{"id":"https://openalex.org/W4398166751","doi":"https://doi.org/10.1152/physiol.2024.39.s1.1670","title":"TAK1 Signaling in Cardiac Fibroblast Contributes to Inflammation Resolution Post Myocardial Infarction","display_name":"TAK1 Signaling in Cardiac Fibroblast Contributes to Inflammation Resolution Post Myocardial Infarction","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4398166751","doi":"https://doi.org/10.1152/physiol.2024.39.s1.1670"},"language":"en","primary_location":{"id":"doi:10.1152/physiol.2024.39.s1.1670","doi":"https://doi.org/10.1152/physiol.2024.39.s1.1670","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1152/physiol.2024.39.s1.1670","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040900373","display_name":"Daniel Nguyen","orcid":"https://orcid.org/0009-0005-4526-0636","observed_orcids":["https://orcid.org/0009-0005-4526-0636"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Nguyen","raw_affiliation_strings":["University of louisville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of louisville","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082199895","display_name":"Jonah Stephan","orcid":"https://orcid.org/0000-0002-8957-1277","observed_orcids":["https://orcid.org/0000-0002-8957-1277"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonah Stephan","raw_affiliation_strings":["University of louisville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of louisville","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019018711","display_name":"Nolan L. Boyd","orcid":"https://orcid.org/0000-0001-9537-6040","observed_orcids":["https://orcid.org/0000-0001-9537-6040"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nolan Boyd","raw_affiliation_strings":["University of louisville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of louisville","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Robert Brainard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Brainard","raw_affiliation_strings":["University of louisville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of louisville","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072415149","display_name":"Jason L. Hellmann","orcid":"https://orcid.org/0000-0001-9573-6843","observed_orcids":["https://orcid.org/0000-0001-9573-6843"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Hellmann","raw_affiliation_strings":["University of louisville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of louisville","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003013293","display_name":"Marcin Wysoczynski","orcid":"https://orcid.org/0000-0001-6319-2386","observed_orcids":["https://orcid.org/0000-0001-6319-2386"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcin Wysoczynski","raw_affiliation_strings":["University of louisville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of louisville","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061922767","display_name":"Bradford G. Hill","orcid":"https://orcid.org/0000-0001-5332-8286","observed_orcids":["https://orcid.org/0000-0001-5332-8286"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradford Hill","raw_affiliation_strings":["University of louisville, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of louisville, United States","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I142740786"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13832991,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13254","display_name":"Macrophage Migration Inhibitory Factor","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tak1","display_name":"TAK1","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cardiac-fibroblasts","display_name":"cardiac fibroblasts","score":0.9739999771118164},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9760000109672546},{"id":"https://openalex.org/keywords/resolution-of-inflammation","display_name":"inflammation resolution","score":0.9660000205039978},{"id":"https://openalex.org/keywords/acute-inflammation","display_name":"acute inflammation","score":0.6129999756813049},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.7009999752044678},{"id":"https://openalex.org/keywords/nonclassical-monocytes","display_name":"non-classical monocytes","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tissue-resident-macrophages","display_name":"tissue-resident macrophages","score":0.8669999837875366},{"id":"https://openalex.org/keywords/il-1beta-signaling","display_name":"IL-1\u03b2 signaling","score":0.8980000019073486},{"id":"https://openalex.org/keywords/jnk-signaling","display_name":"JNK signaling","score":0.7620000243186951},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9879999756813049},{"id":"https://openalex.org/keywords/mmp-3","display_name":"MMP-3","score":0.9380000233650208},{"id":"https://openalex.org/keywords/resolvins","display_name":"resolvins","score":0.871999979019165},{"id":"https://openalex.org/keywords/lipoxins","display_name":"lipoxins","score":0.996999979019165},{"id":"https://openalex.org/keywords/lipid-mediators","display_name":"lipid mediators","score":0.824999988079071},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7611593008041382},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.678274929523468},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5592672228813171},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.543509304523468},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4703674018383026},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44632667303085327},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2782656252384186},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0966351330280304},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.07763054966926575}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1152/physiol.2024.39.s1.1670","doi":"https://doi.org/10.1152/physiol.2024.39.s1.1670","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1152/physiol.2024.39.s1.1670","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W3183948672","https://openalex.org/W3173606202","https://openalex.org/W3110381201","https://openalex.org/W2948807893","https://openalex.org/W2935909890","https://openalex.org/W2778153218","https://openalex.org/W2758277628","https://openalex.org/W1531601525","https://openalex.org/W2032406302"],"abstract_inverted_index":{"Introduction:":[0],"Resident":[1,285],"cardiac":[2,16,85,224,286,303],"fibroblasts":[3,19,70,86,166,225,287,304],"are":[4,343],"often":[5],"defined":[6],"by":[7],"their":[8],"extraordinary":[9],"capacity":[10],"to":[11,23,50,67,74,91,119,140],"deposit":[12],"extracellular":[13],"matrix":[14],"after":[15,188,317],"injury;":[17],"however,":[18],"also":[20,30],"react":[21],"avidly":[22],"pro-inflammatory":[24,55,72,93,221],"stimuli,":[25],"suggesting":[26],"that":[27,84,264],"they":[28],"may":[29,219],"be":[31,51],"mediators":[32,259],"of":[33,63,125,163,184,195,257,266],"inflammation.":[34],"Initially":[35],"identified":[36],"as":[37,201,203,249,251],"a":[38,88,108,296,307],"TGF\u03b2":[39],"responsive":[40],"enzyme,":[41],"TGF-\u03b2":[42],"activated":[43],"kinase":[44],"1":[45],"(TAK1)":[46],"has":[47],"been":[48],"shown":[49],"significant":[52],"in":[53,57,165,167,177,197,205,260,310,339,358],"regulating":[54],"signaling":[56,248],"several":[58],"disease":[59],"models.":[60],"The":[61],"goal":[62],"this":[64,352],"study":[65],"was":[66,355],"understand":[68],"how":[69,217],"integrate":[71,92],"signals":[73,94],"regulate":[75,220,288],"acute":[76,290],"inflammation":[77],"following":[78,101,145,293],"myocardial":[79],"infarction":[80],"(MI).":[81],"We":[82],"hypothesize":[83],"utilize":[87],"TAK1-dependent":[89,297],"mechanism":[90],"and":[95,104,131,154,171,180,234,246,276,314,320,335],"orchestrate":[96],"the":[97,151,178,182,198,206,213,289,312,324,329,359],"cellular":[98],"immune":[99,147,291,315],"response":[100,292,316],"injury.":[102],"Methods":[103],"Results:":[105],"To":[106,215],"create":[107],"fibroblast-specific":[109],"model":[110],"for":[111,351],"TAK1":[112,114,133,164,218,227,241,267],"knockdown,":[113],"fl/fl":[115,134,228],"mice":[116,135,229],"were":[117,157,208,230,235],"bred":[118],"Col1a2-CreERT":[120],"mice.":[121],"Following":[122],"2":[123],"weeks":[124],"tamoxifen":[126],"chow":[127],"feeding,":[128],"both":[129],"Cre\u2212":[130],"Cre+":[132],"underwent":[136],"permanent":[137],"coronary":[138],"ligation":[139],"induce":[141],"MI.":[142,318],"Three":[143],"days":[144],"MI,":[146],"cell":[148],"populations":[149,176],"from":[150,226,302],"heart,":[152],"spleen,":[153],"peripheral":[155,199],"blood":[156,200],"evaluated":[158],"through":[159],"flow":[160],"cytometry.":[161],"Deletion":[162],"vivo":[168],"diminished":[169],"neutrophils":[170,196],"Ly6C":[172],"low":[173],"patrolling":[174],"monocytes":[175],"heart":[179],"decreased":[181],"number":[183],"CCR2neg":[185],"resident":[186],"macrophages":[187],"MI":[189,294],"(n=10/group;":[190],"p<0.05).":[191,283],"Interestingly,":[192],"circulating":[193],"levels":[194],"well":[202,250],"those":[204],"spleen":[207],"not":[209,356],"significantly":[210,268],"different":[211],"between":[212],"groups.":[214],"determine":[216],"signaling,":[222],"isolated":[223],"treated":[231,237],"with":[232,238],"Ad-CMV-iCre":[233],"subsequently":[236],"IL1\u03b2.":[239],"Notably,":[240],"knockdown":[242],"suppressed":[243],"IL1\u03b2-dependent":[244],"p-JNK":[245],"NF\u03baB":[247],"MMP3":[252],"production.":[253],"Further":[254],"LC-MS/MS":[255],"evaluation":[256],"lipid":[258],"conditioned":[261],"medium":[262],"showed":[263],"deletion":[265],"increased":[269],"fibroblast-derived":[270],"resolvins":[271],"(RvE2,":[272],"RvD1,":[273],"RvD4,":[274],"RvE4)":[275],"lipoxins":[277],"(LXA4,":[278],"15(":[279],"R)-LXA4)":[280],"(n=":[281],"3-5;":[282],"Conclusion:":[284],"via":[295],"mechanism.":[298],"Secreted":[299],"factors":[300],"derived":[301],"likely":[305],"play":[306],"pivotal":[308],"role":[309],"shaping":[311],"inflammatory":[313],"NIH":[319],"AHA.":[321],"This":[322],"is":[323,336],"full":[325],"abstract":[326],"presented":[327],"at":[328],"American":[330],"Physiology":[331,354],"Summit":[332],"2024":[333],"meeting":[334],"only":[337],"available":[338,350],"HTML":[340],"format.":[341],"There":[342],"no":[344],"additional":[345,348],"versions":[346],"or":[347],"content":[349],"abstract.":[353],"involved":[357],"peer":[360],"review":[361],"process.":[362]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}