{"id":"https://openalex.org/W4398190092","doi":"https://doi.org/10.55782/ane-1994-1026","title":"The effect of lead on dopamine, GABA and histidine spontaneous and KCI-dependent releases from rat brain synaptosomes","display_name":"The effect of lead on dopamine, GABA and histidine spontaneous and KCI-dependent releases from rat brain synaptosomes","publication_year":1994,"publication_date":"1994-09-30","ids":{"openalex":"https://openalex.org/W4398190092","doi":"https://doi.org/10.55782/ane-1994-1026","mag":"2082325190","pmid":"https://pubmed.ncbi.nlm.nih.gov/7817835"},"language":"en","primary_location":{"id":"doi:10.55782/ane-1994-1026","doi":"https://doi.org/10.55782/ane-1994-1026","is_oa":true,"landing_page_url":"https://doi.org/10.55782/ane-1994-1026","pdf_url":null,"source":{"id":"https://openalex.org/S87096862","display_name":"Acta Neurobiologiae Experimentalis","issn_l":"0065-1400","issn":["0065-1400","1689-0035"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310317444","host_organization_name":"Nencki Institute of Experimental Biology","host_organization_lineage":["https://openalex.org/P4310317444","https://openalex.org/P4310317485"],"host_organization_lineage_names":["Nencki Institute of Experimental Biology","Polish Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neurobiologiae Experimentalis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.55782/ane-1994-1026","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069732599","display_name":"Lidia Stru\u017cy\u0144ska","orcid":"https://orcid.org/0000-0002-9007-792X","observed_orcids":["https://orcid.org/0000-0002-9007-792X"]},"institutions":[{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Lidia Stru\u017cy\u0144ska","raw_affiliation_strings":["Department of Neurochemistry, Medical Research Centre, Polish Academy of Sciences, 3 Dworkowa St., 00-784 Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurochemistry, Medical Research Centre, Polish Academy of Sciences, 3 Dworkowa St., 00-784 Warsaw, Poland","institution_ids":["https://openalex.org/I99542240"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111416760","display_name":"Urszula Rafa\u0142owska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Urszula Rafa\u0142owska","raw_affiliation_strings":["Department of Neurochemistry, Medical Research Centre, Polish Academy of Sciences, 3 Dworkowa St., 00-784 Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurochemistry, Medical Research Centre, Polish Academy of Sciences, 3 Dworkowa St., 00-784 Warsaw, Poland","institution_ids":["https://openalex.org/I99542240"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I99542240"],"apc_list":null,"apc_paid":null,"fwci":2.335,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.88557214,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"54","issue":"3","first_page":"201","last_page":"207"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lead","display_name":"lead","score":0.7289999723434448},{"id":"https://openalex.org/keywords/lead-acetate","display_name":"lead acetate","score":0.8980000019073486},{"id":"https://openalex.org/keywords/dopamine-release","display_name":"dopamine release","score":0.6759999990463257},{"id":"https://openalex.org/keywords/gaba-release","display_name":"GABA release","score":0.9980000257492065},{"id":"https://openalex.org/keywords/synaptosomes","display_name":"synaptosomes","score":0.9150000214576721},{"id":"https://openalex.org/keywords/spontaneous-neurotransmitter-release","display_name":"spontaneous neurotransmitter release","score":0.8840000033378601},{"id":"https://openalex.org/keywords/synaptic-transmission","display_name":"synaptic transmission","score":0.7080000042915344},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.7049999833106995},{"id":"https://openalex.org/keywords/rat-brain","display_name":"rat brain","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.7702172994613647},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5793864727020264},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5446982979774475},{"id":"https://openalex.org/C2778460671","wikidata":"https://www.wikidata.org/wiki/Q485277","display_name":"Histidine","level":3,"score":0.5151857137680054},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3744792342185974},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35578757524490356},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.23964518308639526},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22064208984375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20342564582824707},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1750953197479248},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0687248706817627}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007854","descriptor_name":"Lead","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007854","descriptor_name":"Lead","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011189","descriptor_name":"Potassium Chloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013574","descriptor_name":"Synaptosomes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013574","descriptor_name":"Synaptosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.55782/ane-1994-1026","doi":"https://doi.org/10.55782/ane-1994-1026","is_oa":true,"landing_page_url":"https://doi.org/10.55782/ane-1994-1026","pdf_url":null,"source":{"id":"https://openalex.org/S87096862","display_name":"Acta Neurobiologiae Experimentalis","issn_l":"0065-1400","issn":["0065-1400","1689-0035"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310317444","host_organization_name":"Nencki Institute of Experimental Biology","host_organization_lineage":["https://openalex.org/P4310317444","https://openalex.org/P4310317485"],"host_organization_lineage_names":["Nencki Institute of Experimental Biology","Polish Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neurobiologiae Experimentalis","raw_type":"journal-article"},{"id":"pmid:7817835","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7817835","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta neurobiologiae experimentalis","raw_type":"Journal Article"},{"id":"mag:2082325190","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7817835","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"doi:10.55782/ane-1994-1026","doi":"https://doi.org/10.55782/ane-1994-1026","is_oa":true,"landing_page_url":"https://doi.org/10.55782/ane-1994-1026","pdf_url":null,"source":{"id":"https://openalex.org/S87096862","display_name":"Acta Neurobiologiae Experimentalis","issn_l":"0065-1400","issn":["0065-1400","1689-0035"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310317444","host_organization_name":"Nencki Institute of Experimental Biology","host_organization_lineage":["https://openalex.org/P4310317444","https://openalex.org/P4310317485"],"host_organization_lineage_names":["Nencki Institute of Experimental Biology","Polish Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Neurobiologiae Experimentalis","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W112106683","https://openalex.org/W1511953255","https://openalex.org/W1775749144","https://openalex.org/W1964710472","https://openalex.org/W1974023983","https://openalex.org/W1985261967","https://openalex.org/W2033700192","https://openalex.org/W2048929975","https://openalex.org/W2050017635","https://openalex.org/W2061067314","https://openalex.org/W2064902637","https://openalex.org/W2077397595","https://openalex.org/W2130276316","https://openalex.org/W2176224597","https://openalex.org/W2402193292","https://openalex.org/W2406048236"],"related_works":["https://openalex.org/W2082325190","https://openalex.org/W1975623159","https://openalex.org/W2077469447","https://openalex.org/W2002531593","https://openalex.org/W2572704705","https://openalex.org/W2009574784","https://openalex.org/W2073151129","https://openalex.org/W2021174056","https://openalex.org/W2074910263","https://openalex.org/W2051363113"],"abstract_inverted_index":{"The":[0,100],"effect":[1,78],"of":[2,7,15,37,50,62,68,118,128,133,136],"lead":[3,32,40,81,104],"on":[4,80],"the":[5,47,66,85,97,107,115],"release":[6,49,67,117,131],"[14C]GABA,":[8],"[3H]dopamine":[9],"and":[10,26,52,54,75,121,123,138],"[14C]histidine":[11],"(as":[12],"a":[13,44,125,129],"precursor":[14],"histamine)":[16],"was":[17],"studied":[18],"in":[19,27,30,43,46,58,72,89,96,110],"synaptosomes":[20,28,73],"obtained":[21],"from":[22],"chronically":[23],"lead-treated":[24],"rats":[25,38],"with":[29,39],"vitro":[31,59],"added.":[33],"In":[34],"vivo":[35],"treatment":[36],"acetate":[41,82],"results":[42,101],"decrease":[45],"K(+)-depolarization-dependent":[48],"GABA":[51,137],"dopamine":[53,120,139],"histidine.":[55,142],"Lead":[56],"given":[57],"itself":[60],"(independently":[61],"depolarizing":[63],"condition)":[64],"stimulated":[65],"previously":[69],"accumulated":[70],"neurotransmitters":[71],"(GABA":[74],"dopamine).":[76],"This":[77],"depends":[79],"concentration.":[83],"On":[84],"other":[86],"hand":[87],"lead,":[88],"different":[90],"concentrations,":[91],"did":[92],"not":[93,141],"cause":[94],"changes":[95],"histidine":[98,122],"release.":[99],"show":[102],"that":[103],"can":[105],"attack":[106],"synaptic":[108],"neurotransmission":[109],"two":[111],"ways:":[112],"by":[113,124],"depressing":[114],"Ca-KCl-evoked":[116],"GABA,":[119],"selective":[126],"stimulation":[127],"spontaneous":[130],"(independent":[132],"depolarization":[134],"conditions)":[135],"but":[140]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-05-22T00:00:00"}
