{"id":"https://openalex.org/W4398175485","doi":"https://doi.org/10.1152/physiol.2024.39.s1.2143","title":"Ascorbic Acid Infusion Improves Cerebrovascular Reactivity in Middle-Aged and Older Adults","display_name":"Ascorbic Acid Infusion Improves Cerebrovascular Reactivity in Middle-Aged and Older Adults","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4398175485","doi":"https://doi.org/10.1152/physiol.2024.39.s1.2143"},"language":"en","primary_location":{"id":"doi:10.1152/physiol.2024.39.s1.2143","doi":"https://doi.org/10.1152/physiol.2024.39.s1.2143","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiol.2024.39.s1.2143","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089175757","display_name":"Nicholas Rizzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas Rizzi","raw_affiliation_strings":["University of Delaware, Ellicott City, MD, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Delaware, Ellicott City, MD, United States","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044634393","display_name":"Theodore M. DeConne","orcid":"https://orcid.org/0000-0002-9704-6499","observed_orcids":["https://orcid.org/0000-0002-9704-6499"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodore DeConne","raw_affiliation_strings":["University of Delaware"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Delaware","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073559526","display_name":"Faria Sanjana","orcid":"https://orcid.org/0000-0001-6529-6680","observed_orcids":["https://orcid.org/0000-0001-6529-6680"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Faria Sanjana","raw_affiliation_strings":["University of Delaware, Newark, DE, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Delaware, Newark, DE, United States","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098733945","display_name":"Elizabeth M. Habash","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Habash","raw_affiliation_strings":["University of Delaware"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Delaware","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082291562","display_name":"Kevin Decker","orcid":"https://orcid.org/0000-0001-6595-0072","observed_orcids":["https://orcid.org/0000-0001-6595-0072"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Decker","raw_affiliation_strings":["University of Delaware, Newark, DE, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Delaware, Newark, DE, United States","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105470625","display_name":"Joshua C. Hobson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Hobson","raw_affiliation_strings":["University of Delaware"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Delaware","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036205151","display_name":"Christopher R. Martens","orcid":"https://orcid.org/0000-0003-0578-2948","observed_orcids":["https://orcid.org/0000-0003-0578-2948"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Martens","raw_affiliation_strings":["University of Delaware, Delaware"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Delaware, Delaware","institution_ids":["https://openalex.org/I86501945"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I86501945"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14293862,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.736299991607666,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.736299991607666,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.08330000191926956,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.025499999523162842,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cerebrovascular-reactivity","display_name":"cerebrovascular reactivity","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cerebrovascular-conductance","display_name":"cerebrovascular conductance","score":0.9919999837875366},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9660000205039978},{"id":"https://openalex.org/keywords/hypercapnia","display_name":"hypercapnia","score":0.8330000042915344},{"id":"https://openalex.org/keywords/middle-cerebral-artery-blood-flow-velocity","display_name":"middle cerebral artery blood flow velocity","score":0.9779999852180481},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6990000009536743},{"id":"https://openalex.org/keywords/middle-aged-and-older-adults","display_name":"middle-aged and older adults","score":0.8769999742507935},{"id":"https://openalex.org/keywords/antioxidant-supplementation","display_name":"antioxidant supplementation","score":0.5839999914169312},{"id":"https://openalex.org/keywords/age-differences","display_name":"age differences","score":0.5090000033378601},{"id":"https://openalex.org/keywords/stroke-risk","display_name":"stroke risk","score":0.6169999837875366},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.7839999794960022},{"id":"https://openalex.org/keywords/vascular-dysfunction","display_name":"vascular dysfunction","score":0.5210000276565552},{"id":"https://openalex.org/keywords/middle-cerebral-artery","display_name":"middle cerebral artery","score":0.4519999921321869},{"id":"https://openalex.org/keywords/transcranial-doppler","display_name":"transcranial Doppler","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.8045526742935181},{"id":"https://openalex.org/C2776910235","wikidata":"https://www.wikidata.org/wiki/Q18574","display_name":"Reactivity (psychology)","level":3,"score":0.5540432929992676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.528842568397522},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.441249281167984},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3664148449897766},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3622429668903351},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33423855900764465},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.2572780251502991},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14895004034042358},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1152/physiol.2024.39.s1.2143","doi":"https://doi.org/10.1152/physiol.2024.39.s1.2143","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiol.2024.39.s1.2143","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"},{"id":"pmh:oai:digitalcommons.wku.edu:ijesab-8033","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wku.edu/ijesab/vol9/iss12/40","pdf_url":null,"source":{"id":"https://openalex.org/S4377196460","display_name":"TopSCHOLAR (Western Kentucky University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I94339441","host_organization_name":"Western Kentucky University","host_organization_lineage":["https://openalex.org/I94339441"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Exercise Science: Conference Proceedings","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7220437578","https://openalex.org/W4406542415","https://openalex.org/W1493688343","https://openalex.org/W2154375091","https://openalex.org/W4225404347","https://openalex.org/W4312087563","https://openalex.org/W3176307950","https://openalex.org/W3176027880","https://openalex.org/W2887697222","https://openalex.org/W3173618906"],"abstract_inverted_index":{"Aging":[0],"is":[1,31,37,56,447,480,493],"associated":[2],"with":[3,155],"reductions":[4],"in":[5,54,70,86,186,195,209,332,342,361,371,389,401,422,424,455,466,496,515],"cerebrovascular":[6,10,52,471],"reactivity":[7],"(CVR)":[8],"and":[9,22,36,68,72,84,97,99,121,224,228,238,250,278,419,453,492],"conductance":[11],"(CVC),":[12],"which":[13],"may":[14,469],"contribute":[15],"to":[16,33,218,235,339,368,393,396],"the":[17,25,42,115,123,162,183,192,201,207,220,258,330,359,481,486,516],"development":[18],"of":[19,41,114,125,167,203,222,267],"neurodegenerative":[20],"disease":[21],"stroke.":[23],"In":[24],"peripheral":[26],"vasculature,":[27],"increased":[28,161],"oxidative":[29,48,64,467],"stress":[30,65,468],"linked":[32],"vascular":[34],"dysfunction":[35],"ameliorated":[38],"following":[39,272,288,304,319,334,363,426],"infusion":[40,80,124,274,290,321,336,365,428,450],"antioxidant":[43],"ascorbic":[44],"acid":[45],"(AA).":[46],"However,":[47],"stress\u2019":[49],"effect":[50,266,285,316],"on":[51,226,270,286,302,317],"function":[53],"humans":[55],"not":[57,89,458,513],"entirely":[58],"understood.":[59],"PURPOSE:":[60],"To":[61],"determine":[62],"whether":[63],"reduces":[66],"CVR":[67,83,145,179,204,227,271,287,333,362,452],"CVC":[69,85,197,303,318,390,400,423,454],"middle-aged":[71,98],"older":[73,100],"adults":[74,91,103],"(MA/O).":[75],"We":[76],"hypothesized":[77],"that":[78,152,160,329,448,463],"AA":[79,127,223,289,320,364,427,449],"would":[81],"increase":[82,341,370,421],"MA/O":[87,252,372,402,414,425],"but":[88,307,457],"young":[90],"(YA).":[92],"METHODS:":[93],"Young":[94],"(18-29":[95],"years)":[96,102,249,256],"(55-79":[101],"were":[104,216,233,295],"recruited":[105],"for":[106,175,206,508],"two":[107],"identical":[108],"experimental":[109,259],"visits.":[110,260],"Each":[111],"visit":[112],"consisted":[113],"same":[116],"measures":[117],"performed":[118],"both":[119,397],"before":[120],"after":[122],"either":[126],"or":[128,299,504],"saline":[129],"(SAL).":[130],"Middle":[131],"cerebral":[132],"artery":[133],"blood":[134,212],"velocity":[135],"(MCAv)":[136],"was":[137,146,153,180,198,262,309,337,366,391,512],"recorded":[138],"using":[139,148],"a":[140,149,156,176,263,279,310],"transcranial":[141],"Doppler":[142],"ultrasound":[143],"probe.":[144],"tested":[147],"hypercapnia":[150,189],"protocol":[151],"achieved":[154],"computer-based":[157],"gas":[158],"blender":[159],"subjects\u2019":[163],"end-tidal":[164],"partial":[165],"pressure":[166],"carbon":[168],"dioxide":[169],"(PETCO2)":[170],"9":[171],"mmHg":[172],"above":[173],"baseline":[174,399],"3-minute":[177],"period.":[178],"defined":[181,199],"as":[182,200],"percent":[184,202],"change":[185,194],"MCAv":[187],"during":[188],"divided":[190],"by":[191,474],"absolute":[193],"PETCO2.":[196],"normalized":[205],"changes":[208],"mean":[210],"arterial":[211],"pressure.":[213],"Two-way":[214],"ANOVAs":[215],"used":[217,234],"assess":[219,236],"effects":[221,240,301],"SAL":[225,273,305,335],"CVC.":[229],"Fisher\u2019s":[230],"LSD":[231],"tests":[232],"main":[237,265,298,445],"interaction":[239,284,300,315],"when":[241],"necessary.":[242],"RESULTS:":[243],"8":[244],"YA":[245,343,407],"(25":[246],"+":[247,254,345,351,374,380,404,411,430,436],"2":[248],"14":[251],"(65":[253],"6":[255],"completed":[257],"There":[261,294,499],"significant":[264,280,297,311],"condition":[268,283,314],"(pre/post)":[269],"(p":[275,291,322],"=":[276,292,323,356,385,417,441],"0.016),":[277],"age":[281,312],"x":[282,313],"0.016).":[293],"no":[296,501],"infusion,":[306],"there":[308],"0.012).":[324],"Post":[325],"hoc":[326],"testing":[327],"indicated":[328,392],"difference":[331,360,388],"due":[338,367,395],"an":[340,369,420],"(3.0":[344],"0.5":[346,437],"%/mmHg":[347,353,376,382,406,413,432,438],"pre":[348,377,408,433],"vs.":[349,378,409,434],"3.8":[350],"1.1":[352,412,431],"post,":[354,383,439],"p":[355,384,416,440],"0.047),":[357],"whereas":[358],"(3.3":[373],"1.7":[375],"4.1":[379],"1.9":[381],"0.006).":[386],"The":[387],"be":[394],"lower":[398],"(2.3":[403],"0.4":[405],"1.3":[410],"pre,":[415],"0.019)":[418],"(1.3":[429],"2.0":[435],"0.047).":[442],"CONCLUSION:":[443],"Our":[444],"finding":[446,461],"restores":[451],"MA/O,":[456],"YA.":[459],"This":[460,479],"suggests":[462],"age-related":[464],"increases":[465],"impair":[470],"function.":[472],"Supported":[473],"NIH":[475],"Grant":[476],"P20":[477],"GM113125.":[478],"full":[482],"abstract":[483],"presented":[484],"at":[485],"American":[487],"Physiology":[488,511],"Summit":[489],"2024":[490],"meeting":[491],"only":[494],"available":[495,507],"HTML":[497],"format.":[498],"are":[500],"additional":[502,505],"versions":[503],"content":[506],"this":[509],"abstract.":[510],"involved":[514],"peer":[517],"review":[518],"process.":[519]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2024-05-22T00:00:00"}
