{"id":"https://openalex.org/W4398166333","doi":"https://doi.org/10.1152/physiol.2024.39.s1.903","title":"Impaired excitability of nucleus tractus solitarius neurons in a neonatal rat model of hyperbilirubinemia","display_name":"Impaired excitability of nucleus tractus solitarius neurons in a neonatal rat model of hyperbilirubinemia","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4398166333","doi":"https://doi.org/10.1152/physiol.2024.39.s1.903"},"language":"en","primary_location":{"id":"doi:10.1152/physiol.2024.39.s1.903","doi":"https://doi.org/10.1152/physiol.2024.39.s1.903","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1152/physiol.2024.39.s1.903","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108880633","display_name":"Catherine Ann Mayer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Mayer","raw_affiliation_strings":["Case Western Reserve University, Cleveland, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University, Cleveland, OH, United States","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040882620","display_name":"Nicholas C. Rickman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas Rickman","raw_affiliation_strings":["Case Western Reserve University, Cleveland, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University, Cleveland, OH, United States","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012447238","display_name":"Cynthia Frances Bearer","orcid":"https://orcid.org/0000-0003-4809-2250","observed_orcids":["https://orcid.org/0000-0003-4809-2250"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia Bearer","raw_affiliation_strings":["Case Western Reserve University, Cleveland, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University, Cleveland, OH, United States","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078704750","display_name":"Peter Mathew MacFarlane","orcid":"https://orcid.org/0000-0002-5373-7095","observed_orcids":["https://orcid.org/0000-0002-5373-7095"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter MacFarlane","raw_affiliation_strings":["Case Western Reserve University, Cleveland, OH, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University, Cleveland, OH, United States","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0989011,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.8784000277519226,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.11890000104904175,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperbilirubinemia","display_name":"hyperbilirubinemia","score":0.9620000123977661},{"id":"https://openalex.org/keywords/nucleus-tractus-solitarius","display_name":"nucleus tractus solitarius","score":0.9620000123977661},{"id":"https://openalex.org/keywords/neuronal-excitability","display_name":"neuronal excitability","score":0.746999979019165},{"id":"https://openalex.org/keywords/free-bilirubin","display_name":"free bilirubin","score":0.7239999771118164},{"id":"https://openalex.org/keywords/bilirubin-neurotoxicity","display_name":"bilirubin neurotoxicity","score":0.8399999737739563},{"id":"https://openalex.org/keywords/gunn-rats","display_name":"Gunn rats","score":0.6809999942779541},{"id":"https://openalex.org/keywords/sulfadimethoxine","display_name":"sulfadimethoxine","score":0.9660000205039978},{"id":"https://openalex.org/keywords/preterm-infants","display_name":"preterm infants","score":0.652999997138977},{"id":"https://openalex.org/keywords/apnea-of-prematurity","display_name":"apnea of prematurity","score":0.9409999847412109},{"id":"https://openalex.org/keywords/bilirubin-glucuronidation","display_name":"bilirubin glucuronidation","score":0.6700000166893005},{"id":"https://openalex.org/keywords/brainstem","display_name":"brainstem","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6749652624130249},{"id":"https://openalex.org/C2779929655","wikidata":"https://www.wikidata.org/wiki/Q119744","display_name":"Solitary nucleus","level":3,"score":0.518659770488739},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4083726108074188},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.3982830047607422},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38645926117897034},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3434286117553711}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1152/physiol.2024.39.s1.903","doi":"https://doi.org/10.1152/physiol.2024.39.s1.903","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1152/physiol.2024.39.s1.903","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1998376848","https://openalex.org/W2064756065","https://openalex.org/W2009512214","https://openalex.org/W4362506812","https://openalex.org/W2379249785","https://openalex.org/W2364971509","https://openalex.org/W1990002291","https://openalex.org/W2977836103","https://openalex.org/W1984023027","https://openalex.org/W2009265201"],"abstract_inverted_index":{"Hyperbilirubinemia":[0],"is":[1,19,65,118,329,383,396],"associated":[2,66,371],"with":[3,67,331,372],"multiple":[4],"morbidities":[5],"including":[6],"apnea":[7,368],"of":[8,16,34,58,86,96,98,110,148,160,168,190,197,236,271,274,288,300,310,319,336,369],"prematurity":[9,370],"in":[10,25,61,157,210,312,339,353,374,399,418],"preterm":[11,375],"infants.":[12,376],"Bilirubin,":[13],"a":[14,32,55,144,171,203,261],"byproduct":[15],"hemoglobin":[17],"breakdown,":[18],"not":[20,244,416],"excreted":[21],"normally":[22],"and":[23,47,64,74,138,222,303,363,378,395],"results":[24],"high":[26,333],"circulating":[27,161,301],"levels":[28,159],"giving":[29],"rise":[30],"to":[31,40,72,120,187,202,218,248,276,296,324,361,366],"state":[33],"hyperbilirubinemia.":[35],"Free":[36],"bilirubin":[37,59,153,322],"(not":[38],"bound":[39],"albumin)":[41],"can":[42],"cross":[43],"the":[44,62,82,94,99,198,257,297,307,332,367,384,389,419],"blood-brain":[45],"barrier":[46],"be":[48,292],"neurotoxic.":[49],"Prior":[50],"studies":[51],"have":[52,345],"shown":[53],"that":[54],"systemic":[56],"injection":[57,147],"accumulates":[60],"brainstem":[63],"an":[68,75,115,165,293],"impaired":[69,308,325,348],"ventilatory":[70,78,358],"response":[71,201,295,309],"hypercapnia":[73],"augmented":[76],"hypoxic":[77],"depression.":[79],"Here,":[80],"using":[81],"Gunn":[83,106,125],"rat":[84,107,126,140],"model":[85,109],"endogenous":[87],"hyperbilirubinemia,":[88],"we":[89],"investigated":[90],"its":[91],"effects":[92,299,318],"on":[93,180],"excitability":[95],"neurons":[97,182,212,242,287,311,338],"nucleus":[100],"tractus":[101],"solitarius":[102],"(NTS).":[103],"The":[104,284,327],"homozygous":[105],"(jj)":[108],"hyperbilirubinemia":[111,373],"lacks":[112],"uridine":[113],"diphosphate-glucuronosyltransferase-1A1,":[114],"enzyme":[116],"which":[117,151],"needed":[119],"catabolize":[121],"bilirubin.":[122,305],"Heterozygous":[123],"Nj":[124,137],"pups":[127,141,215],"were":[128],"used":[129],"for":[130,347,411],"control.":[131,173],"On":[132],"postnatal":[133],"(P)":[134],"day":[135],"5,":[136],"jj":[139,237],"received":[142],"either":[143],"200mg/kg":[145],"intraperitoneal":[146],"sulfadimethoxine":[149],"(SDMX),":[150],"dissociates":[152],"from":[154,213,220],"albumin":[155],"resulting":[156],"increased":[158,209,227,256,320],"free":[162,321],"bilirubin,":[163],"or":[164,407],"equivalent":[166],"amount":[167],"saline":[169],"as":[170],"vehicle":[172],"Whole":[174],"cell":[175],"patch":[176],"clamp":[177],"was":[178,207,229,280,415],"performed":[179],"NTS":[181,211,241,286,337],"two":[183],"days":[184],"later":[185],"(P7)":[186],"assess":[188],"characteristics":[189],"evoked":[191,199],"excitatory":[192],"postsynaptic":[193],"currents":[194],"(eEPSC).The":[195],"amplitude":[196,228],"stimulus":[200,205,263],"20Hz":[204,262],"train":[206,264],"significantly":[208,255],"jj+saline":[214,240,275,289],"when":[216],"compared":[217],"cells":[219],"Nj+saline":[221,277],"Nj+SDMX":[223],"animals":[224],"(p<0.05).":[225],"This":[226,382],"no":[230,404],"longer":[231],"present":[232],"after":[233],"SDMX":[234,253],"treatment":[235,254],"pups.":[238],"Additionally,":[239],"did":[243],"exhibit":[245],"any":[246],"failure":[247,258,272,334],"solitary":[249],"tract":[250],"stimulation,":[251],"whereas":[252],"rate":[259,273,335],"during":[260],"(jj+saline":[265],"=0.0%\u00b10.0,":[266],"jj+SDMX=":[267],"18.63%\u00b18.82,":[268],"p<0.05).":[269],"Comparison":[270],"(6.63%\u00b13.12,":[278],"p<0.05)":[279],"also":[281],"statistically":[282],"significant.":[283],"hyper-responsive":[285],"rats":[290,314],"may":[291,315,344,364],"adaptive":[294],"deleterious":[298],"(bound":[302],"unbound)":[304],"However,":[306],"jj+SDMX":[313,340],"reflect":[316],"neurotoxic":[317],"leading":[323],"neurotransmission.":[326],"latter":[328],"consistent":[330],"rats.":[341],"These":[342],"data":[343],"implications":[346],"respiratory":[349],"control":[350],"mechanisms":[351],"involved":[352,417],"mediating":[354],"essential":[355],"vagally":[356],"mediated":[357],"defense":[359],"responses":[360],"hypoxemia":[362],"contribute":[365],"William":[377],"Lois":[379],"Briggs":[380],"Endowment.":[381],"full":[385],"abstract":[386],"presented":[387],"at":[388],"American":[390],"Physiology":[391,414],"Summit":[392],"2024":[393],"meeting":[394],"only":[397],"available":[398,410],"HTML":[400],"format.":[401],"There":[402],"are":[403],"additional":[405,408],"versions":[406],"content":[409],"this":[412],"abstract.":[413],"peer":[420],"review":[421],"process.":[422]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2024-05-22T00:00:00"}