{"id":"https://openalex.org/W4399119149","doi":"https://doi.org/10.1088/1758-5090/ad51a5","title":"Development of a biofabricated 3D in vitro vessel model for investigating transendothelial migration in stem cell therapy","display_name":"Development of a biofabricated 3D in vitro vessel model for investigating transendothelial migration in stem cell therapy","publication_year":2024,"publication_date":"2024-05-29","ids":{"openalex":"https://openalex.org/W4399119149","doi":"https://doi.org/10.1088/1758-5090/ad51a5","pmid":"https://pubmed.ncbi.nlm.nih.gov/38810632"},"language":"en","primary_location":{"id":"doi:10.1088/1758-5090/ad51a5","doi":"https://doi.org/10.1088/1758-5090/ad51a5","is_oa":false,"landing_page_url":"https://doi.org/10.1088/1758-5090/ad51a5","pdf_url":null,"source":{"id":"https://openalex.org/S26035906","display_name":"Biofabrication","issn_l":"1758-5082","issn":["1758-5082","1758-5090"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biofabrication","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041694002","display_name":"Mattis Wachend\u00f6rfer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mattis Wachend\u00f6rfer","raw_affiliation_strings":["Department of Dental Materials and Biomaterials Research, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany","Department of Dental Materials and Biomaterials Research, Uniklinik RWTH Aachen, Pauwelsstrasse 30, Aachen, Nordrhein-Westfalen, 52074, GERMANY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dental Materials and Biomaterials Research, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany","institution_ids":["https://openalex.org/I4210120689"]},{"raw_affiliation_string":"Department of Dental Materials and Biomaterials Research, Uniklinik RWTH Aachen, Pauwelsstrasse 30, Aachen, Nordrhein-Westfalen, 52074, GERMANY","institution_ids":["https://openalex.org/I4210120689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009952706","display_name":"Alena Lisa Palkowitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alena Lisa Palkowitz","raw_affiliation_strings":["Department of Dental Materials and Biomaterials Research, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany","Department of Dental Materials and Biomaterials Research, Uniklinik RWTH Aachen, Pauwelsstrasse 30, Aachen, Nordrhein-Westfalen, 52074, GERMANY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dental Materials and Biomaterials Research, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany","institution_ids":["https://openalex.org/I4210120689"]},{"raw_affiliation_string":"Department of Dental Materials and Biomaterials Research, Uniklinik RWTH Aachen, Pauwelsstrasse 30, Aachen, Nordrhein-Westfalen, 52074, GERMANY","institution_ids":["https://openalex.org/I4210120689"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025869893","display_name":"Horst Fischer","orcid":"https://orcid.org/0000-0003-0990-5028","observed_orcids":["https://orcid.org/0000-0003-0990-5028"]},"institutions":[{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Horst Fischer","raw_affiliation_strings":["Department of Dental Materials and Biomaterials Research, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany","Department of Dental Materials and Biomaterials Research, Uniklinik RWTH Aachen, Pauwelsstrasse 30, Aachen, Nordrhein-Westfalen, 52074, GERMANY"],"raw_orcid":"https://orcid.org/0000-0003-0990-5028","affiliations":[{"raw_affiliation_string":"Department of Dental Materials and Biomaterials Research, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany","institution_ids":["https://openalex.org/I4210120689"]},{"raw_affiliation_string":"Department of Dental Materials and Biomaterials Research, Uniklinik RWTH Aachen, Pauwelsstrasse 30, Aachen, Nordrhein-Westfalen, 52074, GERMANY","institution_ids":["https://openalex.org/I4210120689"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025869893"],"corresponding_institution_ids":["https://openalex.org/I4210120689"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":0.0937,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.23061457,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"16","issue":"3","first_page":"035028","last_page":"035028"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.025800000876188278,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.02250000089406967,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transendothelial-migration","display_name":"transendothelial migration","score":0.9750000238418579},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.8629999756813049},{"id":"https://openalex.org/keywords/fibrin-gel","display_name":"fibrin gel","score":0.9309999942779541},{"id":"https://openalex.org/keywords/vascular-endothelium","display_name":"vascular endothelium","score":0.8299999833106995},{"id":"https://openalex.org/keywords/ve-cadherin","display_name":"VE-cadherin","score":0.9169999957084656},{"id":"https://openalex.org/keywords/endothelial-barrier-function","display_name":"endothelial barrier function","score":0.843999981880188},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8169999718666077},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cxcl12","display_name":"CXCL12","score":0.9779999852180481},{"id":"https://openalex.org/keywords/mesoangioblasts","display_name":"mesoangioblasts","score":0.9679999947547913},{"id":"https://openalex.org/keywords/muscular-dystrophy","display_name":"muscular dystrophy","score":0.9580000042915344},{"id":"https://openalex.org/keywords/endothelial-cell-adhesion","display_name":"endothelial cell adhesion","score":0.7770000100135803},{"id":"https://openalex.org/keywords/shear-flow","display_name":"shear flow","score":0.47600001096725464},{"id":"https://openalex.org/keywords/two-photon-microscopy","display_name":"two-photon microscopy","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6090760231018066},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5588790774345398},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5533273220062256},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4353446662425995},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.40965893864631653},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32516908645629883},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30800506472587585},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2823250889778137},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12771642208099365},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10339021682739258}],"mesh":[{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033581","descriptor_name":"Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057705","descriptor_name":"Transendothelial and Transepithelial Migration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1088/1758-5090/ad51a5","doi":"https://doi.org/10.1088/1758-5090/ad51a5","is_oa":false,"landing_page_url":"https://doi.org/10.1088/1758-5090/ad51a5","pdf_url":null,"source":{"id":"https://openalex.org/S26035906","display_name":"Biofabrication","issn_l":"1758-5082","issn":["1758-5082","1758-5090"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biofabrication","raw_type":"journal-article"},{"id":"pmid:38810632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38810632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biofabrication","raw_type":"Journal Article"},{"id":"pmh:oai:publications.rwth-aachen.de:1008019","doi":null,"is_oa":false,"landing_page_url":"https://publications.rwth-aachen.de/record/1008019","pdf_url":null,"source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biofabrication 16(3), 035028 (2024). doi:10.1088/1758-5090/ad51a5","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7366779371","display_name":null,"funder_award_id":"EMR116","funder_id":"https://openalex.org/F4320337753","funder_display_name":"Interreg"}],"funders":[{"id":"https://openalex.org/F4320337753","display_name":"Interreg","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W20228888","https://openalex.org/W810857154","https://openalex.org/W1827878112","https://openalex.org/W1920407368","https://openalex.org/W1973145983","https://openalex.org/W1975697730","https://openalex.org/W2004253114","https://openalex.org/W2006293762","https://openalex.org/W2016975357","https://openalex.org/W2020831247","https://openalex.org/W2024451640","https://openalex.org/W2048382396","https://openalex.org/W2052318709","https://openalex.org/W2056125092","https://openalex.org/W2061140768","https://openalex.org/W2070921289","https://openalex.org/W2073275801","https://openalex.org/W2086499892","https://openalex.org/W2087018283","https://openalex.org/W2089409749","https://openalex.org/W2093158657","https://openalex.org/W2095609344","https://openalex.org/W2103883318","https://openalex.org/W2112371560","https://openalex.org/W2113561239","https://openalex.org/W2117479856","https://openalex.org/W2117752891","https://openalex.org/W2121636548","https://openalex.org/W2124298587","https://openalex.org/W2127715753","https://openalex.org/W2130040661","https://openalex.org/W2165673443","https://openalex.org/W2167871776","https://openalex.org/W2171097197","https://openalex.org/W2175927969","https://openalex.org/W2188997672","https://openalex.org/W2295454854","https://openalex.org/W2324464342","https://openalex.org/W2499221156","https://openalex.org/W2517339935","https://openalex.org/W2561499578","https://openalex.org/W2763839938","https://openalex.org/W2770671163","https://openalex.org/W2781721202","https://openalex.org/W2800059915","https://openalex.org/W2800332302","https://openalex.org/W2807117701","https://openalex.org/W2819785327","https://openalex.org/W2889308220","https://openalex.org/W2895298053","https://openalex.org/W2898326313","https://openalex.org/W2961802256","https://openalex.org/W2970873351","https://openalex.org/W2981653445","https://openalex.org/W2988253730","https://openalex.org/W2996319841","https://openalex.org/W3007566055","https://openalex.org/W3009257182","https://openalex.org/W3033757480","https://openalex.org/W3037640425","https://openalex.org/W3040462048","https://openalex.org/W3046610395","https://openalex.org/W3080940214","https://openalex.org/W3121676456","https://openalex.org/W3131782536","https://openalex.org/W3164592198","https://openalex.org/W3169179040","https://openalex.org/W3188717649","https://openalex.org/W3200603256","https://openalex.org/W3202172472","https://openalex.org/W3214988717","https://openalex.org/W4221028408","https://openalex.org/W4225552085","https://openalex.org/W4283515236","https://openalex.org/W4294068838","https://openalex.org/W4295288945","https://openalex.org/W4307309203","https://openalex.org/W4312074505","https://openalex.org/W4312311710","https://openalex.org/W4377010851"],"related_works":["https://openalex.org/W6906619309","https://openalex.org/W2724219999","https://openalex.org/W2029738015","https://openalex.org/W4286851982","https://openalex.org/W2735373016","https://openalex.org/W2907829274","https://openalex.org/W6964905471","https://openalex.org/W2111588747","https://openalex.org/W2143936011","https://openalex.org/W6962522151"],"abstract_inverted_index":{"Abstract":[0],"Systemic":[1],"stem":[2,21,56,157,191,198],"cell":[3,57,158,199],"therapies":[4],"hold":[5],"promise":[6],"for":[7,34,155],"treating":[8],"severe":[9],"diseases,":[10],"but":[11],"their":[12],"efficiency":[13],"is":[14,32,98,119,135],"hampered":[15],"by":[16,121],"limited":[17],"migration":[18,31,188],"of":[19,76,190,196],"injected":[20,164],"cells":[22,92],"across":[23],"vascular":[24,106],"endothelium":[25,103],"towards":[26],"diseased":[27],"tissues.":[28],"Understanding":[29],"transendothelial":[30,187],"crucial":[33],"improving":[35],"therapy":[36,58,159],"outcomes.":[37],"We":[38],"propose":[39],"a":[40,77,82,101,139,152,156],"novel":[41],"3D":[42,144,178],"in":[43,81,122,137,179],"vitro":[44,180],"vessel":[45,79,167],"model":[46,61,181],"that":[47],"aids":[48],"to":[49,185],"unravel":[50],"these":[51],"mechanisms":[52,189],"and":[53,93,118,142],"thereby":[54],"facilitates":[55],"development.":[59],"Our":[60,177],"simulates":[62],"inflammation":[63],"through":[64],"cytokine":[65,126],"diffusion":[66],"from":[67],"the":[68,72,143,166,194],"tissue":[69],"site":[70],"into":[71,165],"vessel.":[73],"It":[74],"consists":[75],"biofabricated":[78],"embedded":[80],"fibrin":[83],"hydrogel,":[84],"mimicking":[85],"arterial":[86],"wall":[87],"composition":[88],"with":[89,100,115],"smooth":[90],"muscle":[91],"fibroblasts.":[94],"The":[95],"perfusable":[96],"channel":[97],"lined":[99],"functional":[102],"which":[104],"expresses":[105],"endothelial":[107,171],"cadherin,":[108],"provides":[109],"an":[110],"active":[111],"barrier":[112],"function,":[113],"aligns":[114],"flow":[116,175],"direction":[117],"reconstructed":[120],"situ":[123],"two-photon-microscopy.":[124],"Inflammatory":[125],"release":[127],"(tumor":[128],"necrosis":[129],"factor":[130,133],"\u03b1,":[131],"stromal-derived":[132],"(1)":[134],"demonstrated":[136],"both":[138],"transwell":[140],"assay":[141],"model.":[145],"In":[146],"proof-of-principle":[147],"experiments,":[148],"mesoangioblasts,":[149],"known":[150],"as":[151],"promising":[153],"candidate":[154],"against":[160],"muscular":[161],"dystrophies,":[162],"are":[163],"model,":[168],"showing":[169],"shear-resistant":[170],"adhesion":[172],"under":[173],"capillary-like":[174],"conditions.":[176],"offers":[182],"significant":[183],"potential":[184],"study":[186],"cells,":[192],"facilitating":[193],"development":[195],"improved":[197],"therapies.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-05-30T00:00:00"}
