{"id":"https://openalex.org/W4397045271","doi":"https://doi.org/10.1681/asn.20233411s1699c","title":"Identification of Surrogate Biomarkers Reflecting Tubular Failed Repair in CKD","display_name":"Identification of Surrogate Biomarkers Reflecting Tubular Failed Repair in CKD","publication_year":2023,"publication_date":"2023-11-01","ids":{"openalex":"https://openalex.org/W4397045271","doi":"https://doi.org/10.1681/asn.20233411s1699c"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20233411s1699c","doi":"https://doi.org/10.1681/asn.20233411s1699c","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20233411s1699c","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007741485","display_name":"Tobias Bohnenpoll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129223955","display_name":"G\u00f6ttingen Academy of Sciences and Humanities","ror":"https://ror.org/04hsa7a08","country_code":"DE","type":"education","lineage":["https://openalex.org/I3129223955"]},{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias Bohnenpoll","raw_affiliation_strings":["Evotec International GmbH, G\u00f6ttingen, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec International GmbH, G\u00f6ttingen, Germany;","institution_ids":["https://openalex.org/I3129223955","https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024062615","display_name":"I-Ju Lo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129223955","display_name":"G\u00f6ttingen Academy of Sciences and Humanities","ror":"https://ror.org/04hsa7a08","country_code":"DE","type":"education","lineage":["https://openalex.org/I3129223955"]},{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"I-Ju Lo","raw_affiliation_strings":["Evotec International GmbH, G\u00f6ttingen, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec International GmbH, G\u00f6ttingen, Germany;","institution_ids":["https://openalex.org/I3129223955","https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012574636","display_name":"Seamus P. Ragan","orcid":"https://orcid.org/0000-0002-0836-1236","observed_orcids":["https://orcid.org/0000-0002-0836-1236"]},"institutions":[{"id":"https://openalex.org/I4405270553","display_name":"Chinook Therapeutics (United States)","ror":"https://ror.org/00xbahf74","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270553"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seamus Ragan","raw_affiliation_strings":["Chinook Therapeutics Inc, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinook Therapeutics Inc, Seattle, WA","institution_ids":["https://openalex.org/I4405270553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041347295","display_name":"Shawn S. Badal","orcid":"https://orcid.org/0000-0001-6090-9505","observed_orcids":["https://orcid.org/0000-0001-6090-9505"]},"institutions":[{"id":"https://openalex.org/I4405270553","display_name":"Chinook Therapeutics (United States)","ror":"https://ror.org/00xbahf74","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270553"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shawn S. Badal","raw_affiliation_strings":["Chinook Therapeutics Inc, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinook Therapeutics Inc, Seattle, WA","institution_ids":["https://openalex.org/I4405270553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086233987","display_name":"Olivier Radresa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129223955","display_name":"G\u00f6ttingen Academy of Sciences and Humanities","ror":"https://ror.org/04hsa7a08","country_code":"DE","type":"education","lineage":["https://openalex.org/I3129223955"]},{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Olivier Radresa","raw_affiliation_strings":["Evotec International GmbH, G\u00f6ttingen, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec International GmbH, G\u00f6ttingen, Germany;","institution_ids":["https://openalex.org/I3129223955","https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jay Kuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405270553","display_name":"Chinook Therapeutics (United States)","ror":"https://ror.org/00xbahf74","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270553"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay Kuo","raw_affiliation_strings":["Chinook Therapeutics Inc, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinook Therapeutics Inc, Seattle, WA","institution_ids":["https://openalex.org/I4405270553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108260779","display_name":"Jennifer H. Cox","orcid":"https://orcid.org/0000-0002-2810-0340","observed_orcids":["https://orcid.org/0000-0002-2810-0340"]},"institutions":[{"id":"https://openalex.org/I4405270553","display_name":"Chinook Therapeutics (United States)","ror":"https://ror.org/00xbahf74","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270553"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer H. Cox","raw_affiliation_strings":["Chinook Therapeutics Inc, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinook Therapeutics Inc, Seattle, WA","institution_ids":["https://openalex.org/I4405270553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086070807","display_name":"Uwe Andag","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3129223955","display_name":"G\u00f6ttingen Academy of Sciences and Humanities","ror":"https://ror.org/04hsa7a08","country_code":"DE","type":"education","lineage":["https://openalex.org/I3129223955"]},{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Uwe Andag","raw_affiliation_strings":["Evotec International GmbH, G\u00f6ttingen, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec International GmbH, G\u00f6ttingen, Germany;","institution_ids":["https://openalex.org/I3129223955","https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101870144","display_name":"Andrew J. King","orcid":"https://orcid.org/0000-0002-5282-3186","observed_orcids":["https://orcid.org/0000-0002-5282-3186"]},"institutions":[{"id":"https://openalex.org/I4405270553","display_name":"Chinook Therapeutics (United States)","ror":"https://ror.org/00xbahf74","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270553"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. King","raw_affiliation_strings":["Chinook Therapeutics Inc, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinook Therapeutics Inc, Seattle, WA","institution_ids":["https://openalex.org/I4405270553"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038084375","display_name":"N. Eric Olson","orcid":"https://orcid.org/0000-0003-4587-269X","observed_orcids":["https://orcid.org/0000-0003-4587-269X"]},"institutions":[{"id":"https://openalex.org/I4405270553","display_name":"Chinook Therapeutics (United States)","ror":"https://ror.org/00xbahf74","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270553"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Eric Olson","raw_affiliation_strings":["Chinook Therapeutics Inc, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinook Therapeutics Inc, Seattle, WA","institution_ids":["https://openalex.org/I4405270553"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"11S","first_page":"699","last_page":"699"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.05040000006556511,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.9240000247955322},{"id":"https://openalex.org/keywords/surrogate-markers","display_name":"surrogate markers","score":0.9039999842643738},{"id":"https://openalex.org/keywords/noninvasive-biomarkers","display_name":"non-invasive biomarkers","score":0.8180000185966492},{"id":"https://openalex.org/keywords/serum-proteins","display_name":"serum proteins","score":0.6819999814033508},{"id":"https://openalex.org/keywords/urine-protein","display_name":"urinary protein","score":0.9419999718666077},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.5139999985694885},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.5659999847412109},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5440000295639038},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5720610022544861},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.534811794757843},{"id":"https://openalex.org/C141341695","wikidata":"https://www.wikidata.org/wiki/Q2368661","display_name":"Surrogate endpoint","level":2,"score":0.45020100474357605},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.44125375151634216},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40511566400527954},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3928200900554657},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17062968015670776},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20233411s1699c","doi":"https://doi.org/10.1681/asn.20233411s1699c","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20233411s1699c","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7207757274","https://openalex.org/W3164646229","https://openalex.org/W4397001951","https://openalex.org/W4396998346","https://openalex.org/W4397041128","https://openalex.org/W4395071179","https://openalex.org/W4396811539","https://openalex.org/W2770660972","https://openalex.org/W4380448093","https://openalex.org/W4396994296"],"abstract_inverted_index":{"Background:":[0],"Interstitial":[1],"fibrosis,":[2],"tubular":[3,313],"atrophy":[4],"and":[5,22,50,56,91,120,137,154,172,186,196,217,249,253,261,297,302,308],"inflammation":[6],"(IFTA)":[7],"are":[8,51],"common":[9,235],"final":[10],"pathways":[11],"to":[12,18,61,98,107],"end-stage":[13],"kidney":[14,28,89,143,169,204,222,231,259],"disease":[15],"(ESKD),":[16],"contributing":[17],"progressive":[19],"nephron":[20],"loss":[21],"functional":[23],"decline":[24],"in":[25,35,47,72,78,208,251,277,290],"most":[26],"chronic":[27],"diseases":[29],"(CKD),":[30],"including":[31],"those":[32],"typically":[33],"glomerular":[34],"origin.":[36],"Disease-associated":[37],"failed":[38],"repair":[39],"proximal":[40],"tubule":[41],"cells":[42],"(FR-PTs)":[43],"have":[44,65],"been":[45],"described":[46],"rodent":[48],"models":[49],"characterized":[52],"by":[53],"a":[54,157,234,294],"proinflammatory":[55],"profibrotic":[57],"phenotype":[58,296],"that":[59,68],"contributes":[60],"IFTA":[62],"severity.":[63],"We":[64],"recently":[66],"demonstrated":[67],"accumulation":[69,104,274],"of":[70,87,105,147,164,214,240,275],"FR-PTs":[71,106,173,252,276],"humans":[73],"predicts":[74],"reduced":[75],"event-free":[76],"survival":[77],"multiple":[79,127],"CKD":[80,96,209,281],"etiologies.":[81],"Here":[82],"we":[83],"used":[84],"multi-omics":[85],"analysis":[86,163,192],"patient-matched":[88],"biopsies":[90,144],"biofluids":[92],"from":[93,126,129,229,283],"the":[94,130,148,203,230,241,258,273,284],"NURTuRE":[95,131,285],"cohort":[97],"discover":[99],"biomarkers":[100,179,270],"associated":[101,271],"with":[102,168,202,221,247,272,279,293],"an":[103],"non-invasively":[108],"identify":[109],"patients":[110,292],"at":[111,298],"risk":[112,299],"for":[113,145,156,180,300],"progression.":[114],"Methods:":[115],"Serum":[116],"(n":[117,123],"=":[118,124],"99)":[119],"urine":[121,198,219],"samples":[122,149],"22)":[125],"etiologies":[128,282],"biobank":[132],"were":[133,150],"assayed":[134],"using":[135],"Olink":[136],"SomaScan":[138],"proteomics":[139],"platforms,":[140],"respectively.":[141],"Patient-matched":[142],"each":[146],"analyzed":[151],"via":[152],"RNA-Seq":[153],"scored":[155],"gene":[158],"signature":[159,174],"reflecting":[160,257],"FR-PTs.":[161],"Correlation":[162],"biofluid":[165],"protein":[166],"abundance":[167],"mRNA":[170,223],"expression":[171,224,239],"scores":[175],"suggested":[176],"candidate":[177],"non-invasive":[178],"further":[181],"validation":[182,309],"(r":[183],"\u2265":[184],"0.4":[185],"p":[187],"\u2264":[188],"0.05).":[189],"Results:":[190],"Proteomic":[191],"identified":[193,267],"78":[194],"serum":[195,216],"79":[197],"proteins":[199,220,227],"significantly":[200],"correlated":[201,246],"biopsy":[205],"FR-PT":[206],"score":[207],"patients.":[210],"Strong":[211],"positive":[212],"correlation":[213],"14/78":[215],"9/79":[218],"suggests":[225],"these":[226],"originate":[228],"or":[232],"share":[233],"regulatory":[236],"mechanism.":[237],"Importantly,":[238],"respective":[242],"genes":[243],"was":[244],"negatively":[245],"eGFR":[248],"enriched":[250],"immune":[254],"cells,":[255],"likely":[256],"inflammatory":[260],"fibrotic":[262],"microenvironment.":[263],"Conclusions:":[264],"This":[265],"study":[266],"potential":[268],"surrogate":[269],"subjects":[278],"different":[280],"cohort.":[286],"These":[287],"may":[288],"aid":[289],"identifying":[291],"disease-relevant":[295],"progression":[301],"will":[303],"complement":[304],"our":[305],"target":[306],"identification":[307],"focused":[310],"on":[311],"maladaptive":[312],"repair.":[314],"Funding:":[315],"Commercial":[316],"Support":[317],"-":[318],"Chinook":[319],"Therapeutics,":[320],"Evotec":[321],"SE":[322]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2024-05-19T00:00:00"}