{"id":"https://openalex.org/W4399323656","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.e13083","title":"Use of Oncotype vs. Breast Cancer Index (BCI) for extended endocrine therapy decisions: A single center analysis in stage IA hormone receptor positive breast cancer.","display_name":"Use of Oncotype vs. Breast Cancer Index (BCI) for extended endocrine therapy decisions: A single center analysis in stage IA hormone receptor positive breast cancer.","publication_year":2024,"publication_date":"2024-06-01","ids":{"openalex":"https://openalex.org/W4399323656","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.e13083"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2024.42.16_suppl.e13083","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.e13083","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e13083","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035063754","display_name":"Iuliia Kovalenko","orcid":"https://orcid.org/0000-0003-4821-2195","observed_orcids":["https://orcid.org/0000-0003-4821-2195"]},"institutions":[{"id":"https://openalex.org/I2800817755","display_name":"UPMC Central Pa","ror":"https://ror.org/00sdedd93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800817755","https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iuliia Kovalenko","raw_affiliation_strings":["UPMC Harrisburg, Harrisburg, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UPMC Harrisburg, Harrisburg, PA","institution_ids":["https://openalex.org/I2800817755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007085855","display_name":"Faith Seltun","orcid":"https://orcid.org/0009-0004-8804-6990","observed_orcids":["https://orcid.org/0009-0004-8804-6990"]},"institutions":[{"id":"https://openalex.org/I2800817755","display_name":"UPMC Central Pa","ror":"https://ror.org/00sdedd93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800817755","https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Faith Seltun","raw_affiliation_strings":["UPMC Harrisburg, Harrisburg, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UPMC Harrisburg, Harrisburg, PA","institution_ids":["https://openalex.org/I2800817755"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alice He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alice He","raw_affiliation_strings":["Drexel University College of Medicine, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drexel University College of Medicine, Philadelphia, PA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006657079","display_name":"Chandi Garg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800817755","display_name":"UPMC Central Pa","ror":"https://ror.org/00sdedd93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800817755","https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chandi Garg","raw_affiliation_strings":["UPMC Harrisburg, Harrisburg, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UPMC Harrisburg, Harrisburg, PA","institution_ids":["https://openalex.org/I2800817755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023864781","display_name":"Maha Azhar","orcid":"https://orcid.org/0009-0008-3092-6441","observed_orcids":["https://orcid.org/0009-0008-3092-6441"]},"institutions":[{"id":"https://openalex.org/I2800817755","display_name":"UPMC Central Pa","ror":"https://ror.org/00sdedd93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800817755","https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maha Azhar","raw_affiliation_strings":["UPMC Harrisburg, Harrisburg, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UPMC Harrisburg, Harrisburg, PA","institution_ids":["https://openalex.org/I2800817755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023094717","display_name":"Ekaterina Proskuriakova","orcid":"https://orcid.org/0000-0003-2730-2271","observed_orcids":["https://orcid.org/0000-0003-2730-2271"]},"institutions":[{"id":"https://openalex.org/I4210101641","display_name":"Mount Sinai Hospital","ror":"https://ror.org/019jr0130","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210101641","https://openalex.org/I4210149743"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ekaterina Proskuriakova","raw_affiliation_strings":["Mount Sinai Hospital, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mount Sinai Hospital, Chicago, IL","institution_ids":["https://openalex.org/I4210101641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066214719","display_name":"Yijin Wert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yijin Wert","raw_affiliation_strings":["UPMC Hillman Cancer Center, Harrisburg, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UPMC Hillman Cancer Center, Harrisburg, PA","institution_ids":["https://openalex.org/I4210128526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074922101","display_name":"Kit Yu Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800817755","display_name":"UPMC Central Pa","ror":"https://ror.org/00sdedd93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800817755","https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kit Yu Lu","raw_affiliation_strings":["UPMC Cancer Center- UPMC Pinnacle, Harrisburg, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UPMC Cancer Center- UPMC Pinnacle, Harrisburg, PA","institution_ids":["https://openalex.org/I2800817755"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"16_suppl","first_page":"e13083","last_page":"e13083"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extended-endocrine-therapy","display_name":"extended endocrine therapy","score":0.8349999785423279},{"id":"https://openalex.org/keywords/breast-cancer-index","display_name":"Breast Cancer Index","score":0.7269999980926514},{"id":"https://openalex.org/keywords/oncotype-dx-recurrence-score","display_name":"Oncotype DX recurrence score","score":0.8700000047683716},{"id":"https://openalex.org/keywords/hormone-receptor-positive-breast-cancer","display_name":"hormone receptor-positive breast cancer","score":0.7829999923706055},{"id":"https://openalex.org/keywords/her2-negative-breast-cancer","display_name":"HER2-negative breast cancer","score":0.7570000290870667},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.5009999871253967},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6970000267028809},{"id":"https://openalex.org/keywords/treatment-decision-making","display_name":"treatment decision-making","score":0.4449999928474426},{"id":"https://openalex.org/keywords/joint-pain","display_name":"joint pain","score":0.6729999780654907},{"id":"https://openalex.org/keywords/recurrence-risk-stratification","display_name":"recurrence risk stratification","score":0.4860000014305115},{"id":"https://openalex.org/keywords/treatment-escalation-and-de-escalation","display_name":"treatment escalation and de-escalation","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8823355436325073},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7864468097686768},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6808072924613953},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.6521642208099365},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.573806881904602},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5683149695396423},{"id":"https://openalex.org/C2780073493","wikidata":"https://www.wikidata.org/wiki/Q7523837","display_name":"Single Center","level":2,"score":0.4801765978336334},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.4308057725429535},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.4149632155895233},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3774736821651459},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3673722445964813},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2024.42.16_suppl.e13083","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.e13083","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e13083","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2598583756","https://openalex.org/W4399556001","https://openalex.org/W7129766749","https://openalex.org/W7214165115","https://openalex.org/W2622826369","https://openalex.org/W2947129196","https://openalex.org/W2624161141","https://openalex.org/W7162548425","https://openalex.org/W2768262448","https://openalex.org/W4294490883"],"abstract_inverted_index":{"e13083":[0],"Background:":[1],"Extended":[2],"Endocrine":[3],"Therapy":[4],"(EET)":[5],"for":[6,34,53,126,364],"hormone":[7],"receptor":[8,74],"positive":[9,76,91,143,182,369],"HER-2":[10,92,144],"negative":[11,93,145],"early-stage":[12],"breast":[13,77,94,146],"cancer":[14,95,147],"reduces":[15],"late":[16,327,354],"recurrence":[17,328],"risks":[18],"but":[19],"raises":[20],"concerns":[21,63],"about":[22,64],"toxicity.":[23],"Biomarker":[24],"tests":[25],"like":[26],"the":[27,119,123,191,316,345,351],"Breast":[28],"Cancer":[29],"Index":[30],"(BCI)":[31],"are":[32],"vital":[33],"identifying":[35],"patients":[36,69,96,138,229,238,255,277,291],"who":[37,97,148],"could":[38],"benefit":[39],"from":[40,105,251],"continued":[41],"ET,":[42],"reassuring":[43],"others":[44,273],"against":[45,350],"unnecessary":[46],"extension.":[47],"This":[48,80],"study":[49],"evaluates":[50],"prognostic":[51],"implications":[52],"both":[54,99,150],"Oncotype":[55,100,151,185,203,208,213,218,306,333],"Dx":[56,101],"(Recurrence":[57],"score,":[58],"RS)":[59],"and":[60,102,152,186,257,272,282,335],"BCI":[61,103,153,187,247,321,342,357],"amidst":[62],"added":[65],"testing":[66,104,358],"costs":[67],"in":[68,228,315],"with":[70,131,139,230,341],"early":[71,317],"stage,":[72],"estrogen":[73],"(ER)":[75],"cancer.":[78],"Methods:":[79],"is":[81,322],"a":[82,165],"single":[83],"institution":[84],"retrospective":[85],"review":[86],"of":[87,169,347,353],"Stage":[88,140,365],"IA":[89,141],"ER":[90,142,368],"underwent":[98],"January":[106],"2021":[107],"to":[108,117,312,325],"December":[109],"2023.":[110],"Pearson's":[111],"correlation":[112,183],"coefficient":[113],"(r)":[114],"was":[115,129,188,224],"used":[116],"assess":[118],"linear":[120],"relationship":[121],"between":[122,184],"assays":[124],"(p<0.05":[125],"significance),":[127],"analysis":[128,198],"performed":[130],"SAS":[132],"software,":[133],"version":[134],"9.4.":[135],"Results:":[136],"Fifty-eight":[137],"had":[149,240,293],"results":[154],"were":[155,178],"identified":[156],"(100%":[157],"female;":[158],"mean":[159],"age":[160],"72.2":[161],"years":[162],"[54-87]).":[163],"After":[164],"median":[166],"followed":[167],"up":[168],"72":[170],"months":[171],"(63-75),":[172],"no":[173,200],"systemic":[174],"or":[175,331],"locoregional":[176],"recurrences":[177],"reported.":[179],"A":[180],"low":[181],"observed":[189],"across":[190],"entire":[192],"cohort":[193],"(r=0.4058;":[194],"p=0.0016).":[195],"However,":[196],"subgroup":[197],"showed":[199],"significant":[201],"correlations:":[202],"<11":[204],"(n=17;":[205],"r=0.2415;":[206],"p=0.3504),":[207],"\u226418":[209],"(n=43;":[210],"r=0.0914;":[211],"p=0.5600),":[212],"<26":[214],"(n=51;":[215],"r=0.2530;":[216],"p=0.0733);":[217],"\u226526":[219],"(n=7;":[220],"r=-0.5634;":[221],"p=0.1878).":[222],"Correlation":[223],"also":[225],"not":[226,339],"found":[227],"Grade":[231],"1":[232],"tumor":[233,336],"(n=16;":[234],"r=0.3138;":[235],"p=0.2365).":[236],"Thirty-nine":[237],"(67.24%)":[239],"their":[241,297],"treatment":[242,298],"recommendation":[243],"changed":[244],"based":[245],"on":[246,288],"results.":[248],"Side":[249],"effects":[250],"ET":[252,294],"affected":[253],"15":[254],"(25.86%)":[256],"included":[258],"arthralgias":[259],"(60%,":[260],"n=9),":[261],"hot":[262],"flashes":[263],"(26.67%,":[264],"n=4),":[265],"depression":[266],"(13.33%,":[267],"n=2),":[268],"insomnia":[269],"(6.67%,":[270],"n=1),":[271],"(53.3%,":[274],"n=8).":[275],"Twenty-two":[276],"(37.93%)":[278],"developed":[279],"new":[280,285],"osteopenia,":[281],"6":[283],"(10.34%)":[284],"osteoporosis":[286],"while":[287],"EET.":[289],"Eight":[290],"(13.79%)":[292],"interruption":[295],"during":[296],"course.":[299],"Conclusions:":[300],"Despite":[301],"inclination":[302],"towards":[303],"cost-saving":[304],"measures,":[305],"DX":[307],"may":[308,338],"be":[309],"more":[310,323],"useful":[311,324],"give":[313],"prognosis":[314],"adjuvant":[318],"period":[319],"whereas":[320],"evaluate":[326],"risk.":[329],"Low":[330],"high":[332],"scores":[334],"grade":[337],"align":[340],"findings.":[343],"Considering":[344],"importance":[346],"managing":[348],"toxicity":[349],"risk":[352],"recurrence,":[355],"incorporating":[356],"can":[359],"enhance":[360],"EET":[361],"recommendations,":[362],"even":[363],"I,":[366],"node-negative,":[367],"patients.":[370]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2024-06-05T00:00:00"}