{"id":"https://openalex.org/W4397045282","doi":"https://doi.org/10.1681/asn.20233411s1701d","title":"The Role of SRY-box Transcription Factor 4 in Renal Fibrosis","display_name":"The Role of SRY-box Transcription Factor 4 in Renal Fibrosis","publication_year":2023,"publication_date":"2023-11-01","ids":{"openalex":"https://openalex.org/W4397045282","doi":"https://doi.org/10.1681/asn.20233411s1701d"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20233411s1701d","doi":"https://doi.org/10.1681/asn.20233411s1701d","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20233411s1701d","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041320129","display_name":"Hao Du","orcid":"https://orcid.org/0000-0002-7003-4877","observed_orcids":["https://orcid.org/0000-0002-7003-4877"]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Du","raw_affiliation_strings":["UConn Health, Farmington, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UConn Health, Farmington, CT;","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012954499","display_name":"Baihai Jiao","orcid":"https://orcid.org/0000-0002-2217-981X","observed_orcids":["https://orcid.org/0000-0002-2217-981X"]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baihai Jiao","raw_affiliation_strings":["UConn Health, Farmington, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UConn Health, Farmington, CT;","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044913342","display_name":"Melanie Tran","orcid":"https://orcid.org/0000-0003-1427-841X","observed_orcids":["https://orcid.org/0000-0003-1427-841X"]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melanie Tran","raw_affiliation_strings":["UConn Health, Farmington, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UConn Health, Farmington, CT;","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bo Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bo Song","raw_affiliation_strings":["UConn Health, Farmington, CT;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UConn Health, Farmington, CT;","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100350717","display_name":"Yanlin Wang","orcid":"https://orcid.org/0000-0002-6908-1529","observed_orcids":["https://orcid.org/0000-0002-6908-1529"]},"institutions":[{"id":"https://openalex.org/I4210086971","display_name":"VA Connecticut Healthcare System","ror":"https://ror.org/000rgm762","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086971","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanlin Wang","raw_affiliation_strings":["UConn Health, Farmington, CT;","VA Connecticut Healthcare System, West Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UConn Health, Farmington, CT;","institution_ids":["https://openalex.org/I75929689"]},{"raw_affiliation_string":"VA Connecticut Healthcare System, West Haven, CT","institution_ids":["https://openalex.org/I4210086971"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"11S","first_page":"701","last_page":"701"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.043299999088048935,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sox4","display_name":"SOX4","score":0.9919999837875366},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9710000157356262},{"id":"https://openalex.org/keywords/tgf-beta1-smad3-signaling-pathway","display_name":"TGF-\u03b21/Smad3 signaling","score":0.8349999785423279},{"id":"https://openalex.org/keywords/extracellular-matrix-deposition","display_name":"extracellular matrix deposition","score":0.925000011920929},{"id":"https://openalex.org/keywords/fibroblast-activation","display_name":"fibroblast activation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.800000011920929},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.8949999809265137},{"id":"https://openalex.org/keywords/unilateral-ureteral-obstruction","display_name":"unilateral ureteral obstruction","score":0.8619999885559082},{"id":"https://openalex.org/keywords/conditional-knockout-mice","display_name":"conditional knockout mice","score":0.8370000123977661},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C73456138","wikidata":"https://www.wikidata.org/wiki/Q409114","display_name":"Testis determining factor","level":4,"score":0.8975903987884521},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5366525053977966},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.410595178604126},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33836060762405396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3172401189804077},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19849076867103577},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07960981130599976},{"id":"https://openalex.org/C2780246931","wikidata":"https://www.wikidata.org/wiki/Q202771","display_name":"Y chromosome","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20233411s1701d","doi":"https://doi.org/10.1681/asn.20233411s1701d","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20233411s1701d","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4414578775","https://openalex.org/W4403831974","https://openalex.org/W4396990409","https://openalex.org/W2111928834","https://openalex.org/W4398234318","https://openalex.org/W7135042005","https://openalex.org/W4416586689","https://openalex.org/W7164365872","https://openalex.org/W4397045228","https://openalex.org/W3009751248"],"abstract_inverted_index":{"Background:":[0],"Chronic":[1],"kidney":[2,276],"disease":[3],"(CKD)":[4],"is":[5,23,43],"a":[6,332],"widely":[7],"prevalent":[8],"disorder":[9],"around":[10],"the":[11,28,53,68,81,114,165,177,190,198,206,253,275,315],"world,":[12],"which":[13],"affects":[14],"over":[15],"10%":[16],"adults.":[17],"The":[18,37,214],"pathological":[19],"feature":[20],"of":[21,33,41,70,83,117,167,203,208,216,317],"CKD":[22],"renal":[24,318],"fibrosis,":[25],"characterized":[26],"by":[27,92,283,320],"excessive":[29],"production":[30,38,251,273],"and":[31,39,119,126,149,153,159,174,200,237,242,248,265,270,324],"deposition":[32,188,247,269],"extracellular":[34],"matrix":[35],"(ECM).":[36],"accumulation":[40],"ECM":[42,249,271],"partly":[44],"due":[45],"to":[46,106,131,163,184,196,227,293,300],"tubular":[47],"epithelial":[48],"cell":[49],"(TEC)":[50],"dedifferentiation.":[51,303],"However,":[52],"molecular":[54,201],"mechanisms":[55,202],"underlying":[56],"TEC":[57,78,209,221,233,260,286,290,302,322],"dedifferentiation":[58,79,210,234,287,323],"are":[59],"not":[60],"fully":[61],"understood.":[62],"In":[63,225],"this":[64],"study,":[65],"we":[66],"investigated":[67],"role":[69,199,313],"SRY-box":[71],"transcription":[72],"factor":[73],"4":[74],"(SOX4)":[75],"in":[76,176,189,205,211,220,252,274,288,291,314],"regulating":[77,321],"during":[80],"development":[82,316],"CKD.":[84,337],"Methods:":[85],"We":[86],"generated":[87],"SOX4":[88,94,108,204,217,256,282,296,309,328],"conditional":[89],"knockout":[90],"mice":[91,96,102,112,128,231],"crossing":[93],"floxed":[95],"with":[97,235,277],"tamoxifen-inducible":[98],"CAG-CreER":[99],"mice.":[100],"CAG-Cre+/-SOX4f/f":[101],"were":[103,129,137,147,161,194],"given":[104],"tamoxifen":[105,118],"induce":[107],"deletion":[109],"(SOX4GKO).":[110],"CAG-Cre-/-SOX4f/f":[111],"received":[113],"same":[115],"dose":[116],"used":[120],"as":[121,331],"controls":[122],"(SOX4CON).":[123],"Both":[124],"SOX4CON":[125,230],"SOX4GKO":[127],"subjected":[130],"unilateral":[132],"ureteral":[133],"obstruction":[134],"(UUO).":[135],"Kidneys":[136],"harvested":[138],"at":[139],"10":[140],"days":[141],"after":[142,222],"UUO":[143,223,278],"injury.":[144,224,279],"Kidney":[145],"sections":[146],"prepared":[148],"stained":[150],"for":[151,336],"histological":[152],"immunological":[154],"analysis.":[155],"Western":[156],"blot":[157],"analysis":[158],"immunostaining":[160],"performed":[162,183],"detect":[164,185],"levels":[166],"signaling":[168,299],"molecules,":[169],"fibronectin,":[170],"collagen":[171,187,246,268],"type":[172],"I,":[173],"alpha-SMA":[175],"kidneys.":[178],"Sirius":[179],"red":[180],"staining":[181],"was":[182,218],"total":[186,245,267],"kidney.":[191,254],"Cultured":[192],"TECs":[193],"employed":[195],"examine":[197],"regulation":[207],"vitro.":[212],"Results:":[213],"expression":[215],"increased":[219],"response":[226,292],"obstructive":[228],"injury,":[229],"exhibited":[232],"senescence":[236],"G2/M":[238],"arrest,":[239],"fibroblast":[240,263,325],"activation":[241],"developed":[243],"substantial":[244],"protein":[250,272],"Global":[255],"deficiency":[257],"significantly":[258],"alleviated":[259],"dedifferentiation,":[261],"suppressed":[262],"activation,":[264],"reduced":[266],"Furthermore,":[280],"knockdown":[281],"shRNA":[284],"inhibited":[285],"cultured":[289],"TGF-\u03b21.":[294],"Mechanically,":[295],"facilitated":[297],"TGF-\u03b21-Smad3":[298],"promote":[301],"Conclusions:":[304],"Our":[305],"results":[306],"demonstrate":[307],"that":[308],"plays":[310],"an":[311],"essential":[312],"fibrosis":[319],"activation.":[326],"Therefore,":[327],"may":[329],"serve":[330],"novel":[333],"therapeutic":[334],"target":[335],"Funding:":[338],"NIDDK":[339],"Support,":[340],"Veterans":[341],"Affairs":[342],"Support":[343]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2024-05-19T00:00:00"}