{"id":"https://openalex.org/W4397040920","doi":"https://doi.org/10.1681/asn.20233411s1603c","title":"Molecular Similarity Between Chronic Active Antibody-Mediated Rejection (CA-ABMR) and Acute T Cell-Mediated Rejection (TCMR) of Human Kidney Allografts","display_name":"Molecular Similarity Between Chronic Active Antibody-Mediated Rejection (CA-ABMR) and Acute T Cell-Mediated Rejection (TCMR) of Human Kidney Allografts","publication_year":2023,"publication_date":"2023-11-01","ids":{"openalex":"https://openalex.org/W4397040920","doi":"https://doi.org/10.1681/asn.20233411s1603c"},"language":"en","primary_location":{"id":"doi:10.1681/asn.20233411s1603c","doi":"https://doi.org/10.1681/asn.20233411s1603c","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20233411s1603c","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043366355","display_name":"Yajas Shah","orcid":"https://orcid.org/0000-0002-9692-4878","observed_orcids":["https://orcid.org/0000-0002-9692-4878"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yajas Shah","raw_affiliation_strings":["Weill Cornell Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medicine, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037032270","display_name":"Carol Y. Li","orcid":"https://orcid.org/0000-0002-0576-2181","observed_orcids":["https://orcid.org/0000-0002-0576-2181"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol Y. Li","raw_affiliation_strings":["Weill Cornell Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medicine, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101356260","display_name":"Sheavonnie Wright","orcid":"https://orcid.org/0009-0004-9482-7398","observed_orcids":["https://orcid.org/0009-0004-9482-7398"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheavonnie Wright","raw_affiliation_strings":["Weill Cornell Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medicine, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109717957","display_name":"Alex Devito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Devito","raw_affiliation_strings":["Weill Cornell Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medicine, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102974111","display_name":"Thalia Salinas","orcid":"https://orcid.org/0000-0003-1909-4011","observed_orcids":["https://orcid.org/0000-0003-1909-4011"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thalia Salinas","raw_affiliation_strings":["Weill Cornell Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medicine, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073289319","display_name":"Steven Salvatore","orcid":"https://orcid.org/0000-0001-7237-2696","observed_orcids":["https://orcid.org/0000-0001-7237-2696"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Salvatore","raw_affiliation_strings":["Weill Cornell Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medicine, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036989582","display_name":"Deirdre L. Sawinski","orcid":"https://orcid.org/0000-0001-7903-8295","observed_orcids":["https://orcid.org/0000-0001-7903-8295"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deirdre L. Sawinski","raw_affiliation_strings":["Weill Cornell Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medicine, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068404213","display_name":"Darshana M. Dadhania","orcid":"https://orcid.org/0000-0002-7973-1521","observed_orcids":["https://orcid.org/0000-0002-7973-1521"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darshana M. Dadhania","raw_affiliation_strings":["Weill Cornell Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medicine, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071939353","display_name":"Surya V. Seshan","orcid":"https://orcid.org/0000-0003-4384-0694","observed_orcids":["https://orcid.org/0000-0003-4384-0694"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Surya V. Seshan","raw_affiliation_strings":["Weill Cornell Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medicine, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073533672","display_name":"Manikkam Suthanthiran","orcid":"https://orcid.org/0000-0001-6894-0486","observed_orcids":["https://orcid.org/0000-0001-6894-0486"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manikkam Suthanthiran","raw_affiliation_strings":["Weill Cornell Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medicine, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009885369","display_name":"Thangamani Muthukumar","orcid":"https://orcid.org/0000-0002-0294-6209","observed_orcids":["https://orcid.org/0000-0002-0294-6209"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thangamani Muthukumar","raw_affiliation_strings":["Weill Cornell Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medicine, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4387153466"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"11S","first_page":"603","last_page":"603"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-active-antibody-mediated-rejection","display_name":"chronic active antibody-mediated rejection","score":0.9139999747276306},{"id":"https://openalex.org/keywords/acute-cellular-rejection","display_name":"acute cellular rejection","score":0.9200000166893005},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/allograft-rejection","display_name":"allograft rejection","score":0.824999988079071},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.7110000252723694},{"id":"https://openalex.org/keywords/immune-cell-deconvolution","display_name":"immune cell deconvolution","score":0.8790000081062317},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8399999737739563},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.9200000166893005},{"id":"https://openalex.org/keywords/surveillance-biopsy","display_name":"surveillance biopsy","score":0.5979999899864197},{"id":"https://openalex.org/keywords/transcriptomic-biomarkers","display_name":"transcriptomic biomarkers","score":0.47999998927116394},{"id":"https://openalex.org/keywords/rejection-diagnosis","display_name":"rejection diagnosis","score":0.30300000309944153},{"id":"https://openalex.org/keywords/allograft-fibrosis","display_name":"allograft fibrosis","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6783639788627625},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5123111009597778},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5051093697547913},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4688150882720947},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.45341452956199646},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3789866268634796},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.30412018299102783}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.20233411s1603c","doi":"https://doi.org/10.1681/asn.20233411s1603c","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.20233411s1603c","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389117473","https://openalex.org/W4396991307","https://openalex.org/W4391400135","https://openalex.org/W2953800428","https://openalex.org/W2410301821","https://openalex.org/W4225149818","https://openalex.org/W2899041044","https://openalex.org/W4388485170","https://openalex.org/W3048595445","https://openalex.org/W3008451257"],"abstract_inverted_index":{"Background:":[0],"CA-ABMR,":[1,29,63,372],"even":[2],"without":[3],"concomitant":[4],"histological":[5],"TCMR,":[6,65],"is":[7,33],"characterized":[8],"by":[9,35,81],"an":[10,101,354],"increased":[11,121,135],"abundance":[12],"of":[13,38,51,185,196,219,280,303,318,368,371,381],"NK":[14,147,252,385],"Cells":[15],"and":[16,69,96,122,127,136,142,146,154,158,167,203,207,215,226,235,251,345,349,384],"T":[17,145,249,382],"cells.":[18],"We":[19,48,85],"RNA-sequenced":[20],"kidney":[21,56],"allograft":[22,259,286],"biopsies":[23,53,61,72,77,129,169,209,230],"to":[24,45,248,313],"test":[25],"the":[26,36,150,189,243,258,266,272,285,292,304,319,369,378],"hypothesis":[27],"that":[28,42,175,358],"but":[30],"not":[31,239,288],"active-ABMR,":[32],"exemplified":[34],"overexpression":[37],"key":[39],"gene":[40,162],"sets":[41],"are":[43],"similar":[44,183],"TCMR.":[46],"Methods:":[47],"did":[49],"RNA-seq":[50],"57":[52,55],"from":[54,89,205,347],"transplant":[57,83],"recipients;":[58],"39":[59],"for-cause":[60],"(15":[62],"17":[64],"&":[66,131],"7":[67],"active-ABMR),":[68],"18":[70],"surveillance":[71],"(no":[73],"rejection":[74,191,260,294,306],"[NR]).":[75],"All":[76],"were":[78,118,134,138,149,246],"evaluated":[79],"independently":[80],"two":[82,334],"pathologists.":[84],"isolated":[86],"total":[87,267,281,297],"RNA":[88],"stored":[90],"biopsy":[91,331],"samples,":[92],"prepared":[93],"cDNA":[94],"libraries,":[95],"sequenced":[97],"pooled":[98],"libraries":[99],"on":[100,338],"Illumina":[102],"sequencer.":[103],"After":[104],"appropriate":[105],"quality":[106],"checks,":[107],"we":[108],"used":[109],"standard":[110],"bioinformatic":[111],"tools":[112],"for":[113,377],"data":[114],"analysis.":[115],"Results:":[116],"There":[117],"1425":[119],"genes":[120,245],"29":[123],"reduced":[124,139],"between":[125,140,165],"CA-ABMR":[126,157,166,202,220,234,344,352],"NR":[128,143,208,222,229,350],"(FC\u22652":[130],"P-FDR<0.05);":[132],"1829":[133],"164":[137],"TCMR":[141,159,168,204,227,236,346,360],"biopsies.":[144,361],"cells":[148,187,250,283,383,386],"top":[151],"cell":[152,199,213,269,299,322,341],"types":[153],"pathways":[155],"in":[156,188,240,271,284,301,387],"(Fig.1).":[160],"Differential":[161],"expression":[163],"analysis":[164,195,218,317],"yielded":[170],"only":[171],"one":[172],"gene,":[173],"MARCHF4,":[174],"was":[176,287,308],"significantly":[177],"different.":[178],"Cellular":[179],"deconvolution":[180],"revealed":[181],"a":[182,330,374],"proportion":[184,270,279,300],"immune":[186,198,268,282,298,321,340,355],"three":[190,293,305],"categories;":[192],"principal":[193,335],"component":[194,316],"deconvolved":[197,320,339],"transcriptomes":[200,323],"separated":[201,343],"active-ABMR":[206,241],"(Fig.2).Figure":[210],"1::":[211],"PanglaoDB":[212],"type":[214],"KEGG":[216],"pathway":[217],"versus":[221,228],"biopsics":[223],"(left":[224,276],"panel)":[225,325],"(right":[231,324],"panel).":[232,277],"In":[233],"biopsics,":[237],"bat":[238],"biopsies,":[242],"enriched":[244],"linked":[247],"cells,":[253],"as":[254,256],"well":[255],"with":[257],"pathway.Figure":[261],"2::":[262],"Violin":[263],"plots":[264],"depiet":[265],"four":[273],"diagnostic":[274],"categories":[275,307],"The":[278,296,333],"significanly":[289],"different":[290,310],"among":[291],"categories.":[295],"each":[302],"significanlt":[309],"when":[311],"compared":[312],"NR.":[314],"Principal":[315],"Each":[326],"colored":[327],"dot":[328],"represents":[329],"sample.":[332],"components,":[336],"based":[337],"transcriptomes,":[342],"ABMR":[348],"biopsies.Conclusions:":[351],"exhibits":[353],"transcriptome":[356],"profile":[357],"resembles":[359],"Our":[362],"findings,":[363],"besides":[364],"advancing":[365],"our":[366],"knowledge":[367],"pathogenesis":[370],"provide":[373],"compelling":[375],"argument":[376],"pharmacological":[379],"targeting":[380],"CA-ABMR.":[388],"Funding:":[389],"Other":[390],"NIH":[391],"Support":[392],"-":[393],"NIAID":[394]},"counts_by_year":[],"updated_date":"2026-09-22T17:25:34.749102","created_date":"2024-05-19T00:00:00"}
