{"id":"https://openalex.org/W4399298474","doi":"https://doi.org/10.1158/2159-8290.25956421","title":"Oligonucleotide Table from Overcoming Clinical Resistance to EZH2 Inhibition Using Rational Epigenetic Combination Therapy","display_name":"Oligonucleotide Table from Overcoming Clinical Resistance to EZH2 Inhibition Using Rational Epigenetic Combination Therapy","publication_year":2024,"publication_date":"2024-06-03","ids":{"openalex":"https://openalex.org/W4399298474","doi":"https://doi.org/10.1158/2159-8290.25956421"},"language":"en","primary_location":{"id":"doi:10.1158/2159-8290.25956421","doi":"https://doi.org/10.1158/2159-8290.25956421","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.25956421","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2159-8290.25956421","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070459580","display_name":"Yaniv Kazansky","orcid":"https://orcid.org/0000-0003-3467-5703","observed_orcids":["https://orcid.org/0000-0003-3467-5703"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yaniv Kazansky","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3467-5703","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005519615","display_name":"Daniel Cameron","orcid":"https://orcid.org/0009-0001-4102-0935","observed_orcids":["https://orcid.org/0009-0001-4102-0935"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Cameron","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-4102-0935","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003463612","display_name":"Helen S. Mueller","orcid":"https://orcid.org/0000-0001-5813-873X","observed_orcids":["https://orcid.org/0000-0001-5813-873X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helen S. Mueller","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5813-873X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022314946","display_name":"Phillip Demarest","orcid":"https://orcid.org/0009-0005-0330-8785","observed_orcids":["https://orcid.org/0009-0005-0330-8785"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Phillip Demarest","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-0330-8785","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075803217","display_name":"Nadia Zaffaroni","orcid":"https://orcid.org/0000-0002-4669-0890","observed_orcids":["https://orcid.org/0000-0002-4669-0890"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nadia Zaffaroni","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4669-0890","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065275137","display_name":"Noemi Arrighetti","orcid":"https://orcid.org/0000-0001-9848-3239","observed_orcids":["https://orcid.org/0000-0001-9848-3239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Noemi Arrighetti","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9848-3239","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071309513","display_name":"Valentina Zuco","orcid":"https://orcid.org/0000-0001-7882-9095","observed_orcids":["https://orcid.org/0000-0001-7882-9095"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valentina Zuco","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7882-9095","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068589183","display_name":"Yasumichi Kuwahara","orcid":"https://orcid.org/0000-0002-0139-8503","observed_orcids":["https://orcid.org/0000-0002-0139-8503"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasumichi Kuwahara","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0139-8503","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030479930","display_name":"Romel Somwar","orcid":"https://orcid.org/0000-0002-5282-6889","observed_orcids":["https://orcid.org/0000-0002-5282-6889"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Romel Somwar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5282-6889","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046345178","display_name":"Marc Ladanyi","orcid":"https://orcid.org/0000-0001-9055-7213","observed_orcids":["https://orcid.org/0000-0001-9055-7213"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marc Ladanyi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9055-7213","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066880828","display_name":"Rui Qu","orcid":"https://orcid.org/0009-0009-1185-9076","observed_orcids":["https://orcid.org/0009-0009-1185-9076"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rui Qu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-1185-9076","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004111432","display_name":"Elisa de Stanchina","orcid":"https://orcid.org/0000-0002-3873-315X","observed_orcids":["https://orcid.org/0000-0002-3873-315X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elisa de Stanchina","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3873-315X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062320984","display_name":"Filemon S. Dela Cruz","orcid":"https://orcid.org/0000-0002-8356-5191","observed_orcids":["https://orcid.org/0000-0002-8356-5191"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Filemon S. Dela Cruz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8356-5191","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059247439","display_name":"Andrew L. Kung","orcid":"https://orcid.org/0000-0002-9091-488X","observed_orcids":["https://orcid.org/0000-0002-9091-488X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew L. Kung","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9091-488X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034595315","display_name":"Mrinal M. Gounder","orcid":"https://orcid.org/0000-0001-8468-0119","observed_orcids":["https://orcid.org/0000-0001-8468-0119"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mrinal M. Gounder","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8468-0119","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055053315","display_name":"Alex Kentsis","orcid":"https://orcid.org/0000-0002-8063-9191","observed_orcids":["https://orcid.org/0000-0002-8063-9191"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alex Kentsis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8063-9191","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ezh2-inhibition","display_name":"EZH2 inhibition","score":0.9760000109672546},{"id":"https://openalex.org/keywords/guide-rna","display_name":"guide RNA","score":0.5529999732971191},{"id":"https://openalex.org/keywords/oligonucleotides","display_name":"oligonucleotides","score":0.8119999766349792},{"id":"https://openalex.org/keywords/crispr-cas9","display_name":"CRISPR/Cas9","score":0.7260000109672546},{"id":"https://openalex.org/keywords/epigenetic-reprogramming","display_name":"epigenetic reprogramming","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.6751745939254761},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6524540185928345},{"id":"https://openalex.org/C45235069","wikidata":"https://www.wikidata.org/wiki/Q278425","display_name":"Table (database)","level":2,"score":0.6022825241088867},{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.5695618391036987},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5159035921096802},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.49390655755996704},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.360614150762558},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34504473209381104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.332683801651001},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30375924706459045},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2495206594467163},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.15211179852485657},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.08588287234306335},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0800175666809082}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2159-8290.25956421","doi":"https://doi.org/10.1158/2159-8290.25956421","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.25956421","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2159-8290.25956421","doi":"https://doi.org/10.1158/2159-8290.25956421","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.25956421","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.5199999809265137}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4366603091","https://openalex.org/W2293624935","https://openalex.org/W3112098854","https://openalex.org/W3029316033","https://openalex.org/W2130686293","https://openalex.org/W4284991400","https://openalex.org/W1971791563","https://openalex.org/W1976749758","https://openalex.org/W2485141070","https://openalex.org/W2411374999"],"abstract_inverted_index":{"Oligonucleotide":[0],"Table:":[1],"Complete":[2],"list":[3],"of":[4],"gRNAs":[5],"and":[6],"primers":[7],"used":[8],"in":[9],"this":[10],"study.":[11]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2025-10-10T00:00:00"}
