{"id":"https://openalex.org/W4399301050","doi":"https://doi.org/10.3390/ijms25116099","title":"Michael Acceptors as Anti-Cancer Compounds: Coincidence or Causality?","display_name":"Michael Acceptors as Anti-Cancer Compounds: Coincidence or Causality?","publication_year":2024,"publication_date":"2024-06-01","ids":{"openalex":"https://openalex.org/W4399301050","doi":"https://doi.org/10.3390/ijms25116099","pmid":"https://pubmed.ncbi.nlm.nih.gov/38892287","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11172677"},"language":"en","primary_location":{"id":"doi:10.3390/ijms25116099","doi":"https://doi.org/10.3390/ijms25116099","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25116099","pdf_url":"https://www.mdpi.com/1422-0067/25/11/6099/pdf?version=1717220332","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/25/11/6099/pdf?version=1717220332","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065999204","display_name":"Celia Mar\u00eda Curieses Andr\u00e9s","orcid":"https://orcid.org/0000-0003-4731-6398","observed_orcids":["https://orcid.org/0000-0003-4731-6398"]},"institutions":[{"id":"https://openalex.org/I4210157802","display_name":"Hospital Cl\u00ednico Universitario de Valladolid","ror":"https://ror.org/04fffmj41","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210157802"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Celia Mar\u00eda Curieses Andr\u00e9s","raw_affiliation_strings":["Hospital Cl\u00ednico Universitario of Valladolid, Avenida de Ram\u00f3n y Cajal, 3, 47003 Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Cl\u00ednico Universitario of Valladolid, Avenida de Ram\u00f3n y Cajal, 3, 47003 Valladolid, Spain","institution_ids":["https://openalex.org/I4210157802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036537808","display_name":"Jos\u00e9 Manuel P\u00e9rez de la Lastra","orcid":"https://orcid.org/0000-0003-4663-5565","observed_orcids":["https://orcid.org/0000-0003-4663-5565"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210112570","display_name":"Instituto de Productos Naturales y Agrobiolog\u00eda","ror":"https://ror.org/028ev2d94","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210112570"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jos\u00e9 Manuel P\u00e9rez de la Lastra","raw_affiliation_strings":["Institute of Natural Products and Agrobiology, CSIC-Spanish Research Council, Avda. Astrof\u00edsico Fco. S\u00e1nchez, 3, 38206 La Laguna, Spain"],"raw_orcid":"https://orcid.org/0000-0003-4663-5565","affiliations":[{"raw_affiliation_string":"Institute of Natural Products and Agrobiology, CSIC-Spanish Research Council, Avda. Astrof\u00edsico Fco. S\u00e1nchez, 3, 38206 La Laguna, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210112570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074496020","display_name":"Elena Bustamante Munguira","orcid":"https://orcid.org/0000-0002-5657-9547","observed_orcids":["https://orcid.org/0000-0002-5657-9547"]},"institutions":[{"id":"https://openalex.org/I4210157802","display_name":"Hospital Cl\u00ednico Universitario de Valladolid","ror":"https://ror.org/04fffmj41","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210157802"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Elena Bustamante Munguira","raw_affiliation_strings":["Hospital Cl\u00ednico Universitario of Valladolid, Avenida de Ram\u00f3n y Cajal, 3, 47003 Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Cl\u00ednico Universitario of Valladolid, Avenida de Ram\u00f3n y Cajal, 3, 47003 Valladolid, Spain","institution_ids":["https://openalex.org/I4210157802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019257540","display_name":"Celia Andr\u00e9s","orcid":"https://orcid.org/0000-0003-1583-7439","observed_orcids":["https://orcid.org/0000-0003-1583-7439"]},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Celia Andr\u00e9s Juan","raw_affiliation_strings":["Cinquima Institute and Department of Organic Chemistry, Faculty of Sciences, Valladolid University, Paseo de Bel\u00e9n, 7, 47011 Valladolid, Spain"],"raw_orcid":"https://orcid.org/0000-0003-1583-7439","affiliations":[{"raw_affiliation_string":"Cinquima Institute and Department of Organic Chemistry, Faculty of Sciences, Valladolid University, Paseo de Bel\u00e9n, 7, 47011 Valladolid, Spain","institution_ids":["https://openalex.org/I108103353"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108126730","display_name":"Eduardo P\u00e9rez\u2010Lebe\u00f1a","orcid":"https://orcid.org/0000-0002-5335-8175","observed_orcids":["https://orcid.org/0000-0002-5335-8175"]},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eduardo P\u00e9rez-Lebe\u00f1a","raw_affiliation_strings":["Sistemas de Biotecnolog\u00eda y Recursos Naturales, 47625 Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sistemas de Biotecnolog\u00eda y Recursos Naturales, 47625 Valladolid, Spain","institution_ids":["https://openalex.org/I108103353"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5036537808"],"corresponding_institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210112570"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3296},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3296},"fwci":1.9671,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.87958115,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"25","issue":"11","first_page":"6099","last_page":"6099"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.7827000021934509,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.7827000021934509,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.1665000021457672,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/michael-acceptors","display_name":"Michael acceptors","score":1.0},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.9459999799728394},{"id":"https://openalex.org/keywords/electrophilic-compounds","display_name":"electrophilic compounds","score":0.6909999847412109},{"id":"https://openalex.org/keywords/apoptosis-induction","display_name":"apoptosis induction","score":0.8100000023841858},{"id":"https://openalex.org/keywords/tumor-cell-death","display_name":"cancer cell death","score":0.8109999895095825},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.6290000081062317},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C178907741","wikidata":"https://www.wikidata.org/wiki/Q745930","display_name":"Nucleophile","level":3,"score":0.6515610218048096},{"id":"https://openalex.org/C50027330","wikidata":"https://www.wikidata.org/wiki/Q908086","display_name":"Electrophile","level":3,"score":0.6012481451034546},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5842000246047974},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5452519059181213},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49985456466674805},{"id":"https://openalex.org/C112423150","wikidata":"https://www.wikidata.org/wiki/Q642233","display_name":"Michael reaction","level":3,"score":0.49055641889572144},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3917149305343628},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3634496331214905},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3498934209346771},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32685720920562744},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.088274747133255},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms25116099","doi":"https://doi.org/10.3390/ijms25116099","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25116099","pdf_url":"https://www.mdpi.com/1422-0067/25/11/6099/pdf?version=1717220332","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11172677","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11172677","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:38892287","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38892287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:digital.csic.es:10261/360000","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/360000","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"art\u00edculo"}],"best_oa_location":{"id":"doi:10.3390/ijms25116099","doi":"https://doi.org/10.3390/ijms25116099","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms25116099","pdf_url":"https://www.mdpi.com/1422-0067/25/11/6099/pdf?version=1717220332","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4687697941","display_name":null,"funder_award_id":"2021-2023","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"},{"id":"https://openalex.org/G7339391204","display_name":null,"funder_award_id":"PLEC2022-009507","funder_id":"https://openalex.org/F4320322930","funder_display_name":"Ministerio de Ciencia e Innovaci\u00f3n"}],"funders":[{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4399301050.pdf","grobid_xml":"https://content.openalex.org/works/W4399301050.grobid-xml"},"referenced_works_count":346,"referenced_works":["https://openalex.org/W808397578","https://openalex.org/W815450842","https://openalex.org/W1509405108","https://openalex.org/W1547109494","https://openalex.org/W1608837661","https://openalex.org/W1813072770","https://openalex.org/W1938013031","https://openalex.org/W1964483457","https://openalex.org/W1964708136","https://openalex.org/W1966542159","https://openalex.org/W1970554113","https://openalex.org/W1975410532","https://openalex.org/W1977090526","https://openalex.org/W1979070712","https://openalex.org/W1979553058","https://openalex.org/W1980577287","https://openalex.org/W1982380290","https://openalex.org/W1982768470","https://openalex.org/W1983865998","https://openalex.org/W1984841807","https://openalex.org/W1986938616","https://openalex.org/W1987756203","https://openalex.org/W1990014661","https://openalex.org/W1990143663","https://openalex.org/W1990789249","https://openalex.org/W1991154912","https://openalex.org/W1993175857","https://openalex.org/W1995038735","https://openalex.org/W1999081551","https://openalex.org/W1999596279","https://openalex.org/W1999957893","https://openalex.org/W2002122394","https://openalex.org/W2003086868","https://openalex.org/W2004412542","https://openalex.org/W2004717341","https://openalex.org/W2006901327","https://openalex.org/W2008563568","https://openalex.org/W2008734203","https://openalex.org/W2009386327","https://openalex.org/W2010930767","https://openalex.org/W2011275571","https://openalex.org/W2011684274","https://openalex.org/W2013611824","https://openalex.org/W2015318023","https://openalex.org/W2016141715","https://openalex.org/W2016153572","https://openalex.org/W2017630738","https://openalex.org/W2019216438","https://openalex.org/W2019792957","https://openalex.org/W2023274616","https://openalex.org/W2023412782","https://openalex.org/W2027033941","https://openalex.org/W2028972576","https://openalex.org/W2029150276","https://openalex.org/W2029927025","https://openalex.org/W2031385838","https://openalex.org/W2032785100","https://openalex.org/W2033004457","https://openalex.org/W2035494241","https://openalex.org/W2035516417","https://openalex.org/W2036705051","https://openalex.org/W2037690301","https://openalex.org/W2038286187","https://openalex.org/W2038458062","https://openalex.org/W2039898390","https://openalex.org/W2040076764","https://openalex.org/W2040556616","https://openalex.org/W2040826892","https://openalex.org/W2044227662","https://openalex.org/W2044695669","https://openalex.org/W2045228408","https://openalex.org/W2046497407","https://openalex.org/W2047222465","https://openalex.org/W2047818755","https://openalex.org/W2048072131","https://openalex.org/W2048639599","https://openalex.org/W2048729590","https://openalex.org/W2048883883","https://openalex.org/W2051078827","https://openalex.org/W2053213651","https://openalex.org/W2055953269","https://openalex.org/W2061782012","https://openalex.org/W2064026596","https://openalex.org/W2064370962","https://openalex.org/W2064683980","https://openalex.org/W2065863066","https://openalex.org/W2066727978","https://openalex.org/W2067216473","https://openalex.org/W2069447860","https://openalex.org/W2071638430","https://openalex.org/W2077386479","https://openalex.org/W2077682572","https://openalex.org/W2078445100","https://openalex.org/W2080487902","https://openalex.org/W2080869463","https://openalex.org/W2081058334","https://openalex.org/W2081562982","https://openalex.org/W2082162959","https://openalex.org/W2082746308","https://openalex.org/W2083802827","https://openalex.org/W2084560735","https://openalex.org/W2085213714","https://openalex.org/W2086598626","https://openalex.org/W2086816976","https://openalex.org/W2089353165","https://openalex.org/W2090371347","https://openalex.org/W2090690774","https://openalex.org/W2090775669","https://openalex.org/W2094088075","https://openalex.org/W2094461289","https://openalex.org/W2096441034","https://openalex.org/W2097101830","https://openalex.org/W2097774235","https://openalex.org/W2099257830","https://openalex.org/W2099655761","https://openalex.org/W2103518432","https://openalex.org/W2103732306","https://openalex.org/W2105451463","https://openalex.org/W2106281303","https://openalex.org/W2106942695","https://openalex.org/W2107236047","https://openalex.org/W2109882555","https://openalex.org/W2111650168","https://openalex.org/W2113024198","https://openalex.org/W2115943711","https://openalex.org/W2117799351","https://openalex.org/W2120175350","https://openalex.org/W2120801539","https://openalex.org/W2123322767","https://openalex.org/W2124343538","https://openalex.org/W2124569653","https://openalex.org/W2125139572","https://openalex.org/W2126698897","https://openalex.org/W2127549588","https://openalex.org/W2128305224","https://openalex.org/W2130434004","https://openalex.org/W2131054351","https://openalex.org/W2134239687","https://openalex.org/W2137017791","https://openalex.org/W2141701728","https://openalex.org/W2142450574","https://openalex.org/W2145184530","https://openalex.org/W2145955453","https://openalex.org/W2146593189","https://openalex.org/W2151779190","https://openalex.org/W2152656267","https://openalex.org/W2153977062","https://openalex.org/W2154278867","https://openalex.org/W2155085170","https://openalex.org/W2156025284","https://openalex.org/W2157189496","https://openalex.org/W2158383727","https://openalex.org/W2159657185","https://openalex.org/W2160605524","https://openalex.org/W2162343852","https://openalex.org/W2169709967","https://openalex.org/W2169725967","https://openalex.org/W2174003732","https://openalex.org/W2191089917","https://openalex.org/W2214273798","https://openalex.org/W2216606325","https://openalex.org/W2256301219","https://openalex.org/W2261155901","https://openalex.org/W2264693371","https://openalex.org/W2274305986","https://openalex.org/W2288921983","https://openalex.org/W2295971206","https://openalex.org/W2297295275","https://openalex.org/W2323511867","https://openalex.org/W2336177592","https://openalex.org/W2342812346","https://openalex.org/W2346315096","https://openalex.org/W2398775408","https://openalex.org/W2477155298","https://openalex.org/W2519838368","https://openalex.org/W2522386481","https://openalex.org/W2553303154","https://openalex.org/W2564708666","https://openalex.org/W2565099436","https://openalex.org/W2570580727","https://openalex.org/W2573399025","https://openalex.org/W2587781025","https://openalex.org/W2592397452","https://openalex.org/W2613820968","https://openalex.org/W2625324134","https://openalex.org/W2673811133","https://openalex.org/W2735527928","https://openalex.org/W2754751554","https://openalex.org/W2754995279","https://openalex.org/W2760740081","https://openalex.org/W2766902602","https://openalex.org/W2767942628","https://openalex.org/W2774687308","https://openalex.org/W2780557617","https://openalex.org/W2791370644","https://openalex.org/W2792668113","https://openalex.org/W2793402738","https://openalex.org/W2797651546","https://openalex.org/W2802266362","https://openalex.org/W2804561464","https://openalex.org/W2804638973","https://openalex.org/W2807342418","https://openalex.org/W2807785724","https://openalex.org/W2855812087","https://openalex.org/W2883210621","https://openalex.org/W2884966151","https://openalex.org/W2885341903","https://openalex.org/W2891127847","https://openalex.org/W2895949704","https://openalex.org/W2897074743","https://openalex.org/W2902331842","https://openalex.org/W2905111869","https://openalex.org/W2914885691","https://openalex.org/W2919262048","https://openalex.org/W2938065487","https://openalex.org/W2943338024","https://openalex.org/W2949946916","https://openalex.org/W2952519293","https://openalex.org/W2952552566","https://openalex.org/W2955664420","https://openalex.org/W2957253035","https://openalex.org/W2963114734","https://openalex.org/W2966600544","https://openalex.org/W2987438173","https://openalex.org/W2991226916","https://openalex.org/W2996365566","https://openalex.org/W2997624822","https://openalex.org/W2998192482","https://openalex.org/W2998763502","https://openalex.org/W2999775430","https://openalex.org/W3010888591","https://openalex.org/W3014696958","https://openalex.org/W3014996673","https://openalex.org/W3018821257","https://openalex.org/W3022004194","https://openalex.org/W3027057217","https://openalex.org/W3034819388","https://openalex.org/W3035127458","https://openalex.org/W3036183865","https://openalex.org/W3036774394","https://openalex.org/W3037311339","https://openalex.org/W3038015203","https://openalex.org/W3047761937","https://openalex.org/W3048904028","https://openalex.org/W3049642946","https://openalex.org/W3062354935","https://openalex.org/W3080641067","https://openalex.org/W3080650814","https://openalex.org/W3081044980","https://openalex.org/W3082856973","https://openalex.org/W3087992083","https://openalex.org/W3092560102","https://openalex.org/W3093627196","https://openalex.org/W3107647937","https://openalex.org/W3109004530","https://openalex.org/W3117407786","https://openalex.org/W3119529722","https://openalex.org/W3119787068","https://openalex.org/W3120410598","https://openalex.org/W3121385558","https://openalex.org/W3121516100","https://openalex.org/W3126802078","https://openalex.org/W3128262399","https://openalex.org/W3130954936","https://openalex.org/W3133116384","https://openalex.org/W3135638357","https://openalex.org/W3136539940","https://openalex.org/W3142465418","https://openalex.org/W3143757615","https://openalex.org/W3152110994","https://openalex.org/W3152486293","https://openalex.org/W3157298478","https://openalex.org/W3159517011","https://openalex.org/W3165136145","https://openalex.org/W3167514563","https://openalex.org/W3169084803","https://openalex.org/W3187517397","https://openalex.org/W3191932131","https://openalex.org/W3195865831","https://openalex.org/W3196329163","https://openalex.org/W3198795989","https://openalex.org/W3200291856","https://openalex.org/W3201398193","https://openalex.org/W3206321390","https://openalex.org/W3208658142","https://openalex.org/W3210141429","https://openalex.org/W3216439617","https://openalex.org/W4200295576","https://openalex.org/W4200543380","https://openalex.org/W4200586550","https://openalex.org/W4205370675","https://openalex.org/W4206278084","https://openalex.org/W4210263931","https://openalex.org/W4210330701","https://openalex.org/W4210497807","https://openalex.org/W4210673819","https://openalex.org/W4211144854","https://openalex.org/W4211176144","https://openalex.org/W4213216610","https://openalex.org/W4214662907","https://openalex.org/W4214726407","https://openalex.org/W4220897749","https://openalex.org/W4223930506","https://openalex.org/W4223969474","https://openalex.org/W4282975692","https://openalex.org/W4283391697","https://openalex.org/W4283813503","https://openalex.org/W4285495992","https://openalex.org/W4285733154","https://openalex.org/W4289175147","https://openalex.org/W4293413341","https://openalex.org/W4293538935","https://openalex.org/W4296525262","https://openalex.org/W4304014509","https://openalex.org/W4306385459","https://openalex.org/W4306969889","https://openalex.org/W4308123718","https://openalex.org/W4308866011","https://openalex.org/W4309210811","https://openalex.org/W4311131980","https://openalex.org/W4311367289","https://openalex.org/W4313362366","https://openalex.org/W4318776770","https://openalex.org/W4319080692","https://openalex.org/W4321482963","https://openalex.org/W4362475058","https://openalex.org/W4367394089","https://openalex.org/W4378650425","https://openalex.org/W4378903849","https://openalex.org/W4379794345","https://openalex.org/W4382728075","https://openalex.org/W4384008298","https://openalex.org/W4385259364","https://openalex.org/W4385496410","https://openalex.org/W4386837613","https://openalex.org/W4386879562","https://openalex.org/W4387692565","https://openalex.org/W4388551427","https://openalex.org/W4389462361","https://openalex.org/W4390538788","https://openalex.org/W4392103716","https://openalex.org/W4392984053","https://openalex.org/W4393857115","https://openalex.org/W6656479497","https://openalex.org/W6681247383","https://openalex.org/W6757153655"],"related_works":["https://openalex.org/W4296550727","https://openalex.org/W7207027882","https://openalex.org/W4411597594","https://openalex.org/W815450842","https://openalex.org/W1465750003","https://openalex.org/W4412885743","https://openalex.org/W2778712697","https://openalex.org/W7134952107","https://openalex.org/W4316673183","https://openalex.org/W7143341179"],"abstract_inverted_index":{"Michael":[0,60,84],"acceptors":[1,61,85],"represent":[2],"a":[3,46],"class":[4],"of":[5,32,83,101,133,150],"compounds":[6,103],"with":[7,65,74],"potential":[8],"anti-cancer":[9,81],"properties.":[10],"They":[11],"act":[12],"by":[13],"binding":[14],"to":[15,39,72,92,106,145],"nucleophilic":[16,109],"sites":[17],"in":[18,68,115,122],"biological":[19],"molecules,":[20],"thereby":[21],"disrupting":[22],"cancer":[23,51,66,138],"cell":[24,28],"function":[25],"and":[26,42,62,77,96,119,136,153],"inducing":[27],"death.":[29],"This":[30,125],"mode":[31],"action,":[33],"as":[34,36],"well":[35],"their":[37,63,70,93],"ability":[38,71],"be":[40],"modified":[41],"targeted,":[43],"makes":[44],"them":[45,105,155],"promising":[47],"avenue":[48],"for":[49,130],"advancing":[50],"therapy.":[52],"We":[53],"are":[54,86,90,143],"investigating":[55],"the":[56,131,148],"molecular":[57],"mechanisms":[58],"underlying":[59],"interactions":[64],"cells,":[67],"particular":[69],"interfere":[73],"cellular":[75],"processes":[76],"induce":[78],"apoptosis.":[79],"The":[80,98],"properties":[82],"not":[87],"accidental":[88],"but":[89],"due":[91],"chemical":[94],"structure":[95],"reactivity.":[97],"electrophilic":[99],"nature":[100],"these":[102],"allows":[104],"selectively":[107],"target":[108],"residues":[110],"on":[111],"disease-associated":[112],"proteins,":[113],"resulting":[114],"significant":[116],"therapeutic":[117],"benefits":[118],"minimal":[120],"toxicity":[121],"various":[123],"diseases.":[124],"opens":[126],"up":[127],"new":[128],"perspectives":[129],"development":[132],"more":[134],"effective":[135],"precise":[137],"drugs.":[139],"Nevertheless,":[140],"further":[141],"studies":[142],"essential":[144],"fully":[146],"understand":[147],"impact":[149],"our":[151],"discoveries":[152],"translate":[154],"into":[156],"clinical":[157],"practice.":[158]},"counts_by_year":[{"year":2026,"cited_by_count":25},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":9}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-06-04T00:00:00"}
