{"id":"https://openalex.org/W4398166314","doi":"https://doi.org/10.1152/physiol.2024.39.s1.1897","title":"Polycyclic aromatic hydrocarbon (PAH) activation of AhR inhibits glutathione S-transferase (GST) activity in primary human small airway epithelial cells (hSAECs)","display_name":"Polycyclic aromatic hydrocarbon (PAH) activation of AhR inhibits glutathione S-transferase (GST) activity in primary human small airway epithelial cells (hSAECs)","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4398166314","doi":"https://doi.org/10.1152/physiol.2024.39.s1.1897"},"language":"en","primary_location":{"id":"doi:10.1152/physiol.2024.39.s1.1897","doi":"https://doi.org/10.1152/physiol.2024.39.s1.1897","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiol.2024.39.s1.1897","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079694390","display_name":"Elizabeth Zimmerman","orcid":"https://orcid.org/0009-0004-5425-7511","observed_orcids":["https://orcid.org/0009-0004-5425-7511"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Zimmerman","raw_affiliation_strings":["University of Utah, Salt Lake City, UT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah, Salt Lake City, UT, United States","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mingyang A. Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingyang A. Zhang","raw_affiliation_strings":["University of Utah, Salt Lake City, UT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah, Salt Lake City, UT, United States","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044620477","display_name":"My N. Helms","orcid":"https://orcid.org/0000-0002-0954-8481","observed_orcids":["https://orcid.org/0000-0002-0954-8481"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"My N. Helms","raw_affiliation_strings":["University of Utah, Salt Lake City, UT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah, Salt Lake City, UT, United States","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087218579","display_name":"Robert Paine","orcid":"https://orcid.org/0000-0002-4511-4437","observed_orcids":["https://orcid.org/0000-0002-4511-4437"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Paine","raw_affiliation_strings":["University of Utah, Salt Lake City, UT, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah, Salt Lake City, UT, United States","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I223532165"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04168912,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.4871000051498413,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.4871000051498413,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.3379000127315521,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.07750000059604645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.996999979019165},{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor","display_name":"aryl hydrocarbon receptor","score":0.9789999723434448},{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.9279999732971191},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8830000162124634},{"id":"https://openalex.org/keywords/small-airway-epithelial-cells","display_name":"small airway epithelial cells","score":0.8999999761581421},{"id":"https://openalex.org/keywords/particulate-matter","display_name":"particulate matter","score":0.9020000100135803},{"id":"https://openalex.org/keywords/ficz","display_name":"FICZ","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cyp1a1","display_name":"CYP1A1","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cyp1b1","display_name":"CYP1B1","score":0.996999979019165},{"id":"https://openalex.org/keywords/air-pollution","display_name":"air pollution","score":0.5730000138282776},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.7229999899864197},{"id":"https://openalex.org/keywords/ch223191","display_name":"CH223191","score":0.8799999952316284},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C2776907368","wikidata":"https://www.wikidata.org/wiki/Q307302","display_name":"Glutathione S-transferase","level":4,"score":0.6243168115615845},{"id":"https://openalex.org/C2779033964","wikidata":"https://www.wikidata.org/wiki/Q407212","display_name":"Polycyclic aromatic hydrocarbon","level":2,"score":0.558485746383667},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4948977828025818},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.4805319905281067},{"id":"https://openalex.org/C2777720266","wikidata":"https://www.wikidata.org/wiki/Q19834818","display_name":"Aromatic hydrocarbon","level":3,"score":0.45062002539634705},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4195689857006073},{"id":"https://openalex.org/C2777207669","wikidata":"https://www.wikidata.org/wiki/Q43648","display_name":"Hydrocarbon","level":2,"score":0.415115088224411},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3862878680229187},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37239599227905273},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3097442388534546},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.19016221165657043},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06976169347763062}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1152/physiol.2024.39.s1.1897","doi":"https://doi.org/10.1152/physiol.2024.39.s1.1897","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiol.2024.39.s1.1897","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4200613064","https://openalex.org/W2067716481","https://openalex.org/W2367237044","https://openalex.org/W173958657","https://openalex.org/W2049763386","https://openalex.org/W2335927495","https://openalex.org/W2386782843","https://openalex.org/W2560315094","https://openalex.org/W2382438757","https://openalex.org/W2187703029"],"abstract_inverted_index":{"Background:":[0],"PAH":[1,32,86,141,166,208,252,284,332,378],"represents":[2],"the":[3,15,47,79,204,386,408,419,424,454],"organic":[4],"phase":[5],"of":[6,18,34,72,83,108,116,143,151,165,183,200,207,306,331,336,355,395],"particulate":[7],"matter":[8],"(PM)":[9],"in":[10,43,104,123,154,275,282,308,342,366,407,434,453],"air":[11],"pollution":[12],"emitted":[13],"via":[14,149,388],"incomplete":[16],"combustion":[17],"various":[19],"compounds":[20],"(i.e.":[21],"diesel":[22],"fuel,":[23],"wood,":[24],"and":[25,67,179,194,209,214,224,253,259,264,267,348,414,430],"plastics).":[26],"It":[27],"is":[28,76,418,431],"widely":[29],"regarded":[30],"that":[31,118,140,360,376],"activation":[33,82,95,142,199,305,335],"aryl":[35],"hydrocarbon":[36],"receptor":[37],"(AhR)":[38],"plays":[39,119,362],"an":[40,120,363],"important":[41,121,364],"role":[42,122,365],"pro-inflammatory":[44],"signaling,":[45],"however":[46],"mechanisms":[48],"remain":[49],"unknown.":[50],"In":[51,278],"contrast-":[52],"endogenous":[53,97,197],"AhR":[54,84,144,234,307,337,361,390,396],"agonists,":[55],"such":[56],"as":[57,271],"6-Formylindolo[3,2-b]carbazole":[58],"(FICZ),":[59],"exert":[60],"pleiotropic":[61],"protective":[62],"effects":[63,330,384],"against":[64],"inflammation,":[65],"fibrosis,":[66],"oxidative":[68,102,127,147,289,370],"stress.":[69,371],"The":[70],"objective":[71],"our":[73,276],"research":[74],"program":[75],"to":[77,91,133,146,162,173,180,191,400],"delineate":[78],"differences":[80],"between":[81],"by":[85,96,211],"(with":[87],"adverse":[88],"effects)":[89],"compared":[90],"its":[92],"beneficial":[93],"homeostatic":[94],"FICZ.":[98],"PM":[99,176],"may":[100],"induce":[101],"stress":[103,148,219,290],"part":[105],"through":[106],"inhibition":[107,150,354],"antioxidant":[109],"defense":[110],"mechanisms.":[111],"GSTs":[112],"are":[113,268,438],"a":[114,279,312],"superfamily":[115],"enzymes":[117],"protecting":[124,367],"cells":[125,350,368],"from":[126,311,323,369],"damage":[128],"(by":[129],"conjugating":[130],"reduced":[131],"glutathione":[132],"substrates":[134],"under":[135],"pro-oxidizing":[136],"conditions).":[137],"We":[138,202],"hypothesize":[139],"contributes":[145],"GST":[152,225,299,339,356],"activity":[153,226,235,301,358,394],"primary":[155,309],"hSAECs.":[156],"Methods:":[157],"Primary":[158],"hSAECs":[159,310,347],"were":[160,340],"subjected":[161],"varying":[163],"dosages":[164],"[0,":[167,185],"250,":[168],"500,":[169],"1000,":[170],"5000":[171],"ng/mL]":[172],"model":[174,192],"airborne":[175,377],"exposure":[177,379],"levels,":[178],"increasing":[181],"doses":[182],"FICZ":[184,210,254,292,304,334],"0.50,":[186],"10,":[187],"100,":[188],"1000":[189],"nM]":[190],"normal":[193],"excessively":[195],"high":[196],"ligand":[198],"AhR.":[201],"determined":[203],"relative":[205],"potencies":[206],"measuring":[212],"CYP1A1":[213,258],"CYP1B1":[215,260],"gene":[216],"expression.":[217],"Oxidative":[218],"was":[220,227,236,244,450],"measured":[221,228],"using":[222,239,246],"DHE-labeling":[223],"with":[229,345],"enzymatic":[230,357],"kits":[231],"(Sigma":[232],"Aldrich).":[233],"pharmacologically":[237],"inhibited":[238],"10\u03bcM":[240],"CH223191.":[241],"Statistical":[242],"analysis":[243],"conducted":[245],"SigmaPlot":[247],"14.0":[248],"(Systat":[249],"Software).":[250],"Results:":[251],"maximally":[255],"stimulate":[256],"hSAEC":[257,288],"expression":[261],"at":[262,423],"1000ng/mL":[263],"100nM,":[265],"respectively,":[266],"therefore":[269],"defined":[270],"equipotent":[272,303],"concentrations":[273],"used":[274],"studies.":[277],"representative":[280],"experiment":[281],"hSAECs,":[283],"(1000ng/mL)":[285],"significantly":[286,297],"increased":[287],"vs":[291,302,319,333],"(100nM)":[293],"n=6,":[294],"p<0.01),":[295],"while":[296],"decreasing":[298],"specific":[300],"66-year-old":[313],"female":[314],"without":[315],"lung":[316,387],"disease":[317],"(26.6\u00b10.874":[318],"28.3\u00b1.611":[320],"nmol/mL/min);":[321],"n=6":[322],"2":[324],"independent":[325],"assays;":[326],"p=0.032.":[327],"Similar":[328],"differential":[329],"on":[338,385],"seen":[341],"additional":[343,440,443],"experiments":[344],"male":[346],"Calu-3":[349],"(male).":[351],"Importantly,":[352],"CH223191":[353],"suggests":[359],"Conclusions:":[372],"Our":[373],"studies":[374],"indicate":[375],"can":[380,398],"have":[381],"detrimental":[382],"health":[383],"aberrant":[389],"signaling.":[391],"Significance:":[392],"Understanding":[393],"signaling":[397],"leads":[399],"novel":[401],"therapeutic":[402],"options":[403],"for":[404,446],"redox":[405],"disorders":[406],"lung.":[409],"Funding:":[410],"VA":[411],"5I01BX001777-05":[412],"(RP)":[413],"R01HL137033":[415],"(MH).":[416],"This":[417],"full":[420],"abstract":[421],"presented":[422],"American":[425],"Physiology":[426,449],"Summit":[427],"2024":[428],"meeting":[429],"only":[432],"available":[433,445],"HTML":[435],"format.":[436],"There":[437],"no":[439],"versions":[441],"or":[442],"content":[444],"this":[447],"abstract.":[448],"not":[451],"involved":[452],"peer":[455],"review":[456],"process.":[457]},"counts_by_year":[],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2025-10-10T00:00:00"}
