{"id":"https://openalex.org/W4399323170","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.e12586","title":"Retrospective observational study of patients with luminal breast cancer in early stages: 10-year follow-up\u2014Which luminal breast cancer relapse?","display_name":"Retrospective observational study of patients with luminal breast cancer in early stages: 10-year follow-up\u2014Which luminal breast cancer relapse?","publication_year":2024,"publication_date":"2024-06-01","ids":{"openalex":"https://openalex.org/W4399323170","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.e12586"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2024.42.16_suppl.e12586","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.e12586","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e12586","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111219853","display_name":"Andrea Puertas","orcid":"https://orcid.org/0009-0004-5779-0880","observed_orcids":["https://orcid.org/0009-0004-5779-0880"]},"institutions":[{"id":"https://openalex.org/I4210108548","display_name":"Hospital Regional Universitario de M\u00e1laga","ror":"https://ror.org/01mqsmm97","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210108548"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Andrea Puertas","raw_affiliation_strings":["Radiation Oncology, Hospital Universitario Regional M\u00e1laga, M\u00e1laga, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology, Hospital Universitario Regional M\u00e1laga, M\u00e1laga, Spain","institution_ids":["https://openalex.org/I4210108548"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068012185","display_name":"Ismael Herruzo Cabrera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108548","display_name":"Hospital Regional Universitario de M\u00e1laga","ror":"https://ror.org/01mqsmm97","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210108548"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ismael Herruzo Cabrera","raw_affiliation_strings":["Hospital Universitario Regional M\u00e1laga, M\u00e1laga, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario Regional M\u00e1laga, M\u00e1laga, Spain","institution_ids":["https://openalex.org/I4210108548"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068165836","display_name":"Mar\u00eda Bel\u00e9n R\u00edos Pozo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108548","display_name":"Hospital Regional Universitario de M\u00e1laga","ror":"https://ror.org/01mqsmm97","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210108548"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Bel\u00e9n R\u00edos Pozo","raw_affiliation_strings":["Hospital Universitario Regional M\u00e1laga, M\u00e1laga, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario Regional M\u00e1laga, M\u00e1laga, Spain","institution_ids":["https://openalex.org/I4210108548"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210108548"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"16_suppl","first_page":"e12586","last_page":"e12586"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/luminal-breast-cancer","display_name":"luminal breast cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/early-breast-cancer","display_name":"early breast cancer","score":0.8119999766349792},{"id":"https://openalex.org/keywords/prosigna","display_name":"Prosigna","score":0.5879999995231628},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.4169999957084656},{"id":"https://openalex.org/keywords/locoregional-recurrence","display_name":"locoregional recurrence","score":0.746999979019165},{"id":"https://openalex.org/keywords/distant-recurrence","display_name":"distant recurrence","score":0.9359999895095825},{"id":"https://openalex.org/keywords/breast-conserving-surgery","display_name":"breast-conserving surgery","score":0.7170000076293945},{"id":"https://openalex.org/keywords/hypofractionated-radiotherapy","display_name":"hypofractionated radiotherapy","score":0.9760000109672546},{"id":"https://openalex.org/keywords/adjuvant-endocrine-therapy","display_name":"adjuvant endocrine therapy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tumor-infiltrating-macrophages","display_name":"tumor-infiltrating macrophages","score":0.6809999942779541},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.6309999823570251},{"id":"https://openalex.org/keywords/long-term-prognosis","display_name":"long-term prognosis","score":0.7120000123977661},{"id":"https://openalex.org/keywords/t1n0-breast-cancer","display_name":"T1N0 breast cancer","score":0.7450000047683716},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.3700000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9062296152114868},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7838683128356934},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.6170036792755127},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.6094889640808105},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5469779968261719},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5363904237747192},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49407485127449036}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2024.42.16_suppl.e12586","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.e12586","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e12586","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4378678167","https://openalex.org/W2592359723","https://openalex.org/W2912724156","https://openalex.org/W2509082983","https://openalex.org/W2406245660","https://openalex.org/W4293214355","https://openalex.org/W3162456028","https://openalex.org/W7161984050","https://openalex.org/W2898977750","https://openalex.org/W2171015116"],"abstract_inverted_index":{"e12586":[0],"Background:":[1],"Luminal":[2,49,179,200,267,356],"BC":[3,30,51,130,201,268,357],"is":[4,42,61,71,306,358],"a":[5,62,87,93,217,232,249,253,277,320,336,349,384],"heterogeneous":[6],"group":[7,74,337],"of":[8,15,20,75,83,174,197,211,226,243,264,280,283,331,338,344,364,369,379],"breast":[9,119],"cancer":[10,120],"(1),":[11],"with":[12,111,143,146,220,235,252,361],"molecular":[13,29],"signatures":[14],"better":[16],"prognoses":[17,22],"and":[18,55,66,79,135,152,185,240,272,296,381],"others":[19],"worse":[21],"being":[23],"found.":[24],"Prosigna":[25,171,218,233,250,291],"test":[26,219,234,251],"provide":[27],"the":[28,81,98,124,162,212,227,244,261,273,281,294,300,328,342,362],"subtype,":[31],"an":[32,236],"individualized":[33],"prognostic":[34],"score":[35,239,275],"called":[36],"\u201cROR":[37],"score\u201d.":[38],"Our":[39],"main":[40,100],"objective":[41,70],"to":[43,161,172,292,299,326,340],"analyze":[44,80,341],"in":[45,102,123,199,224,241,266,354,376],"10":[46],"years":[47,110],"which":[48],"early":[50],"patients":[52,76,140,213,228,245,339,380],"have":[53],"local":[54],"distant":[56,207],"relapses.":[57],"See":[58],"if":[59],"there":[60,305,318],"correlation":[63],"between":[64],"ROR":[65,222,238,255,274,295],"relapse.":[67,284],"As":[68],"second":[69],"select":[72],"this":[73,377],"who":[77],"relapse":[78],"presence":[82,343,363],"CAF":[84,345],"S1":[85,346],"for":[86,323,348,386],"future":[88,350,387],"study.":[89,351],"Methods:":[90],"We":[91,105,156,167,334],"performed":[92],"retrospective":[94],"observational":[95],"study":[96,260,311],"from":[97,159],"two":[99],"hospitals":[101],"M\u00e1laga":[103],"(Spain)":[104],"included":[106],"415":[107,165],"women":[108],"43-79":[109],"EBC":[112],"defined":[113],"as":[114,290],"T1":[115],"or":[116,309],"T2":[117],"primary":[118],"<30":[121],"mm":[122],"largest":[125],"dimension)":[126],"node":[127],"negative.":[128],"Molecular":[129],"subtype":[131],"analyzed":[132],"by":[133],"IHC":[134],"genomic":[136,288],"platform":[137,170],"Prosigna)":[138],"The":[139,188,194,367],"were":[141],"treated":[142],"breast-conserving":[144],"surgery":[145],"clear":[147],"excision":[148],"margins":[149],"hypofractionated":[150],"radiotherapy":[151],"adjuvant":[153],"endocrine":[154],"therapy.":[155],"followed":[157],"them":[158,175],"2014":[160],"present.":[163],"Results:":[164],"patients.":[166,333],"made":[168],"genetic":[169],"all":[173],"luminal":[176,315],"A":[177],"55%,":[178],"B":[180],"37%,":[181],"Basal":[182],"like":[183],"4.8%":[184],"Her2":[186],"3.6%.":[187],"median":[189],"follow-up":[190],"was":[191,202,269],"9.1":[192],"years.":[193],"cumulative":[195,262],"incidence":[196,263],"recurrence":[198,265,353,375],"2.29%":[203],"(44.4%":[204],"locoregional":[205],"55.55%":[206,210],"recurrence).":[208],"In":[209,258],"that":[214,229,246],"relapsed":[215,230,247],"had":[216,231,248],"high":[221],"score,":[223],"11.11%":[225],"intermediate":[237],"33.33":[242],"low":[254],"score.":[256],"Conclusions:":[257],"our":[259],"2.29":[270],"%":[271],"provided":[276],"good":[278],"estimate":[279,293],"risk":[282],"Currently":[285],"we":[286],"use":[287],"platforms":[289],"adapt":[297],"treatments":[298],"risk.":[301],"However,":[302],"until":[303],"now":[304],"no":[307],"biological":[308],"translational":[310],"focusing":[312],"on":[313],"T1N0":[314,355],"BC.":[316],"Subsequently,":[317],"exists":[319],"real":[321],"need":[322],"new":[324],"strategies":[325],"determine":[327],"long-term":[329],"prognosis":[330],"these":[332],"selected":[335],"fibroblast":[347,366],"Distant":[352],"strongly":[359],"associated":[360],"CAF-S1":[365,370],"determination":[368],"could":[371,382],"more":[372],"accurately":[373],"predict":[374],"subgroup":[378],"be":[383],"target":[385],"treatments.":[388]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2024-06-05T00:00:00"}