{"id":"https://openalex.org/W4399323683","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.1024","title":"Real world experience of trastuzumab deruxtecan for the treatment of metastatic breast cancer in the UK.","display_name":"Real world experience of trastuzumab deruxtecan for the treatment of metastatic breast cancer in the UK.","publication_year":2024,"publication_date":"2024-06-01","ids":{"openalex":"https://openalex.org/W4399323683","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.1024"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2024.42.16_suppl.1024","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.1024","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2024.42.16_suppl.1024","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041227247","display_name":"Andy J. Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169248724","display_name":"Royal Free London NHS Foundation Trust","ror":"https://ror.org/04rtdp853","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andy Cheng","raw_affiliation_strings":["Royal Free London NHS Foundation Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Free London NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I169248724"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004634233","display_name":"Suzanne Frank","orcid":"https://orcid.org/0000-0001-5081-4000","observed_orcids":["https://orcid.org/0000-0001-5081-4000"]},"institutions":[{"id":"https://openalex.org/I4210133995","display_name":"The Christie NHS Foundation Trust","ror":"https://ror.org/03v9efr22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Suzanne Frank","raw_affiliation_strings":["The Christie NHS Foundation Trust, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Christie NHS Foundation Trust, Manchester, United Kingdom","institution_ids":["https://openalex.org/I4210133995"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Katherine Baines","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I225661044","display_name":"Barts Health NHS Trust","ror":"https://ror.org/00b31g692","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Katherine Baines","raw_affiliation_strings":["Barts Health NHS Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barts Health NHS Trust, London, United Kingdom","institution_ids":["https://openalex.org/I225661044"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mark Nathan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark Nathan","raw_affiliation_strings":["Guys' and St Thomas' NHS Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guys' and St Thomas' NHS Trust, London, United Kingdom","institution_ids":["https://openalex.org/I200166805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061602220","display_name":"Rosalie V. Douglas","orcid":"https://orcid.org/0009-0001-7493-0580","observed_orcids":["https://orcid.org/0009-0001-7493-0580"]},"institutions":[{"id":"https://openalex.org/I1289110261","display_name":"Belfast Health and Social Care Trust","ror":"https://ror.org/02tdmfk69","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1289110261"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rosalie V. Douglas","raw_affiliation_strings":["Belfast Health and Social Care Trust, Belfast, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Belfast Health and Social Care Trust, Belfast, United Kingdom","institution_ids":["https://openalex.org/I1289110261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071743090","display_name":"Rushan Sylva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802445252","display_name":"University Hospitals of Leicester NHS Trust","ror":"https://ror.org/02fha3693","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802445252"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rushan Sylva","raw_affiliation_strings":["University Hospitals Of Leicester NHS Trust, Leicester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospitals Of Leicester NHS Trust, Leicester, United Kingdom","institution_ids":["https://openalex.org/I2802445252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038487435","display_name":"Jessica Ball","orcid":"https://orcid.org/0000-0001-7996-888X","observed_orcids":["https://orcid.org/0000-0001-7996-888X"]},"institutions":[{"id":"https://openalex.org/I4392738148","display_name":"University Hospitals Bristol and Weston NHS Foundation Trust","ror":"https://ror.org/03jzzxg14","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4392738148","https://openalex.org/I4405276282"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jessica Ball","raw_affiliation_strings":["University Hospitals Bristol and Weston NHS Trust, Bristol, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospitals Bristol and Weston NHS Trust, Bristol, United Kingdom","institution_ids":["https://openalex.org/I4392738148"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027352987","display_name":"Constantinos Savva","orcid":"https://orcid.org/0000-0003-0805-4719","observed_orcids":["https://orcid.org/0000-0003-0805-4719"]},"institutions":[{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Constantinos Savva","raw_affiliation_strings":["University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom","institution_ids":["https://openalex.org/I2802965805"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Thomas Talbot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thomas Talbot","raw_affiliation_strings":["Imperial College Healthcare NHS Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College Healthcare NHS Trust, London, United Kingdom","institution_ids":["https://openalex.org/I153355300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091117757","display_name":"Olga Oikonomidou","orcid":"https://orcid.org/0000-0002-7762-7042","observed_orcids":["https://orcid.org/0000-0002-7762-7042"]},"institutions":[{"id":"https://openalex.org/I1324252669","display_name":"NHS Lothian","ror":"https://ror.org/03q82t418","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669"]},{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Olga Oikonomidou","raw_affiliation_strings":["University of Edinburgh/Western General Hospital/NHS Lothian, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Edinburgh/Western General Hospital/NHS Lothian, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I1324252669","https://openalex.org/I2800150677","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073109900","display_name":"Jenny Smith","orcid":"https://orcid.org/0000-0003-0405-0251","observed_orcids":["https://orcid.org/0000-0003-0405-0251"]},"institutions":[{"id":"https://openalex.org/I2801663869","display_name":"Newcastle upon Tyne Hospitals NHS Foundation Trust","ror":"https://ror.org/05p40t847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jenny Smith","raw_affiliation_strings":["Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, United Kingdom","institution_ids":["https://openalex.org/I2801663869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010277875","display_name":"Alastair H. Thomson","orcid":"https://orcid.org/0000-0001-6666-1088","observed_orcids":["https://orcid.org/0000-0001-6666-1088"]},"institutions":[{"id":"https://openalex.org/I2799477489","display_name":"Royal Cornwall Hospital Trust","ror":"https://ror.org/026xdcm93","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799477489"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alastair Thomson","raw_affiliation_strings":["Royal Cornwall Hospitals NHS Trust, Truro, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Cornwall Hospitals NHS Trust, Truro, United Kingdom","institution_ids":["https://openalex.org/I2799477489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111219874","display_name":"Felicity Ross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I312843336","display_name":"Hampshire Hospitals NHS Foundation Trust","ror":"https://ror.org/04shzs249","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I312843336"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Felicity Ross","raw_affiliation_strings":["Hampshire Hospitals NHS Foundation Trust, Basingstoke, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hampshire Hospitals NHS Foundation Trust, Basingstoke, United Kingdom","institution_ids":["https://openalex.org/I312843336"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052643310","display_name":"Apostolos Konstantis","orcid":"https://orcid.org/0000-0003-2277-5264","observed_orcids":["https://orcid.org/0000-0003-2277-5264"]},"institutions":[{"id":"https://openalex.org/I2800657366","display_name":"Princess Alexandra Hospital NHS Trust","ror":"https://ror.org/04kpzy923","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800657366"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Apostolos Konstantis","raw_affiliation_strings":["The Princess Alexandra Hospital NHS Trust, Harlow, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Princess Alexandra Hospital NHS Trust, Harlow, United Kingdom","institution_ids":["https://openalex.org/I2800657366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042294700","display_name":"Nicola L. Ainsworth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107711","display_name":"Queen Elizabeth Hospital King's Lynn NHS Foundation Trust","ror":"https://ror.org/01m6k8878","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210107711"]},{"id":"https://openalex.org/I4210142213","display_name":"Queen Elizabeth Hospital","ror":"https://ror.org/03npxtg86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210107711","https://openalex.org/I4210142213"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicola Ainsworth","raw_affiliation_strings":["The Queen Elizabeth Hospital Kings Lynn NHS Trust, King's Lynn, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Queen Elizabeth Hospital Kings Lynn NHS Trust, King's Lynn, United Kingdom","institution_ids":["https://openalex.org/I4210107711","https://openalex.org/I4210142213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111219875","display_name":"Pietro Luciano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pietro Luciano","raw_affiliation_strings":["Edinburgh Cancer Centre, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Edinburgh Cancer Centre, Edinburgh, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Pooja Iyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102902","display_name":"Sheffield Teaching Hospitals NHS Foundation Trust","ror":"https://ror.org/018hjpz25","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210102902"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pooja Iyer","raw_affiliation_strings":["Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom","institution_ids":["https://openalex.org/I4210102902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017248297","display_name":"Shyamika Mirisse Acharige","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090003","display_name":"Portsmouth Hospitals NHS Trust","ror":"https://ror.org/009fk3b63","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210090003"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shyamika Acharige","raw_affiliation_strings":["Portsmouth Hospitals University NHS Trust, Portsmouth, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Portsmouth Hospitals University NHS Trust, Portsmouth, United Kingdom","institution_ids":["https://openalex.org/I4210090003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110217699","display_name":"Shaikh Rana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800951516","display_name":"Worcestershire Acute Hospitals NHS Trust","ror":"https://ror.org/030zsh764","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800951516"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Shaikh Rana","raw_affiliation_strings":["Worcestershire Acute Hospitals NHS Trust, Worcester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worcestershire Acute Hospitals NHS Trust, Worcester, United Kingdom","institution_ids":["https://openalex.org/I2800951516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087075605","display_name":"James P. King","orcid":"https://orcid.org/0000-0003-0993-9076","observed_orcids":["https://orcid.org/0000-0003-0993-9076"]},"institutions":[{"id":"https://openalex.org/I169248724","display_name":"Royal Free London NHS Foundation Trust","ror":"https://ror.org/04rtdp853","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Judy King","raw_affiliation_strings":["Royal Free London NHS Foundation Trust, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Free London NHS Foundation Trust, London, United Kingdom","institution_ids":["https://openalex.org/I169248724"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":21,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"16_suppl","first_page":"1024","last_page":"1024"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trastuzumab-deruxtecan","display_name":"trastuzumab deruxtecan","score":0.9869999885559082},{"id":"https://openalex.org/keywords/her2-positive-metastatic-breast-cancer","display_name":"HER2-positive metastatic breast cancer","score":0.9729999899864197},{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.8970000147819519},{"id":"https://openalex.org/keywords/real-world-effectiveness","display_name":"real-world effectiveness","score":0.753000020980835},{"id":"https://openalex.org/keywords/treatment-tolerability","display_name":"treatment tolerability","score":0.6209999918937683},{"id":"https://openalex.org/keywords/interstitial-lung-disease","display_name":"interstitial lung disease","score":0.902999997138977},{"id":"https://openalex.org/keywords/dose-reduction","display_name":"dose reduction","score":0.7829999923706055},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/overall-response-rate","display_name":"overall response rate","score":0.7360000014305115},{"id":"https://openalex.org/keywords/visceral-disease","display_name":"visceral disease","score":0.625}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9286928176879883},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.926995575428009},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.6999087929725647},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.602668046951294},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5847859978675842},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49639636278152466},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49563491344451904}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2024.42.16_suppl.1024","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.1024","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2024.42.16_suppl.1024","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4376613621","https://openalex.org/W7129616711","https://openalex.org/W4410821382","https://openalex.org/W4388928404","https://openalex.org/W4411287638","https://openalex.org/W4410819706","https://openalex.org/W4379285821","https://openalex.org/W4376613774","https://openalex.org/W7129717854","https://openalex.org/W4381431796"],"abstract_inverted_index":{"1024":[0],"Background:":[1],"Trastuzumab":[2,149],"deruxtecan":[3],"(TDXd),":[4],"an":[5,395],"antibody":[6],"drug":[7,255,347],"conjugate,":[8],"was":[9,103,119,127,170,284,385],"first":[10],"approved":[11],"in":[12,31,43,65,320,338,353,359,366],"the":[13,16,37,66,79,274,307,322,330,339,354,367,383],"UK":[14,46,67,107],"for":[15,89],"treatment":[17,85,125,166,239,247,272],"of":[18,41,81,163,165,258,276,282,333,346,397],"human":[19],"epidermal":[20],"growth":[21],"factor":[22],"receptor":[23],"2":[24],"positive":[25],"(HER2+)":[26],"metastatic":[27],"breast":[28],"cancer":[29,108],"(mBC)":[30],"2021.":[32],"We":[33,49],"aimed":[34],"to":[35,71,168,174,263,305],"review":[36],"efficacy":[38,365],"and":[39,52,84,87,139,143,150,185,227,265,325,342,349,378],"tolerability":[40],"TDXd":[42,64,117,169,246,283,319],"a":[44,182],"real-world":[45,298,355,368,380,398],"setting.":[47,369],"Methods:":[48],"collected":[50,104],"clinical":[51],"demographic":[53],"data":[54,299,356,377],"from":[55,68,105],"medical":[56],"records":[57],"on":[58,110,181,364],"HER2+":[59],"mBC":[60],"patients":[61,93,133,141,154,177,188,197,234,242,270,315,335],"treated":[62,337],"with":[63],"Jan":[69],"2021":[70],"Dec":[72],"2023":[73],"inclusive.":[74],"This":[75],"included:":[76],"radiological":[77],"response,":[78],"frequency":[80],"dose":[82,184,194,203],"reductions":[83],"delays,":[86],"reasons":[88],"discontinuation.":[90],"Clinical":[91],"trial":[92,376],"were":[94,99,179,261,336,351],"excluded.":[95],"Descriptive":[96],"statistical":[97],"techniques":[98],"applied.":[100],"Results:":[101],"Data":[102,390],"26":[106],"centres":[109],"280":[111],"patients.":[112],"The":[113,160,278,297,344],"median":[114,161],"age":[115],"at":[116,191,200,273],"initiation":[118],"56":[120],"years":[121],"(range":[122,130,172],"29-85).":[123],"Median":[124],"duration":[126],"9":[128],"cycles":[129],"1-40).":[131],"239":[132],"(85%)":[134],"had":[135,146,156,199,235,244,317],"visceral":[136],"disease.":[137],"257":[138],"196":[140],"(92%":[142],"70%,":[144],"respectively)":[145],"received":[147,157,318],"prior":[148,158,167],"Pertuzumab,":[151],"respectively.":[152],"233":[153],"(83%)":[155],"TDM1.":[159],"number":[162],"lines":[164],"3":[171],"1":[173],"9).":[175],"20":[176],"(7%)":[178],"initiated":[180],"reduced":[183],"115":[186],"further":[187],"(41%)":[189],"required":[190],"least":[192,201],"one":[193,202,238],"reduction.":[195],"151":[196],"(54%)":[198],"interruption":[204,348],"due":[205,248,262],"to:":[206,249],"infection":[207],"or":[208,252,309],"neutropenia":[209],"(n=61),":[210],"other":[211,223],"toxicity":[212,256],"(n=85),":[213],"interstitial":[214],"lung":[215],"disease":[216,250,288],"(ILD)":[217],"investigation":[218,229],"(n=39),":[219],"patient":[220,266],"request":[221],"(n=81),":[222],"concurrent":[224],"illness":[225],"(n=10),":[226],"cardiac":[228],"(n=6).":[230],"Of":[231],"these,":[232],"55":[233],"more":[236],"than":[237,358],"break.":[240],"157":[241],"(56%)":[243],"discontinued":[245],"progression":[251,399],"death":[253],"(n=100),":[254],"(n=39)":[257],"which":[259,361],"22":[260],"ILD,":[264],"choice":[267],"(n=8).":[268],"123":[269],"remained":[271],"time":[275],"analysis.":[277],"overall":[279],"response":[280,291,294,371],"rate":[281,372],"63%":[285],"overall:":[286],"stable":[287],"23%,":[289],"partial":[290],"56%,":[292],"complete":[293],"7%.":[295],"Conclusions:":[296],"set":[300,357],"is":[301,373,392],"not":[302,386],"directly":[303],"comparable":[304],"either":[306],"DB02":[308],"DB03":[310],"trials,":[311],"as":[312],"it":[313],"included":[314],"who":[316],"both":[321],"second":[323],"line":[324,327,341],"later":[326],"settings.":[328],"However,":[329],"majority":[331],"(80%)":[332],"these":[334],"third":[340],"beyond.":[343],"rates":[345],"reduction":[350],"higher":[352],"DB02,":[360],"may":[362],"impact":[363],"Overall":[370],"similar":[374],"between":[375],"our":[379],"data,":[381],"although":[382],"latter":[384],"measured":[387],"by":[388],"RECIST.":[389],"collection":[391],"ongoing,":[393],"including":[394],"analysis":[396],"free":[400],"survival.":[401],"[Table:":[402],"see":[403],"text]":[404]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-06-05T00:00:00"}