass":[258],"time.":[260],"The":[261],"GapmeR":[263],"ability":[268],"circulate":[273],"disseminate":[275],"distant":[277],"organs.":[278],"After":[279],"performing":[280],"ChIRP-seq":[281],"we":[286],"988":[288],"genome-wide":[289],"binding":[290],"exhibit":[293],"interactions,":[295],"which":[297],"79%":[298],"intergenic":[300,377],"21%":[302],"genic":[304],"regions.":[305],"Furthermore,":[306],"127":[307],"ChIRP":[309],"peaks":[310],"overlap":[314,380],"fragile":[316,382],"genome,":[320,397],"indicating":[321],"provides":[323],"sites.":[327],"Conclusions:":[328],"These":[329],"data":[330,389],"suggest":[331],"has":[335,405],"therapeutic":[336,406],"potential":[337],"\u201cMANCR-high\u201d":[341,355],"disrupting":[345,399],"stability.":[347],"Indeed,":[348],"our":[349],"demonstrate":[353],"require":[358],"rapidly":[361],"grow":[362],"promote":[364],"disease":[365],"progression.":[366],"Lastly,":[367],"MANCR-chromatin":[371],"interactions":[372],"regions":[378],"within":[384],"genome.":[386],"Collectively":[387],"strongly":[390],"indicate":[391],"stabilizes":[394],"potential.":[407]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2024-06-05T00:00:00"}