{"id":"https://openalex.org/W4399012829","doi":"https://doi.org/10.52711/0974-360x.2024.00267","title":"Impact of Penetration Enhancer and Natural Oil on Transdermal Delivery of Modified Karaya Gum Gel","display_name":"Impact of Penetration Enhancer and Natural Oil on Transdermal Delivery of Modified Karaya Gum Gel","publication_year":2024,"publication_date":"2024-04-22","ids":{"openalex":"https://openalex.org/W4399012829","doi":"https://doi.org/10.52711/0974-360x.2024.00267"},"language":"en","primary_location":{"id":"doi:10.52711/0974-360x.2024.00267","doi":"https://doi.org/10.52711/0974-360x.2024.00267","is_oa":false,"landing_page_url":"https://doi.org/10.52711/0974-360x.2024.00267","pdf_url":null,"source":{"id":"https://openalex.org/S4210228335","display_name":"Research Journal of Pharmacy and Technology","issn_l":"0974-360X","issn":["0974-360X","0974-3618"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Journal of Pharmacy and Technology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057371048","display_name":"Nimmathota Madhavi","orcid":"https://orcid.org/0000-0002-0458-7406","observed_orcids":["https://orcid.org/0000-0002-0458-7406"]},"institutions":[{"id":"https://openalex.org/I10874241","display_name":"Jawaharlal Nehru Technological University, Hyderabad","ror":"https://ror.org/002tchr49","country_code":"IN","type":"education","lineage":["https://openalex.org/I10874241"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nimmathota Madhavi","raw_affiliation_strings":["Department of Pharmaceutics, CMR College of Pharmacy,  Affiliated to JNTUH, Hyderabad, Telangana, India - 501401"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, CMR College of Pharmacy,  Affiliated to JNTUH, Hyderabad, Telangana, India - 501401","institution_ids":["https://openalex.org/I10874241"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056331650","display_name":"Beeravelli Sudhakar","orcid":"https://orcid.org/0000-0002-6565-0472","observed_orcids":["https://orcid.org/0000-0002-6565-0472"]},"institutions":[{"id":"https://openalex.org/I100887729","display_name":"Andhra University","ror":"https://ror.org/049skhf47","country_code":"IN","type":"education","lineage":["https://openalex.org/I100887729"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Beeravelli Sudhakar","raw_affiliation_strings":["Department of Pharmaceutics, AU College of Pharmaceutical Science,  Andhra University, Visakhapatnam, Andhra Pradesh - 530003, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, AU College of Pharmaceutical Science,  Andhra University, Visakhapatnam, Andhra Pradesh - 530003, India","institution_ids":["https://openalex.org/I100887729"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1582,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.33437622,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":"1685","last_page":"1691"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/etodolac","display_name":"etodolac","score":0.9330000281333923},{"id":"https://openalex.org/keywords/peanut-oil","display_name":"peanut oil","score":0.8989999890327454},{"id":"https://openalex.org/keywords/transdermal-drug-delivery","display_name":"transdermal drug delivery","score":0.9229999780654907},{"id":"https://openalex.org/keywords/skin-penetration-enhancers","display_name":"skin penetration enhancers","score":0.7170000076293945},{"id":"https://openalex.org/keywords/topical-gel-formulation","display_name":"topical gel formulation","score":0.6679999828338623},{"id":"https://openalex.org/keywords/treatment-of-inflammation","display_name":"inflammation treatment","score":0.5839999914169312},{"id":"https://openalex.org/keywords/in-vitro-drug-release","display_name":"in vitro drug release","score":0.6840000152587891},{"id":"https://openalex.org/keywords/gel-viscosity","display_name":"gel viscosity","score":0.7009999752044678},{"id":"https://openalex.org/keywords/drug-excipient-compatibility","display_name":"drug-excipient compatibility","score":0.906000018119812}],"concepts":[{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.8211816549301147},{"id":"https://openalex.org/C80107235","wikidata":"https://www.wikidata.org/wiki/Q7162625","display_name":"Penetration (warfare)","level":2,"score":0.6015240550041199},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.46037110686302185},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4420264959335327},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4341149926185608},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.4173828065395355},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3626391887664795},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3571207523345947},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32465803623199463},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32437795400619507},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11552160978317261},{"id":"https://openalex.org/C42475967","wikidata":"https://www.wikidata.org/wiki/Q194292","display_name":"Operations research","level":1,"score":0.08044871687889099},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.52711/0974-360x.2024.00267","doi":"https://doi.org/10.52711/0974-360x.2024.00267","is_oa":false,"landing_page_url":"https://doi.org/10.52711/0974-360x.2024.00267","pdf_url":null,"source":{"id":"https://openalex.org/S4210228335","display_name":"Research Journal of Pharmacy and Technology","issn_l":"0974-360X","issn":["0974-360X","0974-3618"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Journal of Pharmacy and Technology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W2025905362","https://openalex.org/W2060929621","https://openalex.org/W2074223886","https://openalex.org/W2095505433","https://openalex.org/W2278873923","https://openalex.org/W2281338616","https://openalex.org/W2328305290","https://openalex.org/W2906440379","https://openalex.org/W2911845838","https://openalex.org/W3021217373","https://openalex.org/W3036758157","https://openalex.org/W4310209576","https://openalex.org/W4310980318"],"related_works":["https://openalex.org/W2112557421","https://openalex.org/W3033069657","https://openalex.org/W4205665639","https://openalex.org/W2159874258","https://openalex.org/W2890669347","https://openalex.org/W4404830368","https://openalex.org/W1522472419","https://openalex.org/W2153594456","https://openalex.org/W2409833063","https://openalex.org/W2591749906"],"abstract_inverted_index":{"The":[0,39,103,122],"etodolac":[1,86,90,138],"based":[2],"modified":[3],"karaya":[4],"gum":[5],"(MKG)":[6],"gel":[7,20,87],"was":[8,44,70,120],"developed":[9],"using":[10,35],"32":[11,36],"factorial":[12,37],"design":[13],"to":[14,21,51,62,72,78],"enhance":[15],"the":[16,47,57,93,126,135,144,152],"therapeutic":[17,153],"effect":[18,154],"of":[19,30,41,49,59,76,85,128,137,146,155],"treat":[22],"inflammation.":[23],"Gels":[24],"were":[25,97,133],"prepared":[26],"with":[27],"different":[28],"concentrations":[29],"MKG":[31,129],"and":[32,65,88,100,105,130,148],"arachis":[33,131],"oil":[34,132,149],"design.":[38],"percentage":[40],"drug":[42,68,104],"content":[43],"found":[45,71],"in":[46,56,66,74],"range":[48,58,75],"96":[50],"99%,":[52],"viscosity":[53],"results":[54,123],"shown":[55,98],"842":[60],"CPS":[61,64],"2560":[63],"vitro":[67],"release":[69],"be":[73],"38%":[77],"98%":[79],"respectively.":[80,102],"Whereas":[81],"ex-vivo":[82],"permeation":[83],"studies":[84,108],"pure":[89],"solution":[91],"across":[92],"burned":[94,140],"pig":[95,141],"skin":[96,142],"72%":[99],"42%":[101],"excipient":[106],"compatibility":[107],"by":[109],"FTIR":[110],"confirms":[111],"that,":[112,125],"there":[113],"is":[114],"no":[115],"major":[116],"functional":[117],"group":[118],"change":[119],"observed.":[121],"concluded":[124],"combination":[127,145],"improved":[134],"penetration":[136],"through":[139],"thereby":[143],"PE":[147],"successfully":[150],"enhanced":[151],"etodolac.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-05T08:02:43.246662","created_date":"2024-05-26T00:00:00"}