{"id":"https://openalex.org/W4398166300","doi":"https://doi.org/10.1152/physiol.2024.39.s1.2140","title":"The Role of Microvascular Rarefaction in Dysfunctional Pericardial Adipose Tissue","display_name":"The Role of Microvascular Rarefaction in Dysfunctional Pericardial Adipose Tissue","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4398166300","doi":"https://doi.org/10.1152/physiol.2024.39.s1.2140"},"language":"en","primary_location":{"id":"doi:10.1152/physiol.2024.39.s1.2140","doi":"https://doi.org/10.1152/physiol.2024.39.s1.2140","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiol.2024.39.s1.2140","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037428702","display_name":"Katie Anne Fopiano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katie Anne Fopiano","raw_affiliation_strings":["Medical College of Georgia, Augusta University, Augusta, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Georgia, Augusta University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039428584","display_name":"Claire M Cotton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire M Cotton","raw_affiliation_strings":["Medical College of Georgia, Augusta University, Augusta, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Georgia, Augusta University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016702603","display_name":"Vijay S Patel","orcid":"https://orcid.org/0000-0002-8402-2682","observed_orcids":["https://orcid.org/0000-0002-8402-2682"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vijay S Patel","raw_affiliation_strings":["Medical College of Georgia, Augusta University, Augusta, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Georgia, Augusta University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015124366","display_name":"Zsolt A Bagi","orcid":"https://orcid.org/0000-0001-8755-2980","observed_orcids":["https://orcid.org/0000-0001-8755-2980"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zsolt Bagi","raw_affiliation_strings":["Medical College of Georgia, Augusta University, Augusta, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical College of Georgia, Augusta University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I25041050"],"apc_list":null,"apc_paid":null,"fwci":0.2722,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.58514121,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"39","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12291","display_name":"Pericarditis and Cardiac Tamponade","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pericardial-adipose-tissue","display_name":"pericardial adipose tissue","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adipose-tissue-vascularization","display_name":"adipose tissue vascularization","score":0.7049999833106995},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7570000290870667},{"id":"https://openalex.org/keywords/adipocyte-size","display_name":"adipocyte size","score":0.8149999976158142},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.875},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9110000133514404},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.9599999785423279},{"id":"https://openalex.org/keywords/microvascular-rarefaction","display_name":"microvascular rarefaction","score":0.7829999923706055},{"id":"https://openalex.org/keywords/adipose-tissue-dysfunction","display_name":"adipose tissue dysfunction","score":0.7490000128746033},{"id":"https://openalex.org/keywords/perfusion","display_name":"perfusion","score":0.45899999141693115},{"id":"https://openalex.org/keywords/3d-vessel-reconstruction","display_name":"3D vessel reconstruction","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.7426546812057495},{"id":"https://openalex.org/C27502469","wikidata":"https://www.wikidata.org/wiki/Q906343","display_name":"Dysfunctional family","level":2,"score":0.6016756296157837},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5100098848342896},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.48188644647598267},{"id":"https://openalex.org/C2909906576","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Epicardial adipose tissue","level":3,"score":0.4576624035835266},{"id":"https://openalex.org/C2778875491","wikidata":"https://www.wikidata.org/wiki/Q193302","display_name":"Pericardium","level":2,"score":0.4359700083732605},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3946800231933594},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3770475387573242},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3447663187980652},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3275078237056732},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1152/physiol.2024.39.s1.2140","doi":"https://doi.org/10.1152/physiol.2024.39.s1.2140","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiol.2024.39.s1.2140","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7900000214576721}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2509948331","https://openalex.org/W4247167749","https://openalex.org/W4235404868","https://openalex.org/W4248285285","https://openalex.org/W2358819679","https://openalex.org/W2102614095","https://openalex.org/W2193481794","https://openalex.org/W1601153898","https://openalex.org/W2291596319","https://openalex.org/W2033211496"],"abstract_inverted_index":{"Pericardial":[0],"adipose":[1,37,259],"tissue":[2,38,97,260],"(PAT)":[3],"in":[4,123,150,268,290,328,347],"obesity":[5],"has":[6],"been":[7],"shown":[8],"to":[9,28,179,191,236,247,254,284,301],"be":[10,297,302],"an":[11,100,110,154,226],"independent":[12],"risk":[13],"factor":[14],"for":[15,146,340],"coronary":[16,47],"heart":[17,48],"disease":[18,49],"but":[19],"the":[20,30,36,63,96,198,229,243,249,282,292,313,318,348],"underlying":[21],"mechanism":[22],"remains":[23],"incompletely":[24],"understood.":[25],"We":[26],"aimed":[27],"elucidate":[29],"interrelationship":[31],"between":[32],"PAT":[33,40,78,230,251],"expansion":[34],"and":[35,62,65,76,121,142,148,171,184,207,257,324],"vascularization.":[39],"samples":[41,57],"were":[42,58,84,118,134,143],"collected":[43],"from":[44],"patients":[45],"with":[46,128,161,214,225,276],"(19":[50],"patients;":[51],"age:":[52],"48-79;":[53],"BMI:":[54],"22.29-41.09).":[55],"Tissue":[56],"stained":[59],"using":[60,71,86,99,109],"H&E":[61],"number":[64,131,167,199],"size":[66,157,223],"of":[67,95,132,139,163,168,200],"adipocytes":[68],"was":[69,107,264,344],"quantified":[70,108],"unbiased":[72],"techniques":[73],"via":[74],"AdipoCount":[75],"ImageJ.":[77,151],"samples,":[79],"cut":[80],"40":[81],"\u03bcm":[82],"thick,":[83],"immunolabelled":[85],"DyLight":[87],"594":[88],"fluorescent":[89],"tomato-lectin":[90],"dye":[91],"followed":[92],"by":[93,197],"quantification":[94],"vasculature":[98,244],"unbiased,":[101],"automatic":[102],"3D":[103],"reconstruction":[104],"(Vesselucida360).":[105],"Angiogenesis":[106],"ex":[111],"vivo":[112,291],"angiogenic":[113,140,269,287,294],"assay":[114],"whereby":[115],"pericardial":[116],"vessels":[117,280],"isolated,":[119],"cut,":[120],"embedded":[122],"a":[124,137,176,211,233,265],"collagen":[125],"matrix":[126],"sustained":[127],"growth":[129,277],"factors;":[130],"sprouts":[133],"used":[135],"as":[136,158,166],"measure":[138],"potential":[141,270],"further":[144,303],"analyzed":[145],"length":[147],"branching":[149,169,205,208],"Patients":[152],"exhibited":[153],"increased":[155,160],"adipocyte":[156,222],"BMI":[159],"measures":[162],"vascularization,":[164],"such":[165],"nodes":[170],"total":[172],"vessel":[173,185,201],"length,":[174,204,206],"showed":[175,188,210],"negative":[177,234],"correlation":[178,190,235],"increasing":[180,215,227,237,250],"BMI.":[181,193,216,238],"Vessel":[182],"volume":[183],"surface":[186],"area":[187],"no":[189,333],"patient":[192],"Angiogenic":[194],"potential,":[195,288],"measured":[196],"sprouts,":[202],"sprouting":[203],"interval,":[209],"significant":[212,266],"association":[213],"Our":[217],"data":[218],"show":[219],"that":[220,242,271,273],"while":[221],"increases":[224],"BMI,":[228],"vascularization":[231],"had":[232],"These":[239],"results":[240],"suggest":[241],"is":[245,312,325],"insuffcient":[246],"supply":[248],"demand,":[252],"leading":[253],"impaired":[255],"perfusion":[256],"eventual":[258],"dysfunction.":[261],"However,":[262],"there":[263],"increase":[267,285],"shows":[272],"when":[274],"provided":[275],"factors,":[278],"these":[279],"have":[281],"ability":[283],"their":[286],"yet":[289],"vascular":[293],"response":[295],"may":[296],"hindered,":[298],"which":[299],"needs":[300],"studied.":[304],"T32":[305],"HL155011":[306],"(KAF)":[307],"F31":[308],"NS132564":[309],"(KAF).":[310],"This":[311],"full":[314],"abstract":[315],"presented":[316],"at":[317],"American":[319],"Physiology":[320,343],"Summit":[321],"2024":[322],"meeting":[323],"only":[326],"available":[327,339],"HTML":[329],"format.":[330],"There":[331],"are":[332],"additional":[334,337],"versions":[335],"or":[336],"content":[338],"this":[341],"abstract.":[342],"not":[345],"involved":[346],"peer":[349],"review":[350],"process.":[351]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2025-10-10T00:00:00"}
