{"id":"https://openalex.org/W4398166164","doi":"https://doi.org/10.1152/physiol.2024.39.s1.1393","title":"Characterization of Diabetic Intramuscular Adipose Tissue and its Impact on Skeletal Muscle","display_name":"Characterization of Diabetic Intramuscular Adipose Tissue and its Impact on Skeletal Muscle","publication_year":2024,"publication_date":"2024-05-01","ids":{"openalex":"https://openalex.org/W4398166164","doi":"https://doi.org/10.1152/physiol.2024.39.s1.1393"},"language":"en","primary_location":{"id":"doi:10.1152/physiol.2024.39.s1.1393","doi":"https://doi.org/10.1152/physiol.2024.39.s1.1393","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiol.2024.39.s1.1393","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070199376","display_name":"Chang Gui","orcid":"https://orcid.org/0009-0001-4589-674X","observed_orcids":["https://orcid.org/0009-0001-4589-674X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chang Gui","raw_affiliation_strings":["Washington University In St. Louis, SAINT LOUIS, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University In St. Louis, SAINT LOUIS, MO, United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040866146","display_name":"Kathryn L. Bohnert","orcid":"https://orcid.org/0000-0003-2612-6771","observed_orcids":["https://orcid.org/0000-0003-2612-6771"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn Bohnert","raw_affiliation_strings":["Washington University In St. Louis School of Medicine, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University In St. Louis School of Medicine, MO, United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080777770","display_name":"Jeremy J. McCormick","orcid":"https://orcid.org/0000-0001-6391-9645","observed_orcids":["https://orcid.org/0000-0001-6391-9645"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy McCormick","raw_affiliation_strings":["Washington University In St. Louis School of Medicine, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University In St. Louis School of Medicine, MO, United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098730624","display_name":"Jonathon Bakus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathon Bakus","raw_affiliation_strings":["Washington University In St. Louis School of Medicine, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University In St. Louis School of Medicine, MO, United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015510354","display_name":"Jeffrey E. Johnson","orcid":"https://orcid.org/0000-0003-2055-9998","observed_orcids":["https://orcid.org/0000-0003-2055-9998"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Johnson","raw_affiliation_strings":["Washington University In St. Louis School of Medicine, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University In St. Louis School of Medicine, MO, United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083260275","display_name":"Sandra E. Klein","orcid":"https://orcid.org/0000-0003-2416-1186","observed_orcids":["https://orcid.org/0000-0003-2416-1186"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra Klein","raw_affiliation_strings":["Washington University In St. Louis School of Medicine, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University In St. Louis School of Medicine, MO, United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068159926","display_name":"Gretchen A. Meyer","orcid":"https://orcid.org/0000-0001-9268-3993","observed_orcids":["https://orcid.org/0000-0001-9268-3993"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gretchen Meyer","raw_affiliation_strings":["Washington University In St. Louis School of Medicine, Saint Louis, MO, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University In St. Louis School of Medicine, Saint Louis, MO, United States","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09777239,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.5346999764442444,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.5346999764442444,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.4140999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.020999999716877937,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intramuscular-fat","display_name":"intramuscular fat","score":0.9890000224113464},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9660000205039978},{"id":"https://openalex.org/keywords/skeletal-muscle-regeneration","display_name":"skeletal muscle regeneration","score":0.6669999957084656},{"id":"https://openalex.org/keywords/fatty-infiltration","display_name":"fatty infiltration","score":0.6650000214576721},{"id":"https://openalex.org/keywords/adipose-progenitor-cells","display_name":"adipose progenitor cells","score":0.781000018119812},{"id":"https://openalex.org/keywords/wnt2","display_name":"Wnt2","score":0.8009999990463257},{"id":"https://openalex.org/keywords/myogenesis","display_name":"myogenesis","score":0.6930000185966492},{"id":"https://openalex.org/keywords/brown-adipose-tissue-browning","display_name":"brown adipose tissue browning","score":0.7139999866485596},{"id":"https://openalex.org/keywords/subcutaneous-adipose-tissue","display_name":"subcutaneous adipose tissue","score":0.8769999742507935},{"id":"https://openalex.org/keywords/abductor-hallucis-muscle","display_name":"abductor hallucis muscle","score":0.7860000133514404},{"id":"https://openalex.org/keywords/myosin-heavy-chain","display_name":"myosin heavy chain","score":0.7139999866485596},{"id":"https://openalex.org/keywords/conditioned-medium","display_name":"conditioned medium","score":0.5809999704360962},{"id":"https://openalex.org/keywords/adipose-tissue-secretome","display_name":"adipose tissue secretome","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.762126088142395},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.750940203666687},{"id":"https://openalex.org/C2778514504","wikidata":"https://www.wikidata.org/wiki/Q797559","display_name":"Muscle tissue","level":2,"score":0.431857705116272},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.41954857110977173},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.415394127368927},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3807506561279297},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3706855773925781},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3653700053691864},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.35686439275741577}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1152/physiol.2024.39.s1.1393","doi":"https://doi.org/10.1152/physiol.2024.39.s1.1393","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiol.2024.39.s1.1393","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4415641676","https://openalex.org/W6977819115","https://openalex.org/W4414199454","https://openalex.org/W3045635355","https://openalex.org/W2163557041","https://openalex.org/W4387742216","https://openalex.org/W1602327320","https://openalex.org/W7169188589","https://openalex.org/W4224871277","https://openalex.org/W1639022033"],"abstract_inverted_index":{"Obesity":[0],"and":[1,29,59,62,80,112,123,141,146,168,216,241,321,356,370,399],"type":[2,125],"2":[3,126],"Diabetes":[4],"exhibit":[5],"a":[6,91,202,242,294,312,350,375,381],"muscle":[7,16,67,82,111,231,369],"pathology":[8],"called":[9],"fatty":[10],"infiltration":[11],"where":[12],"adipocytes":[13],"develop":[14],"between":[15,166,353,368],"fibers":[17],"in":[18,32,56,135,190,205,307,326,403,422],"the":[19,36,75,108,182,245,254,291,336,366,388,393,423],"intramuscular":[20,52],"space.":[21],"This":[22,333,386],"is":[23,187,304,387,400],"associated":[24],"with":[25,90,122,273,293,311,316,328,346],"reduced":[26],"contractile":[27],"strength":[28],"physical":[30],"function":[31],"these":[33,198],"populations.":[34],"However,":[35],"mechanisms":[37],"governing":[38],"this":[39,46,97,136,208,416],"phenomenon":[40],"are":[41,407],"not":[42,269,420],"well":[43],"understood.":[44],"In":[45,207],"study,":[47],"we":[48,85,154],"aim":[49],"to":[50,94,133,219,225,300,343,361],"characterize":[51],"adipose":[53,147,354],"tissue":[54,331,355],"(IMAT)":[55],"both":[57,121],"healthy":[58],"diabetic":[60,193,322],"patients":[61,116],"explore":[63],"its":[64],"impact":[65,252],"on":[66,257],"regeneration.":[68,83],"We":[69,103,195,297],"hypothesized":[70],"that":[71,164,181,278,302],"diabetes":[72],"would":[73],"alter":[74],"secretory":[76,162],"profile":[77,339],"of":[78,228,244,253,285,340],"IMAT":[79,106,167,191,308,341],"hinder":[81],"Finally,":[84],"treated":[86,310],"IMAT-derived":[87],"progenitor":[88,148],"cells":[89],"browning":[92,295,313],"agent":[93],"determine":[95],"whether":[96],"intervention":[98],"could":[99],"modulate":[100],"IMAT-muscle":[101],"cross-talk.":[102],"collected":[104,237,248],"human":[105,230],"from":[107,115,279],"abductor":[109],"hallucis":[110],"subcutaneous":[113,169,344],"fat":[114,170,372],"during":[117],"elective":[118],"below-knee":[119],"amputation,":[120],"without":[124],"Diabetes.":[127],"All":[128],"participants":[129],"gave":[130],"informed":[131],"consent":[132],"participate":[134],"study.":[137],"Samples":[138],"were":[139,211,235,298],"divided":[140],"processed":[142],"for":[143,238,249,415],"RNA":[144],"sequencing":[145],"cell":[149],"(APC)":[150],"isolation.":[151],"Following":[152],"sequencing,":[153],"identified":[155,348],"top":[156],"differentially":[157,305],"expressed":[158,306],"genes":[159,200],"(DEGs)":[160],"encoding":[161],"proteins":[163],"differed":[165],"across":[171],"participants,":[172],"including":[173,277],"WNT2,":[174],"BMP5,":[175],"OSTN.":[176],"Additionally,":[177],"IPA":[178],"analysis":[179,240],"revealed":[180],"Wound":[183],"Healing":[184],"Signaling":[185],"pathway":[186],"more":[188,376],"activated":[189],"under":[192,213],"conditions.":[194],"then":[196,217],"screened":[197],"target":[199],"using":[201],"co-culture":[203],"system":[204],"vitro.":[206],"system,":[209],"APCs":[210,292,309],"cultured":[212],"different":[214],"conditions":[215,323],"used":[218],"condition":[220],"media":[221,246,256],"which":[222],"was":[223,247,259,268,287,419],"applied":[224],"separate":[226],"cultures":[227],"isolated":[229],"myoblasts.":[232],"Cultured":[233],"ASCs":[234],"additionally":[236],"qPCR":[239],"sample":[243],"screening.":[250],"The":[251,359],"conditioned":[255,275],"myogenesis":[258,286,364],"assayed":[260],"by":[261,271,289],"Myosin":[262],"Heavy":[263],"Chain":[264],"(MHC)":[265],"immunostaining.":[266],"Myogenesis":[267],"affected":[270],"treatment":[272],"any":[274],"media,":[276],"Diabetic":[280],"IMAT.":[281],"Furthermore,":[282],"no":[283,408],"improvement":[284],"observed":[288],"treating":[290],"agent.":[296],"able":[299],"confirm":[301],"WNT2":[303,347],"agent,":[314],"compared":[315,342],"SQ":[317],"(p=0.0406,":[318],"n=4,":[319],"FC=0.47)":[320],"(p=0.1581,":[324],"n=5),":[325],"line":[327],"our":[329],"intact":[330],"RNAseq.":[332],"study":[334],"highlights":[335],"distinct":[337],"transcriptional":[338],"fat,":[345],"as":[349],"potential":[351],"mediator":[352],"skeletal":[357],"muscle.":[358],"failure":[360],"observe":[362],"decreased":[363],"implies":[365],"crosstalk":[367],"muscle-associated":[371],"might":[373],"involve":[374],"complex":[377],"cell-cell":[378],"network":[379],"than":[380],"simple":[382],"ASC-myoblast":[383],"interaction.":[384],"1R01AR075773-01.":[385],"full":[389],"abstract":[390],"presented":[391],"at":[392],"American":[394],"Physiology":[395,418],"Summit":[396],"2024":[397],"meeting":[398],"only":[401],"available":[402,414],"HTML":[404],"format.":[405],"There":[406],"additional":[409,412],"versions":[410],"or":[411],"content":[413],"abstract.":[417],"involved":[421],"peer":[424],"review":[425],"process.":[426]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2024-05-22T00:00:00"}
