{"id":"https://openalex.org/W4397048436","doi":"https://doi.org/10.1681/asn.20233411s1812b","title":"Intracellular Acetyl-CoA Levels Are Pivotal for Nephron Progenitor Cell Fate Decisions","display_name":"Intracellular Acetyl-CoA Levels Are Pivotal for Nephron Progenitor Cell Fate Decisions","publication_year":2023,"publication_date":"2023-11-01","ids":{"openalex":"https://openalex.org/W4397048436","doi":"https://doi.org/10.1681/asn.20233411s1812b"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20233411s1812b","doi":"https://doi.org/10.1681/asn.20233411s1812b","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20233411s1812b","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065730559","display_name":"Giovane G. Tortelote","orcid":"https://orcid.org/0000-0002-9312-3442","observed_orcids":["https://orcid.org/0000-0002-9312-3442"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giovane G. Tortelote","raw_affiliation_strings":["Tulane University School of Medicine, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane University School of Medicine, New Orleans, LA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080632636","display_name":"Fabiola Diniz","orcid":"https://orcid.org/0000-0003-3302-0510","observed_orcids":["https://orcid.org/0000-0003-3302-0510"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fabiola Diniz","raw_affiliation_strings":["Tulane University School of Medicine, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane University School of Medicine, New Orleans, LA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071227922","display_name":"Sylvia A. Hilliard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sylvia Hilliard","raw_affiliation_strings":["Tulane University School of Medicine, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane University School of Medicine, New Orleans, LA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044765791","display_name":"Samir Sayem El-Dahr","orcid":"https://orcid.org/0000-0001-7571-4292","observed_orcids":["https://orcid.org/0000-0001-7571-4292"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samir S. El-Dahr","raw_affiliation_strings":["Tulane University School of Medicine, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane University School of Medicine, New Orleans, LA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"last","author":{"id":null,"display_name":"Tortelote Lab.","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tortelote Lab.","raw_affiliation_strings":["Tulane University School of Medicine, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane University School of Medicine, New Orleans, LA","institution_ids":["https://openalex.org/I114832834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114832834"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"11S","first_page":"812","last_page":"812"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nephron-progenitor-cells","display_name":"nephron progenitor cells","score":0.949999988079071},{"id":"https://openalex.org/keywords/acetyl-coa","display_name":"acetyl-CoA","score":0.9829999804496765},{"id":"https://openalex.org/keywords/nephron-endowment","display_name":"nephron endowment","score":0.8270000219345093},{"id":"https://openalex.org/keywords/kidney-development","display_name":"kidney development","score":0.6809999942779541},{"id":"https://openalex.org/keywords/glycolysis-inhibition","display_name":"glycolysis inhibition","score":0.9179999828338623},{"id":"https://openalex.org/keywords/sodium-acetate","display_name":"sodium acetate","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cholesterol-synthesis","display_name":"cholesterol biosynthesis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.6510000228881836},{"id":"https://openalex.org/keywords/cell-fate-differentiation","display_name":"cell fate differentiation","score":0.5770000219345093},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.7089999914169312},{"id":"https://openalex.org/keywords/mitochondrial-pyruvate-carrier","display_name":"mitochondrial pyruvate carrier","score":0.8859999775886536},{"id":"https://openalex.org/keywords/extracellular-acidification-rate","display_name":"extracellular acidification rate","score":0.7429999709129333},{"id":"https://openalex.org/keywords/hypertension-risk","display_name":"hypertension risk","score":0.574999988079071},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.5529999732971191},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.968999981880188},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C2781231759","wikidata":"https://www.wikidata.org/wiki/Q58184","display_name":"Nephron","level":3,"score":0.8423303961753845},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.7712497711181641},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.7023727893829346},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5139462351799011},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.4869445562362671},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.4311858117580414},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4309769570827484},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4072097837924957},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40616369247436523},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3559478521347046},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.338795006275177},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3266807794570923},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3184100389480591},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23197254538536072},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20233411s1812b","doi":"https://doi.org/10.1681/asn.20233411s1812b","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20233411s1812b","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4388998615","https://openalex.org/W3016416318","https://openalex.org/W4397041497","https://openalex.org/W2740277539","https://openalex.org/W3202295138","https://openalex.org/W2001693447","https://openalex.org/W4396994441","https://openalex.org/W4300690745","https://openalex.org/W2753457244","https://openalex.org/W4397048415"],"abstract_inverted_index":{"Background:":[0],"Low":[1],"nephron":[2,26],"endowment":[3,16],"at":[4,17,242],"birth":[5,18],"correlates":[6],"with":[7,112,181,209,284],"the":[8,60,69,74,94,113,162,201,217,243,288],"development":[9,305,318],"of":[10,38,62,164,205,236,245,267,291],"hypertension":[11],"in":[12,59,140,161,250],"later":[13],"life.":[14],"Nephron":[15],"is":[19,263],"governed":[20],"by":[21,105,232],"a":[22,63,146,211,228,300,309],"delicate":[23],"balance":[24],"between":[25,149],"progenitor":[27,46],"cells":[28],"(NPC)":[29],"self-renewal":[30],"and":[31,44,100,116,118,123,134,152,172,196,203,259,275,306,317],"differentiation.":[32,198,282],"Previous":[33],"studies":[34],"showed":[35,145,166,183],"that":[36],"inhibition":[37],"glycolysis":[39,70,292],"pushes":[40],"NPC":[41,153,194,207,240,281],"to":[42,92,215,313],"differentiation":[43,174,241],"causes":[45],"pool":[47],"depletion.":[48],"Methods:":[49],"Organ":[50],"culture":[51],"experiments:":[52],"E12.5":[53,157,177],"embryonic":[54,158,178],"kidneys":[55,159,179],"cultured":[56,109,160],"for":[57,110,121,303],"24h-48h":[58],"presence":[61,163],"vehicle":[64],"or":[65,83,213],"several":[66],"pharmacological":[67],"agents:":[68],"inhibitor":[71],"drug,":[72],"YN1;":[73],"mitochondrial":[75],"pyruvate":[76],"carrier":[77],"1":[78],"blocker,":[79],"UK5099;":[80],"sodium":[81],"acetate":[82],"canonical":[84],"Wnt":[85],"signaling":[86],"activator":[87],"(CHIR99021).":[88],"Immunofluorescence":[89],"was":[90],"performed":[91,139],"characterize":[93],"observed":[95],"phenotypes.":[96],"Bulk.":[97],"RNA":[98,125],"seq.":[99],"Proteomics:":[101],"NPCs":[102],"were":[103,138],"extracted":[104],"MACS":[106],"(passage":[107],"0),":[108],"24h":[111],"vehicle,":[114],"CHIR,":[115],"YN1,":[117],"then":[119],"processed":[120],"proteomics":[122],"bulk":[124],"sequencing.":[126],"Data":[127],"Analysis.":[128],"Differential":[129],"gene":[130],"expression,":[131],"pathway":[132,230],"analysis,":[133],"GO":[135],"enrichment":[136],"analysis":[137],"R.":[141],"Results:":[142],"Here,":[143],"we":[144],"direct":[147],"relationship":[148],"glucose":[150,260],"metabolism":[151],"fate":[154],"decisions.":[155],"First,":[156],"YN1":[165,214,253],"reduced":[167,187,197],"extracellular":[168],"acidification":[169],"rate":[170],"(ECAR),":[171],"increased":[173,185,271],"rate.":[175],"Second,":[176],"stimulated":[180,208,239],"UK5099":[182],"an":[184,264],"ECAR,":[186],"ATP":[188],"production":[189,258],"from":[190],"oxidative":[191],"phosphorylation,":[192],"augmented":[193],"pool,":[195],"We":[199],"compared":[200],"proteome":[202],"transcriptome":[204],"E13.5":[206],"either":[210],"CHIR":[212],"dissect":[216],"molecular":[218],"mechanism":[219],"underlying":[220],"these":[221],"phenomena.":[222],"Decreased":[223],"cholesterol":[224,237,257],"biosynthesis":[225],"emerged":[226],"as":[227,299,308],"top":[229],"targeted":[231],"both":[233],"drugs.":[234],"Inhibition":[235],"synthesis":[238],"cost":[244],"cap":[246,276],"mesenchyme":[247,277],"depletion,":[248],"which,":[249],"turn,":[251],"phenocopied":[252],"treatment.":[254],"Acetyl-CoA":[255],"links":[256],"metabolism.":[261],"Sodium-acetate":[262,269],"alternative":[265],"source":[266],"acetyl-CoA.":[268],"supplementation":[270],"cytosolic":[272],"acetyl-CoA":[273,298],"levels":[274],"size,":[278],"without":[279],"hindering":[280],"Co-treatment":[283],"exogenous":[285,311],"sodium-acetate":[286,307],"abrogated":[287],"adverse":[289],"effects":[290],"inhibition.":[293],"Conclusions:":[294],"This":[295],"study":[296],"identifies":[297],"key":[301],"metabolite":[302],"kidney":[304,315],"potential":[310],"substrate":[312],"promote":[314],"growth":[316],"Funding:":[319],"NIDDK":[320],"Support":[321]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2024-05-19T00:00:00"}
