{"id":"https://openalex.org/W4399257574","doi":"https://doi.org/10.18502/ijph.v53i5.15598","title":"Short Chain Fatty Acid Sodium Butyrate Increases miR-21, miR-143 and miR-145 Expression in Human Colorectal Cancer HCT-116 Cell Line","display_name":"Short Chain Fatty Acid Sodium Butyrate Increases miR-21, miR-143 and miR-145 Expression in Human Colorectal Cancer HCT-116 Cell Line","publication_year":2024,"publication_date":"2024-06-01","ids":{"openalex":"https://openalex.org/W4399257574","doi":"https://doi.org/10.18502/ijph.v53i5.15598","pmid":"https://pubmed.ncbi.nlm.nih.gov/38912155","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11188656"},"language":"en","primary_location":{"id":"doi:10.18502/ijph.v53i5.15598","doi":"https://doi.org/10.18502/ijph.v53i5.15598","is_oa":true,"landing_page_url":"https://doi.org/10.18502/ijph.v53i5.15598","pdf_url":null,"source":{"id":"https://openalex.org/S4210187943","display_name":"Iranian Journal of Public Health","issn_l":"0304-4556","issn":["0304-4556","2251-6085","2251-6093"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319396","host_organization_name":"Knowledge E","host_organization_lineage":["https://openalex.org/P4310319396"],"host_organization_lineage_names":["Knowledge E"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian Journal of Public Health","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.18502/ijph.v53i5.15598","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113426707","display_name":"Parastoo Mohammadi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110525433","display_name":"Islamic Azad University, Tehran","ror":"https://ror.org/01kzn7k21","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433"]},{"id":"https://openalex.org/I2800744764","display_name":"Islamic Azad University Medical Branch of Tehran","ror":"https://ror.org/00eaebe27","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I2800744764"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Parastoo Mohammadi","raw_affiliation_strings":["Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran","institution_ids":["https://openalex.org/I110525433","https://openalex.org/I2800744764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072363092","display_name":"Flora Forouzesh","orcid":"https://orcid.org/0000-0002-2747-3479","observed_orcids":["https://orcid.org/0000-0002-2747-3479"]},"institutions":[{"id":"https://openalex.org/I110525433","display_name":"Islamic Azad University, Tehran","ror":"https://ror.org/01kzn7k21","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433"]},{"id":"https://openalex.org/I2800744764","display_name":"Islamic Azad University Medical Branch of Tehran","ror":"https://ror.org/00eaebe27","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I2800744764"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Flora Forouzesh","raw_affiliation_strings":["Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran","institution_ids":["https://openalex.org/I110525433","https://openalex.org/I2800744764"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030558790","display_name":"Fatemeh Kouhkan","orcid":"https://orcid.org/0000-0001-7262-0207","observed_orcids":["https://orcid.org/0000-0001-7262-0207"]},"institutions":[{"id":"https://openalex.org/I4210128240","display_name":"Stem Cell Technology Research Center","ror":"https://ror.org/034akh239","country_code":"IR","type":"facility","lineage":["https://openalex.org/I194604659","https://openalex.org/I4210128240"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Fatemeh Kouhkan","raw_affiliation_strings":["Stem Cell Technology Research Center, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Technology Research Center, Tehran, Iran","institution_ids":["https://openalex.org/I4210128240"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072363092"],"corresponding_institution_ids":["https://openalex.org/I110525433","https://openalex.org/I2800744764"],"apc_list":{"value":6000000,"currency":"IRR","value_usd":300},"apc_paid":{"value":6000000,"currency":"IRR","value_usd":300},"fwci":0.5993,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.6206458,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"53","issue":"5","first_page":"1164","last_page":"1174"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.5893999934196472,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.5893999934196472,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.33329999446868896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.03660000115633011,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-butyrate","display_name":"sodium butyrate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/short-chain-fatty-acids","display_name":"short-chain fatty acids","score":0.9729999899864197},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9639999866485596},{"id":"https://openalex.org/keywords/mir-21","display_name":"miR-21","score":0.9210000038146973},{"id":"https://openalex.org/keywords/mir-143","display_name":"miR-143","score":1.0},{"id":"https://openalex.org/keywords/mir-145","display_name":"miR-145","score":1.0},{"id":"https://openalex.org/keywords/microrna-expression","display_name":"microRNA expression","score":0.9200000166893005},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7609999775886536},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7200000286102295},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/microrna-promoters","display_name":"microRNA promoters","score":0.5839999914169312},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C2778942008","wikidata":"https://www.wikidata.org/wiki/Q305004","display_name":"Sodium butyrate","level":3,"score":0.9198678731918335},{"id":"https://openalex.org/C2776979534","wikidata":"https://www.wikidata.org/wiki/Q193213","display_name":"Butyrate","level":3,"score":0.7904340028762817},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6408975124359131},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6253833770751953},{"id":"https://openalex.org/C2776229602","wikidata":"https://www.wikidata.org/wiki/Q2698455","display_name":"Short-chain fatty acid","level":4,"score":0.544672966003418},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5158826112747192},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.503929078578949},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.46906113624572754},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43015438318252563},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37874650955200195},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34635236859321594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33949628472328186},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3348084092140198},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2616364359855652},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24909943342208862},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17890769243240356},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.18502/ijph.v53i5.15598","doi":"https://doi.org/10.18502/ijph.v53i5.15598","is_oa":true,"landing_page_url":"https://doi.org/10.18502/ijph.v53i5.15598","pdf_url":null,"source":{"id":"https://openalex.org/S4210187943","display_name":"Iranian Journal of Public Health","issn_l":"0304-4556","issn":["0304-4556","2251-6085","2251-6093"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319396","host_organization_name":"Knowledge E","host_organization_lineage":["https://openalex.org/P4310319396"],"host_organization_lineage_names":["Knowledge E"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian Journal of Public Health","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11188656","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11188656","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11188656/pdf/IJPH-53-1164.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Public Health","raw_type":"Text"},{"id":"pmid:38912155","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38912155","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian journal of public health","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.18502/ijph.v53i5.15598","doi":"https://doi.org/10.18502/ijph.v53i5.15598","is_oa":true,"landing_page_url":"https://doi.org/10.18502/ijph.v53i5.15598","pdf_url":null,"source":{"id":"https://openalex.org/S4210187943","display_name":"Iranian Journal of Public Health","issn_l":"0304-4556","issn":["0304-4556","2251-6085","2251-6093"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319396","host_organization_name":"Knowledge E","host_organization_lineage":["https://openalex.org/P4310319396"],"host_organization_lineage_names":["Knowledge E"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian Journal of Public Health","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321389","display_name":"Islamic Azad University","ror":"https://ror.org/01kzn7k21"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1606653994","https://openalex.org/W1862292403","https://openalex.org/W1893584805","https://openalex.org/W1948266836","https://openalex.org/W1990359808","https://openalex.org/W1996600340","https://openalex.org/W2004172747","https://openalex.org/W2010012244","https://openalex.org/W2013313605","https://openalex.org/W2014610388","https://openalex.org/W2030911950","https://openalex.org/W2035213975","https://openalex.org/W2039606711","https://openalex.org/W2043486373","https://openalex.org/W2043780904","https://openalex.org/W2072356428","https://openalex.org/W2091042488","https://openalex.org/W2091209624","https://openalex.org/W2096528675","https://openalex.org/W2101485813","https://openalex.org/W2106357158","https://openalex.org/W2114383470","https://openalex.org/W2125280578","https://openalex.org/W2135232490","https://openalex.org/W2143181288","https://openalex.org/W2145571102","https://openalex.org/W2154551754","https://openalex.org/W2221837786","https://openalex.org/W2538948871","https://openalex.org/W2560000204","https://openalex.org/W2756832185","https://openalex.org/W2760403167","https://openalex.org/W2804864274","https://openalex.org/W2899117337","https://openalex.org/W2910969205","https://openalex.org/W2980103372","https://openalex.org/W4211199921"],"related_works":["https://openalex.org/W3021549807","https://openalex.org/W2945404240","https://openalex.org/W3126651784","https://openalex.org/W3130963566","https://openalex.org/W1981181520","https://openalex.org/W2793238663","https://openalex.org/W4293538911","https://openalex.org/W7098947188","https://openalex.org/W2981473247","https://openalex.org/W2066389184"],"abstract_inverted_index":{"Background:":[0],"Sodium":[1],"butyrate":[2],"(NaBu)":[3],"is":[4,10,232],"a":[5,147,168,194,243],"short-chain":[6],"fatty":[7],"acid;":[8],"it":[9],"one":[11],"of":[12,33,38,72,102,132,153,174,191,200,214,228,239],"the":[13,31,36,91,99,137,151,154,172,175,198,201,226],"histone":[14,235],"deacetylase":[15],"inhibitors,":[16],"which":[17],"can":[18],"alter":[19],"both":[20],"genetic":[21],"and":[22,41,82,105,123,129,157,178,204,217,225],"epigenetic":[23],"expressions.":[24],"The":[25,212,237],"present":[26],"study":[27,52],"aimed":[28],"to":[29,76,97,136],"elucidate":[30],"effect":[32],"NaBu":[34,73,142,166,187,240],"on":[35],"expression":[37,101,152,173,199,219],"miR-21,":[39,103,155,176,202,215],"miR-143,":[40,104,156,177,203,216],"miR-145":[42,158,179,205,218],"in":[43,55,150,171,197],"human":[44],"colorectal":[45],"cancer":[46],"HCT-116":[47,64,117],"cell":[48,65],"lines.":[49],"Methods:":[50],"This":[51],"was":[53,67,87,95,118],"done":[54],"Tehran":[56],"Medical":[57],"Sciences,":[58],"Islamic":[59],"Azad":[60],"University,":[61],"Tehran,":[62],"Iran.":[63],"line":[66],"treated":[68,182],"with":[69,184,207],"diverse":[70],"concentrations":[71],"(6.25":[74],"mM":[75,125,141,165,186],"200":[77],"mM)":[78],"at":[79],"24,":[80,127],"48,":[81,128],"72":[83,130,189],"h.":[84],"MTT":[85,113],"assay":[86],"used":[88],"for":[89,116,126,246,251],"assessing":[90],"cytotoxicity.":[92],"Quantitative":[93],"Real-Time-PCR":[94,138],"performed":[96],"investigate":[98],"gene":[100],"miR-145.":[106],"Results:":[107],"IC50":[108,115],"values":[109],"were":[110],"evaluated":[111],"by":[112,222,234],"assay.":[114],"50":[119,140],"mM,":[120,122],"12.5":[121,164],"6.25":[124,185],"h":[131,145,190],"incubation,":[133,163],"respectively.":[134],"According":[135],"results,":[139],"after":[143,188],"24":[144],"caused":[146,167,193],"significant":[148,169,195],"up-regulation":[149,170,196],"(P<0.05).":[159,180,210],"In":[160,181],"48":[161],"h,":[162],"cells":[183,209],"incubation":[192],"compared":[206],"untreated":[208],"Conclusion:":[211],"upregulation":[213],"are":[220],"mediated":[221],"transcriptional":[223],"regulation":[224],"activation":[227],"this":[229],"miR":[230],"promoter":[231],"modulated":[233],"acetylation.":[236],"employment":[238],"may":[241],"represent":[242],"promising":[244],"approach":[245],"improving":[247],"HDACi":[248],"drug-based":[249],"therapies":[250],"colon":[252],"cancers.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2024-06-02T00:00:00"}