{"id":"https://openalex.org/W4398242597","doi":"https://doi.org/10.2174/011574888x305349240511125540","title":"The Mechanisms of Mesenchymal Stem Cells in the Treatment of Experimental Autoimmune Encephalomyelitis","display_name":"The Mechanisms of Mesenchymal Stem Cells in the Treatment of Experimental Autoimmune Encephalomyelitis","publication_year":2024,"publication_date":"2024-05-23","ids":{"openalex":"https://openalex.org/W4398242597","doi":"https://doi.org/10.2174/011574888x305349240511125540","pmid":"https://pubmed.ncbi.nlm.nih.gov/38778596"},"language":"en","primary_location":{"id":"doi:10.2174/011574888x305349240511125540","doi":"https://doi.org/10.2174/011574888x305349240511125540","is_oa":false,"landing_page_url":"https://doi.org/10.2174/011574888x305349240511125540","pdf_url":null,"source":{"id":"https://openalex.org/S4210223497","display_name":"Current Stem Cell Research & Therapy","issn_l":"1574-888X","issn":["1574-888X","2212-3946"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Stem Cell Research &amp; Therapy","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028642550","display_name":"Chunran Xue","orcid":"https://orcid.org/0000-0002-2817-1843","observed_orcids":["https://orcid.org/0000-0002-2817-1843"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chunran Xue","raw_affiliation_strings":["Department of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 160 Pujian Rd,\nShanghai, 200127, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 160 Pujian Rd,\nShanghai, 200127, P.R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102070847","display_name":"Haojun Yu","orcid":"https://orcid.org/0009-0004-5291-8363","observed_orcids":["https://orcid.org/0009-0004-5291-8363"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haojun Yu","raw_affiliation_strings":["Department of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 160 Pujian Rd,\nShanghai, 200127, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 160 Pujian Rd,\nShanghai, 200127, P.R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ye Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ye Sun","raw_affiliation_strings":["Department of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 160 Pujian Rd,\nShanghai, 200127, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 160 Pujian Rd,\nShanghai, 200127, P.R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101894410","display_name":"Xiying Wang","orcid":"https://orcid.org/0000-0003-3312-9612","observed_orcids":["https://orcid.org/0000-0003-3312-9612"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiying Wang","raw_affiliation_strings":["Department of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 160 Pujian Rd,\nShanghai, 200127, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 160 Pujian Rd,\nShanghai, 200127, P.R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001141538","display_name":"Xuzhong Pei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuzhong Pei","raw_affiliation_strings":["School of Medicine, Shanghai University, Shanghai, 200444, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Shanghai University, Shanghai, 200444, P.R. China","institution_ids":["https://openalex.org/I113940042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112579706","display_name":"Yi Chen","orcid":"https://orcid.org/0000-0002-4891-8289","observed_orcids":["https://orcid.org/0000-0002-4891-8289","https://orcid.org/0009-0008-5587-1635"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Chen","raw_affiliation_strings":["Department of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 160 Pujian Rd,\nShanghai, 200127, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 160 Pujian Rd,\nShanghai, 200127, P.R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028964836","display_name":"Yangtai Guan","orcid":"https://orcid.org/0000-0003-0813-4073","observed_orcids":["https://orcid.org/0000-0003-0813-4073"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yangtai Guan","raw_affiliation_strings":["Department of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 160 Pujian Rd,\nShanghai, 200127, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 160 Pujian Rd,\nShanghai, 200127, P.R. China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5028642550","https://openalex.org/A5028964836"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"],"apc_list":null,"apc_paid":null,"fwci":0.3785,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.36758242,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"20","issue":"5","first_page":"524","last_page":"537"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.6172000169754028,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.6172000169754028,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.38040000200271606,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/experimental-autoimmune-encephalomyelitis","display_name":"experimental autoimmune encephalomyelitis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":1.0},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8880000114440918},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.7369999885559082},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.9570000171661377},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9290000200271606},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8539999723434448},{"id":"https://openalex.org/keywords/oligodendrocytes","display_name":"oligodendrocytes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/stem-cell-transplantation","display_name":"stem cell transplantation","score":0.7200000286102295},{"id":"https://openalex.org/keywords/clinical-application-of-stem-cells","display_name":"clinical applications of stem cells","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C2778486448","wikidata":"https://www.wikidata.org/wiki/Q494066","display_name":"Experimental autoimmune encephalomyelitis","level":3,"score":0.9022952914237976},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.8146436214447021},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.7700761556625366},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5824984312057495},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5714200139045715},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5612598657608032},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5586881637573242},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5347816944122314},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.5118045210838318},{"id":"https://openalex.org/C2777899865","wikidata":"https://www.wikidata.org/wiki/Q1634879","display_name":"Encephalomyelitis","level":3,"score":0.48739010095596313},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.44055506587028503},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.429951936006546},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33371949195861816},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28531500697135925},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.18914130330085754},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1259687840938568},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.11811470985412598},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.05273643136024475},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004681","descriptor_name":"Encephalomyelitis, Autoimmune, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004681","descriptor_name":"Encephalomyelitis, Autoimmune, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004681","descriptor_name":"Encephalomyelitis, Autoimmune, Experimental","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D045164","descriptor_name":"Mesenchymal Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/011574888x305349240511125540","doi":"https://doi.org/10.2174/011574888x305349240511125540","is_oa":false,"landing_page_url":"https://doi.org/10.2174/011574888x305349240511125540","pdf_url":null,"source":{"id":"https://openalex.org/S4210223497","display_name":"Current Stem Cell Research & Therapy","issn_l":"1574-888X","issn":["1574-888X","2212-3946"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Stem Cell Research &amp; Therapy","raw_type":"journal-article"},{"id":"pmid:38778596","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38778596","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current stem cell research & therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G314545363","display_name":null,"funder_award_id":"2020YFA0113100","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5534530679","display_name":null,"funder_award_id":"82071341","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7461601604","display_name":null,"funder_award_id":"20JC1412000","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":138,"referenced_works":["https://openalex.org/W316228584","https://openalex.org/W1520986136","https://openalex.org/W1607206274","https://openalex.org/W1967524272","https://openalex.org/W1968255500","https://openalex.org/W1977547355","https://openalex.org/W1981621288","https://openalex.org/W1982021670","https://openalex.org/W1987938700","https://openalex.org/W1995922650","https://openalex.org/W1996573718","https://openalex.org/W2006132805","https://openalex.org/W2013758266","https://openalex.org/W2015202415","https://openalex.org/W2018558728","https://openalex.org/W2018997003","https://openalex.org/W2024971445","https://openalex.org/W2028935955","https://openalex.org/W2029817323","https://openalex.org/W2056315364","https://openalex.org/W2064919073","https://openalex.org/W2075235867","https://openalex.org/W2079293100","https://openalex.org/W2087353148","https://openalex.org/W2097227226","https://openalex.org/W2098893605","https://openalex.org/W2100608530","https://openalex.org/W2103893610","https://openalex.org/W2105674052","https://openalex.org/W2109662685","https://openalex.org/W2122412498","https://openalex.org/W2122542523","https://openalex.org/W2124161791","https://openalex.org/W2125373439","https://openalex.org/W2128391607","https://openalex.org/W2137142305","https://openalex.org/W2140530956","https://openalex.org/W2141111992","https://openalex.org/W2143742274","https://openalex.org/W2144013613","https://openalex.org/W2144795369","https://openalex.org/W2150291254","https://openalex.org/W2155937459","https://openalex.org/W2156509094","https://openalex.org/W2156642970","https://openalex.org/W2156943890","https://openalex.org/W2156969855","https://openalex.org/W2158424311","https://openalex.org/W2159073672","https://openalex.org/W2168406554","https://openalex.org/W2169611778","https://openalex.org/W2171292508","https://openalex.org/W2232273857","https://openalex.org/W2286433771","https://openalex.org/W2345604850","https://openalex.org/W2408347227","https://openalex.org/W2467552490","https://openalex.org/W2473015308","https://openalex.org/W2495833664","https://openalex.org/W2526963422","https://openalex.org/W2527008232","https://openalex.org/W2530062074","https://openalex.org/W2554214255","https://openalex.org/W2560140067","https://openalex.org/W2575340406","https://openalex.org/W2591362217","https://openalex.org/W2609412611","https://openalex.org/W2732251601","https://openalex.org/W2746918144","https://openalex.org/W2769378959","https://openalex.org/W2782743749","https://openalex.org/W2784314693","https://openalex.org/W2788933778","https://openalex.org/W2789900283","https://openalex.org/W2790148039","https://openalex.org/W2796020748","https://openalex.org/W2802557594","https://openalex.org/W2802821887","https://openalex.org/W2807167499","https://openalex.org/W2807425198","https://openalex.org/W2808158796","https://openalex.org/W2883248411","https://openalex.org/W2883485350","https://openalex.org/W2888711295","https://openalex.org/W2896014118","https://openalex.org/W2896358322","https://openalex.org/W2904668262","https://openalex.org/W2904871119","https://openalex.org/W2945524045","https://openalex.org/W2946906538","https://openalex.org/W2972804872","https://openalex.org/W2982149669","https://openalex.org/W2984544781","https://openalex.org/W2989919770","https://openalex.org/W2992284195","https://openalex.org/W2992845257","https://openalex.org/W2999396804","https://openalex.org/W2999689705","https://openalex.org/W3005755963","https://openalex.org/W3011865555","https://openalex.org/W3023142433","https://openalex.org/W3034939602","https://openalex.org/W3041912951","https://openalex.org/W3042308502","https://openalex.org/W3043861550","https://openalex.org/W3047476089","https://openalex.org/W3049429323","https://openalex.org/W3049431618","https://openalex.org/W3088933438","https://openalex.org/W3092022707","https://openalex.org/W3096668286","https://openalex.org/W3108854088","https://openalex.org/W3109300923","https://openalex.org/W3111697687","https://openalex.org/W3111711272","https://openalex.org/W3115762668","https://openalex.org/W3118946978","https://openalex.org/W3131957723","https://openalex.org/W3132240972","https://openalex.org/W3138847539","https://openalex.org/W3157163723","https://openalex.org/W3157428588","https://openalex.org/W3193847703","https://openalex.org/W3202764751","https://openalex.org/W3205986596","https://openalex.org/W3206847161","https://openalex.org/W4211090999","https://openalex.org/W4214496040","https://openalex.org/W4214554915","https://openalex.org/W4220859680","https://openalex.org/W4223549364","https://openalex.org/W4296111817","https://openalex.org/W4307959215","https://openalex.org/W4309967127","https://openalex.org/W4319460637","https://openalex.org/W4323923561","https://openalex.org/W4361195693","https://openalex.org/W4392656469"],"related_works":["https://openalex.org/W2014875829","https://openalex.org/W2142707077","https://openalex.org/W7097871846","https://openalex.org/W2782696480","https://openalex.org/W2413161350","https://openalex.org/W7100912898","https://openalex.org/W2103043060","https://openalex.org/W1443305069","https://openalex.org/W2322019522","https://openalex.org/W3026773973"],"abstract_inverted_index":{"Multiple":[0],"sclerosis":[1],"(MS)":[2],"is":[3,14,82],"an":[4],"inflammatory":[5],"demyelinating":[6],"disease":[7],"of":[8,18,33,91,100,105,140,145,153,165],"the":[9,34,87,97,103,108,138,143,150,161],"central":[10,123],"nervous":[11,124],"system":[12],"and":[13,39,57,69,89,122,163],"a":[15,60,76],"leading":[16],"cause":[17],"disability":[19],"in":[20,42,102,142],"young":[21],"adults.":[22],"Most":[23],"therapeutic":[24,62,98],"strategies":[25,135],"are":[26,58],"based":[27],"on":[28,110],"immunosuppressant":[29],"effects.":[30],"However,":[31],"none":[32],"drugs":[35],"showed":[36],"complete":[37],"remission":[38],"may":[40],"result":[41],"serious":[43],"adverse":[44],"events":[45],"such":[46],"as":[47,131,133,158,160],"infection.":[48],"Mesenchymal":[49],"stem":[50],"cells":[51,112,126],"(MSCs)":[52],"have":[53],"gained":[54],"much":[55],"attention":[56],"considered":[59],"potential":[61],"strategy":[63],"owing":[64],"to":[65,85,136],"their":[66],"immunomodulatory":[67],"effects":[68,109],"neuroprotective":[70],"functions.":[71],"Experimental":[72],"autoimmune":[73],"encephalomyelitis":[74],"(EAE),":[75],"classical":[77],"animal":[78],"model":[79],"for":[80,155],"MS,":[81],"widely":[83],"used":[84],"explore":[86],"efficacy":[88,139],"mechanism":[90,99],"MSC":[92,166],"transplantation.":[93,167],"This":[94],"review":[95],"summarises":[96],"MSCs":[101,141,154],"treatment":[104,144],"EAE,":[106],"including":[107],"immune":[111],"(T":[113],"cells,":[114,116,118],"B":[115],"dendritic":[117],"natural":[119],"killer":[120],"cells)":[121],"system-resident":[125],"(astroglia,":[127],"microglia,":[128],"oligodendrocytes,":[129],"neurons)":[130],"well":[132,159],"various":[134],"improve":[137],"EAE.":[146],"Additionally,":[147],"we":[148],"discuss":[149],"clinical":[151],"application":[152],"MS":[156],"patients":[157],"challenges":[162],"prospects":[164]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-05-24T00:00:00"}
