{"id":"https://openalex.org/W4398234635","doi":"https://doi.org/10.1093/ndt/gfae069.1013","title":"#623 One-year outcome of kidney transplant recipients harbouring complement regulatory gene mutation","display_name":"#623 One-year outcome of kidney transplant recipients harbouring complement regulatory gene mutation","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4398234635","doi":"https://doi.org/10.1093/ndt/gfae069.1013"},"language":"en","primary_location":{"id":"doi:10.1093/ndt/gfae069.1013","doi":"https://doi.org/10.1093/ndt/gfae069.1013","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/gfae069.1013","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4398234635"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014150065","display_name":"Ankur Mittal","orcid":"https://orcid.org/0000-0001-8745-3202","observed_orcids":["https://orcid.org/0000-0001-8745-3202"]},"institutions":[{"id":"https://openalex.org/I2800452302","display_name":"Muljibhai Patel Urological Hospital","ror":"https://ror.org/059h1d250","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2800452302"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ankur Mittal","raw_affiliation_strings":["Muljibhai Patel Urological Hospital , Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Muljibhai Patel Urological Hospital , Gujarat, India","institution_ids":["https://openalex.org/I2800452302"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073190837","display_name":"Abhijit Konnur","orcid":"https://orcid.org/0000-0001-7101-8169","observed_orcids":["https://orcid.org/0000-0001-7101-8169"]},"institutions":[{"id":"https://openalex.org/I2800452302","display_name":"Muljibhai Patel Urological Hospital","ror":"https://ror.org/059h1d250","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2800452302"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Abhijit Konnur","raw_affiliation_strings":["Muljibhai Patel Urological Hospital , Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Muljibhai Patel Urological Hospital , Gujarat, India","institution_ids":["https://openalex.org/I2800452302"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109127444","display_name":"Sishir D. Gang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800452302","display_name":"Muljibhai Patel Urological Hospital","ror":"https://ror.org/059h1d250","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2800452302"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sishir Gang","raw_affiliation_strings":["Muljibhai Patel Urological Hospital , Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Muljibhai Patel Urological Hospital , Gujarat, India","institution_ids":["https://openalex.org/I2800452302"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051461623","display_name":"Umapati N. Hegde","orcid":"https://orcid.org/0000-0002-4076-6153","observed_orcids":["https://orcid.org/0000-0002-4076-6153"]},"institutions":[{"id":"https://openalex.org/I2800452302","display_name":"Muljibhai Patel Urological Hospital","ror":"https://ror.org/059h1d250","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2800452302"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Umapati Hegde","raw_affiliation_strings":["Muljibhai Patel Urological Hospital , Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Muljibhai Patel Urological Hospital , Gujarat, India","institution_ids":["https://openalex.org/I2800452302"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039286467","display_name":"Hardik Patel","orcid":"https://orcid.org/0000-0003-0716-4510","observed_orcids":["https://orcid.org/0000-0003-0716-4510"]},"institutions":[{"id":"https://openalex.org/I2800452302","display_name":"Muljibhai Patel Urological Hospital","ror":"https://ror.org/059h1d250","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I2800452302"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Hardik Patel","raw_affiliation_strings":["Muljibhai Patel Urological Hospital , Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Muljibhai Patel Urological Hospital , Gujarat, India","institution_ids":["https://openalex.org/I2800452302"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2800452302"],"apc_list":{"value":3613,"currency":"EUR","value_usd":3910},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/thrombotic-microangiopathy","display_name":"thrombotic microangiopathy","score":0.9769999980926514},{"id":"https://openalex.org/keywords/atypical-hemolytic-uremic-syndrome","display_name":"atypical hemolytic uremic syndrome","score":0.8479999899864197},{"id":"https://openalex.org/keywords/graft-failure","display_name":"graft failure","score":0.8769999742507935},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.6370000243186951},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.8830000162124634},{"id":"https://openalex.org/keywords/complement-regulatory-proteins","display_name":"complement regulatory proteins","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.6524386405944824},{"id":"https://openalex.org/C2994498544","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplant","level":4,"score":0.5602023601531982},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.456296443939209},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44981107115745544},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4484708607196808},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41050493717193604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3706713318824768},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.3205028176307678},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.21190491318702698},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.11418992280960083},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.04914367198944092}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/ndt/gfae069.1013","doi":"https://doi.org/10.1093/ndt/gfae069.1013","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/gfae069.1013","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4296290501","https://openalex.org/W2035128042","https://openalex.org/W4402799531","https://openalex.org/W2571318451","https://openalex.org/W4396995917","https://openalex.org/W4353015420","https://openalex.org/W4397043472","https://openalex.org/W4285494518","https://openalex.org/W4415426792","https://openalex.org/W4396991218"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"and":[2,48,108,161,170,237],"Aims":[3],"Thrombotic":[4],"Microangiopathy":[5],"(TMA)":[6],"is":[7,33,189,235],"associated":[8],"with":[9,83,106,115,186,216,242,263,289],"genetic":[10],"abnormalities":[11],"in":[12,27,54,58,81,85,130,148,167,184,198,212,233,261,286],"complement":[13,19,88],"regulatory":[14,20,89],"pathways.":[15],"The":[16,176,228,250],"impact":[17],"of":[18,51,76,119,135,178,201,214,224,230,240,256,275,283],"gene":[21,138,267],"(CRG)":[22],"mutation":[23,127,220,232,277],"on":[24],"post-transplant":[25,44,77,243],"TMA":[26,47,80,183,246],"Indian":[28],"kidney":[29],"transplant":[30,180],"recipients":[31],"(KTR)":[32],"unknown.":[34],"This":[35,269],"study":[36,270],"was":[37,70,104,128,142,196,208],"conducted":[38],"to":[39,72,194],"ascertain":[40],"an":[41],"association":[42],"between":[43],"renal":[45,78,181],"limited":[46,79,182],"the":[49,74,136,222,238,254,273,281],"risk":[50],"graft":[52,251],"failure":[53],"KTRs":[55,82,114,185,234],"harbouring":[56],"mutations":[57,84,147,188],"genes":[59,86,172],"encoding":[60,87],"complement-regulatory":[61],"proteins.":[62,90],"Method":[63],"A":[64],"Single":[65],"Centre,":[66],"Prospective":[67],"Cohort":[68],"Study":[69],"undertaken":[71],"assess":[73],"incidence":[75],"Patients":[91],"enrolled":[92],"over":[93],"one":[94],"year":[95,258],"were":[96,124,173,259],"followed":[97,145],"up":[98],"for":[99],"one-year":[100],"post-transplantation.":[101],"Genetic":[102],"testing":[103],"performed":[105],"MLPA":[107],"Clinical":[109],"exome":[110],"sequencing.":[111],"Results":[112],"138":[113],"a":[116,287],"mean":[117],"age":[118],"36.39":[120],"\u00b1":[121],"12.39":[122],"years":[123],"enrolled.":[125],"CRG":[126,187,219,231,248,266,276],"seen":[129,197],"96/138":[131],"(69.6%)":[132],"KTRs.":[133],"Duplication":[134],"CFHR":[137],"(n":[139,150,154,158,163],"=":[140,151,155,159,164],"72)":[141],"most":[143],"prevalent":[144],"by":[146],"CFH":[149],"6),":[152],"CFI":[153],"2),":[156,160],"MCP":[157],"DGKE":[162],"1).":[165],"Mutations":[166],"CFB,":[168],"C3,":[169],"THBD":[171],"not":[174,279],"detected.":[175],"Incidence":[177],"Post":[179],"9.37%":[190],"(9/96).":[191],"Mutation":[192],"related":[193],"aHUS":[195],"9":[199],"out":[200],"11":[202],"patients":[203,215,241,262],"who":[204],"developed":[205],"TMA.":[206],"There":[207],"no":[209],"significant":[210],"difference":[211],"eGFR":[213],"or":[217,264],"without":[218,265],"at":[221,253],"end":[223,255],"1":[225,257],"year.":[226],"Conclusion":[227],"prevalence":[229],"high":[236],"majority":[239],"de":[244],"novo":[245],"had":[247],"mutations.":[249],"functions":[252],"similar":[260],"mutation.":[268],"suggests":[271],"that":[272],"presence":[274],"should":[278],"preclude":[280],"option":[282],"Kidney":[284],"transplantation":[285],"patient":[288],"ESRD.":[290]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2024-05-24T00:00:00"}