{"id":"https://openalex.org/W4397047890","doi":"https://doi.org/10.1681/asn.20233411s1796c","title":"Pharmacological Inhibition of Lysine-Specific Histone Demethylase 1 Protects Against AKI","display_name":"Pharmacological Inhibition of Lysine-Specific Histone Demethylase 1 Protects Against AKI","publication_year":2023,"publication_date":"2023-11-01","ids":{"openalex":"https://openalex.org/W4397047890","doi":"https://doi.org/10.1681/asn.20233411s1796c"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20233411s1796c","doi":"https://doi.org/10.1681/asn.20233411s1796c","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20233411s1796c","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012954499","display_name":"Baihai Jiao","orcid":"https://orcid.org/0000-0002-2217-981X","observed_orcids":["https://orcid.org/0000-0002-2217-981X"]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baihai Jiao","raw_affiliation_strings":["UConn Health, Farmington, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UConn Health, Farmington, CT;","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111484829","display_name":"Hao Du","orcid":"https://orcid.org/0009-0002-6580-4408","observed_orcids":["https://orcid.org/0009-0002-6580-4408"]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Du","raw_affiliation_strings":["UConn Health, Farmington, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UConn Health, Farmington, CT;","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044913342","display_name":"Melanie Tran","orcid":"https://orcid.org/0000-0003-1427-841X","observed_orcids":["https://orcid.org/0000-0003-1427-841X"]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melanie Tran","raw_affiliation_strings":["UConn Health, Farmington, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UConn Health, Farmington, CT;","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110366910","display_name":"Bo Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bo Song","raw_affiliation_strings":["UConn Health, Farmington, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UConn Health, Farmington, CT;","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100350717","display_name":"Yanlin Wang","orcid":"https://orcid.org/0000-0002-6908-1529","observed_orcids":["https://orcid.org/0000-0002-6908-1529"]},"institutions":[{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanlin Wang","raw_affiliation_strings":["UConn Health, Farmington, CT;","VA Connecticut Healthcare System, West Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UConn Health, Farmington, CT;","institution_ids":["https://openalex.org/I75929689"]},{"raw_affiliation_string":"VA Connecticut Healthcare System, West Haven, CT","institution_ids":["https://openalex.org/I4210086971"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"11S","first_page":"796","last_page":"796"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.07450000196695328,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.8510000109672546},{"id":"https://openalex.org/keywords/lsd1-inhibition","display_name":"LSD1 inhibition","score":0.9480000138282776},{"id":"https://openalex.org/keywords/cisplatin-induced-nephrotoxicity","display_name":"cisplatin nephrotoxicity","score":0.9620000123977661},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9929999709129333},{"id":"https://openalex.org/keywords/inflammasome-activation","display_name":"inflammasome activation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.8140000104904175},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9049999713897705},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9409999847412109},{"id":"https://openalex.org/keywords/histone-demethylation","display_name":"histone demethylation","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C2781364455","wikidata":"https://www.wikidata.org/wiki/Q2531584","display_name":"Demethylase","level":4,"score":0.8594259023666382},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5702191591262817},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.5487438440322876},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4940681755542755},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4789034426212311},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36117419600486755},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29645872116088867},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.09669655561447144},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.04662024974822998}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20233411s1796c","doi":"https://doi.org/10.1681/asn.20233411s1796c","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20233411s1796c","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4392651012","https://openalex.org/W2805790499","https://openalex.org/W3033748070","https://openalex.org/W2996155802","https://openalex.org/W7221526352","https://openalex.org/W4403831284","https://openalex.org/W2190592652","https://openalex.org/W4396993325","https://openalex.org/W3004780772","https://openalex.org/W2969700610"],"abstract_inverted_index":{"Background:":[0],"Acute":[1],"kidney":[2,171,183,189],"injury":[3],"(AKI)":[4],"is":[5],"a":[6,42,108,122,262,288],"common":[7],"clinical":[8],"condition":[9],"associated":[10],"with":[11,107,120,179,198,234],"increased":[12,166],"mortality":[13],"and":[14,26,118,148,187,207,217,239,249,268,278],"morbidity.":[15],"Current":[16],"therapeutic":[17,30,290],"options":[18],"for":[19,135,292],"this":[20,65],"serious":[21],"disorder":[22],"are":[23,32,60],"often":[24],"limited":[25],"ineffective.":[27],"Therefore,":[28,283],"new":[29],"strategies":[31],"urgently":[33],"needed":[34],"to":[35,115,144,274],"prevent":[36],"or":[37,129],"treat":[38],"AKI.":[39,50,88,174,225,282,293],"Macrophages":[40],"play":[41],"critical":[43,263],"role":[44,70,93,147],"in":[45,58,77,83,96,99,152,158,167,169,191,212,220,252,271],"the":[46,52,69,78,84,92,146,153,170,182,204,221],"pathogenesis":[47],"of":[48,71,80,86,94,111,150,155,163,177,196,223,232,265,280],"cisplatin-induced":[49,87,97,173,185,224,281],"However,":[51],"molecular":[53],"mechanisms":[54,149],"underlying":[55],"macrophage":[56,81,156,201,237],"activation":[57,82,157,238,251,270],"AKI":[59,98,117,186],"not":[61],"fully":[62],"elucidated.":[63],"In":[64,226],"study,":[66],"we":[67],"investigated":[68],"lysine-specific":[72],"histone":[73],"demethylase":[74],"1":[75,127,216],"(LSD1)":[76],"regulation":[79,154],"development":[85,279],"Methods:":[89],"To":[90],"examine":[91,145],"LSD1":[95,124,151,164,178,197,233,260,285],"vivo,":[100],"wild-type":[101],"C57BL6/J":[102],"mice":[103],"were":[104,142],"administered":[105],"intraperitoneally":[106],"single":[109],"dose":[110],"20":[112],"mg/kg":[113,128],"cisplatin":[114],"induce":[116],"treated":[119],"GSK-LSD1,":[121],"selective":[123],"inhibitor,":[125],"at":[126],"vehicle":[130],"daily":[131],"by":[132],"intraperitoneal":[133],"injection":[134],"3":[136],"days.":[137],"Cultured":[138],"bone":[139,227,253],"marrow-derived":[140,228,254],"macrophages":[141,168],"used":[143],"vitro.":[159],"Results:":[160],"The":[161],"expression":[162,248,267],"was":[165],"following":[172],"Pharmacological":[175],"inhibition":[176,195,231],"GSK-LSD1":[180,199,235,245],"protected":[181],"from":[184],"preserved":[188],"function":[190],"vivo.":[192],"Furthermore,":[193],"pharmacological":[194,230],"suppressed":[200,240],"activation,":[202,210],"attenuated":[203],"NLRP3":[205,247,266],"expression,":[206],"inhibited":[208],"inflammasome":[209,250,269],"resulting":[211],"reduced":[213],"cleaved":[214],"caspase":[215],"IL-1\u03b2":[218],"levels":[219],"kidneys":[222],"macrophages,":[229,272],"abolished":[236],"proinflammatory":[241,275],"cytokine":[242],"production.":[243],"Moreover,":[244],"blocks":[246],"macrophages.":[255],"Conclusions:":[256],"Our":[257],"study":[258],"identifies":[259],"as":[261],"regulator":[264],"leading":[273],"molecule":[276],"production":[277],"targeting":[284],"may":[286],"represent":[287],"novel":[289],"strategy":[291],"Funding:":[294],"NIDDK":[295],"Support,":[296,299],"Veterans":[297],"Affairs":[298],"Private":[300],"Foundation":[301],"Support":[302]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2024-05-19T00:00:00"}
