{"id":"https://openalex.org/W4398174993","doi":"https://doi.org/10.1152/physiol.2024.39.s1.1405","title":"Tongue exercise-induced plasticity in upper airway EMG activity in a model of hypoglossal motor neuron loss","display_name":"Tongue exercise-induced plasticity in upper airway EMG activity in a model of hypoglossal motor neuron loss","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4398174993","doi":"https://doi.org/10.1152/physiol.2024.39.s1.1405"},"language":"en","primary_location":{"id":"doi:10.1152/physiol.2024.39.s1.1405","doi":"https://doi.org/10.1152/physiol.2024.39.s1.1405","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiol.2024.39.s1.1405","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010576415","display_name":"Amy N. Keilholz","orcid":"https://orcid.org/0000-0002-5388-3869","observed_orcids":["https://orcid.org/0000-0002-5388-3869"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Keilholz","raw_affiliation_strings":["University of Missouri, Columbia, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri, Columbia, MO, United States","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031075211","display_name":"Kate L. Osman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kate Osman","raw_affiliation_strings":["University of Missouri, Columbia, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri, Columbia, MO, United States","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029041465","display_name":"Catherine L. Smith","orcid":"https://orcid.org/0000-0001-9327-0154","observed_orcids":["https://orcid.org/0000-0001-9327-0154"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Smith","raw_affiliation_strings":["University of Missouri, Columbia, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri, Columbia, MO, United States","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075081885","display_name":"Kristi Streeter","orcid":"https://orcid.org/0000-0003-2065-8136","observed_orcids":["https://orcid.org/0000-0003-2065-8136"]},"institutions":[{"id":"https://openalex.org/I102461120","display_name":"Marquette University","ror":"https://ror.org/04gr4te78","country_code":"US","type":"education","lineage":["https://openalex.org/I102461120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristi Streeter","raw_affiliation_strings":["Marquette University, Columbia, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marquette University, Columbia, MO, United States","institution_ids":["https://openalex.org/I102461120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067954476","display_name":"Ilker Ozden","orcid":"https://orcid.org/0000-0002-5006-3451","observed_orcids":["https://orcid.org/0000-0002-5006-3451"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ilker Ozden","raw_affiliation_strings":["University of Missouri, Columbia, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri, Columbia, MO, United States","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002972490","display_name":"Teresa E. Lever","orcid":"https://orcid.org/0000-0002-5587-3816","observed_orcids":["https://orcid.org/0000-0002-5587-3816"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teresa Lever","raw_affiliation_strings":["University of Missouri, Columbia, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri, Columbia, MO, United States","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050229766","display_name":"Nicole Louise Nichols","orcid":"https://orcid.org/0000-0003-3837-0069","observed_orcids":["https://orcid.org/0000-0003-3837-0069"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole Nichols","raw_affiliation_strings":["University of Missouri, Columbia, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Missouri, Columbia, MO, United States","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6022,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.67778875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"39","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11358","display_name":"Dysphagia Assessment and Management","score":0.75,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11358","display_name":"Dysphagia Assessment and Management","score":0.75,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.21330000460147858,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10863","display_name":"Voice and Speech Disorders","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoglossal-nerve","display_name":"hypoglossal nerve","score":0.8569999933242798},{"id":"https://openalex.org/keywords/lower-motor-neuron-loss","display_name":"lower motor neuron loss","score":0.8709999918937683},{"id":"https://openalex.org/keywords/tongue-exercises","display_name":"tongue exercises","score":0.8560000061988831},{"id":"https://openalex.org/keywords/geniohyoid-muscle","display_name":"geniohyoid muscle","score":0.828000009059906},{"id":"https://openalex.org/keywords/diaphragm","display_name":"diaphragm","score":0.7179999947547913},{"id":"https://openalex.org/keywords/swallowing","display_name":"swallowing","score":0.5199999809265137},{"id":"https://openalex.org/keywords/breathing","display_name":"breathing","score":0.8209999799728394},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.6000000238418579},{"id":"https://openalex.org/keywords/upper-airway-function","display_name":"upper airway function","score":0.6299999952316284},{"id":"https://openalex.org/keywords/muscle-electrical-activity","display_name":"muscle electrical activity","score":0.6510000228881836},{"id":"https://openalex.org/keywords/aspiration-pneumonia","display_name":"aspiration pneumonia","score":0.6100000143051147},{"id":"https://openalex.org/keywords/respiratory-failure","display_name":"respiratory failure","score":0.8529999852180481},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.527999997138977},{"id":"https://openalex.org/keywords/muscle-growth","display_name":"muscle growth","score":0.35199999809265137},{"id":"https://openalex.org/keywords/plethysmography","display_name":"plethysmography","score":0.9200000166893005}],"concepts":[{"id":"https://openalex.org/C2776752467","wikidata":"https://www.wikidata.org/wiki/Q1133903","display_name":"Motor neuron","level":3,"score":0.7308958172798157},{"id":"https://openalex.org/C2779744641","wikidata":"https://www.wikidata.org/wiki/Q9614","display_name":"Tongue","level":2,"score":0.6530953645706177},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.6494410037994385},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6328864097595215},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.5195003747940063},{"id":"https://openalex.org/C2779209236","wikidata":"https://www.wikidata.org/wiki/Q319577","display_name":"Hypoglossal nerve","level":3,"score":0.49331846833229065},{"id":"https://openalex.org/C79186407","wikidata":"https://www.wikidata.org/wiki/Q472074","display_name":"Plasticity","level":2,"score":0.48167574405670166},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.4567781984806061},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45020192861557007},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4357106685638428},{"id":"https://openalex.org/C2781354215","wikidata":"https://www.wikidata.org/wiki/Q3875059","display_name":"Upper motor neuron","level":4,"score":0.41238895058631897},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36148032546043396},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.16005152463912964},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12586137652397156},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.11267539858818054},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10833495855331421},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07844898104667664},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.07801741361618042},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1152/physiol.2024.39.s1.1405","doi":"https://doi.org/10.1152/physiol.2024.39.s1.1405","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiol.2024.39.s1.1405","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6299999952316284,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4378675159","https://openalex.org/W4402247090","https://openalex.org/W4225401247","https://openalex.org/W4411880075","https://openalex.org/W7160891068","https://openalex.org/W7128613311","https://openalex.org/W7160925863","https://openalex.org/W7160911232","https://openalex.org/W4283724743","https://openalex.org/W4411880180"],"abstract_inverted_index":{"Motor":[0],"neuron":[1],"diseases":[2],"(MNDs)":[3],"are":[4,21,88,195,384,433],"a":[5,78,94,118,168,198],"group":[6],"of":[7,18,35,54,64,80,102,144,161,172,179,246,307,379,392],"neuromuscular":[8],"disorders":[9],"in":[10,113,140,240,268,299,354,376,403,429,448],"which":[11,187,396],"motor":[12,44],"neurons":[13],"(MNs)":[14],"required":[15],"for":[16,84,97,121,204,441],"activities":[17],"daily":[19],"living":[20],"lost.":[22],"Patients":[23],"with":[24,86,115,218,351,405],"MNDs":[25,87,116],"often":[26],"develop":[27],"swallowing":[28,153,192,219,247],"and":[29,59,62,73,91,106,148,154,191,214,226,244,248,262,270,277,296,315,374,409,425],"breathing":[30,155,227,249,272],"dysfunction":[31],"due":[32],"to":[33,70,77,129,151,184,231,304,313,348,364,369,387],"pathology":[34],"the":[36,55,100,142,159,294,377,389,414,419,449],"hypoglossal":[37],"(XII)":[38],"axis":[39,367],"(":[40,220,228],"e.g.,":[41],"XII":[42,145,173,236,366,380],"lower":[43],"neurons,":[45],"LMNs).":[46],"These":[47],"co-dependent,":[48],"vital":[49],"functions":[50],"require":[51],"reciprocal":[52],"roles":[53],"tongue":[56,110,132,189,201,279,327,352,361,393],"during":[57,320,323],"swallowing,":[58],"impaired":[60],"control":[61,310],"coordination":[63,264,375],"these":[65,283],"opposing":[66],"behaviors":[67],"can":[68],"lead":[69],"aspiration":[71],"pneumonia":[72],"respiratory":[74],"failure.":[75],"Due":[76],"lack":[79,160],"research,":[81],"available":[82,428,440],"treatments":[83],"patients":[85,114,404],"largely":[89],"palliative,":[90],"there":[92],"is":[93,127,134,413,426],"critical":[95],"need":[96],"therapies":[98,150],"targeting":[99],"preservation":[101],"upper":[103,211,241,371],"airway":[104,212,242,372],"function":[105,373],"coordination.":[107],"The":[108],"extensive":[109],"muscle":[111,205],"weakness":[112],"suggests":[117],"potential":[119],"role":[120],"therapeutic":[122],"exercise,":[123],"but":[124],"suffcient":[125],"evidence":[126],"lacking":[128],"conclude":[130],"if":[131],"exercise":[133,202,280,328,353,362],"beneficial":[135],"or":[136,309,322,437],"harmful.":[137],"A":[138],"barrier":[139],"studying":[141],"impact":[143],"LMN":[146,174,237,381],"degeneration":[147],"developing":[149],"improve":[152,370],"function/coordination":[156],"has":[157,188],"been":[158],"an":[162],"appropriate":[163],"model.":[164],"We":[165,251],"therefore":[166],"developed":[167],"novel":[169],"rodent":[170],"model":[171],"loss":[175,238],"using":[176],"intralingual":[177,305],"injections":[178],"cholera":[180],"toxin":[181],"B":[182],"conjugated":[183],"saporin":[185],"(CTB-SAP),":[186],"motility":[190],"deficits":[193,243],"that":[194,253,278,346],"mitigated":[196],"by":[197],"high-repetition/low":[199],"resistance":[200],"paradigm":[203],"growth.":[206],"Here,":[207],"we":[208,289],"simultaneously":[209],"studied":[210,316],"(geniohyoid)":[213],"diaphragm":[215,297],"EMG":[216,257,291,318,339],"activity":[217,258,319,340],"via":[221,229],"videofluoroscopy":[222],"swallow":[223],"studies;":[224],"VFSS)":[225],"plethysmography)":[230],"discern":[232],"whether":[233],"CTB-SAP":[234,273,308,355],"induced":[235],"results":[239],"discoordination":[245,345],"functions.":[250],"hypothesized":[252],"geniohyoid":[254,295,335],"(not":[255],"diaphragm)":[256,338],"would":[259,265,281],"be":[260,266,349],"decreased":[261,334],"swallow-breathing":[263],"altered":[267],"unanesthetized":[269],"spontaneously":[271],"rats":[274,302,356],"vs.":[275,357],"controls,":[276],"mitigate":[282],"deficits.":[284],"Using":[285],"custom-made":[286],"headcap":[287],"implants,":[288],"embedded":[290],"electrodes":[292],"into":[293],"muscles":[298],"adult":[300],"male":[301],"prior":[303],"injection":[306],"(CTB":[311],"unconjugated":[312],"SAP)":[314],"chronic":[317],"VFSS":[321],"plethysmography":[324],"studies":[325,402],"+/-":[326],"(N=4-6/group).":[329],"Our":[330],"preliminary":[331],"findings":[332],"show":[333],"(but":[336],"not":[337,446],"as":[341,343],"well":[342],"swallow/breathing":[344],"appears":[347,363],"reversed":[350],"controls.":[358],"In":[359],"conclusion,":[360],"enhance":[365],"plasticity":[368],"face":[378],"degeneration.":[382],"Studies":[383],"now":[385],"underway":[386],"understand":[388],"underlying":[390],"mechanism":[391],"exercise-induced":[394],"neuroplasticity,":[395],"may":[397],"help":[398],"guide":[399],"future":[400],"translational":[401],"MNDs.":[406],"R01":[407],"HL153612":[408],"Phi":[410],"Zeta.":[411],"This":[412],"full":[415],"abstract":[416],"presented":[417],"at":[418],"American":[420],"Physiology":[421,444],"Summit":[422],"2024":[423],"meeting":[424],"only":[427],"HTML":[430],"format.":[431],"There":[432],"no":[434],"additional":[435,438],"versions":[436],"content":[439],"this":[442],"abstract.":[443],"was":[445],"involved":[447],"peer":[450],"review":[451],"process.":[452]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2024-05-22T00:00:00"}
