{"id":"https://openalex.org/W4398250652","doi":"https://doi.org/10.1073/pnas.2400648121","title":"Astrocyte-to-microglia communication via Sema4B-Plexin-B2 modulates injury-induced reactivity of microglia","display_name":"Astrocyte-to-microglia communication via Sema4B-Plexin-B2 modulates injury-induced reactivity of microglia","publication_year":2024,"publication_date":"2024-05-23","ids":{"openalex":"https://openalex.org/W4398250652","doi":"https://doi.org/10.1073/pnas.2400648121","pmid":"https://pubmed.ncbi.nlm.nih.gov/38781210","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11145257"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2400648121","doi":"https://doi.org/10.1073/pnas.2400648121","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2400648121","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1073/pnas.2400648121","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062802816","display_name":"Natania Casden","orcid":"https://orcid.org/0000-0003-2207-0790","observed_orcids":["https://orcid.org/0000-0003-2207-0790"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Natania Casden","raw_affiliation_strings":["Department of Developmental Biology and Cancer Research, The Institute for Medical Research-Israel-Canada, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology and Cancer Research, The Institute for Medical Research-Israel-Canada, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054274799","display_name":"Vitali Belzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Vitali Belzer","raw_affiliation_strings":["Department of Developmental Biology and Cancer Research, The Institute for Medical Research-Israel-Canada, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology and Cancer Research, The Institute for Medical Research-Israel-Canada, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093223359","display_name":"Abdellatif El Khayari","orcid":"https://orcid.org/0000-0002-2803-5024","observed_orcids":["https://orcid.org/0000-0002-2803-5024"]},"institutions":[{"id":"https://openalex.org/I4210131560","display_name":"Universit\u00e9 Mohammed VI Polytechnique","ror":"https://ror.org/03xc55g68","country_code":"MA","type":"education","lineage":["https://openalex.org/I4210131560"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Abdellatif El Khayari","raw_affiliation_strings":["Institute of Biological Sciences (ISSB-P), UM6P Faculty of Medical Sciences, Mohammed VI Polytechnic University, Ben-Guerir 43150, Morocco"],"raw_orcid":"https://orcid.org/0000-0002-2803-5024","affiliations":[{"raw_affiliation_string":"Institute of Biological Sciences (ISSB-P), UM6P Faculty of Medical Sciences, Mohammed VI Polytechnic University, Ben-Guerir 43150, Morocco","institution_ids":["https://openalex.org/I4210131560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057070305","display_name":"Rachid El Fatimy","orcid":"https://orcid.org/0000-0002-7652-5562","observed_orcids":["https://orcid.org/0000-0002-7652-5562"]},"institutions":[{"id":"https://openalex.org/I4210131560","display_name":"Universit\u00e9 Mohammed VI Polytechnique","ror":"https://ror.org/03xc55g68","country_code":"MA","type":"education","lineage":["https://openalex.org/I4210131560"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Rachid El Fatimy","raw_affiliation_strings":["Institute of Biological Sciences (ISSB-P), UM6P Faculty of Medical Sciences, Mohammed VI Polytechnic University, Ben-Guerir 43150, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biological Sciences (ISSB-P), UM6P Faculty of Medical Sciences, Mohammed VI Polytechnic University, Ben-Guerir 43150, Morocco","institution_ids":["https://openalex.org/I4210131560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007715670","display_name":"Oded Behar","orcid":"https://orcid.org/0000-0001-6913-2827","observed_orcids":["https://orcid.org/0000-0001-6913-2827"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Oded Behar","raw_affiliation_strings":["Department of Developmental Biology and Cancer Research, The Institute for Medical Research-Israel-Canada, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel"],"raw_orcid":"https://orcid.org/0000-0001-6913-2827","affiliations":[{"raw_affiliation_string":"Department of Developmental Biology and Cancer Research, The Institute for Medical Research-Israel-Canada, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel","institution_ids":["https://openalex.org/I197251160"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007715670"],"corresponding_institution_ids":["https://openalex.org/I197251160"],"apc_list":null,"apc_paid":null,"fwci":2.9119,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.91176166,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"121","issue":"22","first_page":"e2400648121","last_page":"e2400648121"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plexin-b2","display_name":"Plexin-B2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/central-nervous-system-injury","display_name":"central nervous system injury","score":0.8389999866485596},{"id":"https://openalex.org/keywords/neuronal-death","display_name":"neuronal cell death","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cytokine-expression","display_name":"cytokine expression","score":0.925000011920929},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.9384692907333374},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.5385634899139404},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.5206558108329773},{"id":"https://openalex.org/C2779841796","wikidata":"https://www.wikidata.org/wiki/Q1188964","display_name":"Plexin","level":4,"score":0.5134921669960022},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4513704478740692},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43341392278671265},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.42805713415145874},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.40319138765335083},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.39374399185180664},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3822295069694519},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3276800811290741},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2912343740463257},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2584001421928406},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22681710124015808},{"id":"https://openalex.org/C132538176","wikidata":"https://www.wikidata.org/wiki/Q24768287","display_name":"Semaphorin","level":3,"score":0.19368866086006165},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16722410917282104},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0904618501663208},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D039961","descriptor_name":"Semaphorins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D039961","descriptor_name":"Semaphorins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.2400648121","doi":"https://doi.org/10.1073/pnas.2400648121","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2400648121","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"doi:10.1101/2023.11.07.565986","doi":"https://doi.org/10.1101/2023.11.07.565986","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.11.07.565986","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/11/07/2023.11.07.565986.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11145257","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11145257","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11145257/pdf/pnas.202400648.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:38781210","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38781210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1073/pnas.2400648121","doi":"https://doi.org/10.1073/pnas.2400648121","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2400648121","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G402878478","display_name":null,"funder_award_id":"401/19","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320321950","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4398250652.pdf","grobid_xml":"https://content.openalex.org/works/W4398250652.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1608593799","https://openalex.org/W1847813778","https://openalex.org/W1977584759","https://openalex.org/W1987037769","https://openalex.org/W1989020899","https://openalex.org/W2002875429","https://openalex.org/W2015220242","https://openalex.org/W2027467386","https://openalex.org/W2036897871","https://openalex.org/W2047166961","https://openalex.org/W2049201207","https://openalex.org/W2054275187","https://openalex.org/W2110417468","https://openalex.org/W2116063788","https://openalex.org/W2123106337","https://openalex.org/W2130410032","https://openalex.org/W2134526812","https://openalex.org/W2149756088","https://openalex.org/W2152866851","https://openalex.org/W2153406260","https://openalex.org/W2169456326","https://openalex.org/W2172620322","https://openalex.org/W2179438025","https://openalex.org/W2280077905","https://openalex.org/W2554390311","https://openalex.org/W2776223742","https://openalex.org/W2788807220","https://openalex.org/W2806807230","https://openalex.org/W2901838561","https://openalex.org/W2949193645","https://openalex.org/W2964723434","https://openalex.org/W2977837563","https://openalex.org/W3008198525","https://openalex.org/W3049429323","https://openalex.org/W3083733923","https://openalex.org/W3107395714","https://openalex.org/W3132240972","https://openalex.org/W3163835391","https://openalex.org/W3192196157","https://openalex.org/W4200544872","https://openalex.org/W4247372657","https://openalex.org/W4308150510","https://openalex.org/W4310490584"],"related_works":["https://openalex.org/W2172620322","https://openalex.org/W4310490584","https://openalex.org/W7095913623","https://openalex.org/W2036021162","https://openalex.org/W2026618938","https://openalex.org/W2060027469","https://openalex.org/W3122216389","https://openalex.org/W6939624762","https://openalex.org/W4385969648","https://openalex.org/W1847813778"],"abstract_inverted_index":{"After":[0],"central":[1],"nervous":[2],"system":[3],"injury,":[4,68,91,167,192],"a":[5,39,52,97,187],"rapid":[6],"cellular":[7],"and":[8,19,29,77,144,174],"molecular":[9],"response":[10,14,197],"is":[11,71,80,103,123,163],"induced.":[12],"This":[13],"can":[15],"be":[16],"both":[17,172],"beneficial":[18],"detrimental":[20],"to":[21,50,113,138,203],"neuronal":[22,55,145],"survival":[23],"in":[24,54,73,105,132,154,189],"the":[25,31,86,106,124,169,179,196],"first":[26],"few":[27],"days":[28],"increases":[30],"risk":[32],"for":[33],"neurodegeneration":[34],"if":[35],"persistent.":[36],"Semaphorin4B":[37],"(Sema4B),":[38],"transmembrane":[40],"protein":[41],"primarily":[42],"expressed":[43],"by":[44],"cortical":[45,65,151],"astrocytes,":[46],"has":[47],"been":[48],"shown":[49],"play":[51],"role":[53],"cell":[56,146],"death":[57,147],"following":[58,90,191],"injury.":[59,152],"Our":[60],"study":[61],"shows":[62],"that":[63,121,171],"after":[64,150,166],"stab":[66],"wound":[67],"cytokine":[69],"expression":[70],"attenuated":[72,104,149],"Sema4B":[74,84,94,109,114,125,139,155,173,194],"\u2212/\u2212":[75,110,135,140],"mice,":[76,136,141,160],"microglia/macrophage":[78],"reactivity":[79,87,102,143,162],"altered.":[81],"In":[82,117],"vitro,":[83],"enhances":[85,195],"of":[88,108,178,198],"microglia":[89,101],"suggesting":[92],"astrocytic":[93,193],"functions":[95],"as":[96],"ligand.":[98],"Moreover,":[99],"injury-induced":[100],"presence":[107],"astrocytes":[111],"compared":[112],"+/-":[115],"astrocytes.":[116],"vitro":[118],"experiments":[119],"indicate":[120],"Plexin-B2":[122,134,157,175],"receptor":[126],"on":[127],"microglia.":[128],"Consistent":[129],"with":[130],"this,":[131],"microglia/macrophage-specific":[133],"similar":[137],"microglial/macrophage":[142,161],"are":[148,176],"Finally,":[153],"/":[156],"double":[158],"heterozygous":[159],"also":[164],"reduced":[165],"supporting":[168],"idea":[170],"part":[177],"same":[180],"signaling":[181],"pathway.":[182],"Taken":[183],"together,":[184],"we":[185],"propose":[186],"model":[188],"which":[190],"microglia/macrophages":[199],"via":[200],"Plexin-B2,":[201],"leading":[202],"increased":[204],"reactivity.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2024-05-24T00:00:00"}
