{"id":"https://openalex.org/W4399123748","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.582","title":"Therapeutic response and outcomes with less common breast cancer subtypes in the I-SPY trial 2011-2022.","display_name":"Therapeutic response and outcomes with less common breast cancer subtypes in the I-SPY trial 2011-2022.","publication_year":2024,"publication_date":"2024-05-29","ids":{"openalex":"https://openalex.org/W4399123748","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.582"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2024.42.16_suppl.582","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.582","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2024.42.16_suppl.582","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013288976","display_name":"Alexandra Thomas","orcid":"https://orcid.org/0000-0001-9022-2229","observed_orcids":["https://orcid.org/0000-0001-9022-2229"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Thomas","raw_affiliation_strings":["Duke Cancer Institute, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Cancer Institute, Durham, NC","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4390039326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005988887","display_name":"Denise M. Wolf","orcid":"https://orcid.org/0000-0002-3676-653X","observed_orcids":["https://orcid.org/0000-0002-3676-653X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise M. Wolf","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073258435","display_name":"Ronald Balassanian","orcid":"https://orcid.org/0000-0001-5756-9052","observed_orcids":["https://orcid.org/0000-0001-5756-9052"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald Balassanian","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050450823","display_name":"Yunn\u2010Yi Chen","orcid":"https://orcid.org/0000-0002-3346-8086","observed_orcids":["https://orcid.org/0000-0002-3346-8086"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunn-Yi Chen","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063497120","display_name":"Julia Ye","orcid":"https://orcid.org/0000-0001-8970-9777","observed_orcids":["https://orcid.org/0000-0001-8970-9777"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia Ye","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047701029","display_name":"Poonam Vohra","orcid":"https://orcid.org/0000-0002-6055-4465","observed_orcids":["https://orcid.org/0000-0002-6055-4465"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Poonam Vohra","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110670748","display_name":"Evin H. Gulbahce","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evin H Gulbahce","raw_affiliation_strings":["University of Utah, Salt Lake City, UT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah, Salt Lake City, UT","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071350705","display_name":"Alexander D. Borowsky","orcid":"https://orcid.org/0000-0003-3117-9202","observed_orcids":["https://orcid.org/0000-0003-3117-9202"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander D. Borowsky","raw_affiliation_strings":["University of California, Davis, Davis, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Davis, Davis, CA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023245303","display_name":"Lamorna Brown Swigart","orcid":"https://orcid.org/0000-0003-2076-5177","observed_orcids":["https://orcid.org/0000-0003-2076-5177"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lamorna Brown Swigart","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076178845","display_name":"Gillian L. Hirst","orcid":"https://orcid.org/0000-0002-4502-0035","observed_orcids":["https://orcid.org/0000-0002-4502-0035"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gillian L. Hirst","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066744904","display_name":"Sara J. Venters","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Venters","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005007467","display_name":"Rita Nanda","orcid":"https://orcid.org/0000-0001-5248-0876","observed_orcids":["https://orcid.org/0000-0001-5248-0876"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rita Nanda","raw_affiliation_strings":["University of Chicago Medicine, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago Medicine, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046285132","display_name":"Rebecca Arielle Shatsky","orcid":"https://orcid.org/0000-0003-2289-6234","observed_orcids":["https://orcid.org/0000-0003-2289-6234"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Arielle Shatsky","raw_affiliation_strings":["University of California, San Diego, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, San Diego, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ralph D'Agostino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph D'Agostino","raw_affiliation_strings":["Wake Forest University School of Medicine, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest University School of Medicine, Winston-Salem, NC","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039388595","display_name":"Rita A. Mukhtar","orcid":"https://orcid.org/0000-0001-8079-7846","observed_orcids":["https://orcid.org/0000-0001-8079-7846"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rita A. Mukhtar","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019686954","display_name":"Sarah Hatcher","orcid":"https://orcid.org/0009-0003-9800-4789","observed_orcids":["https://orcid.org/0009-0003-9800-4789"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Hatcher","raw_affiliation_strings":["Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062190609","display_name":"Christina S. F. Yau","orcid":"https://orcid.org/0000-0002-1937-0859","observed_orcids":["https://orcid.org/0000-0002-1937-0859"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Yau","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005537242","display_name":"Angela M. DeMichele","orcid":"https://orcid.org/0000-0003-1297-4251","observed_orcids":["https://orcid.org/0000-0003-1297-4251"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela DeMichele","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014135109","display_name":"Laura van \u2018t Veer","orcid":"https://orcid.org/0000-0002-9838-8298","observed_orcids":["https://orcid.org/0000-0002-9838-8298"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura van 't Veer","raw_affiliation_strings":["Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072789687","display_name":"Laura J. Esserman","orcid":"https://orcid.org/0000-0001-9202-4568","observed_orcids":["https://orcid.org/0000-0001-9202-4568"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Esserman","raw_affiliation_strings":["Department of Surgery, University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"16_suppl","first_page":"582","last_page":"582"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer-subtypes","display_name":"breast cancer subtypes","score":0.8500000238418579},{"id":"https://openalex.org/keywords/i-spy2-trial","display_name":"I-SPY2 trial","score":0.8109999895095825},{"id":"https://openalex.org/keywords/pathological-complete-response","display_name":"pathological complete response","score":0.9010000228881836},{"id":"https://openalex.org/keywords/event-free-survival","display_name":"event-free survival","score":0.875},{"id":"https://openalex.org/keywords/metaplastic-breast-carcinoma","display_name":"metaplastic breast carcinoma","score":0.9290000200271606},{"id":"https://openalex.org/keywords/lobular-breast-carcinoma","display_name":"lobular breast cancer","score":0.9409999847412109},{"id":"https://openalex.org/keywords/mucinous-breast-cancer","display_name":"mucinous breast cancer","score":0.9829999804496765},{"id":"https://openalex.org/keywords/neuroendocrine-breast-cancer","display_name":"neuroendocrine breast cancer","score":0.9769999980926514},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.8679999709129333},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.8529999852180481},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.6190000176429749},{"id":"https://openalex.org/keywords/neoadjuvant-therapy","display_name":"neoadjuvant therapy","score":0.8040000200271606},{"id":"https://openalex.org/keywords/high-risk-breast-cancer","display_name":"high-risk breast cancer","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8801645040512085},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7308494448661804},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7045416235923767},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6892120242118835},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6465247273445129},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5422928333282471},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4934023916721344},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.43367835879325867},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4110545516014099},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32514816522598267},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.1624005138874054}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2024.42.16_suppl.582","doi":"https://doi.org/10.1200/jco.2024.42.16_suppl.582","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2024.42.16_suppl.582","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8299999833106995}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2375584271","https://openalex.org/W1997105855","https://openalex.org/W4301030387","https://openalex.org/W2414286769","https://openalex.org/W2013223288","https://openalex.org/W2994686985","https://openalex.org/W2366529083","https://openalex.org/W2092741754","https://openalex.org/W4281722959"],"abstract_inverted_index":{"582":[0],"Background:":[1],"Uncommon":[2],"histologies":[3],"are":[4,220],"over-represented":[5],"among":[6,328],"high-risk":[7,119],"breast":[8],"cancer":[9],"(BC)":[10],"and":[11,19,33,45,69,125,140,153,169,206,215,251,313,326,340],"denote":[12],"an":[13],"area":[14],"with":[15,114,179,195,232,258,294,360],"limited":[16],"trial":[17,28,60,108,371,388],"data":[18],"of":[20,36,65,135,190,268,330,347],"significant":[21],"unmet":[22],"medical":[23],"need.":[24],"To":[25],"better":[26,233],"understand":[27],"outcomes":[29],"in":[30,53,118,222,277,307,316,324,368],"this":[31,290,378],"group":[32,280,291],"identify":[34],"signals":[35],"tumor":[37,66,218],"responsiveness,":[38],"we":[39],"report":[40,86],"pathologic":[41],"complete":[42],"response":[43,74,88],"(pCR)":[44],"early":[46],"event-free":[47],"survival":[48],"(EFS)":[49],"by":[50,147,182,217],"disease":[51,87],"subtype":[52,76,151],"the":[54,58,162,174,183,223,226,278,300,308,317,369],"I-SPY2":[55,59,82,106,191],"trial.":[56],"Additionally,":[57],"currently":[61],"utilizes":[62],"a":[63,115,256,287,297,342],"combination":[64],"molecular":[67,127],"signature":[68],"receptor":[70,130,211],"status":[71],"to":[72,98,333,372],"determine":[73],"predictive":[75],"(RPS)":[77],"first":[78],"developed":[79],"from":[80],"987":[81],"patients":[83,254],"(1).":[84],"We":[85],"rates":[89,155,322],"for":[90,344,377],"those":[91],"who":[92,281],"received":[93,282],"what":[94],"is":[95],"now":[96],"known":[97],"be":[99,365],"optimal":[100],"RPS":[101,265,283,303,356],"guided":[102],"therapy.":[103],"Methods:":[104],"The":[105],"platform":[107],"tests":[109],"novel":[110,338],"agents":[111],"given":[112],"neo-adjuvantly":[113],"chemotherapy":[116],"backbone":[117],"BC":[120,335,362],"(HER2":[121],"positive,":[122],"triple":[123],"negative":[124],"high":[126],"risk":[128],"estrogen":[129],"positive":[131],"BC).":[132],"Histologic":[133],"images":[134],"research":[136],"biopsies,":[137],"local":[138],"biopsy":[139],"surgical":[141],"pathology":[142],"reports":[143],"were":[144,156,193,351],"reviewed":[145],"centrally":[146],"I-SPY":[148],"pathologists.":[149],"Receptor":[150],"distribution":[152],"pCR":[154,168,213,229,257,305,321],"summarized.":[157],"EFS":[158,170,216,234],"was":[159,171,230,310],"estimated":[160],"using":[161,173],"Kaplan":[163],"Meier":[164],"method.":[165],"Association":[166],"between":[167],"evaluated":[172],"Cox":[175],"proportional":[176],"hazard":[177],"model":[178],"significance":[180],"assessed":[181],"log":[184],"rank":[185],"test.":[186],"Results:":[187],"144/2118":[188],"(7%)":[189],"participants":[192],"identified":[194,367],"metaplastic":[196,247],"(60),":[197],"lobular":[198],"(55),":[199],"mucinous":[200],"(9),":[201],"micropapillary":[202],"(8),":[203],"neuroendocrine":[204],"(4)":[205],"other":[207,327],"(8)":[208],"BCs.":[209,349],"Tumor":[210],"status,":[212],"rate":[214,306],"type":[219],"shown":[221],"Table.":[224],"For":[225],"full":[227],"cohort,":[228],"associated":[231],"(hazard":[235],"ratio":[236],"(95%":[237],"CI):":[238],"0.12":[239],"(0.02":[240],"-":[241],"0.88),":[242],"p":[243],"=":[244],"0.01).":[245],"Within":[246],"(metapBC)":[248],"11/32":[249],"(34%)":[250],"5/28":[252],"(18%)":[253],"had":[255,286,296],"or":[259],"without":[260],"checkpoint":[261],"blockade,":[262],"respectively.":[263],"By":[264],"group,":[266],"9":[267],"18":[269],"(50%)":[270],"(13":[271],"metapBC,":[272],"3":[273],"other,":[274],"2":[275],"lobular)":[276],"HER2-Immune+":[279],"optimized":[284],"therapy":[285,354],"pCR.":[288,298],"In":[289,299],"6/13":[292],"(46%)":[293],"metapBC":[295,325],"HER2+":[301],"driven":[302],"groups,":[304],"HER+HER2orBasal":[309],"88%":[311],"(7/8)":[312],"0%":[314],"(0/3)":[315],"HER2+Luminal.":[318],"Conclusions:":[319],"High":[320],"observed":[323],"subsets":[329],"often":[331],"difficult":[332],"treat":[334],"subtypes":[336,363],"support":[337],"approaches":[339,376],"provide":[341],"roadmap":[343],"future":[345],"study":[346],"uncommon":[348,361],"Outcomes":[350],"improved":[352],"when":[353],"matched":[355],"vulnerabilities.":[357],"Participants":[358],"presenting":[359],"will":[364],"prospectively":[366],"I-SPY2.2":[370],"further":[373],"develop":[374],"effective":[375],"group.":[379],"1.":[380],"Wolf":[381],"et":[382],"al,":[383],"Cancer":[384],"Cell":[385],"2022.":[386],"Clinical":[387],"information:":[389],"NCT01042379":[390],".":[391],"[Table:":[392],"see":[393],"text]":[394]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}