{"id":"https://openalex.org/W4397045943","doi":"https://doi.org/10.1681/asn.20223311s1483d","title":"Proteomic Analysis of Glomeruli in Myeloperoxidase-ANCA Glomerulonephritis","display_name":"Proteomic Analysis of Glomeruli in Myeloperoxidase-ANCA Glomerulonephritis","publication_year":2022,"publication_date":"2022-11-01","ids":{"openalex":"https://openalex.org/W4397045943","doi":"https://doi.org/10.1681/asn.20223311s1483d"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20223311s1483d","doi":"https://doi.org/10.1681/asn.20223311s1483d","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20223311s1483d","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Amit Sethi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amit Sethi","raw_affiliation_strings":["Mayo Foundation for Medical Education and Research, Rochester, MN","University of Minnesota Twin Cities, Minneapolis, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Foundation for Medical Education and Research, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"University of Minnesota Twin Cities, Minneapolis, MN","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056265052","display_name":"Joseph Peter Grande","orcid":"https://orcid.org/0000-0001-5674-1682","observed_orcids":["https://orcid.org/0000-0001-5674-1682"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph P. Grande","raw_affiliation_strings":["Mayo Foundation for Medical Education and Research, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Foundation for Medical Education and Research, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012967877","display_name":"Ulrich Specks","orcid":"https://orcid.org/0000-0002-6559-1206","observed_orcids":["https://orcid.org/0000-0002-6559-1206"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ulrich Specks","raw_affiliation_strings":["Mayo Foundation for Medical Education and Research, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Foundation for Medical Education and Research, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073207965","display_name":"Fernando Custodio Fervenza","orcid":"https://orcid.org/0000-0002-9952-209X","observed_orcids":["https://orcid.org/0000-0002-9952-209X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fernando C. Fervenza","raw_affiliation_strings":["Mayo Foundation for Medical Education and Research, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Foundation for Medical Education and Research, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"11S","first_page":"483","last_page":"483"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.7592999935150146,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.7592999935150146,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.22789999842643738,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crescentic-glomerulonephritis","display_name":"crescentic glomerulonephritis","score":0.9369999766349792},{"id":"https://openalex.org/keywords/fibrinoid-necrosis","display_name":"fibrinoid necrosis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/glomerular-proteome","display_name":"glomerular proteome","score":0.8460000157356262},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.5809999704360962},{"id":"https://openalex.org/keywords/c5","display_name":"C5","score":0.7260000109672546},{"id":"https://openalex.org/keywords/c7","display_name":"C7","score":0.703000009059906},{"id":"https://openalex.org/keywords/c9","display_name":"C9","score":0.8330000042915344},{"id":"https://openalex.org/keywords/actinin-4","display_name":"actinin-4","score":0.8029999732971191},{"id":"https://openalex.org/keywords/laminin","display_name":"laminin","score":0.7110000252723694},{"id":"https://openalex.org/keywords/fibrillin-1","display_name":"fibrillin-1","score":0.8550000190734863},{"id":"https://openalex.org/keywords/agrin","display_name":"agrin","score":0.9390000104904175},{"id":"https://openalex.org/keywords/nidogen-2","display_name":"NID2","score":0.921999990940094},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.9359999895095825},{"id":"https://openalex.org/keywords/desmoplakin","display_name":"desmoplakin","score":0.9549999833106995},{"id":"https://openalex.org/keywords/glomerular-injury","display_name":"glomerular injury","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.7743008136749268},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.7037310004234314},{"id":"https://openalex.org/C2910856063","wikidata":"https://www.wikidata.org/wiki/Q909882","display_name":"Kidney Glomerulus","level":4,"score":0.48575690388679504},{"id":"https://openalex.org/C2777146197","wikidata":"https://www.wikidata.org/wiki/Q138912","display_name":"Podocyte","level":4,"score":0.44436556100845337},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4252821207046509},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4236512780189514},{"id":"https://openalex.org/C2775998817","wikidata":"https://www.wikidata.org/wiki/Q1509367","display_name":"Rapidly progressive glomerulonephritis","level":4,"score":0.4187732934951782},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3725794553756714},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.1964220404624939},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.18608596920967102},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17750519514083862},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.10618704557418823}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20223311s1483d","doi":"https://doi.org/10.1681/asn.20223311s1483d","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20223311s1483d","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4321015402","https://openalex.org/W2588239054","https://openalex.org/W4395031242","https://openalex.org/W4403833317","https://openalex.org/W2102873553","https://openalex.org/W1994929008","https://openalex.org/W4397024767","https://openalex.org/W2168760693","https://openalex.org/W2733733381","https://openalex.org/W4415665594"],"abstract_inverted_index":{"Background:":[0],"Myeloperoxidase":[1],"(MPO)-ANCA-":[2],"associated":[3],"vasculitis":[4],"often":[5],"involves":[6],"the":[7,34,41,51,105,109,182],"kidney":[8],"resulting":[9],"a":[10,31],"severe":[11],"necrotizing":[12,26,42],"and":[13,27,38,43,56,73,196,199,218],"crescentic":[14,28,44],"glomerulonephritis":[15],"(GN).":[16],"Kidney":[17],"biopsy":[18],"shows":[19,120],"varying":[20],"percentages":[21],"of":[22,33,54,66,85,89,123,139,158,192,236],"glomeruli":[23,35,58,67,74,90,113,128,132,176,203,214,228,241,244],"involved":[24,55,68,215],"by":[25,40,99,216],"lesions.":[29,45],"Yet,":[30],"proportion":[32],"appear":[36],"normal":[37,77,240],"uninvolved":[39,57,233],"In":[46,149],"this":[47],"study,":[48],"we":[49],"compared":[50,129,177,204,231],"proteomic":[52,106],"profile":[53,107,119],"in":[59,82,93,108,126,156,174,190,201,213,224,227,239],"MPO-ANCA-GN.":[60,86],"Methods:":[61],"We":[62],"performed":[63],"laser":[64],"microdissection":[65],"be":[69],"crescents/fibrinoid":[70],"necrosis":[71],"(CF),":[72],"that":[75],"appeared":[76],"(N)":[78],"on":[79],"light":[80],"microscopy":[81],"6":[83],"cases":[84],"Equal":[87],"number":[88],"were":[91,114],"dissected":[92],"each":[94],"group/case.":[95],"This":[96],"was":[97],"followed":[98],"mass":[100],"spectrometry":[101],"(MS/MS)":[102],"to":[103,130,178,205,232],"analyze":[104],"2":[110],"groups.":[111],"Sclerosed":[112],"not":[115],"dissected.":[116],"Results:":[117],"Proteomic":[118],"higher":[121,134],"activation":[122,210],"complement":[124],"pathways":[125],"CF":[127,175,206],"N":[131,179,202],"with":[133,229],"total":[135],"spectral":[136],"counts":[137],"(TSC)":[138],"C3":[140],"(2-fold),":[141],"C5":[142],"(7-fold),":[143],"C7":[144],"(10":[145],"fold),":[146],"C9":[147],"(6-fold).":[148],"addition,":[150],"there":[151,185],"is":[152,186,211],"3-7":[153],"fold":[154,188],"increase":[155,189],"TSC":[157,191],"actinin":[159],"4,":[160],"laminin":[161],"subunit":[162],"2,":[163],"fibrinogen":[164],"a,":[165],"fibrillin":[166],"1,":[167],"agrin,":[168],"nidogen-2,":[169],"heat":[170],"shock":[171],"protein":[172,194],"90":[173],"glomeruli.":[180,207,234],"On":[181],"other":[183],"hand,":[184],"3-6":[187],"desmoplakin,":[193],"S100,":[195],"serpin":[197],"B3":[198],"B12":[200],"Conclusions:":[208],"Complement":[209],"greater":[212],"crescents":[217],"necrosis.":[219],"There":[220],"are":[221],"also":[222],"differences":[223],"proteins":[225,238],"expressed":[226],"crescents/necrosis":[230],"Overexpression":[235],"certain":[237],"may":[242],"protect":[243],"from":[245],"developing":[246],"crescents/necrosis.":[247],"Funding:":[248],"Private":[249],"Foundation":[250],"Support":[251]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2024-05-19T00:00:00"}