{"id":"https://openalex.org/W4398176253","doi":"https://doi.org/10.1152/physiol.2024.39.s1.2180","title":"Colostrum Supplementation to Rescue Antibiotic-Induced Dysbiosis and Reduce Long-Term Obesity Risk","display_name":"Colostrum Supplementation to Rescue Antibiotic-Induced Dysbiosis and Reduce Long-Term Obesity Risk","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4398176253","doi":"https://doi.org/10.1152/physiol.2024.39.s1.2180"},"language":"en","primary_location":{"id":"doi:10.1152/physiol.2024.39.s1.2180","doi":"https://doi.org/10.1152/physiol.2024.39.s1.2180","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiol.2024.39.s1.2180","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092043163","display_name":"Karen Antunes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Antunes","raw_affiliation_strings":["University of Wisconsin-Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092043162","display_name":"Cameron T. Leathem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cameron Leathem","raw_affiliation_strings":["University of Wisconsin-Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060754660","display_name":"Tahliyah S. Mims","orcid":"https://orcid.org/0000-0001-8056-695X","observed_orcids":["https://orcid.org/0000-0001-8056-695X"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tahliyah Mims","raw_affiliation_strings":["University of Wisconsin-Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005277370","display_name":"Nathaniel Willis","orcid":"https://orcid.org/0000-0003-1401-8204","observed_orcids":["https://orcid.org/0000-0003-1401-8204"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathaniel Willis","raw_affiliation_strings":["University of Wisconsin-Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085571191","display_name":"Joseph F. Pierre","orcid":"https://orcid.org/0000-0002-4248-1290","observed_orcids":["https://orcid.org/0000-0002-4248-1290"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Pierre","raw_affiliation_strings":["University of WisconsinaMadison, Madison, WI, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of WisconsinaMadison, Madison, WI, United States","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":null,"apc_paid":null,"fwci":0.1363,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.36570834,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"39","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bovine-colostrum","display_name":"bovine colostrum","score":0.9290000200271606},{"id":"https://openalex.org/keywords/antibiotic-associated-dysbiosis","display_name":"antibiotic-induced dysbiosis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7900000214576721},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6779999732971191},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.7680000066757202},{"id":"https://openalex.org/keywords/tylosin-tartrate","display_name":"tylosin tartrate","score":0.8029999732971191},{"id":"https://openalex.org/keywords/akkermansia","display_name":"Akkermansia","score":0.7639999985694885},{"id":"https://openalex.org/keywords/sutterella","display_name":"Sutterella","score":0.9959999918937683},{"id":"https://openalex.org/keywords/enterobacteriaceae","display_name":"Enterobacteriaceae","score":0.9580000042915344},{"id":"https://openalex.org/keywords/goblet-cells","display_name":"goblet cells","score":0.9399999976158142},{"id":"https://openalex.org/keywords/intestinal-epithelium","display_name":"intestinal epithelium","score":0.734000027179718},{"id":"https://openalex.org/keywords/host-microbe-symbiosis","display_name":"host-microbe symbiosis","score":0.8330000042915344},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.4779999852180481},{"id":"https://openalex.org/keywords/prebiotics","display_name":"prebiotics","score":0.6679999828338623},{"id":"https://openalex.org/keywords/nutraceuticals","display_name":"nutraceuticals","score":0.5879999995231628},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.609000027179718},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C2779073587","wikidata":"https://www.wikidata.org/wiki/Q192746","display_name":"Colostrum","level":3,"score":0.7786233425140381},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.7766430974006653},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.7029770612716675},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.49351274967193604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48375821113586426},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.48114049434661865},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4257122576236725},{"id":"https://openalex.org/C2993328841","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotic therapy","level":3,"score":0.41027072072029114},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.38742685317993164},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3620144724845886},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.32581984996795654},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2930299639701843},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.25990307331085205},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2577473521232605},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.13946467638015747},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1152/physiol.2024.39.s1.2180","doi":"https://doi.org/10.1152/physiol.2024.39.s1.2180","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiol.2024.39.s1.2180","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7160927085","https://openalex.org/W2003836872","https://openalex.org/W4403898437","https://openalex.org/W3170881621","https://openalex.org/W7163418738","https://openalex.org/W4294126673","https://openalex.org/W3137271727","https://openalex.org/W2516240402","https://openalex.org/W4313361524","https://openalex.org/W4404883725"],"abstract_inverted_index":{"The":[0,129],"prevalence":[1],"of":[2,76,92,118,139,264,271,287],"metabolic":[3,33,168,232],"disease":[4,34,64],"in":[5,15,67,141,200,278,332,360,379],"the":[6,16,74,96,116,137,142,265,288,325,345,350,380],"United":[7],"States":[8],"has":[9,85],"increased":[10],"from":[11],"30.4%":[12],"to":[13,32,79,197,260,335],"41.9%":[14],"past":[17],"decades,":[18],"with":[19,36,40,59,187,208,239,275,281,301],"rising":[20],"rates":[21],"among":[22],"children.":[23,68],"Emerging":[24],"evidence":[25],"implicates":[26],"intestinal":[27,107,333],"microbiome":[28,267],"function":[29,84],"as":[30,49,152,252],"contributing":[31],"risk,":[35],"dysbiosis":[37],"being":[38],"associated":[39,58],"overweight":[41],"and":[42,55,65,83,105,114,127,165,231,249,273,304,328,356],"obese":[43],"status.":[44],"While":[45],"sometimes":[46],"lifesaving,":[47],"antibioticssuch":[48],"azithromycin":[50],"cause":[51],"microbiota":[52],"ecological":[53],"instability":[54],"are":[56,71,131,364],"significantly":[57],"a":[60,86,153,188,330],"greater":[61],"risk":[62],"ofmetabolic":[63],"obesity":[66],"Since":[69],"antibiotics":[70],"often":[72],"necessary,":[73],"identification":[75],"nutritional":[77],"interventions":[78],"restore":[80],"microbial":[81,160],"membership":[82],"high":[87],"potential":[88],"value":[89],"for":[90,236,372],"millions":[91],"patients.":[93],"Colostrum":[94],"is":[95,344,357],"first":[97],"milk":[98],"produced":[99],"by":[100,284],"mammals":[101],"immediately":[102,223],"after":[103],"birth":[104],"shapes":[106],"colonization":[108,117],"patterns,":[109],"specifically":[110],"enriching":[111],"Bifidobacterium,":[112],"Lactobacillus,":[113],"limiting":[115],"Proteobacteria.":[119],"Bovine":[120],"colostrum":[121,140,150,219,242,255,305,315],"containsimmunomodulators,":[122],"lactoferrin,":[123],"oligosaccharides,":[124],"bioactive":[125],"compounds,":[126],"macronutrients.":[128],"compounds":[130],"similar":[132,246,259],"across":[133],"mammalian":[134],"species.":[135],"Considering":[136],"impact":[138],"sterile":[143],"early-life":[144],"gut,":[145],"we":[146],"hypothesized":[147],"that":[148,320],"bovine":[149],"provided":[151,218],"supplemental":[154],"nutraceutical":[155],"therapy":[156],"would":[157],"augment":[158],"gut":[159,266,289],"recolonization":[161,334],"following":[162,224,243,306],"antibiotic":[163,193],"exposures":[164],"mitigate":[166],"long-term":[167,337],"consequences.":[169],"Specific":[170],"pathogen-free":[171],"(SPF)":[172],"C57BL/6":[173],"mice":[174,199,279],"(male,":[175],"three":[176,206],"weeks":[177],"old,":[178],"Jackson":[179],"Laboratory)":[180],"were":[181,217,234],"housed":[182],"under":[183],"standard":[184],"laboratory":[185],"conditions":[186],"45%":[189],"high-fat":[190],"diet.":[191],"Tylosintartrate":[192],"(ABX)":[194],"was":[195,376],"administered":[196],"some":[198,215],"drinking":[201],"water":[202],"3":[203],"days/week":[204],"over":[205],"weeks,":[207],"four":[209],"days":[210],"washout/week.":[211],"To":[212],"examine":[213],"colostrum,":[214],"animals":[216],"gavage":[220],"during":[221,256],"or":[222,368],"ABX":[225,240,244,257,261,282,292,307],"exposures.":[226],"After":[227],"intervention,":[228],"body":[229,247],"composition":[230,248],"phenotypes":[233],"monitored":[235],"16":[237],"weeks.Compared":[238],"alone,":[241],"maintained":[245],"glucose":[250],"tolerance":[251],"controls,":[253],"while":[254],"appeared":[258],"alone.":[262],"Examination":[263],"showed":[268],"unique":[269],"enrichment":[270],"Akkermansia":[272],"Sutterella":[274],"decreased":[276,293],"Enterobacteriaceae":[277],"treated":[280],"followed":[283],"colostrum.":[285],"Analysis":[286],"mucosa":[290],"demonstrated":[291],"goblet":[294,309],"cell":[295],"numbers":[296],"per":[297],"villi":[298],"(7.2/villus)":[299],"compared":[300],"control":[302],"(9.8/villus),":[303],"elevated":[308],"cells":[310],"(8.6/villus).":[311],"These":[312],"data":[313],"suggest":[314],"may":[316],"stimulate":[317],"epithelial":[318],"responses":[319],"foster":[321],"host-microbial":[322],"symbiosis":[323],"at":[324,349],"mucosal":[326],"surface":[327],"play":[329],"role":[331],"benefit":[336],"homeostasis.":[338],"Dairy":[339],"Innovation":[340],"Hub,":[341],"UW-Madison.":[342],"This":[343],"full":[346],"abstract":[347],"presented":[348],"American":[351],"Physiology":[352,375],"Summit":[353],"2024":[354],"meeting":[355],"only":[358],"available":[359,371],"HTML":[361],"format.":[362],"There":[363],"no":[365],"additional":[366,369],"versions":[367],"content":[370],"this":[373],"abstract.":[374],"not":[377],"involved":[378],"peer":[381],"review":[382],"process.":[383]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2024-05-22T00:00:00"}
