{"id":"https://openalex.org/W439849972","doi":"https://doi.org/10.14670/hh-23.67","title":"Abeta deposition and related pathology in an APP x PS1 transgenic mouse model of Alzheimer's disease.","display_name":"Abeta deposition and related pathology in an APP x PS1 transgenic mouse model of Alzheimer's disease.","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W439849972","doi":"https://doi.org/10.14670/hh-23.67","mag":"439849972","pmid":"https://pubmed.ncbi.nlm.nih.gov/17952859"},"language":"en","primary_location":{"id":"pmid:17952859","doi":"https://doi.org/10.14670/hh-23.67","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17952859","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histology and histopathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10201/29776","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039213849","display_name":"David R Howlett","orcid":"https://orcid.org/0000-0003-4532-7990","observed_orcids":["https://orcid.org/0000-0003-4532-7990"]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D R Howlett","raw_affiliation_strings":["Neurology & GI CEDD, GlaxoSmithKline, Harlow, Essex, UK. david.r.howlett@gsk.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology & GI CEDD, GlaxoSmithKline, Harlow, Essex, UK. david.r.howlett@gsk.com","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113620304","display_name":"Kenneth Bowler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Bowler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084163133","display_name":"Peter E. Soden","orcid":"https://orcid.org/0000-0001-7757-9354","observed_orcids":["https://orcid.org/0000-0001-7757-9354"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P E Soden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016732315","display_name":"David R. Riddell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Riddell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110858195","display_name":"J B Davis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J B Davis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062777125","display_name":"Jill C. Richardson","orcid":"https://orcid.org/0000-0001-6564-3187","observed_orcids":["https://orcid.org/0000-0001-6564-3187"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J C Richardson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017412737","display_name":"Stephen A. Burbidge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S A Burbidge","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100644073","display_name":"Mar\u00eda Isabel Gonz\u00e1lez","orcid":"https://orcid.org/0000-0003-1743-2005","observed_orcids":["https://orcid.org/0000-0003-1743-2005"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M I Gonzalez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111791301","display_name":"Elaine A Irving","orcid":"https://orcid.org/0000-0003-3437-2526","observed_orcids":["https://orcid.org/0000-0003-3437-2526"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E A Irving","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021989943","display_name":"A Lawman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Lawman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058390513","display_name":"Gianluca Miglio","orcid":"https://orcid.org/0000-0002-6602-2099","observed_orcids":["https://orcid.org/0000-0002-6602-2099"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Miglio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073155383","display_name":"Emma L. Dawson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E L Dawson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004602976","display_name":"E R Howlett","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E R Howlett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5051338550","display_name":"Ishrut Hussain","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Hussain","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4998,"has_fulltext":true,"cited_by_count":65,"citation_normalized_percentile":{"value":0.87890952,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"23","issue":"1","first_page":"67","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9559999704360962},{"id":"https://openalex.org/keywords/amyloid-beta-deposition","display_name":"amyloid-beta deposition","score":0.7049999833106995},{"id":"https://openalex.org/keywords/app-ps1-mice","display_name":"APP/PS1 mice","score":0.8669999837875366},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.8029999732971191},{"id":"https://openalex.org/keywords/presenilin-1","display_name":"presenilin 1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.8180000185966492},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.625},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/phosphorylated-tau","display_name":"phosphorylated tau","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cathepsin-d","display_name":"cathepsin D","score":1.0},{"id":"https://openalex.org/keywords/neuronal-loss","display_name":"neuronal loss","score":0.9380000233650208},{"id":"https://openalex.org/keywords/disease-markers","display_name":"disease markers","score":0.42100000381469727},{"id":"https://openalex.org/keywords/familial-alzheimer-s-disease","display_name":"familial Alzheimer's disease","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.7647317051887512},{"id":"https://openalex.org/C175344181","wikidata":"https://www.wikidata.org/wiki/Q907198","display_name":"Presenilin","level":4,"score":0.6681079864501953},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6501827239990234},{"id":"https://openalex.org/C173633252","wikidata":"https://www.wikidata.org/wiki/Q3663475","display_name":"Cathepsin D","level":3,"score":0.5566565990447998},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5398364067077637},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5093141794204712},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5092881917953491},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.4986765384674072},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.48509037494659424},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4703678786754608},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2827029824256897},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2609279751777649},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.22608554363250732},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1107165515422821},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002402","descriptor_name":"Cathepsin D","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002402","descriptor_name":"Cathepsin D","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"pmid:17952859","doi":"https://doi.org/10.14670/hh-23.67","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17952859","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histology and histopathology","raw_type":"Journal Article"},{"id":"pmh:oai:digitum.um.es:10201/29776","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10201/29776","pdf_url":"http://hdl.handle.net/10201/29776","source":{"id":"https://openalex.org/S4306401267","display_name":"Digitum: Institutional Repository of the University of Murcia (University of Murcia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80180929","host_organization_name":"Universidad de Murcia","host_organization_lineage":["https://openalex.org/I80180929"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dnet:digitum_____::6b1c45c89baefeea84e1d59d046d2d08","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10201/29776","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:hispana.mcu.es:61703595","doi":null,"is_oa":true,"landing_page_url":"https://hispana.mcu.es/es/registros/registro.do?tipoRegistro=MTD&idBib=61703595","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unito.it:2318/26819","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2318/26819","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:439849972","doi":"https://doi.org/10.14670/hh-23.67","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17952859","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitum.um.es:10201/29776","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10201/29776","pdf_url":"http://hdl.handle.net/10201/29776","source":{"id":"https://openalex.org/S4306401267","display_name":"Digitum: Institutional Repository of the University of Murcia (University of Murcia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80180929","host_organization_name":"Universidad de Murcia","host_organization_lineage":["https://openalex.org/I80180929"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W439849972.pdf","grobid_xml":"https://content.openalex.org/works/W439849972.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W149130878","https://openalex.org/W1511142149","https://openalex.org/W1517477926","https://openalex.org/W1556113948","https://openalex.org/W1678111194","https://openalex.org/W1918909705","https://openalex.org/W1929267935","https://openalex.org/W1967464880","https://openalex.org/W1968286122","https://openalex.org/W1971003242","https://openalex.org/W1972979638","https://openalex.org/W1976128767","https://openalex.org/W1987365479","https://openalex.org/W1994925004","https://openalex.org/W1995344309","https://openalex.org/W2001210466","https://openalex.org/W2005069707","https://openalex.org/W2006687131","https://openalex.org/W2009266531","https://openalex.org/W2010259789","https://openalex.org/W2024264974","https://openalex.org/W2044126898","https://openalex.org/W2048622057","https://openalex.org/W2062214806","https://openalex.org/W2073724760","https://openalex.org/W2077464099","https://openalex.org/W2100791245","https://openalex.org/W2122185558","https://openalex.org/W2126800086","https://openalex.org/W2140131793","https://openalex.org/W2153747061","https://openalex.org/W2156326104"],"related_works":["https://openalex.org/W7026356574","https://openalex.org/W2144212564","https://openalex.org/W2585905449","https://openalex.org/W78012508","https://openalex.org/W1971003242","https://openalex.org/W1995344309","https://openalex.org/W2884150787","https://openalex.org/W1977002082","https://openalex.org/W137550786","https://openalex.org/W2010489018"],"abstract_inverted_index":{"A":[0],"transgenic":[1],"mouse":[2],"bearing":[3],"mutant":[4],"transgenes":[5],"linked":[6],"to":[7,148],"familial":[8],"forms":[9,81],"of":[10,38,82,100,108,127,130,140,151,160,167,174,182,190,194,206],"Alzheimer's":[11],"disease":[12,143,195,215],"(AD)":[13],"for":[14,204],"the":[15,72,95,106,116,149,152,163,172,180,191],"amyloid":[16],"precursor":[17],"protein":[18],"and":[19,26,89,121,129,133,154,165,199],"presenilin-1":[20],"(TASTPM)":[21],"showed":[22,78,137],"Abeta":[23,35,67,83,96,156,175],"plaque":[24,88],"deposition":[25,176],"age-related":[27],"histological":[28],"changes":[29],"in":[30,61,71,86,112,146,162,197],"associated":[31,178],"brain":[32],"pathology.":[33],"The":[34,125],"present":[36,70,85,111],"was":[37,68,98,118],"multiple":[39],"forms,":[40],"including":[41],"species":[42],"with":[43,94,115,155,179],"a":[44,62,188,202],"C-terminus":[45],"at":[46,56],"position":[47,57],"40":[48],"or":[49,59,213],"42,":[50],"as":[51,53],"well":[52],"an":[54,101],"N-terminus":[55],"1":[58],"truncated":[60],"pyro-3-glutamate":[63],"form.":[64],"Endogenous":[65],"rodent":[66],"also":[69],"deposits.":[73],"Laser":[74],"capture":[75],"microdissection":[76],"extracts":[77],"that":[79,138,171],"multimeric":[80],"were":[84,177],"both":[87,139],"tissue":[90],"surrounding":[91],"plaques.":[92],"Associated":[93],"deposits":[97,117],"evidence":[99],"inflammatory":[102],"response":[103],"characterised":[104],"by":[105],"presence":[107],"astrocytes.":[109],"Also":[110],"close":[113],"association":[114],"phosphorylated":[119,131],"tau":[120,132],"cathepsin":[122,134],"D":[123,135],"immunolabelling.":[124],"incidence":[126],"astrocytes":[128],"load":[136],"these":[141],"potential":[142],"markers":[144],"increased":[145],"parallel":[147],"age":[150],"mice":[153,169],"deposition.":[157],"Immunohistochemical":[158],"labelling":[159],"neurons":[161],"cortex":[164],"hippocampus":[166],"TASTPM":[168,184],"suggested":[170],"areas":[173],"loss":[181],"neurons.":[183],"mice,":[185],"therefore,":[186],"exhibit":[187],"number":[189],"pathological":[192],"characteristics":[193],"progression":[196],"AD":[198],"may":[200],"provide":[201],"means":[203],"assessment":[205],"novel":[207],"therapeutic":[208],"agents":[209],"directed":[210],"towards":[211],"modifying":[212],"halting":[214],"progression.":[216]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
