{"id":"https://openalex.org/W4397043592","doi":"https://doi.org/10.1681/asn.20233411s1887c","title":"Cardiac Autonomic Innervation Is Decreased in Postmortem Tissue from Individuals with ESKD Compared with Those Without","display_name":"Cardiac Autonomic Innervation Is Decreased in Postmortem Tissue from Individuals with ESKD Compared with Those Without","publication_year":2023,"publication_date":"2023-11-01","ids":{"openalex":"https://openalex.org/W4397043592","doi":"https://doi.org/10.1681/asn.20233411s1887c"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20233411s1887c","doi":"https://doi.org/10.1681/asn.20233411s1887c","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20233411s1887c","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068654861","display_name":"Qandeel H. Soomro","orcid":"https://orcid.org/0000-0002-3182-7225","observed_orcids":["https://orcid.org/0000-0002-3182-7225"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qandeel H. Soomro","raw_affiliation_strings":["New York University Grossman School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University Grossman School of Medicine, New York, NY","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068456606","display_name":"Valeria Mezzano","orcid":"https://orcid.org/0000-0003-4675-9146","observed_orcids":["https://orcid.org/0000-0003-4675-9146"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valeria Mezzano","raw_affiliation_strings":["New York University Grossman School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University Grossman School of Medicine, New York, NY","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043435343","display_name":"Navneet Narula","orcid":"https://orcid.org/0000-0002-6832-3645","observed_orcids":["https://orcid.org/0000-0002-6832-3645","https://orcid.org/0009-0001-2133-5884"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Navneet Narula","raw_affiliation_strings":["New York University Grossman School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University Grossman School of Medicine, New York, NY","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088394454","display_name":"David M. Charytan","orcid":"https://orcid.org/0000-0002-7695-3583","observed_orcids":["https://orcid.org/0000-0002-7695-3583"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Charytan","raw_affiliation_strings":["New York University Grossman School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University Grossman School of Medicine, New York, NY","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I57206974"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"11S","first_page":"887","last_page":"887"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.7705000042915344,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.7705000042915344,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.10679999738931656,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.03220000118017197,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cardiac-autonomic-innervation","display_name":"cardiac autonomic innervation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cardiac-sympathetic-nerves","display_name":"cardiac sympathetic nerves","score":0.6769999861717224},{"id":"https://openalex.org/keywords/cardiac-denervation","display_name":"cardiac denervation","score":0.5730000138282776},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.7630000114440918},{"id":"https://openalex.org/keywords/s100-immunohistochemistry","display_name":"S-100 immunohistochemistry","score":0.7739999890327454},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/endocardium","display_name":"endocardium","score":0.6549999713897705},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.7319999933242798},{"id":"https://openalex.org/keywords/left-ventricle","display_name":"left ventricle","score":0.6290000081062317},{"id":"https://openalex.org/keywords/arrhythmia-risk","display_name":"arrhythmia risk","score":0.6489999890327454},{"id":"https://openalex.org/keywords/endocardial-fibrosis","display_name":"endocardial fibrosis","score":0.4580000042915344},{"id":"https://openalex.org/keywords/myocardial-stunning","display_name":"myocardial stunning","score":0.35600000619888306}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5232576131820679},{"id":"https://openalex.org/C2777372248","wikidata":"https://www.wikidata.org/wiki/Q171064","display_name":"Autonomic nervous system","level":4,"score":0.5210820436477661},{"id":"https://openalex.org/C2993386320","wikidata":"https://www.wikidata.org/wiki/Q187215","display_name":"Sympathetic innervation","level":2,"score":0.46655458211898804},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4599669575691223},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.42202654480934143},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.13880515098571777},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.12429040670394897}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20233411s1887c","doi":"https://doi.org/10.1681/asn.20233411s1887c","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20233411s1887c","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2029265693","https://openalex.org/W1991157130","https://openalex.org/W2104500081","https://openalex.org/W4220688709","https://openalex.org/W2145168941","https://openalex.org/W2982144371","https://openalex.org/W7140348956","https://openalex.org/W7055454140","https://openalex.org/W1656503255","https://openalex.org/W3149770288"],"abstract_inverted_index":{"Background:":[0],"Cardiac":[1],"innervation":[2,23,289,300],"changes":[3,20],"can":[4],"lead":[5],"to":[6,201,297,307],"an":[7],"imbalance":[8],"in":[9,16,21,28,79,113,141,148,155,161,185,198,205,224,228,239,243,274,291,302],"neural":[10],"activation":[11],"and":[12,32,38,53,60,64,88,99,105,117,144,212,270,287,304,317,328],"arrhythmias.":[13],"Although":[14],"described":[15],"other":[17],"disease":[18,171],"states,":[19],"cardiac":[22,299],"have":[24],"not":[25,264],"been":[26],"studied":[27],"ESKD.":[29,292],"Methods:":[30],"Age":[31],"DM":[33,145],"matched":[34],"cases":[35],"with":[36,173,241,266],"ESKD":[37,41,132,157,166,199,242,303],"controls":[39,65,135],"without":[40,76],"(10/group)":[42],"who":[43],"underwent":[44],"autopsy":[45,59],"at":[46],"NYU-affiliated":[47],"hospitals":[48],"(2012-2020)":[49],"were":[50,66,107,153],"identified.":[51],"Demographic":[52],"CV":[54],"history":[55],"was":[56,146,196,222,237,263],"collected":[57],"from":[58],"medical":[61],"records.":[62],"Case":[63],"selected":[67],"based":[68],"on":[69],"availability":[70],"of":[71,82,111,175,180,276],"LV":[72],"anterior":[73],"wall":[74],"sections":[75],"extensive":[77],"fibrosis":[78,106,127],"the":[80,114,156,162,206,229,322],"area":[81,262],"interest.":[83],"We":[84],"performed":[85],"H&E":[86],"staining,":[87],"immunohistochemistry":[89],"for":[90,102,259,271,280],"S100":[91,203,315],"(all":[92],"nerves),":[93],"Tyrosine":[94],"hydroxylase":[95],"(TH,":[96],"sympathetic":[97,272,288],"nerves)":[98,273],"trichrome":[100],"staining":[101],"fibrosis.":[103],"Staining":[104],"quantified":[108],"within":[109],"regions":[110,245,275,330],"interest":[112,277],"epi-,":[115],"mid-":[116],"endocardial":[118,213,230],"\u2153":[119],"as":[120],"density":[121,195,204,221,268,286,321],"per":[122],"mm2":[123],"(primary":[124],"outcome)":[125],"or":[126],"%.":[128],"Results:":[129],"Mean":[130],"age:":[131],"66.7":[133],"vs.":[134,159,172,209,215,233,248,252,255],"65.6":[136],"y,":[137],"sex:":[138],"50%":[139],"female":[140],"both":[142,149],"groups":[143],"(80%":[147],"groups),":[150],"whereas":[151],"60%":[152],"Black":[154],"group":[158],"40%":[160],"control":[163],"group.":[164],"All":[165],"patients":[167],"had":[168],"ischemic":[169],"heart":[170],"30%":[174,187],"controls.":[176],"Most":[177],"common":[178],"cause":[179],"death:":[181],"myocardial":[182],"infarction":[183],"(50%":[184],"ESKD,":[186],"controls)":[188],"followed":[189],"by":[190],"pump":[191],"failure.":[192],"Overall":[193],"nerve":[194,220,267,285,320],"lower":[197,223],"compared":[200],"controls:":[202],"mid":[207,326],"(63.97/mm2":[208],"106.7/mm2,":[210],"P=0.04)":[211],"(62.6/mm2":[214],"203.2/mm2,":[216],"P=0.003)":[217],"thirds.":[218],"Sympathetic":[219],"dual-stained":[225],"sections,":[226],"particularly":[227],"region":[231,324],"(65.9/mm2":[232],"180.6/mm2,":[234],"P=0.002).":[235],"Fibrosis":[236],"higher":[238],"those":[240],"all":[244],"(epi=":[246],"0.009":[247],"0.005,":[249],"mid=":[250],"0.024":[251],"0.006,":[253,256],"endo=0.033":[254],"P=":[257],"<0.05":[258],"all).":[260,281],"Fibrotic":[261],"correlated":[265],"(overall":[269],"(P>":[278],"0.05":[279],"Conclusions:":[282],"Reduced":[283],"overall":[284],"observed":[290],"Further":[293],"studies":[294],"are":[295],"needed":[296],"evaluate":[298],"patterns":[301],"its":[305],"link":[306],"arrhythmia.":[308],"Funding:":[309],"Private":[310],"Foundation":[311],"SupportFigure::":[312],"Top":[313],"panel":[314],"positive":[316,319],"dual":[318],"sub-epicardial":[323],"(a,d),":[325],"(b,e)":[327],"sub-endocardial":[329],"(c,f)":[331]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2024-05-19T00:00:00"}
