{"id":"https://openalex.org/W4399288133","doi":"https://doi.org/10.3390/pharmaceutics16060734","title":"Review of Prodrug and Nanodelivery Strategies to Improve the Treatment of Colorectal Cancer with Fluoropyrimidine Drugs","display_name":"Review of Prodrug and Nanodelivery Strategies to Improve the Treatment of Colorectal Cancer with Fluoropyrimidine Drugs","publication_year":2024,"publication_date":"2024-05-29","ids":{"openalex":"https://openalex.org/W4399288133","doi":"https://doi.org/10.3390/pharmaceutics16060734","pmid":"https://pubmed.ncbi.nlm.nih.gov/38931855","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11206923"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics16060734","doi":"https://doi.org/10.3390/pharmaceutics16060734","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics16060734","pdf_url":"https://www.mdpi.com/1999-4923/16/6/734/pdf?version=1716981915","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4923/16/6/734/pdf?version=1716981915","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101410345","display_name":"Santu Sarkar","orcid":"https://orcid.org/0000-0002-7732-7410","observed_orcids":["https://orcid.org/0000-0002-7732-7410"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Santu Sarkar","raw_affiliation_strings":["Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011493024","display_name":"Sezgin Kiren","orcid":"https://orcid.org/0000-0002-7971-7244","observed_orcids":["https://orcid.org/0000-0002-7971-7244"]},"institutions":[{"id":"https://openalex.org/I188405335","display_name":"Winston-Salem State University","ror":"https://ror.org/049yc0897","country_code":"US","type":"education","lineage":["https://openalex.org/I188405335"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sezgin Kiren","raw_affiliation_strings":["Department of Chemistry, Winston-Salem State University, Winston-Salem, NC 27110, USA"],"raw_orcid":"https://orcid.org/0000-0002-7971-7244","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Winston-Salem State University, Winston-Salem, NC 27110, USA","institution_ids":["https://openalex.org/I188405335"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024922312","display_name":"William H. Gmeiner","orcid":"https://orcid.org/0000-0003-1883-3791","observed_orcids":["https://orcid.org/0000-0003-1883-3791"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William H. Gmeiner","raw_affiliation_strings":["Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA"],"raw_orcid":"https://orcid.org/0000-0003-1883-3791","affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5024922312"],"corresponding_institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3296},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3296},"fwci":0.4271,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.36261915,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"16","issue":"6","first_page":"734","last_page":"734"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluoropyrimidine","display_name":"fluoropyrimidine","score":0.828000009059906},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9919999837875366},{"id":"https://openalex.org/keywords/prodrugs","display_name":"prodrugs","score":0.9670000076293945},{"id":"https://openalex.org/keywords/nanodelivery","display_name":"nanodelivery","score":0.8899999856948853},{"id":"https://openalex.org/keywords/capecitabine","display_name":"capecitabine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mesoporous-silica-nanoparticles","display_name":"mesoporous silica nanoparticles","score":0.9990000128746033},{"id":"https://openalex.org/keywords/metal-nanoparticles","display_name":"metal nanoparticles","score":0.9890000224113464},{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lipid-nanoparticles","display_name":"lipid nanoparticles","score":0.9409999847412109},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.7164784669876099},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6344225406646729},{"id":"https://openalex.org/C2777909004","wikidata":"https://www.wikidata.org/wiki/Q420207","display_name":"Capecitabine","level":4,"score":0.5976851582527161},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5069849491119385},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.47557511925697327},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47007471323013306},{"id":"https://openalex.org/C19831878","wikidata":"https://www.wikidata.org/wiki/Q659446","display_name":"Therapeutic index","level":3,"score":0.449354887008667},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3582476079463959},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3078310489654541},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17775708436965942},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1697883903980255},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.06254026293754578}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/pharmaceutics16060734","doi":"https://doi.org/10.3390/pharmaceutics16060734","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics16060734","pdf_url":"https://www.mdpi.com/1999-4923/16/6/734/pdf?version=1716981915","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11206923","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11206923","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11206923/pdf/pharmaceutics-16-00734.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmid:38931855","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38931855","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:2ce954d0ef6a4901bb86567a037194cc","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2ce954d0ef6a4901bb86567a037194cc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 16, Iss 6, p 734 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics16060734","doi":"https://doi.org/10.3390/pharmaceutics16060734","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics16060734","pdf_url":"https://www.mdpi.com/1999-4923/16/6/734/pdf?version=1716981915","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2031452055","display_name":null,"funder_award_id":"R01 CA284083","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2077564193","display_name":"Improved Treatment of Colorectal Cancer with CF10","funder_award_id":"R42CA254834","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6010341682","display_name":"Nanodelivery of FP polymers to improve treatment of metastatic colorectal cancer","funder_award_id":"5r01ca284083-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000175484","display_name":null,"funder_award_id":"1R01CA284083-01A1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000328302","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA012197","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000880743","display_name":"Feasibility of artesunate to improve HPV and cervical precancer treatment outcomes among HIV positive women in LMICs","funder_award_id":"R34CA284983","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4399288133.pdf","grobid_xml":"https://content.openalex.org/works/W4399288133.grobid-xml"},"referenced_works_count":100,"referenced_works":["https://openalex.org/W620044983","https://openalex.org/W1914272705","https://openalex.org/W1969215425","https://openalex.org/W1973635345","https://openalex.org/W1978796203","https://openalex.org/W1979984946","https://openalex.org/W1988812533","https://openalex.org/W1991007374","https://openalex.org/W2005829753","https://openalex.org/W2010240044","https://openalex.org/W2044098260","https://openalex.org/W2044970916","https://openalex.org/W2053727857","https://openalex.org/W2055568666","https://openalex.org/W2060311941","https://openalex.org/W2062854941","https://openalex.org/W2086032653","https://openalex.org/W2088558066","https://openalex.org/W2103846273","https://openalex.org/W2126961173","https://openalex.org/W2136040990","https://openalex.org/W2138809265","https://openalex.org/W2158180165","https://openalex.org/W2168600267","https://openalex.org/W2170314104","https://openalex.org/W2171653079","https://openalex.org/W2181728821","https://openalex.org/W2200372568","https://openalex.org/W2207973369","https://openalex.org/W2255757070","https://openalex.org/W2285665565","https://openalex.org/W2315570310","https://openalex.org/W2328471401","https://openalex.org/W2402300954","https://openalex.org/W2470172036","https://openalex.org/W2480743389","https://openalex.org/W2558830623","https://openalex.org/W2742581645","https://openalex.org/W2743008942","https://openalex.org/W2748536775","https://openalex.org/W2766225083","https://openalex.org/W2768020882","https://openalex.org/W2790276829","https://openalex.org/W2797730510","https://openalex.org/W2808772760","https://openalex.org/W2809014346","https://openalex.org/W2890914040","https://openalex.org/W2895022487","https://openalex.org/W2899461675","https://openalex.org/W2901618658","https://openalex.org/W2902417424","https://openalex.org/W2914885890","https://openalex.org/W2921776089","https://openalex.org/W2932309769","https://openalex.org/W2936953054","https://openalex.org/W2937763513","https://openalex.org/W2949428896","https://openalex.org/W2954117295","https://openalex.org/W2970329262","https://openalex.org/W2984360057","https://openalex.org/W3014713533","https://openalex.org/W3018948488","https://openalex.org/W3045654672","https://openalex.org/W3046124964","https://openalex.org/W3048908258","https://openalex.org/W3083672360","https://openalex.org/W3092623103","https://openalex.org/W3097332115","https://openalex.org/W3097742160","https://openalex.org/W3119801270","https://openalex.org/W3129994939","https://openalex.org/W3164497285","https://openalex.org/W3178723556","https://openalex.org/W3186028286","https://openalex.org/W3193786794","https://openalex.org/W3202442063","https://openalex.org/W3216282807","https://openalex.org/W4200161410","https://openalex.org/W4210565373","https://openalex.org/W4284960178","https://openalex.org/W4293544514","https://openalex.org/W4315881514","https://openalex.org/W4321602088","https://openalex.org/W4361009973","https://openalex.org/W4362459011","https://openalex.org/W4365454384","https://openalex.org/W4366292594","https://openalex.org/W4366816116","https://openalex.org/W4367593951","https://openalex.org/W4379184990","https://openalex.org/W4383376410","https://openalex.org/W4385264850","https://openalex.org/W4386625304","https://openalex.org/W4389128316","https://openalex.org/W4390029476","https://openalex.org/W4390760460","https://openalex.org/W4392375125","https://openalex.org/W4393061882","https://openalex.org/W4393081125","https://openalex.org/W6686107159"],"related_works":["https://openalex.org/W2588391650","https://openalex.org/W4403106438","https://openalex.org/W4386565545","https://openalex.org/W3046124964","https://openalex.org/W4400984351","https://openalex.org/W4404682979","https://openalex.org/W7214041774","https://openalex.org/W4285403535","https://openalex.org/W4229366501","https://openalex.org/W4362596797"],"abstract_inverted_index":{"Fluoropyrimidine":[0],"(FP)":[1],"drugs":[2,69],"are":[3,56],"central":[4],"components":[5],"of":[6,13,30,38,98,107,147,170],"combination":[7],"chemotherapy":[8,18],"regimens":[9],"for":[10,54,67,89,104,128,166,186],"the":[11,24,31,36,96,105,145,179],"treatment":[12,177],"colorectal":[14],"cancer":[15,187],"(CRC).":[16],"FP-based":[17],"has":[19],"improved":[20],"survival":[21,185],"outcomes":[22],"over":[23],"last":[25],"several":[26],"decades":[27],"with":[28,115,122],"much":[29],"therapeutic":[32,47,72,167],"benefit":[33],"derived":[34],"from":[35],"optimization":[37],"dose":[39],"and":[40,51,121,137,157,159,182],"delivery.":[41],"To":[42],"provide":[43],"further":[44],"advances":[45,140],"in":[46,118,133,141,178],"efficacy,":[48],"next-generation":[49],"prodrugs":[50],"nanodelivery":[52,65,113,126],"systems":[53,127],"FPs":[55,171],"being":[57],"developed.":[58],"This":[59],"review":[60,139],"focuses":[61],"on":[62],"recent":[63],"innovative":[64],"approaches":[66],"FP":[68,79,99,109,129,143],"that":[70,162],"display":[71,163],"promise.":[73],"We":[74,93],"summarize":[75],"established,":[76],"clinically":[77],"useful":[78],"prodrug":[80],"strategies,":[81],"including":[82],"capecitabine,":[83],"which":[84],"exploit":[85],"tumor-specific":[86],"enzyme":[87],"expression":[88],"optimal":[90],"anticancer":[91],"activity.":[92],"then":[94],"describe":[95],"use":[97],"DNA-based":[100],"polymers":[101],"(e.g.,":[102],"CF10)":[103],"delivery":[106,130],"activated":[108],"nucleotides":[110],"as":[111],"a":[112],"approach":[114],"proven":[116],"activity":[117],"pre-clinical":[119,135],"models":[120,136],"clinical":[123],"potential.":[124],"Multiple":[125],"show":[131],"promise":[132,165],"CRC":[134,176],"we":[138],"albumin-mediated":[142],"delivery,":[144,156],"development":[146],"mesoporous":[148],"silica":[149],"nanoparticles,":[150,152,154],"emulsion-based":[151],"metal":[153],"hydrogel-based":[155],"liposomes":[158],"lipid":[160],"nanoparticles":[161],"particular":[164],"development.":[168],"Nanodelivery":[169],"is":[172],"anticipated":[173],"to":[174,183],"impact":[175],"coming":[180],"years":[181],"improve":[184],"patients.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2024-06-04T00:00:00"}