{"id":"https://openalex.org/W4397047901","doi":"https://doi.org/10.1681/asn.20223311s1485c","title":"MC1R Deficiency Enhances Th1 Response and Impairs Regulatory T Cell Homeostasis in Nephrotoxic Serum Nephritis","display_name":"MC1R Deficiency Enhances Th1 Response and Impairs Regulatory T Cell Homeostasis in Nephrotoxic Serum Nephritis","publication_year":2022,"publication_date":"2022-11-01","ids":{"openalex":"https://openalex.org/W4397047901","doi":"https://doi.org/10.1681/asn.20223311s1485c"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20223311s1485c","doi":"https://doi.org/10.1681/asn.20223311s1485c","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20223311s1485c","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100774169","display_name":"Bohan Chen","orcid":"https://orcid.org/0000-0002-9781-2982","observed_orcids":["https://orcid.org/0000-0002-9781-2982"]},"institutions":[{"id":"https://openalex.org/I12057038","display_name":"University of Toledo Medical Center","ror":"https://ror.org/01600wh70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I12057038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bohan Chen","raw_affiliation_strings":["The University of Toledo Medical Center, Toledo, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Toledo Medical Center, Toledo, OH","institution_ids":["https://openalex.org/I12057038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047289986","display_name":"Xuejing Guan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12057038","display_name":"University of Toledo Medical Center","ror":"https://ror.org/01600wh70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I12057038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuejing Guan","raw_affiliation_strings":["The University of Toledo Medical Center, Toledo, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Toledo Medical Center, Toledo, OH","institution_ids":["https://openalex.org/I12057038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066860889","display_name":"Yan Ge","orcid":"https://orcid.org/0000-0003-2129-9438","observed_orcids":["https://orcid.org/0000-0003-2129-9438"]},"institutions":[{"id":"https://openalex.org/I12057038","display_name":"University of Toledo Medical Center","ror":"https://ror.org/01600wh70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I12057038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Ge","raw_affiliation_strings":["The University of Toledo Medical Center, Toledo, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Toledo Medical Center, Toledo, OH","institution_ids":["https://openalex.org/I12057038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072191588","display_name":"Lance D. Dworkin","orcid":"https://orcid.org/0000-0002-2471-5989","observed_orcids":["https://orcid.org/0000-0002-2471-5989"]},"institutions":[{"id":"https://openalex.org/I12057038","display_name":"University of Toledo Medical Center","ror":"https://ror.org/01600wh70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I12057038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lance D. Dworkin","raw_affiliation_strings":["The University of Toledo Medical Center, Toledo, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Toledo Medical Center, Toledo, OH","institution_ids":["https://openalex.org/I12057038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041867945","display_name":"Rujun Gong","orcid":"https://orcid.org/0000-0002-6302-2800","observed_orcids":["https://orcid.org/0000-0002-6302-2800"]},"institutions":[{"id":"https://openalex.org/I12057038","display_name":"University of Toledo Medical Center","ror":"https://ror.org/01600wh70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I12057038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rujun Gong","raw_affiliation_strings":["The University of Toledo Medical Center, Toledo, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Toledo Medical Center, Toledo, OH","institution_ids":["https://openalex.org/I12057038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I12057038"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"11S","first_page":"485","last_page":"485"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9106000065803528,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9106000065803528,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.026100000366568565,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mc1r","display_name":"MC1R","score":0.9300000071525574},{"id":"https://openalex.org/keywords/nephrotoxic-serum-nephritis","display_name":"nephrotoxic serum nephritis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/crescentic-glomerulonephritis","display_name":"crescentic glomerulonephritis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/th1-response","display_name":"Th1 response","score":0.9269999861717224},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9520000219345093},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.9300000071525574},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7360000014305115},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9729999899864197},{"id":"https://openalex.org/keywords/acth","display_name":"ACTH","score":0.7820000052452087},{"id":"https://openalex.org/keywords/melanocortin-signaling","display_name":"melanocortin signaling","score":0.8640000224113464},{"id":"https://openalex.org/keywords/renal-inflammation","display_name":"renal inflammation","score":0.5630000233650208},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.8180000185966492},{"id":"https://openalex.org/keywords/t-cell-effector-function","display_name":"T cell effector function","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.6954135894775391},{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.5954112410545349},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.56052565574646},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5273075103759766},{"id":"https://openalex.org/C2777058396","wikidata":"https://www.wikidata.org/wiki/Q401402","display_name":"Nephritis","level":2,"score":0.5204234719276428},{"id":"https://openalex.org/C2778296632","wikidata":"https://www.wikidata.org/wiki/Q1550619","display_name":"Regulatory T cell","level":5,"score":0.4555337429046631},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31848910450935364},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.3089756965637207},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.29801931977272034},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.24636492133140564},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.07003176212310791}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20223311s1485c","doi":"https://doi.org/10.1681/asn.20223311s1485c","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20223311s1485c","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4307813160","https://openalex.org/W2005462142","https://openalex.org/W4397002023","https://openalex.org/W4396999048","https://openalex.org/W2411410774","https://openalex.org/W4397042286","https://openalex.org/W1963827794","https://openalex.org/W4310461872","https://openalex.org/W7061580122","https://openalex.org/W2156441987"],"abstract_inverted_index":{"Background:":[0],"The":[1,108,138],"melanocortin":[2,28,31,261],"neuropeptides,":[3],"represented":[4],"by":[5,120,207],"adrenocorticotropic":[6],"hormone,":[7],"have":[8],"recently":[9],"emerged":[10],"as":[11,193,227],"a":[12,22,36,48,53,200],"novel":[13,49],"therapeutic":[14,50],"choice":[15],"for":[16,52,277],"treating":[17],"refractory":[18],"glomerular":[19,65,129],"diseases.":[20,56],"As":[21],"key":[23],"cognate":[24],"receptor":[25,33],"of":[26,55,63,85,89,150,165,168,182,191,212,259,285],"the":[27,61,73,79,90,98,210,218,243,260],"hormone":[29],"system,":[30],"1":[32],"(MC1R)":[34],"plays":[35],"pivotal":[37],"role":[38,59],"in":[39,60,142,157,160,188,217,224,237,282,289,292],"regulating":[40],"immune":[41,203,272],"response":[42,273],"and":[43,45,72,101,125,133,136,153,184,274],"inflammation,":[44],"has":[46],"become":[47],"target":[51],"number":[54,211],"However,":[57],"its":[58],"pathogenesis":[62],"immune-mediated":[64],"disease":[66],"remains":[67],"unknown.":[68],"Methods:":[69],"Wild-type":[70],"mice":[71,76,110,144,174],"recessive":[74],"yellow":[75],"(e/e)":[77],"with":[78,147,175,195,199,229],"naturally":[80],"occurring":[81],"loss-of-function":[82],"null":[83],"mutation":[84],"MC1R":[86,233,264],"received":[87],"injection":[88],"rabbit":[91],"anti-mouse":[92],"nephrotoxic":[93],"serum":[94],"(NTS)":[95],"to":[96],"develop":[97],"NTS":[99,140,176,219,286],"nephritis":[100,141,177],"were":[102],"examined":[103],"2":[104],"weeks":[105],"later.":[106],"Results:":[107],"e/e":[109,143,173,225],"developed":[111],"more":[112],"severe":[113],"crescentic":[114,294],"glomerulonephritis":[115],"than":[116],"WT":[117,196,230,245],"mice,":[118,197,226,246],"marked":[119],"aggravated":[121],"proteinuria,":[122],"kidney":[123],"dysfunction,":[124],"renal":[126,134,180,189,239,290],"lesions":[127],"like":[128],"hypercellularity,":[130],"crescent":[131],"formation,":[132],"inflammation":[135],"fibrosis.":[137],"exacerbated":[139],"was":[145,222,234],"associated":[146],"greater":[148],"levels":[149],"autologous":[151],"IgG2c":[152],"IgG3":[154],"either":[155],"deposited":[156],"glomeruli":[158],"or":[159],"sera.":[161],"In":[162],"addition,":[163],"profiling":[164],"signature":[166],"cytokines":[167],"Th":[169],"immunity":[170],"revealed":[171],"that":[172,251],"exhibited":[178],"higher":[179],"expression":[181,190],"IFN-\u03b3,":[183],"an":[185],"increasing":[186],"trend":[187],"TNF-\u03b1,":[192],"compared":[194,228],"consistent":[198],"reinforced":[201],"Th1":[202,271],"response.":[204],"Moreover,":[205],"shown":[206],"immunohistochemistry":[208],"staining,":[209],"FoxP3+":[213],"regulatory":[214,278],"T":[215,248,252,279],"cells":[216,253,258],"nephritic":[220],"kidneys":[221],"diminished":[223],"mice.":[231],"Mechanistically,":[232],"evidently":[235],"detected":[236],"diverse":[238],"leukocytes":[240],"prepared":[241],"from":[242],"diseased":[244],"including":[247],"lymphocytes,":[249],"suggesting":[250],"may":[254],"be":[255],"direct":[256],"effector":[257],"hormones":[262],"via":[263],"signaling.":[265],"Conclusions:":[266],"MC1R-mediated":[267],"melanocortinergic":[268],"signaling":[269],"represses":[270],"is":[275],"required":[276],"cell":[280],"homeostasis":[281],"murine":[283],"models":[284],"nephritis,":[287],"resulting":[288],"protection":[291],"experimental":[293],"glomerulonephritis.":[295],"Funding:":[296],"NIDDK":[297],"Support,":[298],"Commercial":[299],"Support":[300],"-":[301],"Mallinckrodt":[302],"ARD,":[303],"LLC":[304]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2024-05-19T00:00:00"}