{"id":"https://openalex.org/W4397044752","doi":"https://doi.org/10.1681/asn.20233411s1773b","title":"Plasma Sialic Acid as a Marker for Kidney Function Decline in Preclinical Models of AKI","display_name":"Plasma Sialic Acid as a Marker for Kidney Function Decline in Preclinical Models of AKI","publication_year":2023,"publication_date":"2023-11-01","ids":{"openalex":"https://openalex.org/W4397044752","doi":"https://doi.org/10.1681/asn.20233411s1773b"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20233411s1773b","doi":"https://doi.org/10.1681/asn.20233411s1773b","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20233411s1773b","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004926290","display_name":"Manjula Darshi","orcid":"https://orcid.org/0000-0002-1373-7488","observed_orcids":["https://orcid.org/0000-0002-1373-7488"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manjula Darshi","raw_affiliation_strings":["Janssen Research and Development LLC, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research and Development LLC, Boston, MA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113932157","display_name":"Rong Meng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rong Meng","raw_affiliation_strings":["Janssen Research and Development LLC, Spring House, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research and Development LLC, Spring House, PA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015701268","display_name":"Eugene Myshkin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eugene Myshkin","raw_affiliation_strings":["Janssen Research and Development LLC, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research and Development LLC, Boston, MA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083899750","display_name":"Raul C. Camacho","orcid":"https://orcid.org/0000-0001-6872-8135","observed_orcids":["https://orcid.org/0000-0001-6872-8135"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raul Camacho","raw_affiliation_strings":["Janssen Research and Development LLC, Spring House, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research and Development LLC, Spring House, PA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077932455","display_name":"Fuyong Du","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fuyong Du","raw_affiliation_strings":["Janssen Research and Development LLC, Spring House, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research and Development LLC, Spring House, PA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Li-Jun Ma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li-Jun Ma","raw_affiliation_strings":["Janssen Research and Development LLC, Spring House, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research and Development LLC, Spring House, PA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047669059","display_name":"George Ho","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George Ho","raw_affiliation_strings":["Janssen Research and Development LLC, Spring House, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research and Development LLC, Spring House, PA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108617492","display_name":"Jianying Liu","orcid":"https://orcid.org/0009-0008-7414-6754","observed_orcids":["https://orcid.org/0009-0008-7414-6754","https://orcid.org/0009-0004-8939-8023"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianying Liu","raw_affiliation_strings":["Janssen Research and Development LLC, Spring House, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research and Development LLC, Spring House, PA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qiu Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qiu Li","raw_affiliation_strings":["Janssen Research and Development LLC, Spring House, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research and Development LLC, Spring House, PA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111810290","display_name":"Kamal A. Albarazanji","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kamal A. Albarazanji","raw_affiliation_strings":["Janssen Research and Development LLC, Spring House, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research and Development LLC, Spring House, PA;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004872611","display_name":"Jeramie D. Watrous","orcid":"https://orcid.org/0000-0001-9124-6783","observed_orcids":["https://orcid.org/0000-0001-9124-6783"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeramie Watrous","raw_affiliation_strings":["Sapient Bioanalytics, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sapient Bioanalytics, San Diego, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100697963","display_name":"Tao Long","orcid":"https://orcid.org/0000-0002-2347-2807","observed_orcids":["https://orcid.org/0000-0002-2347-2807"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tao Long","raw_affiliation_strings":["Sapient Bioanalytics, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sapient Bioanalytics, San Diego, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030535593","display_name":"Mo Jain","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mo Jain","raw_affiliation_strings":["Sapient Bioanalytics, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sapient Bioanalytics, San Diego, CA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081029309","display_name":"Andrea R. Nawrocki","orcid":"https://orcid.org/0000-0003-1348-3999","observed_orcids":["https://orcid.org/0000-0003-1348-3999"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea R. Nawrocki","raw_affiliation_strings":["Janssen Research and Development LLC, Spring House, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research and Development LLC, Spring House, PA;","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025511627","display_name":"Dermot F. Reilly","orcid":"https://orcid.org/0000-0002-9456-1364","observed_orcids":["https://orcid.org/0000-0002-9456-1364"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dermot F. Reilly","raw_affiliation_strings":["Janssen Research and Development LLC, Boston, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen Research and Development LLC, Boston, MA;","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"11S","first_page":"773","last_page":"773"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9399999976158142},{"id":"https://openalex.org/keywords/renal-function-decline","display_name":"renal function decline","score":0.6079999804496765},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.75},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9229999780654907},{"id":"https://openalex.org/keywords/uremic-toxins","display_name":"uremic toxins","score":0.7289999723434448},{"id":"https://openalex.org/keywords/gut-microbiota-metabolites","display_name":"gut microbiota metabolites","score":0.8899999856948853},{"id":"https://openalex.org/keywords/serum-creatinine","display_name":"serum creatinine","score":0.6949999928474426},{"id":"https://openalex.org/keywords/zsf1-rats","display_name":"ZSF1 rats","score":0.7390000224113464},{"id":"https://openalex.org/keywords/unilateral-nephrectomy","display_name":"unilateral nephrectomy","score":0.7519999742507935},{"id":"https://openalex.org/keywords/metabolomics","display_name":"metabolomics","score":0.5109999775886536},{"id":"https://openalex.org/keywords/glomerular-filtration-barrier","display_name":"glomerular filtration barrier","score":0.6620000004768372},{"id":"https://openalex.org/keywords/chronic-kidney-disease-progression","display_name":"chronic kidney disease progression","score":0.7160000205039978},{"id":"https://openalex.org/keywords/neutrophil-gelatinase-associated-lipocalin","display_name":"neutrophil gelatinase-associated lipocalin","score":0.6050000190734863},{"id":"https://openalex.org/keywords/kim-1","display_name":"KIM-1","score":0.9269999861717224},{"id":"https://openalex.org/keywords/glomerular-filtration-rate-decline","display_name":"glomerular filtration rate decline","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.7139865756034851},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5562639832496643},{"id":"https://openalex.org/C2780115458","wikidata":"https://www.wikidata.org/wiki/Q419311","display_name":"Sialic acid","level":2,"score":0.5295708179473877},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.46135565638542175},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4365057051181793},{"id":"https://openalex.org/C54847362","wikidata":"https://www.wikidata.org/wiki/Q177635","display_name":"Nephrology","level":2,"score":0.4298703670501709},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4189894199371338},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.41577261686325073},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.4107230603694916},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4091324806213379},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.21760889887809753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12980860471725464},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10366106033325195},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.07199209928512573}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20233411s1773b","doi":"https://doi.org/10.1681/asn.20233411s1773b","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20233411s1773b","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3210328570","https://openalex.org/W4412053363","https://openalex.org/W7140079972","https://openalex.org/W2385748700","https://openalex.org/W4415475930","https://openalex.org/W7207795024","https://openalex.org/W1981062611","https://openalex.org/W4407363092","https://openalex.org/W4389839638","https://openalex.org/W4416876077"],"abstract_inverted_index":{"Background:":[0],"Acute":[1],"kidney":[2,126],"injury":[3,62,127],"(AKI)":[4],"occurs":[5],"in":[6,18,135,156,165,212,257,269,272,277,282,286,296,303],"approximately":[7],"10-15%":[8],"of":[9,16,99,163,170,181,195,200,216,233,242,292],"hospitalized":[10],"patients":[11],"leading":[12],"to":[13,110,113,315],"high":[14,66],"degree":[15],"mortality":[17],"clinic":[19],"and":[20,29,36,54,77,96,130,132,142,179,190,209,224,235,259,280,289,318],"is":[21],"a":[22,133,157,322],"major":[23],"risk":[24],"factor":[25],"for":[26,306,325],"CKD":[27],"development":[28],"progression.":[30],"Novel":[31],"biomarkers":[32],"could":[33,319],"improve":[34],"diagnosis":[35,327],"help":[37],"define":[38],"molecular":[39],"pathways":[40],"associated":[41],"with":[42,192,238,263],"AKI.":[43,293],"Methods:":[44],"Untargeted":[45],"metabolomics":[46,178],"was":[47,118],"performed":[48],"on":[49,188],"plasma":[50,122,239,251,264],"samples":[51],"from":[52,71,176],"rat":[53,274],"mouse":[55,278],"AKI":[56,111,117,164,208,234,258,326],"models":[57,215,232,291,305],"induced":[58,310],"by":[59,120,147],"ischemia":[60],"reperfusion":[61],"(IRI)":[63],"using":[64,88,246],"Rapidfire":[65],"throughput":[67],"LC-MS":[68,248],"technology.":[69],"Samples":[70],"lean":[72,78,114],"Sprague":[73],"Dawley":[74],"(SD)":[75],"rats,":[76],"C57Bl/6J":[79],"mice":[80],"were":[81,145,153,174,183,227],"collected":[82],"24":[83],"hours":[84],"after":[85],"IRI":[86,288,307],"surgery":[87],"bilateral":[89],"clamping.":[90],"We":[91],"also":[92,154],"developed":[93],"an":[94],"obese":[95,103],"diabetic":[97],"model":[98,162],"IRI,":[100,275,279,284],"uninephrectomized":[101],"(Unx)":[102],"ZSF1":[104,115],"rats":[105],"which":[106],"are":[107,254],"more":[108],"susceptible":[109],"compared":[112],"rats.":[116],"confirmed":[119,249],"increased":[121,125,229,256],"Creatinine":[123],"(pCr),":[124],"markers":[128],"(KIM-1":[129],"NGAL)":[131],"decline":[134],"Glomerular":[136],"Filtration":[137],"Rate.":[138],"Plasma":[139],"sialic":[140,225,244,252,299],"acids":[141,152,226,253],"creatinine":[143,265],"levels":[144],"validated":[146],"targeted":[148,247],"LC-MS/MS":[149],"methods.":[150],"Sialic":[151],"measured":[155],"Cecal":[158],"slurry":[159],"(CS)-induced":[160],"Sepsis":[161],"mice.":[166],"Results:":[167],"A":[168],"total":[169],"20,472":[171],"spectral":[172],"features":[173],"extracted":[175],"untargeted":[177],"123":[180],"them":[182],"assigned":[184],"putative":[185],"annotations":[186],"based":[187],"m/z":[189],"RT":[191],"the":[193,201],"library":[194],"standards.":[196],"Principal":[197],"component":[198],"analysis":[199],"annotated":[202],"metabolites":[203],"showed":[204],"distinct":[205],"separation":[206],"between":[207],"control":[210],"groups":[211],"all":[213,231],"3":[214],"IRI.":[217],"Several":[218],"gut-microbiome":[219],"derived":[220],"metabolites,":[221],"uremic":[222],"toxins":[223],"significantly":[228,255],"across":[230],"correlated":[236,261],"highly":[237],"creatinine.":[240],"Validation":[241],"free":[243,298],"acid":[245],"that":[250],"strongly":[260],"positively":[262],"(Pearson":[266],"r2:":[267],"0.95":[268],"CS,":[270],"0.91":[271],"SD":[273],"0.77":[276],"0.60":[281],"ZSF":[283],"p<0.0001)":[285],"both":[287],"sepsis":[290,309],"Conclusions:":[294],"Increases":[295],"circulating":[297],"acid,":[300],"consistently":[301],"observed":[302],"preclinical":[304],"or":[308],"AKI,":[311],"may":[312],"be":[313],"due":[314],"impaired":[316],"filtration":[317],"serve":[320],"as":[321],"surrogate":[323],"marker":[324]},"counts_by_year":[],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2024-05-19T00:00:00"}