{"id":"https://openalex.org/W4398233530","doi":"https://doi.org/10.1093/ndt/gfae069.458","title":"#2440 https://era.m-anage.com/era24/en-GB/Submit/submission/abstracts/197764/guidelines","display_name":"#2440 https://era.m-anage.com/era24/en-GB/Submit/submission/abstracts/197764/guidelines","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4398233530","doi":"https://doi.org/10.1093/ndt/gfae069.458"},"language":"en","primary_location":{"id":"doi:10.1093/ndt/gfae069.458","doi":"https://doi.org/10.1093/ndt/gfae069.458","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ndt/gfae069.458","pdf_url":"https://academic.oup.com/ndt/article-pdf/39/Supplement_1/gfae069-0458-2440/57792773/gfae069-0458-2440.pdf","source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/ndt/article-pdf/39/Supplement_1/gfae069-0458-2440/57792773/gfae069-0458-2440.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052344563","display_name":"Wei Jiang","orcid":"https://orcid.org/0000-0002-1374-053X","observed_orcids":["https://orcid.org/0000-0002-1374-053X"]},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Jiang","raw_affiliation_strings":["Zhongda Hospital of Southeast University , P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhongda Hospital of Southeast University , P.R. China","institution_ids":["https://openalex.org/I4210105806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010557940","display_name":"Tao\u2010Tao Tang","orcid":"https://orcid.org/0000-0003-0220-3285","observed_orcids":["https://orcid.org/0000-0003-0220-3285"]},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao-Tao Tang","raw_affiliation_strings":["Zhongda Hospital of Southeast University , P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhongda Hospital of Southeast University , P.R. China","institution_ids":["https://openalex.org/I4210105806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091891066","display_name":"Lin\u2010Li Lv","orcid":"https://orcid.org/0000-0003-4118-4304","observed_orcids":["https://orcid.org/0000-0003-4118-4304"]},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linli LV","raw_affiliation_strings":["Zhongda Hospital of Southeast University , P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhongda Hospital of Southeast University , P.R. China","institution_ids":["https://openalex.org/I4210105806"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058396165","display_name":"Bi\u2010Cheng Liu","orcid":"https://orcid.org/0000-0002-4584-1853","observed_orcids":["https://orcid.org/0000-0002-4584-1853"]},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bicheng Liu","raw_affiliation_strings":["Zhongda Hospital of Southeast University , P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhongda Hospital of Southeast University , P.R. China","institution_ids":["https://openalex.org/I4210105806"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210105806"],"apc_list":{"value":3613,"currency":"EUR","value_usd":3910},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11506623,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chronic-kidney-disease-progression","display_name":"chronic kidney disease progression","score":0.8880000114440918},{"id":"https://openalex.org/keywords/tubulointerstitial-inflammation","display_name":"tubulointerstitial inflammation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/t-cell-infiltration","display_name":"T cell infiltration","score":0.781000018119812},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8920000195503235},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.6480000019073486},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.9269999861717224},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.8730000257492065},{"id":"https://openalex.org/keywords/endothelial-cell-apoptosis","display_name":"endothelial cell apoptosis","score":0.8309999704360962},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/t-cell-subsets","display_name":"T cell subsets","score":0.5329999923706055},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.6790000200271606},{"id":"https://openalex.org/keywords/pseudotime","display_name":"pseudotime","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.38740062713623047},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.275748074054718}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/ndt/gfae069.458","doi":"https://doi.org/10.1093/ndt/gfae069.458","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ndt/gfae069.458","pdf_url":"https://academic.oup.com/ndt/article-pdf/39/Supplement_1/gfae069-0458-2440/57792773/gfae069-0458-2440.pdf","source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/ndt/gfae069.458","doi":"https://doi.org/10.1093/ndt/gfae069.458","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ndt/gfae069.458","pdf_url":"https://academic.oup.com/ndt/article-pdf/39/Supplement_1/gfae069-0458-2440/57792773/gfae069-0458-2440.pdf","source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4398233530.pdf","grobid_xml":"https://content.openalex.org/works/W4398233530.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4399127073","https://openalex.org/W4397046592","https://openalex.org/W4225397165","https://openalex.org/W4282004841","https://openalex.org/W4225094756","https://openalex.org/W4403812092","https://openalex.org/W4398234281","https://openalex.org/W3211336110","https://openalex.org/W4396993507","https://openalex.org/W4380447993"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"and":[2,66,80,123,157,182,197,216,230,255,261,313,326,388,394],"Aims":[3],"Acute":[4],"kidney":[5,24],"injury":[6,65,115,135,270],"(AKI)":[7],"is":[8,13,31,401],"a":[9,35,103,110,405],"critical":[10],"condition":[11],"that":[12,264,334,377],"strongly":[14],"related":[15],"to":[16,60,83,101,119,125,143,164,221,274,298,358,367,391,403],"elevated":[17],"risks":[18],"for":[19,46],"the":[20,42,47,69,73,84,145,150,166,223,235,245,265,281,286,294,359,368,383,410],"progression":[21,369],"of":[22,49,68,76,87,106,112,147,169,177,205,225,234,267,288,318,347,361,370,385,397],"chronic":[23,85,282],"disease":[25],"(CKD).":[26],"While":[27],"tubulointerstitial":[28],"inflammation":[29],"(TII)":[30],"widely":[32],"accepted":[33],"as":[34],"significant":[36],"factor":[37],"in":[38,63,109,253,256,409],"driving":[39],"this":[40,93,130,324],"process,":[41],"underlying":[43],"mechanisms":[44],"responsible":[45],"development":[48],"TII":[50],"are":[51,57],"still":[52],"largely":[53,90],"unknown.":[54],"T":[55,77,107,170,178,183,206,226,238,289,300,331,341,379,399],"cells":[56,108,171,179,290,301,342,350,380,400],"increasingly":[58],"recognized":[59],"be":[61,303],"involved":[62],"tissue":[64],"exacerbation":[67],"inflammatory":[70],"response.":[71],"However,":[72],"dynamic":[74,167,203],"landscape":[75],"cell":[78,184,207,227,239,307,332],"infiltration":[79],"their":[81,127,198],"contribution":[82],"transition":[86,122,276,295],"AKI":[88,118,273,297],"remain":[89],"unclear.":[91],"In":[92,280],"study,":[94],"we":[95],"used":[96,142,220],"single-cell":[97,155,158],"RNA":[98,159,214],"sequencing":[99,160,246],"(scRNA-seq)":[100],"obtain":[102],"high-resolution":[104],"profile":[105],"model":[111,266],"unilateral":[113,268],"ischemia-reperfusion":[114,134,269],"(uIRI)":[116,136,271],"induced":[117,272],"CKD":[120,275],"(AtoC)":[121],"intended":[124],"explain":[126],"roles":[128],"during":[129,172,209,242,323],"progress.":[131],"Method":[132],"Unilateral":[133],"at":[137],"multiple":[138],"time":[139],"points":[140],"was":[141,162,277],"simulate":[144],"transformation":[146,211],"AtoC.":[148,243],"Next,":[149],"kidneys":[151],"were":[152,180,186,192,200,212,219,248],"isolated":[153],"into":[154,305],"suspensions":[156],"(sRNA-seg)":[161],"performed":[163],"observe":[165,222],"evolution":[168,224],"AtoC":[173,210,411],"transition.":[174],"Further":[175],"subpopulations":[176,191],"analyzed":[181],"maps":[185],"constructed":[187],"by":[188,194,237,251],"UMAP.":[189],"These":[190],"defined":[193],"characteristic":[195],"genes":[196],"functions":[199],"analyzed.":[201],"The":[202,316],"changes":[204],"subsets":[208,240,320],"observed.":[213],"velocity":[215],"pseudotime":[217],"analysis":[218,233],"subpopulations.":[228],"Receptor":[229],"ligand":[231,353],"interaction":[232],"mechanism":[236],"role":[241],"Finally,":[244],"results":[247,375],"further":[249],"verified":[250],"detailed":[252],"vitro":[254],"vivo":[257],"experiments.":[258],"Results":[259],"PAS":[260],"Masson":[262],"showed":[263],"successfully":[278],"established.":[279],"phase":[283],"after":[284,337],"AKI,":[285],"aggregation":[287],"gradually":[291],"increased.":[292],"During":[293],"from":[296,329],"CKD,":[299],"can":[302,343,381],"divided":[304],"9":[306],"subsets,":[308],"mainly":[309],"including":[310],"CD8,":[311],"TH1":[312],"Treg":[314],"cells.":[315],"proportion":[317],"CD8":[319,340,378,398],"increased":[321],"significantly":[322],"process":[325],"may":[327],"originate":[328],"proliferating":[330],"subtypes":[333],"emerged":[335],"rapidly":[336],"AKI.":[338],"Interestingly,":[339],"specifically":[344],"induce":[345],"apoptosis":[346],"vascular":[348],"endothelial":[349],"through":[351],"Fas":[352],"(FasI)-Fas":[354],"signaling,":[355],"which":[356],"leads":[357],"thinning":[360],"peritubular":[362,386],"capillaries":[363,387],"(PTCs),":[364],"ultimately":[365,389],"leading":[366],"renal":[371,392],"fibrosis.":[372],"Conclusion":[373],"Our":[374],"suggest":[376],"cause":[382],"rarefaction":[384],"lead":[390],"fibrosis,":[393],"targeted":[395],"clearance":[396],"expected":[402],"become":[404],"new":[406],"therapeutic":[407],"target":[408],"process.":[412]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-05-24T00:00:00"}