{"id":"https://openalex.org/W4398166243","doi":"https://doi.org/10.1152/physiol.2024.39.s1.1630","title":"Determination of surfactant secretion in precision-cut lung slices","display_name":"Determination of surfactant secretion in precision-cut lung slices","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4398166243","doi":"https://doi.org/10.1152/physiol.2024.39.s1.1630"},"language":"en","primary_location":{"id":"doi:10.1152/physiol.2024.39.s1.1630","doi":"https://doi.org/10.1152/physiol.2024.39.s1.1630","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1152/physiol.2024.39.s1.1630","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113921135","display_name":"B. Khade","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bipin Khade","raw_affiliation_strings":["Vagelos College of P&S of Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vagelos College of P&S of Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049223369","display_name":"Mohammad Naimul Islam","orcid":"https://orcid.org/0000-0001-7929-9444","observed_orcids":["https://orcid.org/0000-0001-7929-9444"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad Islam","raw_affiliation_strings":["Vagelos College of P&S of Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vagelos College of P&S of Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089054248","display_name":"Sunita Bhattacharya","orcid":"https://orcid.org/0000-0002-2476-1280","observed_orcids":["https://orcid.org/0000-0002-2476-1280"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunita Bhattacharya","raw_affiliation_strings":["Vagelos College of P&S of Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vagelos College of P&S of Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076054649","display_name":"Jahar Bhattacharya","orcid":"https://orcid.org/0000-0002-5588-6211","observed_orcids":["https://orcid.org/0000-0002-5588-6211"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jahar Bhattacharya","raw_affiliation_strings":["Vagelos College of P&S of Columbia University, New York, NY, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vagelos College of P&S of Columbia University, New York, NY, United States","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113921135"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12356252,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-surfactant-secretion","display_name":"pulmonary surfactant secretion","score":0.9599999785423279},{"id":"https://openalex.org/keywords/alveolar-type-ii-cells","display_name":"alveolar type II cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/precision-cut-lung-slices","display_name":"precision-cut lung slices","score":0.9819999933242798},{"id":"https://openalex.org/keywords/atpgammas","display_name":"ATP gamma S","score":0.4449999928474426},{"id":"https://openalex.org/keywords/intercellular-heterogeneity","display_name":"intercellular heterogeneity","score":0.6399999856948853},{"id":"https://openalex.org/keywords/lysotracker-red","display_name":"LysoTracker Red","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.7709277868270874},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6894144415855408},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5104135870933533},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44163867831230164},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3830357789993286},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3734963834285736},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.289895236492157},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2685074210166931},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1919969618320465}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1152/physiol.2024.39.s1.1630","doi":"https://doi.org/10.1152/physiol.2024.39.s1.1630","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1152/physiol.2024.39.s1.1630","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7096345390","https://openalex.org/W4396515709","https://openalex.org/W2304344479","https://openalex.org/W2023727546","https://openalex.org/W2042903540","https://openalex.org/W206100492","https://openalex.org/W2064634791","https://openalex.org/W2089627678","https://openalex.org/W3176470400","https://openalex.org/W2076945592"],"abstract_inverted_index":{"Surfactant,":[0],"secreted":[1],"from":[2],"type":[3],"2":[4],"(AT2)":[5],"cells":[6],"of":[7,18,24,39,109,114,119,127,169],"the":[8,16,61,68,83,100,122,135,170,184,189,219],"alveolar":[9,13,85],"epithelium":[10],"(AE),":[11],"maintains":[12],"stability.":[14],"However,":[15],"variability":[17],"surfactant":[19,115,159],"secretion,":[20],"a":[21,151],"possible":[22],"cause":[23],"regional":[25],"lung":[26,36,41,176],"disease,":[27],"remains":[28],"unquantified.":[29],"To":[30],"address":[31],"this,":[32],"we":[33,56],"cultured":[34],"precision-cut":[35],"slices":[37],"(PCLS)":[38],"mouse":[40],"explants,":[42],"using":[43],"low-melting":[44],"point":[45],"agarose":[46],"as":[47,78],"per":[48],"reported":[49],"protocols.":[50],"For":[51],"real-time":[52],"confocal":[53],"imaging":[54],"(RCM),":[55],"loaded":[57],"day-old":[58],"PCLS":[59,149],"with":[60,94],"cytosolic":[62],"marker":[63],"calcein":[64],"green":[65],"(CG)":[66],"and":[67,195],"AT2":[69,97,120,156,165],"cell":[70],"marker,":[71],"lysotracker":[72],"red":[73],"(LTR).":[74],"RCM":[75],"revealed":[76],"alveoli":[77],"CG-stained":[79],"AE":[80],"that":[81],"circumscribed":[82],"non-fluorescent":[84],"lumen.":[86],"Each":[87],"slice":[88,101],"(n=3)":[89],"contained":[90],">300":[91],"alveoli,":[92],"each":[93],"an":[95],"LTR+":[96],"cell.":[98],"Exposing":[99],"to":[102,125,138],"ATPgamma-s":[103],"(4":[104],"microM)":[105],"induced":[106],"progressive":[107],"loss":[108],"LTR":[110],"fluorescence,":[111],"denoting":[112],"induction":[113],"secretion.":[116],"In":[117,133,140],"60%":[118],"cells,":[121],"fluorescence":[123],"decreased":[124],"40\u00b12%":[126],"initial":[128],"in":[129,199,218],"50":[130],"min":[131],"(p<0.01).":[132],"11%,":[134],"decrease":[136],"was":[137,143,215],"59\u00b11%.":[139],"29%,":[141],"there":[142],"no":[144,204],"decrease.":[145],"We":[146],"conclude:":[147],"(i)":[148],"provide":[150],"robust":[152],"platform":[153],"for":[154,211],"quantifying":[155],"secretion;":[157],"(ii)":[158],"secretion":[160],"rates":[161],"vary":[162],"considerably":[163],"amongst":[164],"cells.":[166],"Mechanistic":[167],"basis":[168],"variation,":[171],"hence":[172],"its":[173],"impact":[174],"on":[175],"function":[177],"must":[178],"be":[179],"understood.":[180],"HL36024.":[181],"This":[182],"is":[183,196],"full":[185],"abstract":[186],"presented":[187],"at":[188],"American":[190],"Physiology":[191,214],"Summit":[192],"2024":[193],"meeting":[194],"only":[197],"available":[198,210],"HTML":[200],"format.":[201],"There":[202],"are":[203],"additional":[205,208],"versions":[206],"or":[207],"content":[209],"this":[212],"abstract.":[213],"not":[216],"involved":[217],"peer":[220],"review":[221],"process.":[222]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2024-05-22T00:00:00"}
