{"id":"https://openalex.org/W43976263","doi":null,"title":"Melanocyte photobiology, ultraviolet radiation and melanoma.","display_name":"Melanocyte photobiology, ultraviolet radiation and melanoma.","publication_year":2010,"publication_date":"2010-10-01","ids":{"openalex":"https://openalex.org/W43976263","mag":"43976263","pmid":"https://pubmed.ncbi.nlm.nih.gov/20930695"},"language":"en","primary_location":{"id":"pmid:20930695","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20930695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108450015","display_name":"S-J Seo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S-J Seo","raw_affiliation_strings":["Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078874539","display_name":"David E. Fisher","orcid":"https://orcid.org/0000-0002-5506-0575","observed_orcids":["https://orcid.org/0000-0002-5506-0575"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D E Fisher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4194,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.59011647,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"145","issue":"5","first_page":"603","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.42410001158714294,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.42410001158714294,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.4138000011444092,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.11330000311136246,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanocytes","display_name":"melanocytes","score":0.9559999704360962},{"id":"https://openalex.org/keywords/ultraviolet-radiation","display_name":"ultraviolet radiation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/skin-cancer","display_name":"skin cancer","score":0.6330000162124634},{"id":"https://openalex.org/keywords/photobiology","display_name":"photobiology","score":0.6359999775886536},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.5619999766349792},{"id":"https://openalex.org/keywords/skin-carcinogenesis","display_name":"skin carcinogenesis","score":0.6200000047683716},{"id":"https://openalex.org/keywords/radiation-induced-mutagenesis","display_name":"radiation mutagenesis","score":0.5649999976158142},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.746999979019165},{"id":"https://openalex.org/keywords/chemotherapy-targets","display_name":"chemotherapeutic target","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C2777789703","wikidata":"https://www.wikidata.org/wiki/Q192102","display_name":"Skin cancer","level":3,"score":0.7516732811927795},{"id":"https://openalex.org/C2987742019","wikidata":"https://www.wikidata.org/wiki/Q11391","display_name":"Ultraviolet radiation","level":2,"score":0.6582242250442505},{"id":"https://openalex.org/C15095095","wikidata":"https://www.wikidata.org/wiki/Q908917","display_name":"Photobiology","level":2,"score":0.6508105993270874},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6120911836624146},{"id":"https://openalex.org/C2776798109","wikidata":"https://www.wikidata.org/wiki/Q11391","display_name":"Ultraviolet","level":2,"score":0.5808274149894714},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.50413978099823},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.48773011565208435},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47820019721984863},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4628787040710449},{"id":"https://openalex.org/C2779769559","wikidata":"https://www.wikidata.org/wiki/Q247101","display_name":"Melanocyte","level":3,"score":0.45908135175704956},{"id":"https://openalex.org/C107538193","wikidata":"https://www.wikidata.org/wiki/Q187526","display_name":"Melanin","level":2,"score":0.4221193492412567},{"id":"https://openalex.org/C2776960578","wikidata":"https://www.wikidata.org/wiki/Q3705873","display_name":"Photoaging","level":2,"score":0.4215394854545593},{"id":"https://openalex.org/C2987116853","wikidata":"https://www.wikidata.org/wiki/Q11391","display_name":"Ultraviolet light","level":2,"score":0.4121747314929962},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3802376389503479},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3165320158004761},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27902835607528687},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2740294933319092},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.13647523522377014},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13308897614479065},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07736527919769287},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008543","descriptor_name":"Melanins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008543","descriptor_name":"Melanins","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D052817","descriptor_name":"Phototrophic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:20930695","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20930695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia","raw_type":"Journal Article"},{"id":"mag:43976263","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20930695","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000877509","display_name":"MITF from control of pigmentation to melanoma risk","funder_award_id":"R01AR043369","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2735913246","https://openalex.org/W2012846873","https://openalex.org/W2807965241","https://openalex.org/W2409730740","https://openalex.org/W4409116550","https://openalex.org/W3038570307","https://openalex.org/W2792144160","https://openalex.org/W2740195203","https://openalex.org/W2059339966","https://openalex.org/W7052507545"],"abstract_inverted_index":{"Of":[0],"all":[1],"the":[2,5,8,24,30,49,55,64,75,86,91,94,98,112,126,129,133,136,153,171,185,190,196],"organs":[3],"of":[4,32,51,90,97,111,115,128,135,152,157,170,173,187],"human":[6],"body,":[7],"skin":[9,56,65,137,158],"is":[10,57,162,192],"most":[11,154],"commonly":[12],"affected":[13,99],"by":[14,198],"malignancy,":[15],"and":[16,72,178,221],"ultraviolet":[17,52,70,142,174,203],"radiation":[18,53,175,204],"has":[19,42,45],"long":[20],"been":[21],"implicated":[22],"as":[23,37,211],"primary":[25],"mutagenic":[26],"exposure":[27,140],"leading":[28],"to":[29,69,138,141,149,202,207],"development":[31],"many":[33],"cutaneous":[34],"cancers.":[35],"However,":[36],"research":[38],"in":[39,184],"this":[40],"field":[41],"continued,":[43],"it":[44,161],"become":[46],"clear":[47],"that":[48,164,179],"effect":[50,172],"on":[54,85,123,176],"quite":[58],"complex.":[59],"Distinct":[60],"cell":[61,77],"types":[62,156],"within":[63,74],"exhibit":[66],"differing":[67],"responses":[68,102],"radiation,":[71,92],"even":[73],"same":[76],"type,":[78],"divergent":[79],"effects":[80],"may":[81],"be":[82,104,208],"observed;":[83],"depending":[84],"dose":[87],"or":[88,93],"wavelength":[89],"maturational":[95],"state":[96],"cell,":[100],"unique":[101],"can":[103],"elicited.":[105],"Melanocytes":[106],"form":[107],"a":[108,167],"minor":[109],"component":[110],"outermost":[113],"layer":[114],"skin,":[116,130],"but":[117,131],"they":[118,215],"have":[119],"an":[120],"enormous":[121],"impact":[122],"not":[124],"only":[125],"appearance":[127],"also":[132],"ability":[134],"withstand":[139],"radiation.":[143],"In":[144],"addition,":[145],"melanocytes":[146,200],"give":[147],"rise":[148],"melanoma,":[150],"one":[151],"deadly":[155],"cancer.":[159],"Clearly,":[160],"critical":[163],"we":[165,180],"achieve":[166],"better":[168],"understanding":[169],"melanocytes,":[177],"clarify":[181],"its":[182],"role":[183],"oncogenesis":[186],"melanoma.":[188],"Although":[189],"picture":[191],"far":[193],"from":[194],"complete,":[195],"mechanisms":[197],"which":[199],"respond":[201],"are":[205],"beginning":[206],"elucidated,":[209],"and,":[210],"these":[212],"pathways":[213],"emerge,":[214],"offer":[216],"new":[217],"targets":[218],"for":[219],"chemopreventive":[220],"chemotherapeutic":[222],"intervention.":[223]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}