{"id":"https://openalex.org/W4399324113","doi":"https://doi.org/10.1158/0008-5472.can-23-3332","title":"CENP-E Inhibition Induces Chromosomal Instability and Synergizes with Diverse Microtubule-Targeting Agents in Breast Cancer","display_name":"CENP-E Inhibition Induces Chromosomal Instability and Synergizes with Diverse Microtubule-Targeting Agents in Breast Cancer","publication_year":2024,"publication_date":"2024-06-04","ids":{"openalex":"https://openalex.org/W4399324113","doi":"https://doi.org/10.1158/0008-5472.can-23-3332","pmid":"https://pubmed.ncbi.nlm.nih.gov/38832939","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11326998"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-23-3332","doi":"https://doi.org/10.1158/0008-5472.can-23-3332","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-23-3332","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11326998/pdf/nihms-2001498.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022088555","display_name":"John B. Tucker","orcid":"https://orcid.org/0000-0002-5009-934X","observed_orcids":["https://orcid.org/0000-0002-5009-934X"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John B. Tucker","raw_affiliation_strings":["Cancer Biology Graduate Training Program, University of Wisconsin\u2013Madison, Madison, Wisconsin. 1"],"raw_orcid":"https://orcid.org/0000-0002-5009-934X","affiliations":[{"raw_affiliation_string":"Cancer Biology Graduate Training Program, University of Wisconsin\u2013Madison, Madison, Wisconsin. 1","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093127871","display_name":"Caleb L. Carlsen","orcid":"https://orcid.org/0000-0002-0353-7095","observed_orcids":["https://orcid.org/0000-0002-0353-7095"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caleb L. Carlsen","raw_affiliation_strings":["Cellular and Molecular Biology Graduate Training Program, University of Wisconsin\u2013Madison, Madison, Wisconsin. 2"],"raw_orcid":"https://orcid.org/0000-0002-0353-7095","affiliations":[{"raw_affiliation_string":"Cellular and Molecular Biology Graduate Training Program, University of Wisconsin\u2013Madison, Madison, Wisconsin. 2","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071363739","display_name":"Christina M. Scribano","orcid":"https://orcid.org/0000-0002-4002-5101","observed_orcids":["https://orcid.org/0000-0002-4002-5101"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina M. Scribano","raw_affiliation_strings":["Cellular and Molecular Pharmacology Graduate Training Program, University of Wisconsin\u2013Madison, Madison, Wisconsin. 3"],"raw_orcid":"https://orcid.org/0000-0002-4002-5101","affiliations":[{"raw_affiliation_string":"Cellular and Molecular Pharmacology Graduate Training Program, University of Wisconsin\u2013Madison, Madison, Wisconsin. 3","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093127873","display_name":"Srishrika M. Pattaswamy","orcid":"https://orcid.org/0009-0009-4528-7440","observed_orcids":["https://orcid.org/0009-0009-4528-7440"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srishrika M. Pattaswamy","raw_affiliation_strings":["Department of Cell and Regenerative Biology, University of Wisconsin\u2013Madison, Madison, Wisconsin. 4"],"raw_orcid":"https://orcid.org/0009-0009-4528-7440","affiliations":[{"raw_affiliation_string":"Department of Cell and Regenerative Biology, University of Wisconsin\u2013Madison, Madison, Wisconsin. 4","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050180604","display_name":"Mark E. Burkard","orcid":"https://orcid.org/0000-0002-4215-7722","observed_orcids":["https://orcid.org/0000-0002-4215-7722"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark E. Burkard","raw_affiliation_strings":["Carbone Cancer Center, University of Wisconsin\u2013Madison, Madison, Wisconsin. 7","Department of Medicine, University of Wisconsin\u2013Madison, Madison, Wisconsin. 6","Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin\u2013Madison, Madison, Wisconsin. 5"],"raw_orcid":"https://orcid.org/0000-0002-4215-7722","affiliations":[{"raw_affiliation_string":"Carbone Cancer Center, University of Wisconsin\u2013Madison, Madison, Wisconsin. 7","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]},{"raw_affiliation_string":"Department of Medicine, University of Wisconsin\u2013Madison, Madison, Wisconsin. 6","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin\u2013Madison, Madison, Wisconsin. 5","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008049256","display_name":"Beth A. A. Weaver","orcid":"https://orcid.org/0000-0002-7830-3816","observed_orcids":["https://orcid.org/0000-0002-7830-3816"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beth A. Weaver","raw_affiliation_strings":["Carbone Cancer Center, University of Wisconsin\u2013Madison, Madison, Wisconsin. 7","Department of Cell and Regenerative Biology, University of Wisconsin\u2013Madison, Madison, Wisconsin. 4","Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin\u2013Madison, Madison, Wisconsin. 5"],"raw_orcid":"https://orcid.org/0000-0002-7830-3816","affiliations":[{"raw_affiliation_string":"Carbone Cancer Center, University of Wisconsin\u2013Madison, Madison, Wisconsin. 7","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]},{"raw_affiliation_string":"Department of Cell and Regenerative Biology, University of Wisconsin\u2013Madison, Madison, Wisconsin. 4","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin\u2013Madison, Madison, Wisconsin. 5","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4609,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.88769167,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"84","issue":"16","first_page":"2674","last_page":"2689"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cenp-e","display_name":"CENP-E","score":0.9900000095367432},{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.9089999794960022},{"id":"https://openalex.org/keywords/microtubule-inhibitors","display_name":"microtubule inhibitors","score":0.9760000109672546},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9520000219345093},{"id":"https://openalex.org/keywords/mitotic-kinesin","display_name":"mitotic kinesin","score":0.781000018119812},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8529999852180481},{"id":"https://openalex.org/keywords/synergistic-drug-combination","display_name":"synergistic drug combination","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C10447061","wikidata":"https://www.wikidata.org/wiki/Q190769","display_name":"Centrosome","level":4,"score":0.8524764776229858},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.7636187076568604},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.7136378288269043},{"id":"https://openalex.org/C140752955","wikidata":"https://www.wikidata.org/wiki/Q1087752","display_name":"Chromosome instability","level":4,"score":0.6586576700210571},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5624581575393677},{"id":"https://openalex.org/C53420372","wikidata":"https://www.wikidata.org/wiki/Q22299157","display_name":"Anaphase","level":4,"score":0.5598609447479248},{"id":"https://openalex.org/C3453395","wikidata":"https://www.wikidata.org/wiki/Q6935034","display_name":"Multipolar spindles","level":5,"score":0.5261014699935913},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5130993127822876},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4998176097869873},{"id":"https://openalex.org/C47432576","wikidata":"https://www.wikidata.org/wiki/Q918594","display_name":"Spindle apparatus","level":4,"score":0.4914957284927368},{"id":"https://openalex.org/C186000732","wikidata":"https://www.wikidata.org/wiki/Q6881914","display_name":"Mitotic catastrophe","level":4,"score":0.4530505836009979},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3604243993759155},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33088597655296326},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.31195229291915894},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.29714637994766235},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.27819764614105225},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1865798830986023},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.12663665413856506},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077235","descriptor_name":"Vinorelbine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002868","descriptor_name":"Chromosomal Proteins, Non-Histone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002868","descriptor_name":"Chromosomal Proteins, Non-Histone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005784","descriptor_name":"Gene Amplification","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018385","descriptor_name":"Centrosome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043171","descriptor_name":"Chromosomal Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.can-23-3332","doi":"https://doi.org/10.1158/0008-5472.can-23-3332","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-23-3332","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:38832939","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38832939","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11326998","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11326998","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11326998/pdf/nihms-2001498.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11326998","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11326998","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11326998/pdf/nihms-2001498.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1125583517","display_name":null,"funder_award_id":"T32 CA009135","funder_id":"https://openalex.org/F4320310176","funder_display_name":"University of Wisconsin Carbone Cancer Center"},{"id":"https://openalex.org/G3002731596","display_name":"Training in Cancer Biology Training Grant","funder_award_id":"T32CA009135","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4004214011","display_name":null,"funder_award_id":"P30 CA 014520","funder_id":"https://openalex.org/F4320310176","funder_display_name":"University of Wisconsin Carbone Cancer Center"},{"id":"https://openalex.org/G5167078133","display_name":"Impact of chromosomal instability on sensitivity to microtubule-targeting drugs in breast cancer","funder_award_id":"R01CA234904","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000870050","display_name":"UW Comprehensive Cancer Center Support","funder_award_id":"P30CA014520","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000890244","display_name":"Graduate Training in Molecular and Cellular Pharmacology","funder_award_id":"T32GM141013","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000894157","display_name":"Mechanisms of paclitaxel sensitivity and resistance","funder_award_id":"R01CA284747","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310176","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/02mqqhj42"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4399324113.pdf","grobid_xml":"https://content.openalex.org/works/W4399324113.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1566131907","https://openalex.org/W1568060924","https://openalex.org/W1594629389","https://openalex.org/W1616592835","https://openalex.org/W1895414556","https://openalex.org/W1963759286","https://openalex.org/W1965467117","https://openalex.org/W1968145208","https://openalex.org/W1971579914","https://openalex.org/W1976033985","https://openalex.org/W1980923728","https://openalex.org/W1982746572","https://openalex.org/W1994406643","https://openalex.org/W1995947461","https://openalex.org/W1997862376","https://openalex.org/W1999159829","https://openalex.org/W2001978323","https://openalex.org/W2004658596","https://openalex.org/W2010561642","https://openalex.org/W2010972982","https://openalex.org/W2034121120","https://openalex.org/W2036530157","https://openalex.org/W2047521557","https://openalex.org/W2050953095","https://openalex.org/W2059072630","https://openalex.org/W2065847664","https://openalex.org/W2071359790","https://openalex.org/W2074890479","https://openalex.org/W2081406767","https://openalex.org/W2090578629","https://openalex.org/W2096439168","https://openalex.org/W2098989944","https://openalex.org/W2103726956","https://openalex.org/W2116376484","https://openalex.org/W2118562565","https://openalex.org/W2118612987","https://openalex.org/W2122077019","https://openalex.org/W2122129877","https://openalex.org/W2125610733","https://openalex.org/W2126441143","https://openalex.org/W2127232551","https://openalex.org/W2128343541","https://openalex.org/W2134590240","https://openalex.org/W2141195225","https://openalex.org/W2145555831","https://openalex.org/W2151805953","https://openalex.org/W2153304690","https://openalex.org/W2154603906","https://openalex.org/W2154747925","https://openalex.org/W2162643935","https://openalex.org/W2166042057","https://openalex.org/W2168908838","https://openalex.org/W2253467674","https://openalex.org/W2326740736","https://openalex.org/W2400356771","https://openalex.org/W2401349859","https://openalex.org/W2464465175","https://openalex.org/W2476874854","https://openalex.org/W2747691959","https://openalex.org/W2949766210","https://openalex.org/W2967026866","https://openalex.org/W3087372666","https://openalex.org/W3119400275","https://openalex.org/W3155811702","https://openalex.org/W3196956620","https://openalex.org/W4313261172","https://openalex.org/W4387954332"],"related_works":["https://openalex.org/W4387954332","https://openalex.org/W7207877080","https://openalex.org/W4392861251","https://openalex.org/W2886296919","https://openalex.org/W2031646505","https://openalex.org/W2042221836","https://openalex.org/W2324616681","https://openalex.org/W2474544413","https://openalex.org/W3133040751","https://openalex.org/W2084268878"],"abstract_inverted_index":{"Drugs":[0],"that":[1,55,109,169,213],"perturb":[2],"microtubules":[3],"are":[4,23],"commonly":[5],"used":[6,129],"to":[7,103,134,156,195,216,252],"treat":[8],"breast":[9,51],"cancers":[10,52],"of":[11,29,33,64,76,83,88,111,225,231,237],"all":[12],"subtypes":[13],"in":[14,25,40,148,181,199,206],"both":[15],"early":[16],"stage":[17],"and":[18,49,100,202,249],"metastatic":[19,50],"disease,":[20],"but":[21],"they":[22],"effective":[24],"only":[26,58],"approximately":[27],"50%":[28],"patients.":[30],"High":[31],"concentrations":[32],"microtubule-targeting":[34,127,217,253],"agents":[35,57,128],"can":[36,79,96,219],"elicit":[37],"mitotic":[38,68,71,113,239],"arrest":[39],"cell":[41,197,200,247],"culture":[42],"models;":[43],"however,":[44],"recent":[45],"evidence":[46],"from":[47],"primary":[48,214],"has":[53],"revealed":[54],"these":[56],"accumulate":[59],"at":[60,145,172],"intratumoral":[61],"levels":[62],"capable":[63],"inducing":[65],"abnormal":[66],"multipolar":[67,77,90,123,136],"spindles,":[69],"not":[70],"arrest.":[72],"Although":[73],"the":[74,112,182,238],"maintenance":[75],"spindles":[78,91,95,137,165],"generate":[80],"cytotoxic":[81],"rates":[82],"chromosomal":[84,243],"instability":[85],"(CIN),":[86],"focusing":[87,122,152],"aberrant":[89],"into":[92],"normal":[93],"bipolar":[94],"dramatically":[97],"reduce":[98],"CIN":[99,162],"confer":[101],"resistance":[102,119,155,215],"microtubule":[104,193],"poisons.":[105],"Here,":[106],"we":[107],"showed":[108],"inhibition":[110,160,187,224,236],"kinesin":[114,240],"centromeric-associated":[115],"protein-E":[116],"(CENP-E)":[117],"overcomes":[118],"caused":[120],"by":[121,166,222,235],"spindles.":[124],"Clinically":[125],"relevant":[126,192],"a":[130],"mechanistically":[131],"conserved":[132],"pathway":[133],"induce":[135],"without":[138],"requiring":[139],"centrosome":[140],"amplification.":[141],"Focusing":[142],"could":[143],"occur":[144],"any":[146],"point":[147],"mitosis,":[149],"with":[150,189],"earlier":[151],"conferring":[153],"greater":[154],"antimicrotubule":[157],"agents.":[158],"CENP-E":[159,186,241],"increased":[161,179,229],"on":[163],"focused":[164],"generating":[167],"chromosomes":[168,233],"remained":[170],"misaligned":[171],"spindle":[173],"poles":[174],"during":[175],"anaphase,":[176],"which":[177],"substantially":[178],"death":[180,198],"resulting":[183],"daughter":[184,246],"cells.":[185],"synergized":[188],"diverse,":[190],"clinically":[191],"poisons":[194],"potentiate":[196],"lines":[201],"suppress":[203],"tumor":[204,208],"growth":[205],"orthotopic":[207],"models.":[209],"These":[210],"results":[211],"suggest":[212],"drugs":[218],"be":[220],"overcome":[221],"simultaneous":[223],"CENP-E.":[226],"Significance:":[227],"The":[228],"incidence":[230],"polar":[232],"induced":[234],"exacerbates":[242],"instability,":[244],"reduces":[245],"viability,":[248],"improves":[250],"sensitivity":[251],"therapies.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-06-05T00:00:00"}
