{"id":"https://openalex.org/W4399301830","doi":"https://doi.org/10.1016/j.esmoop.2024.103483","title":"Systemic treatment of mismatch repair deficient/microsatellite instability-high metastatic colorectal cancer\u2014single versus double checkpoint inhibition","display_name":"Systemic treatment of mismatch repair deficient/microsatellite instability-high metastatic colorectal cancer\u2014single versus double checkpoint inhibition","publication_year":2024,"publication_date":"2024-06-01","ids":{"openalex":"https://openalex.org/W4399301830","doi":"https://doi.org/10.1016/j.esmoop.2024.103483","pmid":"https://pubmed.ncbi.nlm.nih.gov/38833965","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11179058"},"language":"en","primary_location":{"id":"doi:10.1016/j.esmoop.2024.103483","doi":"https://doi.org/10.1016/j.esmoop.2024.103483","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.esmoop.2024.103483","pdf_url":null,"source":{"id":"https://openalex.org/S4210217024","display_name":"ESMO Open","issn_l":"2059-7029","issn":["2059-7029"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO Open","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.esmoop.2024.103483","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060183078","display_name":"Daniele Marinelli","orcid":"https://orcid.org/0000-0002-6002-363X","observed_orcids":["https://orcid.org/0000-0002-6002-363X"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D. Marinelli","raw_affiliation_strings":["Department of Experimental Medicine, Sapienza Universit\u00e0 di Roma, Rome"],"raw_orcid":"https://orcid.org/0000-0002-6002-363X","affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Sapienza Universit\u00e0 di Roma, Rome","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Sabatini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Sabatini","raw_affiliation_strings":["Department of Radiological, Oncological and Pathological Sciences, Sapienza Universit\u00e0 di Roma, Rome"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiological, Oncological and Pathological Sciences, Sapienza Universit\u00e0 di Roma, Rome","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012579673","display_name":"Elisabetta Bengala","orcid":"https://orcid.org/0009-0005-8721-809X","observed_orcids":["https://orcid.org/0009-0005-8721-809X"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E. Bengala","raw_affiliation_strings":["Department of Radiological, Oncological and Pathological Sciences, Sapienza Universit\u00e0 di Roma, Rome"],"raw_orcid":"https://orcid.org/0009-0005-8721-809X","affiliations":[{"raw_affiliation_string":"Department of Radiological, Oncological and Pathological Sciences, Sapienza Universit\u00e0 di Roma, Rome","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052767587","display_name":"Fabio Ciurluini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Ciurluini","raw_affiliation_strings":["Department of Radiological, Oncological and Pathological Sciences, Sapienza Universit\u00e0 di Roma, Rome"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiological, Oncological and Pathological Sciences, Sapienza Universit\u00e0 di Roma, Rome","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102771717","display_name":"V. Picone","orcid":"https://orcid.org/0009-0007-4415-8650","observed_orcids":["https://orcid.org/0009-0007-4415-8650"]},"institutions":[{"id":"https://openalex.org/I2800330116","display_name":"Policlinico Umberto I","ror":"https://ror.org/011cabk38","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800330116"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"V. Picone","raw_affiliation_strings":["Division of Medical Oncology, Policlinico Umberto I, Rome"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Policlinico Umberto I, Rome","institution_ids":["https://openalex.org/I2800330116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080607660","display_name":"D. Santini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800330116","display_name":"Policlinico Umberto I","ror":"https://ror.org/011cabk38","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800330116"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D. Santini","raw_affiliation_strings":["Division of Medical Oncology, Policlinico Umberto I, Rome"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Policlinico Umberto I, Rome","institution_ids":["https://openalex.org/I2800330116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011993444","display_name":"Filippo Pietrantonio","orcid":"https://orcid.org/0000-0002-8530-8420","observed_orcids":["https://orcid.org/0000-0002-8530-8420"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Pietrantonio","raw_affiliation_strings":["Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan","institution_ids":["https://openalex.org/I4210156707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072503801","display_name":"Daniele Rossini","orcid":"https://orcid.org/0009-0000-3777-8471","observed_orcids":["https://orcid.org/0009-0000-3777-8471"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"D. Rossini","raw_affiliation_strings":["Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence. Electronic address: danielerossini87@gmail.com","Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence"],"raw_orcid":"https://orcid.org/0009-0000-3777-8471","affiliations":[{"raw_affiliation_string":"Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence. Electronic address: danielerossini87@gmail.com","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081985776","display_name":"Chiara Cremolini","orcid":"https://orcid.org/0000-0002-0520-4841","observed_orcids":["https://orcid.org/0000-0002-0520-4841"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Cremolini","raw_affiliation_strings":["Unit of Medical Oncology 2, Azienda Ospedaliera Universitaria Pisana, Pisa; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy","Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy","Unit of Medical Oncology 2, Azienda Ospedaliera Universitaria Pisana, Pisa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Medical Oncology 2, Azienda Ospedaliera Universitaria Pisana, Pisa; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504","https://openalex.org/I4210165410"]},{"raw_affiliation_string":"Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Unit of Medical Oncology 2, Azienda Ospedaliera Universitaria Pisana, Pisa","institution_ids":["https://openalex.org/I4210165410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5072503801"],"corresponding_institution_ids":["https://openalex.org/I45084792"],"apc_list":{"value":3730,"currency":"USD","value_usd":3730},"apc_paid":{"value":3730,"currency":"USD","value_usd":3730},"fwci":null,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"6","first_page":"103483","last_page":"103483"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.5917999744415283,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.5917999744415283,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.26829999685287476,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.13130000233650208,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.9169999957084656},{"id":"https://openalex.org/keywords/microsatellite-instability-high","display_name":"microsatellite instability-high","score":0.9229999780654907},{"id":"https://openalex.org/keywords/mismatch-repair-deficiency","display_name":"mismatch repair deficiency","score":0.9639999866485596},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.8579999804496765},{"id":"https://openalex.org/keywords/systemic-treatment","display_name":"systemic therapy","score":0.6740000247955322},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.6639999747276306},{"id":"https://openalex.org/keywords/neoantigens","display_name":"neoantigens","score":0.7850000262260437},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.9054441452026367},{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.8879412412643433},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7755604982376099},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6763283014297485},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6184170246124268},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5547354817390442},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5382909774780273},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5178347229957581},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5092428922653198},{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.45640289783477783},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.44646337628364563},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.4225155711174011},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.35445424914360046},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3535914719104767},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12037530541419983},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.06174653768539429},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D053842","descriptor_name":"Microsatellite Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053843","descriptor_name":"DNA Mismatch Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.esmoop.2024.103483","doi":"https://doi.org/10.1016/j.esmoop.2024.103483","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.esmoop.2024.103483","pdf_url":null,"source":{"id":"https://openalex.org/S4210217024","display_name":"ESMO Open","issn_l":"2059-7029","issn":["2059-7029"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO Open","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11179058","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11179058","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11179058/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO Open","raw_type":"Text"},{"id":"pmid:38833965","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38833965","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO open","raw_type":"Editorial"},{"id":"pmh:oai:iris.uniroma1.it:11573/1711332","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11573/1711332","pdf_url":"https://iris.uniroma1.it/bitstream/11573/1711332/1/Marinelli_Systemic_2024.pdf","source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:arpi.unipi.it:11568/1282330","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11568/1282330","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.esmoop.2024.103483","doi":"https://doi.org/10.1016/j.esmoop.2024.103483","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.esmoop.2024.103483","pdf_url":null,"source":{"id":"https://openalex.org/S4210217024","display_name":"ESMO Open","issn_l":"2059-7029","issn":["2059-7029"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO Open","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1984642649","https://openalex.org/W2127951115","https://openalex.org/W2944675676","https://openalex.org/W3095395930","https://openalex.org/W3163923489","https://openalex.org/W3206775306","https://openalex.org/W4223510971","https://openalex.org/W4307401860","https://openalex.org/W4323362598","https://openalex.org/W4386741066","https://openalex.org/W4387809627","https://openalex.org/W4403058198","https://openalex.org/W6860749453"],"related_works":["https://openalex.org/W4285744607","https://openalex.org/W3133781842","https://openalex.org/W2897071269","https://openalex.org/W4388009424","https://openalex.org/W3189980802","https://openalex.org/W7168253186","https://openalex.org/W4406818157","https://openalex.org/W4295678035","https://openalex.org/W4224871297","https://openalex.org/W7129100309"],"abstract_inverted_index":{"Microsatellite":[0],"instability":[1],"(MSI)":[2],"is":[3],"found":[4],"in":[5],"\u223c5%":[6],"of":[7],"all":[8],"patients":[9],"with":[10],"metastatic":[11],"colorectal":[12],"cancer":[13],"(mCRC).":[14],"Solid":[15],"evidence":[16],"has":[17],"shown":[18],"that":[19],"MSI-high/mismatch":[20],"repair":[21],"deficient":[22],"(MSI-H/dMMR)":[23],"tumors":[24],"are":[25],"less":[26],"responsive":[27],"to":[28,32,35],"chemotherapy":[29],"and":[30,41],"sensitive":[31],"immunotherapy":[33],"due":[34],"a":[36],"higher":[37],"tumor":[38],"neoantigen":[39],"load":[40],"immune":[42],"cell":[43],"infiltration.1,2":[44]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-06-04T00:00:00"}
