{"id":"https://openalex.org/W4399123760","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.108","title":"Circulating tumor DNA analysis guiding adjuvant therapy in stage II colon cancer: Overall survival and updated 5-year results from the randomized DYNAMIC trial.","display_name":"Circulating tumor DNA analysis guiding adjuvant therapy in stage II colon cancer: Overall survival and updated 5-year results from the randomized DYNAMIC trial.","publication_year":2024,"publication_date":"2024-05-29","ids":{"openalex":"https://openalex.org/W4399123760","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.108"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2024.42.16_suppl.108","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.108","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2024.42.16_suppl.108","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075700550","display_name":"Jeanne Tie","orcid":"https://orcid.org/0000-0001-9244-2057","observed_orcids":["https://orcid.org/0000-0001-9244-2057"]},"institutions":[{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]},{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jeanne Tie","raw_affiliation_strings":["Department of Medical Oncology, Peter MacCallum Cancer Centre and Personalised Oncology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Peter MacCallum Cancer Centre and Personalised Oncology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia","institution_ids":["https://openalex.org/I196021976","https://openalex.org/I2800555584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100375980","display_name":"Yuxuan Wang","orcid":"https://orcid.org/0000-0002-2932-6042","observed_orcids":["https://orcid.org/0000-0002-2932-6042"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuxuan Wang","raw_affiliation_strings":["Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040969461","display_name":"Serigne Lo","orcid":"https://orcid.org/0000-0001-5092-5544","observed_orcids":["https://orcid.org/0000-0001-5092-5544"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I4210118383","display_name":"Melanoma Institute Australia","ror":"https://ror.org/02jxrhq31","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210118383"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Serigne N Lo","raw_affiliation_strings":["Melanoma Institute Australia, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melanoma Institute Australia, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I4210118383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039890022","display_name":"Kamel Lahouel","orcid":"https://orcid.org/0000-0002-4339-5749","observed_orcids":["https://orcid.org/0000-0002-4339-5749"]},"institutions":[{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kamel Lahouel","raw_affiliation_strings":["Center for Cancer Prevention and Early Detection, City of Hope, Phoenix, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Prevention and Early Detection, City of Hope, Phoenix, AZ","institution_ids":["https://openalex.org/I4210110459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025323401","display_name":"Joshua David Cohen","orcid":"https://orcid.org/0000-0003-1158-5668","observed_orcids":["https://orcid.org/0000-0003-1158-5668"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua D. Cohen","raw_affiliation_strings":["Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090229354","display_name":"Rachel Wong","orcid":"https://orcid.org/0000-0002-4926-5689","observed_orcids":["https://orcid.org/0000-0002-4926-5689"]},"institutions":[{"id":"https://openalex.org/I4210098920","display_name":"Eastern Health","ror":"https://ror.org/00vyyx863","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210098920"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Rachel Wong","raw_affiliation_strings":["Eastern Health & Epworth Healthcare & Eastern Health Clinical School, Monash University, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eastern Health & Epworth Healthcare & Eastern Health Clinical School, Monash University, Melbourne, Australia","institution_ids":["https://openalex.org/I4210098920","https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086640363","display_name":"Jeremy David Shapiro","orcid":"https://orcid.org/0009-0007-9290-8145","observed_orcids":["https://orcid.org/0009-0007-9290-8145"]},"institutions":[{"id":"https://openalex.org/I4210093052","display_name":"Cabrini Hospital","ror":"https://ror.org/00qbkg805","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210093052"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jeremy David Shapiro","raw_affiliation_strings":["Cabrini Health, Melbourne, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cabrini Health, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I4210093052"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Samuel John Harris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147384","display_name":"Bendigo Health","ror":"https://ror.org/03w6p2n94","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210147384"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Samuel John Harris","raw_affiliation_strings":["Bendigo Cancer Centre, Bendigo Health, Bendigo, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bendigo Cancer Centre, Bendigo Health, Bendigo, VIC, Australia","institution_ids":["https://openalex.org/I4210147384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112390975","display_name":"Adnan Khattak","orcid":"https://orcid.org/0000-0002-4633-3818","observed_orcids":["https://orcid.org/0000-0002-4633-3818","https://orcid.org/0009-0008-2954-119X"]},"institutions":[{"id":"https://openalex.org/I12079687","display_name":"Edith Cowan University","ror":"https://ror.org/05jhnwe22","country_code":"AU","type":"education","lineage":["https://openalex.org/I12079687"]},{"id":"https://openalex.org/I2800728469","display_name":"Fiona Stanley Hospital","ror":"https://ror.org/027p0bm56","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799506148","https://openalex.org/I2800728469","https://openalex.org/I2800882159","https://openalex.org/I4388446375","https://openalex.org/I4388482742"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Adnan Khattak","raw_affiliation_strings":["Fiona Stanley Hospital and Edith Cowan University, Perth, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fiona Stanley Hospital and Edith Cowan University, Perth, VIC, Australia","institution_ids":["https://openalex.org/I12079687","https://openalex.org/I2800728469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015610217","display_name":"Matthew Burge","orcid":"https://orcid.org/0000-0003-2562-7806","observed_orcids":["https://orcid.org/0000-0003-2562-7806"]},"institutions":[{"id":"https://openalex.org/I2799393793","display_name":"Royal Brisbane and Women's Hospital","ror":"https://ror.org/05p52kj31","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2799393793","https://openalex.org/I2801244131"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Matthew E. Burge","raw_affiliation_strings":["Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia","institution_ids":["https://openalex.org/I2799393793"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102750074","display_name":"Margaret Lee","orcid":"https://orcid.org/0000-0003-0421-6290","observed_orcids":["https://orcid.org/0000-0003-0421-6290"]},"institutions":[{"id":"https://openalex.org/I4210098920","display_name":"Eastern Health","ror":"https://ror.org/00vyyx863","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210098920"]},{"id":"https://openalex.org/I4210116486","display_name":"Western Health","ror":"https://ror.org/02p4mwa83","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210116486"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Margaret Lee","raw_affiliation_strings":["Department of Medical Oncology, Western Health, Eastern Health, Eastern Health Clinical School, Monash University, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Western Health, Eastern Health, Eastern Health Clinical School, Monash University, Melbourne, Australia","institution_ids":["https://openalex.org/I4210098920","https://openalex.org/I4210116486","https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086605611","display_name":"Marion Harris","orcid":"https://orcid.org/0000-0003-4420-1915","observed_orcids":["https://orcid.org/0000-0003-4420-1915"]},"institutions":[{"id":"https://openalex.org/I4210121067","display_name":"Monash Health","ror":"https://ror.org/02t1bej08","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210121067"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Marion Harris","raw_affiliation_strings":["Monash Health, Bentleigh East, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Monash Health, Bentleigh East, VIC, Australia","institution_ids":["https://openalex.org/I4210121067"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060453465","display_name":"Sue\u2010Anne McLachlan","orcid":"https://orcid.org/0000-0002-1072-0322","observed_orcids":["https://orcid.org/0000-0002-1072-0322"]},"institutions":[{"id":"https://openalex.org/I4210087110","display_name":"St Vincent's Hospital Melbourne","ror":"https://ror.org/001kjn539","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087110","https://openalex.org/I4210098850"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sue-Anne McLachlan","raw_affiliation_strings":["St. Vincent's Hospital, Fitzroy, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Vincent's Hospital, Fitzroy, Australia","institution_ids":["https://openalex.org/I4210087110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108840995","display_name":"Sumitra S. Ananda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sumitra Ananda","raw_affiliation_strings":["Peter MacCallum Cancer Centre and Epworth Healthcare, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peter MacCallum Cancer Centre and Epworth Healthcare, Melbourne, Australia","institution_ids":["https://openalex.org/I2800555584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011528245","display_name":"Craig R. Underhill","orcid":"https://orcid.org/0000-0001-9335-2678","observed_orcids":["https://orcid.org/0000-0001-9335-2678"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"CRAIG R UNDERHILL","raw_affiliation_strings":["Border Medical Oncology Research Unit, Albury Wodonga Regional Cancer Centre & Rural Medical School, Albury Campus, University of New South Wales, Albury-Wodonga, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Border Medical Oncology Research Unit, Albury Wodonga Regional Cancer Centre & Rural Medical School, Albury Campus, University of New South Wales, Albury-Wodonga, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037021577","display_name":"Nickolas Papadopoulos","orcid":"https://orcid.org/0000-0001-7135-7451","observed_orcids":["https://orcid.org/0000-0001-7135-7451"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nickolas Papadopoulos","raw_affiliation_strings":["Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003062527","display_name":"Cristian Tomasetti","orcid":"https://orcid.org/0000-0003-3277-4804","observed_orcids":["https://orcid.org/0000-0003-3277-4804"]},"institutions":[{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristian Tomasetti","raw_affiliation_strings":["Center for Cancer Prevention and Early Detection, City of Hope, Phoenix, AZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Prevention and Early Detection, City of Hope, Phoenix, AZ","institution_ids":["https://openalex.org/I4210110459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059462255","display_name":"Kenneth W. Kinzler","orcid":"https://orcid.org/0000-0001-5591-1176","observed_orcids":["https://orcid.org/0000-0001-5591-1176"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth W. Kinzler","raw_affiliation_strings":["Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072858943","display_name":"Bert Vogelstein","orcid":"https://orcid.org/0000-0003-0766-3854","observed_orcids":["https://orcid.org/0000-0003-0766-3854"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bert Vogelstein","raw_affiliation_strings":["Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047478386","display_name":"Peter Gibbs","orcid":"https://orcid.org/0000-0003-1423-4484","observed_orcids":["https://orcid.org/0000-0003-1423-4484"]},"institutions":[{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]},{"id":"https://openalex.org/I4210116486","display_name":"Western Health","ror":"https://ror.org/02p4mwa83","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210116486"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Peter Gibbs","raw_affiliation_strings":["Walter & Eliza Hall Institute of Medical Research and Western Health, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Walter & Eliza Hall Institute of Medical Research and Western Health, Melbourne, Australia","institution_ids":["https://openalex.org/I196021976","https://openalex.org/I4210116486"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":18,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"16_suppl","first_page":"108","last_page":"108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.6772000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.6772000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.15919999778270721,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.11739999800920486,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.9850000143051147},{"id":"https://openalex.org/keywords/stage-ii-colon-cancer","display_name":"stage II colon cancer","score":0.9670000076293945},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.9750000238418579},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7620000243186951},{"id":"https://openalex.org/keywords/recurrence-free-survival","display_name":"recurrence-free survival","score":0.9610000252723694},{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.8230000138282776},{"id":"https://openalex.org/keywords/mismatch-repair-status","display_name":"mismatch repair status","score":0.5400000214576721},{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":0.75},{"id":"https://openalex.org/keywords/fluoropyrimidine","display_name":"fluoropyrimidine","score":0.9120000004768372},{"id":"https://openalex.org/keywords/ctdna-clearance","display_name":"ctDNA clearance","score":0.8050000071525574},{"id":"https://openalex.org/keywords/non-inferiority","display_name":"non-inferiority","score":0.7080000042915344},{"id":"https://openalex.org/keywords/early-detection-of-recurrence","display_name":"early detection of recurrence","score":0.31200000643730164},{"id":"https://openalex.org/keywords/treatment-de-escalation","display_name":"treatment de-escalation","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.891907811164856},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6908833980560303},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.665347695350647},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5709299445152283},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.54599928855896},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.528958797454834},{"id":"https://openalex.org/C2777982462","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant therapy","level":3,"score":0.5148652791976929},{"id":"https://openalex.org/C2781335228","wikidata":"https://www.wikidata.org/wiki/Q19596321","display_name":"Circulating tumor DNA","level":3,"score":0.46504202485084534},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.46392664313316345},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.44260331988334656},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.423970103263855},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2024.42.16_suppl.108","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.108","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2024.42.16_suppl.108","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8299999833106995,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4251003423","https://openalex.org/W2386116568","https://openalex.org/W2944387023","https://openalex.org/W4280584969","https://openalex.org/W4361814886","https://openalex.org/W4361814952","https://openalex.org/W4361814871","https://openalex.org/W4361815103","https://openalex.org/W4361814885","https://openalex.org/W4381233175"],"abstract_inverted_index":{"108":[0],"Background:":[1],"Previous":[2],"results":[3],"of":[4,39,48,52,151,167,176,359,364,381,395,397,435,454],"the":[5,46,392,412,422,452],"DYNAMIC":[6,65],"study":[7],"demonstrated":[8],"that":[9],"a":[10,67,105,116,148,173,320,400,443],"ctDNA-guided":[11,92,103,137,188,204,401],"approach":[12,402],"versus":[13,230],"standard":[14,95,140,190,209],"management":[15,93,96,210,453],"in":[16,227,281,356,375,451],"stage":[17,40,78,406,455],"II":[18,41,71,79,407,456],"colon":[19],"cancer":[20],"(CC)":[21],"reduced":[22],"adjuvant":[23],"chemotherapy":[24],"(ACT)":[25],"use":[26,159],"without":[27],"compromising":[28],"2-year":[29],"recurrence-free":[30],"survival":[31,58,62],"(RFS).":[32],"MMR":[33,438],"status":[34],"defines":[35],"two":[36],"distinct":[37],"subsets":[38],"CC.":[42,408,457],"Here,":[43],"we":[44],"report":[45],"impact":[47,434],"ctDNA":[49,168,275,289,292,322,353,371,424,446],"burden,":[50],"end":[51],"ACT":[53,158,404,436],"(EOT)":[54],"ctDNA,":[55],"and":[56,81,132,138,160,185,189,208,253,258,296,325,361,378,383],"updated":[57],"data":[59,390,427,441],"including":[60,448],"overall":[61],"(OS).":[63],"Methods:":[64],"is":[66,428],"multi-center":[68],"randomized":[69],"phase":[70],"trial.":[72],"Eligible":[73],"patients":[74],"(pts)":[75],"had":[76,319],"resected":[77],"CC":[80],"were":[82,87,126,157,183,256,294],"suitable":[83],"for":[84,203,250,287,405,445],"ACT.":[85],"Pts":[86,309],"randomly":[88],"assigned":[89],"2:1":[90],"to":[91,199,217,242,266,304,403,430],"or":[94,110,121],"(clinician-guided":[97],"based":[98],"on":[99],"conventional":[100],"criteria).":[101],"For":[102,271,409],"management,":[104,191],"ctDNA-positive":[106,229,273,410],"result":[107],"at":[108,279],"4":[109],"7":[111],"weeks":[112],"after":[113],"surgery":[114],"with":[115,147,162,187,310,330,399],"tumor-informed":[117],"assay":[118],"prompted":[119],"oxaliplatin-based":[120],"fluoropyrimidine":[122],"ACT;":[123],"ctDNA-negative":[124,232,251],"pts":[125,233,329],"not":[127],"treated.":[128],"Between":[129],"Aug":[130,133],"2015":[131],"2019,":[134],"302":[135],"received":[136],"153":[139],"management.":[141],"The":[142,247,284],"primary":[143],"endpoint":[144,166],"was":[145,206,224,277,354,373],"RFS,":[146],"non-inferiority":[149,396],"margin":[150],"8.5%.":[152],"Pre-specified":[153],"key":[154],"secondary":[155,165],"endpoints":[156],"OS,":[161],"an":[163,368],"additional":[164,417],"clearance":[169,276,290,323,335,372],"rate.":[170],"Results:":[171],"With":[172],"median":[174],"follow-up":[175],"59.6":[177],"months":[178],"(IQR":[179],"55.0\u201361.5),":[180],"5-year":[181,201,222,248,285,342],"RFS":[182,286,327,343,398],"88%":[184],"87%":[186],"respectively":[192,260,298],"(difference":[193],"1.1%,":[194],"95%":[195,214,239,263,301],"confidence":[196],"interval,":[197],"-5.8%":[198],"8.0%).":[200],"OS":[202,223,249],"treatment":[205],"93.8%":[207],"93.3%":[211],"(HR":[212,261,299],"1.05;":[213],"CI,":[215,240,264,302],"0.47":[216],"2.37;":[218],"P":[219,244,268,306,339,349],"=":[220,245,269,340,350],"0.887).":[221],"significantly":[225],"worse":[226,326],"treated":[228,272],"untreated":[231],"(85.6%":[234],"vs":[235,291,337,345],"95.3%,":[236],"HR":[237,347],"3.30;":[238],"1.02":[241],"9.05;":[243],"0.014).":[246],"T3":[252],"T4":[254],"disease":[255],"96.0%":[257],"90.6%,":[259],"2.45;":[262],"0.65":[265],"9.25;":[267],"0.171).":[270],"pts,":[274,411],"observed":[278,374],"EOT":[280,288,423],"35/40":[282],"(87.5%).":[283],"persistence":[293],"85.2%":[295],"20.0%,":[297],"15.4;":[300],"3.91":[303],"61.0;":[305],"<":[307,331],"0.001).":[308],"\u2265":[311],"0.38":[312,332],"(the":[313],"median)":[314],"mutant":[315],"tumor":[316],"molecules":[317],"(MTM/mL)":[318],"lower":[321],"rate":[324],"than":[328],"MTM/mL":[333],"(ctDNA":[334],"75%":[336],"100%,":[338],"0.047;":[341],"58.9%":[344],"95.2%,":[346],"10.62,":[348],"0.005).":[351],"Post-op":[352],"detected":[355],"5/59":[357],"(8.5%)":[358],"dMMR":[360,382],"40/235":[362],"(17%)":[363],"pMMR":[365,384],"cases.":[366],"In":[367],"exploratory":[369],"analysis,":[370,447],"3/4":[376],"(75%)":[377],"32/36":[379],"(89%)":[380],"cases,":[385],"respectively.":[386],"Conclusions:":[387],"Mature":[388],"outcome":[389],"confirms":[391],"previous":[393],"finding":[394],"post-surgery":[413],"mutation":[414],"burden":[415],"provides":[416],"prognostic":[418],"information,":[419],"as":[420],"does":[421],"result.":[425],"Additional":[426],"needed":[429],"define":[431],"any":[432],"differential":[433],"by":[437],"status.":[439],"This":[440],"supports":[442],"role":[444],"serial":[449],"sampling,":[450],"Clinical":[458],"trial":[459],"information:":[460],"ACTRN12615000381583":[461],".":[462]},"counts_by_year":[{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":3}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}